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Q8CJ69

- BMPER_MOUSE

UniProt

Q8CJ69 - BMPER_MOUSE

Protein

BMP-binding endothelial regulator protein

Gene

Bmper

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: Ensembl
    2. endothelial cell activation Source: Ensembl
    3. inner ear development Source: MGI
    4. negative regulation of BMP signaling pathway Source: MGI
    5. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    6. regulation of endothelial cell migration Source: Ensembl
    7. regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    8. ureteric bud development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BMP-binding endothelial regulator protein
    Alternative name(s):
    Bone morphogenetic protein-binding endothelial cell precursor-derived regulator
    Protein crossveinless-2
    Short name:
    mCV2
    Gene namesi
    Name:Bmper
    Synonyms:Cv2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1920480. Bmper.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Chaini40 – 685646BMP-binding endothelial regulator proteinPRO_0000020821Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8CJ69.

    PTM databases

    PhosphoSiteiQ8CJ69.

    Miscellaneous databases

    PMAP-CutDBQ8CJ69.

    Expressioni

    Developmental stagei

    At E9<.0 day, expressed in the ventral tail bud and also in the closing anterior neuropore and in the roof of the neural tube, at E10.5, also expressed in mesonephric ridge.1 Publication

    Gene expression databases

    BgeeiQ8CJ69.
    CleanExiMM_BMPER.
    GenevestigatoriQ8CJ69.

    Interactioni

    Subunit structurei

    Interacts with BMP4.1 Publication

    Protein-protein interaction databases

    BioGridi215850. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CJ69.
    SMRiQ8CJ69. Positions 42-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 10556VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini108 – 16356VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini164 – 22562VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini238 – 28952VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini299 – 35860VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini363 – 574212VWFDPROSITE-ProRule annotationAdd
    BLAST
    Domaini629 – 68254TILAdd
    BLAST

    Sequence similaritiesi

    Contains 5 VWFC domains.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG283828.
    GeneTreeiENSGT00730000110288.
    HOGENOMiHOG000234284.
    HOVERGENiHBG050704.
    InParanoidiQ8CJ69.
    OMAiEFCNRPQ.
    OrthoDBiEOG7G7KNN.
    PhylomeDBiQ8CJ69.
    TreeFamiTF343473.

    Family and domain databases

    InterProiIPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 1 hit.
    PF01826. TIL. 1 hit.
    PF00093. VWC. 2 hits.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00832. C8. 1 hit.
    SM00214. VWC. 5 hits.
    SM00216. VWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 1 hit.
    PROSITEiPS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CJ69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWFFSVRAL AERPCRRSPG ITCCVLLLLN CSGVPMSLAS SFLTGSVAKC    50
    ENEGEVLQIP FITDNPCIMC VCLNKEVTCK REKCPVLSRD CALAIKQRGA 100
    CCERCKGCTH EGRTYNSSFK WQTPAEPCVL RQCQEGVVTE SEVRCVVHCK 150
    NPAEHQGACC PTCPGCVFEG VQYREGEEFQ PEGNKCITCS CVGGRTQCVR 200
    EVCPILSCPQ HLSHTPSGQC CPKCLGQRKV FDLPFGSCLF RSDVYDNGAS 250
    FVYDNCTVCT CKDSTMVCKK KCSHPGVCNS DEDACCEDCL LRVPPEDIKV 300
    CKFGSKIFRD GEMWSSVNCS ICACVKGKTE CRKKQCVPVS SCPQGKILNR 350
    KGCCPICTEK PGVCTVFGDP HYNTFDGRTF NFQGTCQYVL TKDCSSPASP 400
    FQVLVKNDAR RTRSFSWTKS VELMLGESTV SLQQHLTVRW NGSRIALPCH 450
    TPHFHIDLDG YLLKVTTRAG LEISWDGDSF VEVMAAPHLK GKLCGLCGNY 500
    NGHKRDDLIG GDGNFKFDVD DFAESWRVES NEFCNRPQRK PVPELCQGTV 550
    KVKLRAHREC QKLKSWEFQT CHSTVDYTTF YRSCVTDMCE CPVHKNCYCE 600
    SFLAYTRACQ REGIKVHWEP QQSCAATQCK HGAVYDTCGP GCVKTCDNWN 650
    EIGPCNKPCI AGCHCPANLV LHKGRCIKPV LCPQR 685
    Length:685
    Mass (Da):76,148
    Last modified:March 1, 2003 - v1
    Checksum:i4FF98D53E2C57656
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1511N → K in AAH66153. (PubMed:15489334)Curated
    Sequence conflicti224 – 23512CLGQR…FDLPF → MFGSEKSIRPSL in BAB29213. (PubMed:16141072)CuratedAdd
    BLAST
    Sequence conflicti350 – 3501R → G in AAP88382. (PubMed:12897139)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454954 mRNA. Translation: AAN45857.1.
    AY263358 mRNA. Translation: AAP88382.1.
    BC042718 mRNA. Translation: AAH42718.1.
    BC066153 mRNA. Translation: AAH66153.1.
    AK014221 mRNA. Translation: BAB29213.1.
    CCDSiCCDS22929.1.
    RefSeqiNP_082748.1. NM_028472.2.
    UniGeneiMm.335020.

