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Q8CJ69

- BMPER_MOUSE

UniProt

Q8CJ69 - BMPER_MOUSE

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Protein

BMP-binding endothelial regulator protein

Gene

Bmper

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.By similarity

GO - Biological processi

  1. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: Ensembl
  2. endothelial cell activation Source: Ensembl
  3. inner ear development Source: MGI
  4. negative regulation of BMP signaling pathway Source: MGI
  5. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  6. regulation of endothelial cell migration Source: Ensembl
  7. regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  8. ureteric bud development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BMP-binding endothelial regulator protein
Alternative name(s):
Bone morphogenetic protein-binding endothelial cell precursor-derived regulator
Protein crossveinless-2
Short name:
mCV2
Gene namesi
Name:Bmper
Synonyms:Cv2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1920480. Bmper.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 685646BMP-binding endothelial regulator proteinPRO_0000020821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8CJ69.

PTM databases

PhosphoSiteiQ8CJ69.

Miscellaneous databases

PMAP-CutDBQ8CJ69.

Expressioni

Developmental stagei

At E9<.0 day, expressed in the ventral tail bud and also in the closing anterior neuropore and in the roof of the neural tube, at E10.5, also expressed in mesonephric ridge.1 Publication

Gene expression databases

BgeeiQ8CJ69.
CleanExiMM_BMPER.
GenevestigatoriQ8CJ69.

Interactioni

Subunit structurei

Interacts with BMP4.1 Publication

Protein-protein interaction databases

BioGridi215850. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ69.
SMRiQ8CJ69. Positions 42-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 10556VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini108 – 16356VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini164 – 22562VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini238 – 28952VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini299 – 35860VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini363 – 574212VWFDPROSITE-ProRule annotationAdd
BLAST
Domaini629 – 68254TILAdd
BLAST

Sequence similaritiesi

Contains 5 VWFC domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG283828.
GeneTreeiENSGT00760000118896.
HOGENOMiHOG000234284.
HOVERGENiHBG050704.
InParanoidiQ8CJ69.
OMAiEFCNRPQ.
OrthoDBiEOG7G7KNN.
PhylomeDBiQ8CJ69.
TreeFamiTF343473.

Family and domain databases

InterProiIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 1 hit.
PF01826. TIL. 1 hit.
PF00093. VWC. 2 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 5 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJ69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWFFSVRAL AERPCRRSPG ITCCVLLLLN CSGVPMSLAS SFLTGSVAKC
60 70 80 90 100
ENEGEVLQIP FITDNPCIMC VCLNKEVTCK REKCPVLSRD CALAIKQRGA
110 120 130 140 150
CCERCKGCTH EGRTYNSSFK WQTPAEPCVL RQCQEGVVTE SEVRCVVHCK
160 170 180 190 200
NPAEHQGACC PTCPGCVFEG VQYREGEEFQ PEGNKCITCS CVGGRTQCVR
210 220 230 240 250
EVCPILSCPQ HLSHTPSGQC CPKCLGQRKV FDLPFGSCLF RSDVYDNGAS
260 270 280 290 300
FVYDNCTVCT CKDSTMVCKK KCSHPGVCNS DEDACCEDCL LRVPPEDIKV
310 320 330 340 350
CKFGSKIFRD GEMWSSVNCS ICACVKGKTE CRKKQCVPVS SCPQGKILNR
360 370 380 390 400
KGCCPICTEK PGVCTVFGDP HYNTFDGRTF NFQGTCQYVL TKDCSSPASP
410 420 430 440 450
FQVLVKNDAR RTRSFSWTKS VELMLGESTV SLQQHLTVRW NGSRIALPCH
460 470 480 490 500
TPHFHIDLDG YLLKVTTRAG LEISWDGDSF VEVMAAPHLK GKLCGLCGNY
510 520 530 540 550
NGHKRDDLIG GDGNFKFDVD DFAESWRVES NEFCNRPQRK PVPELCQGTV
560 570 580 590 600
KVKLRAHREC QKLKSWEFQT CHSTVDYTTF YRSCVTDMCE CPVHKNCYCE
610 620 630 640 650
SFLAYTRACQ REGIKVHWEP QQSCAATQCK HGAVYDTCGP GCVKTCDNWN
660 670 680
EIGPCNKPCI AGCHCPANLV LHKGRCIKPV LCPQR
Length:685
Mass (Da):76,148
Last modified:March 1, 2003 - v1
Checksum:i4FF98D53E2C57656
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511N → K in AAH66153. (PubMed:15489334)Curated
Sequence conflicti224 – 23512CLGQR…FDLPF → MFGSEKSIRPSL in BAB29213. (PubMed:16141072)CuratedAdd
BLAST
Sequence conflicti350 – 3501R → G in AAP88382. (PubMed:12897139)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454954 mRNA. Translation: AAN45857.1.
AY263358 mRNA. Translation: AAP88382.1.
BC042718 mRNA. Translation: AAH42718.1.
BC066153 mRNA. Translation: AAH66153.1.
AK014221 mRNA. Translation: BAB29213.1.
CCDSiCCDS22929.1.
RefSeqiNP_082748.1. NM_028472.2.
UniGeneiMm.335020.

