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Q8CJ69

- BMPER_MOUSE

UniProt

Q8CJ69 - BMPER_MOUSE

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Protein
BMP-binding endothelial regulator protein
Gene
Bmper, Cv2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: Ensembl
  2. endothelial cell activation Source: Ensembl
  3. inner ear development Source: MGI
  4. negative regulation of BMP signaling pathway Source: MGI
  5. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  6. regulation of endothelial cell migration Source: Ensembl
  7. regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  8. ureteric bud development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BMP-binding endothelial regulator protein
Alternative name(s):
Bone morphogenetic protein-binding endothelial cell precursor-derived regulator
Protein crossveinless-2
Short name:
mCV2
Gene namesi
Name:Bmper
Synonyms:Cv2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1920480. Bmper.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939 Reviewed prediction
Add
BLAST
Chaini40 – 685646BMP-binding endothelial regulator protein
PRO_0000020821Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi255 – 2551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi441 – 4411N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8CJ69.

PTM databases

PhosphoSiteiQ8CJ69.

Miscellaneous databases

PMAP-CutDBQ8CJ69.

Expressioni

Developmental stagei

At E9<.0 day, expressed in the ventral tail bud and also in the closing anterior neuropore and in the roof of the neural tube, at E10.5, also expressed in mesonephric ridge.1 Publication

Gene expression databases

BgeeiQ8CJ69.
CleanExiMM_BMPER.
GenevestigatoriQ8CJ69.

Interactioni

Subunit structurei

Interacts with BMP4.1 Publication

Protein-protein interaction databases

BioGridi215850. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ69.
SMRiQ8CJ69. Positions 42-107.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 10556VWFC 1
Add
BLAST
Domaini108 – 16356VWFC 2
Add
BLAST
Domaini164 – 22562VWFC 3
Add
BLAST
Domaini238 – 28952VWFC 4
Add
BLAST
Domaini299 – 35860VWFC 5
Add
BLAST
Domaini363 – 574212VWFD
Add
BLAST
Domaini629 – 68254TIL
Add
BLAST

Sequence similaritiesi

Contains 5 VWFC domains.
Contains 1 VWFD domain.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG283828.
GeneTreeiENSGT00730000110288.
HOGENOMiHOG000234284.
HOVERGENiHBG050704.
InParanoidiQ8CJ69.
OMAiEFCNRPQ.
OrthoDBiEOG7G7KNN.
PhylomeDBiQ8CJ69.
TreeFamiTF343473.

Family and domain databases

InterProiIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 1 hit.
PF01826. TIL. 1 hit.
PF00093. VWC. 2 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 5 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJ69-1 [UniParc]FASTAAdd to Basket