    Genome annotation databases

    EnsembliENSMUST00000071982; ENSMUSP00000071872; ENSMUSG00000031963.
    GeneIDi73230.
    KEGGimmu:73230.
    UCSCiuc009oow.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454954 mRNA. Translation: AAN45857.1 .
    AY263358 mRNA. Translation: AAP88382.1 .
    BC042718 mRNA. Translation: AAH42718.1 .
    BC066153 mRNA. Translation: AAH66153.1 .
    AK014221 mRNA. Translation: BAB29213.1 .
    CCDSi CCDS22929.1.
    RefSeqi NP_082748.1. NM_028472.2.
    UniGenei Mm.335020.

    3D structure databases

    ProteinModelPortali Q8CJ69.
    SMRi Q8CJ69. Positions 42-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 215850. 1 interaction.

    PTM databases

    PhosphoSitei Q8CJ69.

    Proteomic databases

    PRIDEi Q8CJ69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071982 ; ENSMUSP00000071872 ; ENSMUSG00000031963 .
    GeneIDi 73230.
    KEGGi mmu:73230.
    UCSCi uc009oow.1. mouse.

    Organism-specific databases

    CTDi 168667.
    MGIi MGI:1920480. Bmper.

    Phylogenomic databases

    eggNOGi NOG283828.
    GeneTreei ENSGT00730000110288.
    HOGENOMi HOG000234284.
    HOVERGENi HBG050704.
    InParanoidi Q8CJ69.
    OMAi EFCNRPQ.
    OrthoDBi EOG7G7KNN.
    PhylomeDBi Q8CJ69.
    TreeFami TF343473.

    Miscellaneous databases

    NextBioi 337713.
    PMAP-CutDB Q8CJ69.
    PROi Q8CJ69.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CJ69.
    CleanExi MM_BMPER.
    Genevestigatori Q8CJ69.

    Family and domain databases

    InterProi IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 1 hit.
    PF01826. TIL. 1 hit.
    PF00093. VWC. 2 hits.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00832. C8. 1 hit.
    SM00214. VWC. 5 hits.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 1 hit.
    PROSITEi PS01208. VWFC_1. 3 hits.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling."
      Coffinier C., Ketpura N., Tran U., Geissert D., De Robertis E.M.
      Mech. Dev. 119:S179-S184(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
      Strain: C57BL/6J.
    2. "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation."
      Moser M., Binder O., Wu Y., Aitsebaomo J., Ren R., Bode C., Bautch V.L., Conlon F.L., Patterson C.
      Mol. Cell. Biol. 23:5664-5679(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH BMP4.
      Strain: Swiss Webster.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CD-1.
      Tissue: Mammary tumor and Neural stem cell.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 224-685.
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry nameiBMPER_MOUSE
    AccessioniPrimary (citable) accession number: Q8CJ69
    Secondary accession number(s): Q7TN57, Q80UZ1, Q9CXM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3