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Q8CJ52

- PROM2_RAT

UniProt

Q8CJ52 - PROM2_RAT

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Protein

Prominin-2

Gene

Prom2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. cholesterol binding Source: UniProt
  2. growth factor activity Source: RGD
  3. transmembrane signaling receptor activity Source: RGD

GO - Biological processi

  1. signal transduction Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Prominin-2
Short name:
PROM-2
Alternative name(s):
Prominin-like protein 2
Short name:
rPROML2
Testosterone-regulated prominin-related protein
Gene namesi
Name:Prom2
Synonyms:Proml2, Trprp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621435. Prom2.

Subcellular locationi

Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell projectionmicrovillus membrane; Multi-pass membrane protein. Cell projectioncilium membrane; Multi-pass membrane protein
Note: Localizes to the apical and basolateral membranes of epithelial cells. Associates with membrane in a cholesterol-dependent manner. Colocalizes with PROM1.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 10679ExtracellularSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST
Topological domaini128 – 15326CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Topological domaini175 – 434260ExtracellularSequence AnalysisAdd
BLAST
Transmembranei435 – 45521HelicalSequence AnalysisAdd
BLAST
Topological domaini456 – 47217CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence AnalysisAdd
BLAST
Topological domaini494 – 779286ExtracellularSequence AnalysisAdd
BLAST
Transmembranei780 – 80021HelicalSequence AnalysisAdd
BLAST
Topological domaini801 – 83434CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. cilium Source: UniProt
  3. cytoplasmic vesicle Source: UniProt
  4. integral component of plasma membrane Source: UniProt
  5. microspike Source: UniProt
  6. microvillus Source: UniProt
  7. nuclear envelope Source: RGD
  8. prominosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 834807Prominin-2PRO_0000331241Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CJ52.
PRIDEiQ8CJ52.

Expressioni

Tissue specificityi

In the ventral prostate, expressed in glandular epithelial cells.1 Publication

Inductioni

Up-regulated by androgen.1 Publication

Gene expression databases

GenevestigatoriQ8CJ52.

Interactioni

Subunit structurei

Binds to cholesterol.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020354.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili637 – 67438Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the prominin family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322325.
HOGENOMiHOG000115705.
HOVERGENiHBG101108.
InParanoidiQ8CJ52.
KOiK15602.
PhylomeDBiQ8CJ52.

Family and domain databases

InterProiIPR008795. Prominin.
[Graphical view]
PANTHERiPTHR22730. PTHR22730. 1 hit.
PfamiPF05478. Prominin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CJ52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRTLDLMVP LLGLSLGLAL SLPRAVAADC GSLGRVEHLA FAPVPGTEPT
60 70 80 90 100
APRVRAPWPL DSLYGTVRRF LSVVQLNPFP AELIKTLLND PSSVKTDEVV
110 120 130 140 150
RYEAGYVVCA VIAGLYLLLV PITGLCFCCC RCRRRCGGRV KTEHKAMACE
160 170 180 190 200
RGTLMTFLLL TTLMLLIGMV CAFATNQFTH SQTGPSVEAV PETLLSLRGL
210 220 230 240 250
VSDVPKKLQA VADQFSSPQK QVSKDLDGVG ENLGNIIHNQ LKSTVYPVLA
260 270 280 290 300
SVHGLGQALQ VSIDHLQSVN ATSVELREGQ QHLGPPVQAH RERLLALLQE
310 320 330 340 350
SWCHENCKGA LSQASALQLG ADFSQMPPVD DVLHRLQGVP EANFSSMVQE
360 370 380 390 400
ENATFNNLPI LVHMQMVSVV KDLKKALAEQ PEGVRMLAQA FPGSEATSRW
410 420 430 440 450
SQALEGLEQR SRPYLQDVQR YETYRWILGC VLCSAILLVV ICNLLGLSLG
460 470 480 490 500
IWGLFAREDP SHSETKGEAG ARFLMAGVAF SFLFAAPLIL LVFATFLVGG
510 520 530 540 550
NVQTLVCRSW ESGELYEFVD TPGNLPPSMN LSYLLGLRKN ISVFQAYRQC
560 570 580 590 600
KAGTALWKVL QLNDSYDLDK HLDIKQYTHE LQQELQSFKV DLKDLDLLNP
610 620 630 640 650
AARQNLEALQ SSGLEKIHYR DFLVQIQKPV VKTDMGQLAK ELEGLAQAQN
660 670 680 690 700
ESLRRQQLQE EARELRSLYQ EKVVPQENLV AKLNPSIRVL ESSAPKLQVN
710 720 730 740 750
TSDLLDIVAR LKGELPAQLN HILRNATECF LTREMGYFSQ YVTWVREEVT
760 770 780 790 800
QHIATCQPFS KALDDGHMIL CDMMANPWNA FWFCLGWCTF FLIPSIIFAV
810 820 830
KTSKYFRPIR KRLSSTSSEE TQLFHIPRVT SLKL
Length:834
Mass (Da):92,841
Last modified:March 1, 2003 - v1
Checksum:iCE1A53DB5CBEF57A
GO

