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Protein

BMP-binding endothelial regulator protein

Gene

Bmper

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BMP-binding endothelial regulator protein
Alternative name(s):
Bone morphogenetic protein-binding endothelial cell precursor-derived regulator
Protein crossveinless-2
Short name:
mCV2
Gene namesi
Name:Bmper
Synonyms:Cv2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1920480 Bmper

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000002082140 – 685BMP-binding endothelial regulator proteinAdd BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8CJ69
PaxDbiQ8CJ69
PRIDEiQ8CJ69

PTM databases

PhosphoSitePlusiQ8CJ69

Miscellaneous databases

PMAP-CutDBiQ8CJ69

Expressioni

Developmental stagei

At E9<.0 day, expressed in the ventral tail bud and also in the closing anterior neuropore and in the roof of the neural tube, at E10.5, also expressed in mesonephric ridge.1 Publication

Gene expression databases

BgeeiENSMUSG00000031963
CleanExiMM_BMPER
ExpressionAtlasiQ8CJ69 baseline and differential
GenevisibleiQ8CJ69 MM

Interactioni

Subunit structurei

Interacts with BMP4.1 Publication

Protein-protein interaction databases

BioGridi215850, 1 interactor
STRINGi10090.ENSMUSP00000071872

Structurei

3D structure databases

ProteinModelPortaliQ8CJ69
SMRiQ8CJ69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 105VWFC 1PROSITE-ProRule annotationAdd BLAST56
Domaini108 – 163VWFC 2PROSITE-ProRule annotationAdd BLAST56
Domaini164 – 225VWFC 3PROSITE-ProRule annotationAdd BLAST62
Domaini238 – 289VWFC 4PROSITE-ProRule annotationAdd BLAST52
Domaini299 – 358VWFC 5PROSITE-ProRule annotationAdd BLAST60
Domaini363 – 574VWFDPROSITE-ProRule annotationAdd BLAST212
Domaini629 – 682TILAdd BLAST54

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR8G Eukaryota
ENOG410XW0S LUCA
GeneTreeiENSGT00840000129763
HOGENOMiHOG000234284
HOVERGENiHBG050704
InParanoidiQ8CJ69
OMAiWHFANSW
OrthoDBiEOG091G0O1O
PhylomeDBiQ8CJ69
TreeFamiTF343473

Family and domain databases

InterProiView protein in InterPro
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR001007 VWF_dom
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF08742 C8, 1 hit
PF01826 TIL, 1 hit
PF00093 VWC, 2 hits
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM00832 C8, 1 hit
SM00214 VWC, 5 hits
SM00216 VWD, 1 hit
SUPFAMiSSF57567 SSF57567, 1 hit
PROSITEiView protein in PROSITE
PS01208 VWFC_1, 3 hits
PS50184 VWFC_2, 2 hits
PS51233 VWFD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJ69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWFFSVRAL AERPCRRSPG ITCCVLLLLN CSGVPMSLAS SFLTGSVAKC
60 70 80 90 100
ENEGEVLQIP FITDNPCIMC VCLNKEVTCK REKCPVLSRD CALAIKQRGA
110 120 130 140 150
CCERCKGCTH EGRTYNSSFK WQTPAEPCVL RQCQEGVVTE SEVRCVVHCK
160 170 180 190 200
NPAEHQGACC PTCPGCVFEG VQYREGEEFQ PEGNKCITCS CVGGRTQCVR
210 220 230 240 250
EVCPILSCPQ HLSHTPSGQC CPKCLGQRKV FDLPFGSCLF RSDVYDNGAS
260 270 280 290 300
FVYDNCTVCT CKDSTMVCKK KCSHPGVCNS DEDACCEDCL LRVPPEDIKV
310 320 330 340 350
CKFGSKIFRD GEMWSSVNCS ICACVKGKTE CRKKQCVPVS SCPQGKILNR
360 370 380 390 400
KGCCPICTEK PGVCTVFGDP HYNTFDGRTF NFQGTCQYVL TKDCSSPASP
410 420 430 440 450
FQVLVKNDAR RTRSFSWTKS VELMLGESTV SLQQHLTVRW NGSRIALPCH
460 470 480 490 500
TPHFHIDLDG YLLKVTTRAG LEISWDGDSF VEVMAAPHLK GKLCGLCGNY
510 520 530 540 550
NGHKRDDLIG GDGNFKFDVD DFAESWRVES NEFCNRPQRK PVPELCQGTV
560 570 580 590 600
KVKLRAHREC QKLKSWEFQT CHSTVDYTTF YRSCVTDMCE CPVHKNCYCE
610 620 630 640 650
SFLAYTRACQ REGIKVHWEP QQSCAATQCK HGAVYDTCGP GCVKTCDNWN
660 670 680
EIGPCNKPCI AGCHCPANLV LHKGRCIKPV LCPQR
Length:685
Mass (Da):76,148
Last modified:March 1, 2003 - v1
Checksum:i4FF98D53E2C57656
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151N → K in AAH66153 (PubMed:15489334).Curated1
Sequence conflicti224 – 235CLGQR…FDLPF → MFGSEKSIRPSL in BAB29213 (PubMed:16141072).CuratedAdd BLAST12
Sequence conflicti350R → G in AAP88382 (PubMed:12897139).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454954 mRNA Translation: AAN45857.1
AY263358 mRNA Translation: AAP88382.1
BC042718 mRNA Translation: AAH42718.1
BC066153 mRNA Translation: AAH66153.1
AK014221 mRNA Translation: BAB29213.1
CCDSiCCDS22929.1
RefSeqiNP_082748.1, NM_028472.2
UniGeneiMm.335020

Genome annotation databases

EnsembliENSMUST00000071982; ENSMUSP00000071872; ENSMUSG00000031963
GeneIDi73230
KEGGimmu:73230
UCSCiuc009oow.2 mouse

Entry informationi

Entry nameiBMPER_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ69
Secondary accession number(s): Q7TN57, Q80UZ1, Q9CXM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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