Genome annotation databases

EnsembliENSMUST00000071982; ENSMUSP00000071872; ENSMUSG00000031963.
GeneIDi73230.
KEGGimmu:73230.
UCSCiuc009oow.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454954 mRNA. Translation: AAN45857.1 .
AY263358 mRNA. Translation: AAP88382.1 .
BC042718 mRNA. Translation: AAH42718.1 .
BC066153 mRNA. Translation: AAH66153.1 .
AK014221 mRNA. Translation: BAB29213.1 .
CCDSi CCDS22929.1.
RefSeqi NP_082748.1. NM_028472.2.
UniGenei Mm.335020.

3D structure databases

ProteinModelPortali Q8CJ69.
SMRi Q8CJ69. Positions 42-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 215850. 1 interaction.

PTM databases

PhosphoSitei Q8CJ69.

Proteomic databases

PRIDEi Q8CJ69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071982 ; ENSMUSP00000071872 ; ENSMUSG00000031963 .
GeneIDi 73230.
KEGGi mmu:73230.
UCSCi uc009oow.1. mouse.

Organism-specific databases

CTDi 168667.
MGIi MGI:1920480. Bmper.

Phylogenomic databases

eggNOGi NOG283828.
GeneTreei ENSGT00760000118896.
HOGENOMi HOG000234284.
HOVERGENi HBG050704.
InParanoidi Q8CJ69.
OMAi EFCNRPQ.
OrthoDBi EOG7G7KNN.
PhylomeDBi Q8CJ69.
TreeFami TF343473.

Miscellaneous databases

NextBioi 337713.
PMAP-CutDB Q8CJ69.
PROi Q8CJ69.
SOURCEi Search...

Gene expression databases

Bgeei Q8CJ69.
CleanExi MM_BMPER.
Genevestigatori Q8CJ69.

Family and domain databases

InterProi IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 1 hit.
PF01826. TIL. 1 hit.
PF00093. VWC. 2 hits.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00214. VWC. 5 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 1 hit.
PROSITEi PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling."
    Coffinier C., Ketpura N., Tran U., Geissert D., De Robertis E.M.
    Mech. Dev. 119:S179-S184(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
  2. "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation."
    Moser M., Binder O., Wu Y., Aitsebaomo J., Ren R., Bode C., Bautch V.L., Conlon F.L., Patterson C.
    Mol. Cell. Biol. 23:5664-5679(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH BMP4.
    Strain: Swiss Webster.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CD-1.
    Tissue: Mammary tumor and Neural stem cell.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 224-685.
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiBMPER_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ69
Secondary accession number(s): Q7TN57, Q80UZ1, Q9CXM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3