Sequence cautioni

The sequence AAM03109.1 differs from that shown. Reason: Frameshift at position 775. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti217 – 2171S → L in AAM03109. (PubMed:12446606)Curated
Sequence conflicti534 – 5341L → I in AAM03109. (PubMed:12446606)Curated
Sequence conflicti580 – 5801E → K in AAM03109. (PubMed:12446606)Curated
Sequence conflicti649 – 6491Q → H in AAM03109. (PubMed:12446606)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486828 mRNA. Translation: AAM03109.1. Frameshift.
AF508942 mRNA. Translation: AAN63818.1.
RefSeqiNP_620212.1. NM_138857.1.
UniGeneiRn.82155.

Genome annotation databases

GeneIDi192211.
KEGGirno:192211.
UCSCiRGD:621435. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486828 mRNA. Translation: AAM03109.1 . Frameshift.
AF508942 mRNA. Translation: AAN63818.1 .
RefSeqi NP_620212.1. NM_138857.1.
UniGenei Rn.82155.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000020354.

Proteomic databases

PaxDbi Q8CJ52.
PRIDEi Q8CJ52.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 192211.
KEGGi rno:192211.
UCSCi RGD:621435. rat.

Organism-specific databases

CTDi 150696.
RGDi 621435. Prom2.

Phylogenomic databases

eggNOGi NOG322325.
HOGENOMi HOG000115705.
HOVERGENi HBG101108.
InParanoidi Q8CJ52.
KOi K15602.
PhylomeDBi Q8CJ52.

Miscellaneous databases

NextBioi 622797.
PROi Q8CJ52.

Gene expression databases

Genevestigatori Q8CJ52.

Family and domain databases

InterProi IPR008795. Prominin.
[Graphical view ]
PANTHERi PTHR22730. PTHR22730. 1 hit.
Pfami PF05478. Prominin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of a novel testosterone-regulated prominin-like gene in the rat ventral prostate."
    Zhang Q., Haleem R., Cai X., Wang Z.
    Endocrinology 143:4788-4796(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
  2. "Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins."
    Fargeas C.A., Florek M., Huttner W.B., Corbeil D.
    J. Biol. Chem. 278:8586-8596(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  3. "AC133 antigen, CD133, prominin-1, prominin-2, etc.: prominin family gene products in need of a rational nomenclature."
    Fargeas C.A., Corbeil D., Huttner W.B.
    Stem Cells 21:506-508(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  4. "Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine."
    Florek M., Bauer N., Janich P., Wilsch-Braeuninger M., Fargeas C.A., Marzesco A.-M., Ehninger G., Thiele C., Huttner W.B., Corbeil D.
    Cell Tissue Res. 328:31-47(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CHOLESTEROL, GLYCOSYLATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPROM2_RAT
AccessioniPrimary (citable) accession number: Q8CJ52
Secondary accession number(s): Q8R4B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3