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Protein

Death domain-containing membrane protein NRADD

Gene

Nradd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Death domain-containing membrane protein NRADD
Alternative name(s):
Neurotrophin receptor homolog-2
Short name:
NRH2
Neurotrophin receptor-alike death domain protein
Gene namesi
Name:Nradd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914419. Nradd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularCuratedAdd BLAST52
Transmembranei53 – 73Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini74 – 228CytoplasmicCuratedAdd BLAST155

GO - Cellular componenti

  • cell body membrane Source: Ensembl
  • integral component of plasma membrane Source: GO_Central
  • lamellipodium Source: MGI
  • membrane Source: MGI
  • neuron projection Source: GO_Central
  • neuron projection membrane Source: Ensembl
  • nuclear envelope lumen Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004153831 – 228Death domain-containing membrane protein NRADDAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)1 Publication1
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8CJ26.
PaxDbiQ8CJ26.
PeptideAtlasiQ8CJ26.
PRIDEiQ8CJ26.

PTM databases

iPTMnetiQ8CJ26.
PhosphoSitePlusiQ8CJ26.
SwissPalmiQ8CJ26.

Expressioni

Tissue specificityi

Detected in lung and testis.

Gene expression databases

BgeeiENSMUSG00000032491.
ExpressionAtlasiQ8CJ26. baseline and differential.
GenevisibleiQ8CJ26. MM.

Interactioni

Subunit structurei

Interacts with NGFR. Interacts with NTRK1. Interacts with SORT1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Sort1Q6PHU55EBI-6985725,EBI-6985663

Protein-protein interaction databases

IntActiQ8CJ26. 2 interactors.
MINTiMINT-7290501.
STRINGi10090.ENSMUSP00000035069.

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi140 – 143Combined sources4
Helixi146 – 149Combined sources4
Helixi158 – 165Combined sources8
Helixi169 – 175Combined sources7
Helixi181 – 188Combined sources8
Beta strandi191 – 195Combined sources5
Helixi201 – 207Combined sources7
Turni208 – 210Combined sources3
Helixi212 – 218Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IB1NMR-A138-228[»]
ProteinModelPortaliQ8CJ26.
SMRiQ8CJ26.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CJ26.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 222DeathPROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 142Poly-Gln4

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J99A. Eukaryota.
ENOG4111D5W. LUCA.
GeneTreeiENSGT00730000110974.
HOGENOMiHOG000147886.
HOVERGENiHBG071107.
InParanoidiQ8CJ26.
OMAiAFKCWRS.
OrthoDBiEOG091G0QZB.
PhylomeDBiQ8CJ26.
TreeFamiTF106466.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CJ26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYNVSKGVV YSDTALQGQD GDREGMWVGA GGALAPNTSS LFPPEPPGAS
60 70 80 90 100
SNIIPVYCAL LATVILGLLA YVAFKCWRSH KQRQQLAKAR TVELGDPDRD
110 120 130 140 150
QRRGDSNVFV DSPPSLEPCI PSQGPHPDLG CQLYLHIPQQ QQEEVQRLLM
160 170 180 190 200
MGEPAKGWQE LAGHLGYQAE AVETMACDQM PAYTLLRNWA AQEGNRATLR
210 220
VLEDALAAIG REDVVQVLSS PAESSSVV
Length:228
Mass (Da):24,727
Last modified:March 1, 2003 - v1
Checksum:iD46B7402D8362FDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121P → H in BAE35698 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF534394 mRNA. Translation: AAN05631.1.
AK160222 mRNA. Translation: BAE35698.1.
AC132103 Genomic DNA. No translation available.
BC069856 mRNA. Translation: AAH69856.1.
CCDSiCCDS23569.1.
RefSeqiNP_080288.1. NM_026012.2.
UniGeneiMm.46680.

Genome annotation databases

EnsembliENSMUST00000035069; ENSMUSP00000035069; ENSMUSG00000032491.
GeneIDi67169.
KEGGimmu:67169.
UCSCiuc009ruk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF534394 mRNA. Translation: AAN05631.1.
AK160222 mRNA. Translation: BAE35698.1.
AC132103 Genomic DNA. No translation available.
BC069856 mRNA. Translation: AAH69856.1.
CCDSiCCDS23569.1.
RefSeqiNP_080288.1. NM_026012.2.
UniGeneiMm.46680.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IB1NMR-A138-228[»]
ProteinModelPortaliQ8CJ26.
SMRiQ8CJ26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CJ26. 2 interactors.
MINTiMINT-7290501.
STRINGi10090.ENSMUSP00000035069.

PTM databases

iPTMnetiQ8CJ26.
PhosphoSitePlusiQ8CJ26.
SwissPalmiQ8CJ26.

Proteomic databases

MaxQBiQ8CJ26.
PaxDbiQ8CJ26.
PeptideAtlasiQ8CJ26.
PRIDEiQ8CJ26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035069; ENSMUSP00000035069; ENSMUSG00000032491.
GeneIDi67169.
KEGGimmu:67169.
UCSCiuc009ruk.1. mouse.

Organism-specific databases

CTDi67169.
MGIiMGI:1914419. Nradd.

Phylogenomic databases

eggNOGiENOG410J99A. Eukaryota.
ENOG4111D5W. LUCA.
GeneTreeiENSGT00730000110974.
HOGENOMiHOG000147886.
HOVERGENiHBG071107.
InParanoidiQ8CJ26.
OMAiAFKCWRS.
OrthoDBiEOG091G0QZB.
PhylomeDBiQ8CJ26.
TreeFamiTF106466.

Miscellaneous databases

EvolutionaryTraceiQ8CJ26.
PROiQ8CJ26.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032491.
ExpressionAtlasiQ8CJ26. baseline and differential.
GenevisibleiQ8CJ26. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRADD_MOUSE
AccessioniPrimary (citable) accession number: Q8CJ26
Secondary accession number(s): Q3TVC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.