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Protein

Solute carrier family 13 member 5

Gene

Slc13a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.1 Publication

GO - Molecular functioni

  • citrate transmembrane transporter activity Source: RGD
  • organic acid:sodium symporter activity Source: RGD
  • sodium:dicarboxylate symporter activity Source: RGD
  • succinate transmembrane transporter activity Source: RGD

GO - Biological processi

  • citrate transport Source: RGD
  • succinate transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 5
Alternative name(s):
Na(+)/citrate cotransporter
Short name:
NaCT
Sodium-coupled citrate transporter
Sodium-dependent citrate transporter
Gene namesi
Name:Slc13a5
Synonyms:Nact
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631374. Slc13a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence analysisAdd
BLAST
Transmembranei491 – 51121HelicalSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Solute carrier family 13 member 5PRO_0000260103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence analysis
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CJ44.
PRIDEiQ8CJ44.

Expressioni

Tissue specificityi

Expressed in liver, testis and brain.1 Publication

Gene expression databases

GenevisibleiQ8CJ44. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020043.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ8CJ44.
KOiK14445.
OMAiDRKSMCK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ8CJ44.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CJ44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAKTYVTK FKSFVILFFA PILLLPLIIL VPDKFARCAY VIILMAIYWC
60 70 80 90 100
TDVIPVAITS LLPVLLFPLL KVLDSKQVCV QYMTDTNMLF LGSLIVATAV
110 120 130 140 150
ERWELHKRIA LRMLLFVGTK PSRLMLGFMF VTAFLSMWIS NTATTAMMIP
160 170 180 190 200
IVEAMLEQMV ATNVAVDASQ RTMELLDKNK ASELPGSQVV FEDPSVQKQE
210 220 230 240 250
DEETKNMYKA MNLCVCYAAS IGGTATLTGT GPNVVLLGQM QELFPDSKDV
260 270 280 290 300
MNFASWFAFA LPNMLLMLVM AWLWLLCFYM RPNLKKTCIC CGRKKKDTEK
310 320 330 340 350
IASKVLYEEY RKLGPLSYAE CNVLFCFGLL IILWFSRDPG FMPGWLSIAW
360 370 380 390 400
IEGNTKHVTD ATVAIFVAIL LFIVPSQKPK FNFSRQTEEE RKTPFYPPPL
410 420 430 440 450
LNWKVTQEKV PWGIVLLLGG GFAMAKGCET SGLSEWMARQ MEPLSSVRPA
460 470 480 490 500
IITLILSCIV AMTTECTSNV ATTTLFLPIF ASMARSIGIH PLYVMIPCTL
510 520 530 540 550
SASLAFMLPV ATPPNAIVFA YGHLKVIDMV KTGLVMNILG IASVFLSVNT
560 570
WGRAVFNLDK FPDWANLTHI NT
Length:572
Mass (Da):63,878
Last modified:March 1, 2003 - v1
Checksum:i9CD35A72FC50D374
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522186 mRNA. Translation: AAN52081.1.
RefSeqiNP_733768.1. NM_170668.1.
UniGeneiRn.107996.

Genome annotation databases

GeneIDi266998.
KEGGirno:266998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522186 mRNA. Translation: AAN52081.1.
RefSeqiNP_733768.1. NM_170668.1.
UniGeneiRn.107996.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020043.

Proteomic databases

PaxDbiQ8CJ44.
PRIDEiQ8CJ44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266998.
KEGGirno:266998.

Organism-specific databases

CTDi284111.
RGDi631374. Slc13a5.

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ8CJ44.
KOiK14445.
OMAiDRKSMCK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ8CJ44.
TreeFamiTF312913.

Miscellaneous databases

PROiQ8CJ44.

Gene expression databases

GenevisibleiQ8CJ44. RN.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain."
    Inoue K., Zhuang L., Maddox D.M., Smith S.B., Ganapathy V.
    J. Biol. Chem. 277:39469-39476(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiS13A5_RAT
AccessioniPrimary (citable) accession number: Q8CJ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.