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Protein

Adhesion G-protein coupled receptor G2

Gene

Adgrg2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G2
Alternative name(s):
G-protein coupled receptor 64
Rat epididymis-specific protein 6
Short name:
Re6
Gene namesi
Name:Adgrg2Imported
Synonyms:Gpr64, Re6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi628618. Adgrg2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 623586ExtracellularCuratedAdd
BLAST
Transmembranei624 – 64421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini645 – 66319CytoplasmicCuratedAdd
BLAST
Transmembranei664 – 68421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini685 – 6884ExtracellularCurated
Transmembranei689 – 70921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini710 – 73324CytoplasmicCuratedAdd
BLAST
Transmembranei734 – 75421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini755 – 78531ExtracellularCuratedAdd
BLAST
Transmembranei786 – 80621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini807 – 83024CytoplasmicCuratedAdd
BLAST
Transmembranei831 – 85121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini852 – 8532ExtracellularCurated
Transmembranei854 – 87421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini875 – 1013139CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence analysisAdd
BLAST
Chaini38 – 1013976Adhesion G-protein coupled receptor G2PRO_0000012888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence analysis
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence analysis
Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence analysis
Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence analysis
Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence analysis
Glycosylationi593 – 5931N-linked (GlcNAc...)Sequence analysis
Glycosylationi777 – 7771N-linked (GlcNAc...)Sequence analysis
Glycosylationi853 – 8531N-linked (GlcNAc...)Sequence analysis
Modified residuei1006 – 10061PhosphoserineBy similarity

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.Curated
Highly glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8CJ11.
PRIDEiQ8CJ11.

PTM databases

PhosphoSiteiQ8CJ11.

Expressioni

Tissue specificityi

Epididymis-specific expression (at protein level). Associated with apical membranes of efferent ductule and proximal epididymal duct epithelia (PubMed:12420295).1 Publication

Gene expression databases

GenevisibleiQ8CJ11. RN.

Interactioni

Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039239.

Structurei

3D structure databases

ProteinModelPortaliQ8CJ11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini563 – 61452GPSPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi249 – 2524Poly-Ser
Compositional biasi668 – 6736Poly-Leu
Compositional biasi812 – 8154Poly-Lys
Compositional biasi921 – 9266Poly-Ser

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000231476.
HOVERGENiHBG051817.
InParanoidiQ8CJ11.
KOiK08451.
OMAiFIFYCVA.
OrthoDBiEOG7ZGX28.
PhylomeDBiQ8CJ11.
TreeFamiTF321769.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CJ11-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFSGGQYSP VGRPEEVLLI YKIFLVIICF HAILVTSLKE NAGNSSLLSP
60 70 80 90 100
SAESSLVSLV PYSNGTPDAA SEVLSTLNRT EKSKITILKT FNASGVKSQR
110 120 130 140 150
NICNLSSICS DSVFFRGEIV FQHDDHYNVT QNQDIVNSTF AGVLSLSELK
160 170 180 190 200
RTELNKTLQT LSETYFIVCA TAEAQNTLNC TFTVKLNETM NVCAMMVTFK
210 220 230 240 250
SVQIRPMEQC CCSPRTPCPS SPEELEKLQC DLQDPIVCLA DQPHGPPVSS
260 270 280 290 300
SSKPVPVVPQ ATIFSHVASD FSLAEPLDHA LMTSSTPSLA QETRLPSPQP
310 320 330 340 350
TISLTSSPAI DLPVQHVVAS SSLPQTDLSH TLSPVQSSIP SPTTAAPSVP
360 370 380 390 400
EKVVAISTPP GETVVNTSSV PDLEAQVSQM EKALSLGSLE PNLAGEMVNR
410 420 430 440 450
VSKLLHSPLA LLAPLAQRLL KVVDAIGLQL NFSSTTISLT SPSLALAVIR
460 470 480 490 500
VNASNFNTTT FAAQDPANLQ VSLEAQAPKN SIGAITLPSS LMSNLPASEV
510 520 530 540 550
ELASRVQFNF FETPALFQDP SLENLSLISY VISSSVTNMT IKNLTRNVTV
560 570 580 590 600
ALKHINPSQD DLTVKCVFWD LNRNGGRGGW SSDGCSVKEK RMNETICTCS
610 620 630 640 650
HLTSFGILLD LSRTSLPPSQ MMALTFITYI GCGLSSIFLS VTLVTYIAFE
660 670 680 690 700
KIRRDYPSKI LIQLCAALLL LNLVFLLDSW IALYNARGFC ISVAVFLHYF
710 720 730 740 750
LLVSFTWMGL EAFHMYLALV KVFNTYIRKY ILKFCIVGWG IPAVVVSIVL
760 770 780 790 800
TISPDNYGIG SYGKFPNGTP DDFCWINSSV VFYITVVGYF CVIFLLNVSM
810 820 830 840 850
FIVVLVQLCR IKKKKQLGAQ RKTSIQDLRS IAGLTFLLGI TWGFAFFAWG
860 870 880 890 900
PVNLTFMYLF AIFNTLQGFF IFIFYCAAKE NVRKQWRRYL CCGKLRLAEN
910 920 930 940 950
SDWSKTATNG LKKQTVNQGV SSSSNSLQSS CNSTNSTTLL VNSDCSVHAS
960 970 980 990 1000
GNGNASTERN GVSFSVQNGD VCLHDLTGKQ HMFSDKEDSC NGKSRMALRR
1010
TSKRGSLHFI EQM
Length:1,013
Mass (Da):110,701
Last modified:March 1, 2003 - v1
Checksum:i03C5467D84527216
GO
Isoform 2 (identifier: Q8CJ11-2) [UniParc]FASTAAdd to basket

Also known as: d2

The sequence of this isoform differs from the canonical sequence as follows:
     40-67: Missing.

Show »
Length:985
Mass (Da):107,941
Checksum:i5178E23EC0A1E700
GO
Isoform 3 (identifier: Q8CJ11-3) [UniParc]FASTAAdd to basket

Also known as: d1

The sequence of this isoform differs from the canonical sequence as follows:
     52-67: Missing.

Show »
Length:997
Mass (Da):109,098
Checksum:i064D277C6278E5F3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei40 – 6728Missing in isoform 2. 1 PublicationVSP_009810Add
BLAST
Alternative sequencei52 – 6716Missing in isoform 3. 1 PublicationVSP_009811Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF538953 mRNA. Translation: AAN33055.1.
AF538958 mRNA. Translation: AAN33060.1.
AF538959 mRNA. Translation: AAN33061.1.
RefSeqiNP_001257800.1. NM_001270871.1. [Q8CJ11-3]
NP_001257801.1. NM_001270872.1. [Q8CJ11-2]
NP_852031.1. NM_181366.2. [Q8CJ11-1]
XP_008771377.1. XM_008773155.1. [Q8CJ11-3]
UniGeneiRn.57243.

Genome annotation databases

EnsembliENSRNOT00000040770; ENSRNOP00000039239; ENSRNOG00000032472. [Q8CJ11-1]
ENSRNOT00000058833; ENSRNOP00000055623; ENSRNOG00000032472. [Q8CJ11-2]
ENSRNOT00000058834; ENSRNOP00000055624; ENSRNOG00000032472. [Q8CJ11-3]
GeneIDi266735.
KEGGirno:266735.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF538953 mRNA. Translation: AAN33055.1.
AF538958 mRNA. Translation: AAN33060.1.
AF538959 mRNA. Translation: AAN33061.1.
RefSeqiNP_001257800.1. NM_001270871.1. [Q8CJ11-3]
NP_001257801.1. NM_001270872.1. [Q8CJ11-2]
NP_852031.1. NM_181366.2. [Q8CJ11-1]
XP_008771377.1. XM_008773155.1. [Q8CJ11-3]
UniGeneiRn.57243.

3D structure databases

ProteinModelPortaliQ8CJ11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039239.

Protein family/group databases

MEROPSiP02.007.
GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8CJ11.

Proteomic databases

PaxDbiQ8CJ11.
PRIDEiQ8CJ11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040770; ENSRNOP00000039239; ENSRNOG00000032472. [Q8CJ11-1]
ENSRNOT00000058833; ENSRNOP00000055623; ENSRNOG00000032472. [Q8CJ11-2]
ENSRNOT00000058834; ENSRNOP00000055624; ENSRNOG00000032472. [Q8CJ11-3]
GeneIDi266735.
KEGGirno:266735.

Organism-specific databases

CTDi10149.
RGDi628618. Adgrg2.

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000231476.
HOVERGENiHBG051817.
InParanoidiQ8CJ11.
KOiK08451.
OMAiFIFYCVA.
OrthoDBiEOG7ZGX28.
PhylomeDBiQ8CJ11.
TreeFamiTF321769.

Miscellaneous databases

PROiQ8CJ11.

Gene expression databases

GenevisibleiQ8CJ11. RN.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia."
    Obermann H., Samalecos A., Osterhoff C., Schroeder B., Heller R., Kirchhoff C.
    Mol. Reprod. Dev. 64:13-26(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), GLYCOSYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Lewis.
    Tissue: Epididymis.

Entry informationi

Entry nameiAGRG2_RAT
AccessioniPrimary (citable) accession number: Q8CJ11
Secondary accession number(s): Q8CJ06, Q8CJ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.