« Hide

MLWFFSVRAL AERPCRRSPG ITCCVLLLLN CSGVPMSLAS SFLTGSVAKC    50
ENEGEVLQIP FITDNPCIMC VCLNKEVTCK REKCPVLSRD CALAIKQRGA 100
CCERCKGCTH EGRTYNSSFK WQTPAEPCVL RQCQEGVVTE SEVRCVVHCK 150
NPAEHQGACC PTCPGCVFEG VQYREGEEFQ PEGNKCITCS CVGGRTQCVR 200
EVCPILSCPQ HLSHTPSGQC CPKCLGQRKV FDLPFGSCLF RSDVYDNGAS 250
FVYDNCTVCT CKDSTMVCKK KCSHPGVCNS DEDACCEDCL LRVPPEDIKV 300
CKFGSKIFRD GEMWSSVNCS ICACVKGKTE CRKKQCVPVS SCPQGKILNR 350
KGCCPICTEK PGVCTVFGDP HYNTFDGRTF NFQGTCQYVL TKDCSSPASP 400
FQVLVKNDAR RTRSFSWTKS VELMLGESTV SLQQHLTVRW NGSRIALPCH 450
TPHFHIDLDG YLLKVTTRAG LEISWDGDSF VEVMAAPHLK GKLCGLCGNY 500
NGHKRDDLIG GDGNFKFDVD DFAESWRVES NEFCNRPQRK PVPELCQGTV 550
KVKLRAHREC QKLKSWEFQT CHSTVDYTTF YRSCVTDMCE CPVHKNCYCE 600
SFLAYTRACQ REGIKVHWEP QQSCAATQCK HGAVYDTCGP GCVKTCDNWN 650
EIGPCNKPCI AGCHCPANLV LHKGRCIKPV LCPQR 685
Length:685
Mass (Da):76,148
Last modified:March 1, 2003 - v1
Checksum:i4FF98D53E2C57656
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511N → K in AAH66153. 1 Publication
Sequence conflicti224 – 23512CLGQR…FDLPF → MFGSEKSIRPSL in BAB29213. 1 Publication
Add
BLAST
Sequence conflicti350 – 3501R → G in AAP88382. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF454954 mRNA. Translation: AAN45857.1.
AY263358 mRNA. Translation: AAP88382.1.
BC042718 mRNA. Translation: AAH42718.1.
BC066153 mRNA. Translation: AAH66153.1.
AK014221 mRNA. Translation: BAB29213.1.
CCDSiCCDS22929.1.
RefSeqiNP_082748.1. NM_028472.2.
UniGeneiMm.335020.

Genome annotation databases

EnsembliENSMUST00000071982; ENSMUSP00000071872; ENSMUSG00000031963.
GeneIDi73230.
KEGGimmu:73230.
UCSCiuc009oow.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF454954 mRNA. Translation: AAN45857.1 .
AY263358 mRNA. Translation: AAP88382.1 .
BC042718 mRNA. Translation: AAH42718.1 .
BC066153 mRNA. Translation: AAH66153.1 .
AK014221 mRNA. Translation: BAB29213.1 .
CCDSi CCDS22929.1.
RefSeqi NP_082748.1. NM_028472.2.
UniGenei Mm.335020.

3D structure databases

ProteinModelPortali Q8CJ69.
SMRi Q8CJ69. Positions 42-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 215850. 1 interaction.

PTM databases

PhosphoSitei Q8CJ69.

Proteomic databases

PRIDEi Q8CJ69.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071982 ; ENSMUSP00000071872 ; ENSMUSG00000031963 .
GeneIDi 73230.
KEGGi mmu:73230.
UCSCi uc009oow.1. mouse.

Organism-specific databases

CTDi 168667.
MGIi MGI:1920480. Bmper.

Phylogenomic databases

eggNOGi NOG283828.
GeneTreei ENSGT00730000110288.
HOGENOMi HOG000234284.
HOVERGENi HBG050704.
InParanoidi Q8CJ69.
OMAi EFCNRPQ.
OrthoDBi EOG7G7KNN.
PhylomeDBi Q8CJ69.
TreeFami TF343473.

Miscellaneous databases

NextBioi 337713.
PMAP-CutDB Q8CJ69.
PROi Q8CJ69.
SOURCEi Search...

Gene expression databases

Bgeei Q8CJ69.
CleanExi MM_BMPER.
Genevestigatori Q8CJ69.

Family and domain databases

InterProi IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 1 hit.
PF01826. TIL. 1 hit.
PF00093. VWC. 2 hits.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00214. VWC. 5 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 1 hit.
PROSITEi PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling."
    Coffinier C., Ketpura N., Tran U., Geissert D., De Robertis E.M.
    Mech. Dev. 119:S179-S184(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
  2. "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation."
    Moser M., Binder O., Wu Y., Aitsebaomo J., Ren R., Bode C., Bautch V.L., Conlon F.L., Patterson C.
    Mol. Cell. Biol. 23:5664-5679(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH BMP4.
    Strain: Swiss Webster.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CD-1.
    Tissue: Mammary tumor and Neural stem cell.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 224-685.
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiBMPER_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ69
Secondary accession number(s): Q7TN57, Q80UZ1, Q9CXM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi