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Q8CIZ8

- VWF_MOUSE

UniProt

Q8CIZ8 - VWF_MOUSE

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Protein

von Willebrand factor

Gene
Vwf
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma By similarity.By similarity

GO - Molecular functioni

  1. chaperone binding Source: UniProtKB
  2. collagen binding Source: UniProtKB
  3. glycoprotein binding Source: UniProtKB
  4. immunoglobulin binding Source: UniProtKB
  5. integrin binding Source: UniProtKB
  6. protease binding Source: UniProtKB
  7. protein binding Source: MGI
  8. protein homodimerization activity Source: UniProtKB
  9. protein N-terminus binding Source: UniProtKB

GO - Biological processi

  1. blood coagulation Source: UniProtKB
  2. cell adhesion Source: UniProtKB
  3. cell-substrate adhesion Source: UniProtKB
  4. hemostasis Source: UniProtKB
  5. liver development Source: MGI
  6. placenta development Source: MGI
  7. platelet activation Source: UniProtKB
  8. protein homooligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_216309. Integrin cell surface interactions.
REACT_225107. Platelet Adhesion to exposed collagen.

Protein family/group databases

MEROPSiI08.950.

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
Cleaved into the following chain:
Alternative name(s):
von Willebrand antigen II
Gene namesi
Name:Vwf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:98941. Vwf.

Subcellular locationi

Secreted By similarity. Secretedextracellular spaceextracellular matrix By similarity
Note: Localized to storage granules By similarity.

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. external side of plasma membrane Source: MGI
  3. extracellular matrix Source: UniProtKB
  4. extracellular region Source: UniProtKB
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
  6. Weibel-Palade body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1205 – 12051R → H: Accelerated clearance of VWF from blood plasma. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarityBy similarityAdd
BLAST
Chaini23 – 763741von Willebrand antigen 2By similarityPRO_0000022684Add
BLAST
Chaini764 – 28132050von Willebrand factorBy similarityPRO_0000022685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 2811 By similarityBy similarity
Disulfide bondi? ↔ 996 By similarityBy similarity
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi666 – 6661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi767 ↔ 808 By similarityBy similarity
Disulfide bondi776 ↔ 804 By similarityBy similarity
Disulfide bondi810 ↔ 821 By similarityBy similarity
Glycosylationi857 – 8571N-linked (GlcNAc...) By similarityBy similarity
Disulfide bondi889 ↔ 1031 By similarityBy similarity
Disulfide bondi898 ↔ 993 By similarityBy similarity
Disulfide bondi914 ↔ 921 By similarityBy similarity
Glycosylationi1005 – 10051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1060 ↔ 1084 By similarityBy similarity
Disulfide bondi1071 ↔ 1111 By similarityBy similarity
Disulfide bondi1089 ↔ 1091 By similarityBy similarity
Disulfide bondi1126 ↔ 1130 By similarityBy similarity
Glycosylationi1147 – 11471N-linked (GlcNAc...); atypical By similarityBy similarity
Disulfide bondi1149 ↔ 1169 By similarityBy similarity
Disulfide bondi1153 ↔ 1165 By similarityBy similarity
Disulfide bondi1196 ↔ 1199 By similarityBy similarity
Glycosylationi1231 – 12311N-linked (GlcNAc...) By similarityBy similarity
Disulfide bondi1234 ↔ 1237 By similarityBy similarity
Glycosylationi1248 – 12481O-linked (GalNAc...) By similarity
Glycosylationi1255 – 12551O-linked (GalNAc...) By similarity
Glycosylationi1256 – 12561O-linked (GalNAc...) By similarity
Disulfide bondi1272 ↔ 1458By similarity1 Publication
Glycosylationi1468 – 14681O-linked (GalNAc...) By similarity
Glycosylationi1477 – 14771O-linked (GalNAc...) By similarity
Glycosylationi1486 – 14861O-linked (GalNAc...) By similarity
Glycosylationi1515 – 15151N-linked (GlcNAc...) By similarityBy similarity
Glycosylationi1574 – 15741N-linked (GlcNAc...) By similarityBy similarity
Disulfide bondi1669 ↔ 1670 By similarityBy similarity
Glycosylationi1679 – 16791O-linked (GalNAc...) By similarity
Disulfide bondi1686 ↔ 1872 By similarityBy similarity
Cross-linki1720 – 1720Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Disulfide bondi1879 ↔ 1904 By similarityBy similarity
Disulfide bondi1899 ↔ 1940Or C-1899 with C-1942 By similarityBy similarity
Disulfide bondi1927 ↔ 2088 By similarityBy similarity
Disulfide bondi1950 ↔ 2085 By similarityBy similarity
Disulfide bondi1972 ↔ 2123 By similarityBy similarity
Disulfide bondi1993 ↔ 2001 By similarityBy similarity
Glycosylationi2223 – 22231N-linked (GlcNAc...) By similarityBy similarity
Glycosylationi2290 – 22901N-linked (GlcNAc...) By similarityBy similarity
Glycosylationi2298 – 22981O-linked (GalNAc...) By similarity
Glycosylationi2400 – 24001N-linked (GlcNAc...) By similarityBy similarity
Glycosylationi2546 – 25461N-linked (GlcNAc...) By similarityBy similarity
Glycosylationi2585 – 25851N-linked (GlcNAc...) By similarityBy similarity
Disulfide bondi2724 ↔ 2774 By similarityBy similarity
Disulfide bondi2739 ↔ 2788 By similarityBy similarity
Disulfide bondi2750 ↔ 2804 By similarityBy similarity
Disulfide bondi2754 ↔ 2806 By similarityBy similarity
Glycosylationi2790 – 27901N-linked (GlcNAc...) By similarityBy similarity
Glycosylationi2810 – 28101N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

All cysteine residues are involved in intrachain or interchain disulfide bonds By similarity.By similarity
N- and O-glycosylated By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8CIZ8.
PaxDbiQ8CIZ8.
PRIDEiQ8CIZ8.

PTM databases

PhosphoSiteiQ8CIZ8.

Expressioni

Tissue specificityi

Plasma. Expressed in liver.1 Publication

Gene expression databases

ArrayExpressiQ8CIZ8.
BgeeiQ8CIZ8.
CleanExiMM_VWF.
GenevestigatoriQ8CIZ8.

Interactioni

Subunit structurei

Multimeric. Interacts with F8 By similarity.

Protein-protein interaction databases

IntActiQ8CIZ8. 1 interaction.
MINTiMINT-4140177.

Structurei

Secondary structure

1
2813
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1274 – 128310
Beta strandi1285 – 12884
Helixi1290 – 130415
Beta strandi1311 – 132919
Helixi1337 – 13459
Helixi1357 – 136610
Turni1367 – 13693
Beta strandi1377 – 13859
Helixi1391 – 13944
Helixi1397 – 140610
Beta strandi1409 – 142012
Helixi1422 – 14309
Beta strandi1438 – 14425
Helixi1443 – 145816

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U0OX-ray2.70C1261-1468[»]
ProteinModelPortaliQ8CIZ8.
SMRiQ8CIZ8. Positions 1270-1464, 1494-1671, 1685-1873, 2721-2813.

Miscellaneous databases

EvolutionaryTraceiQ8CIZ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 240207VWFD 1Add
BLAST
Domaini295 – 34854TIL 1Add
BLAST
Domaini387 – 598212VWFD 2Add
BLAST
Domaini652 – 70756TIL 2Add
BLAST
Domaini804 – 82724TIL 3Add
BLAST
Domaini866 – 1074209VWFD 3Add
BLAST
Domaini1146 – 119651TIL 4Add
BLAST
Domaini1277 – 1453177VWFA 1; binding site for platelet glycoprotein Ib1 PublicationAdd
BLAST
Domaini1498 – 1665168VWFA 2Add
BLAST
Domaini1691 – 1871181VWFA 3; principal binding site for collagens type I and III1 PublicationAdd
BLAST
Domaini1949 – 2153205VWFD 4Add
BLAST
Domaini2255 – 232874VWFC 1Add
BLAST
Domaini2429 – 249567VWFC 2Add
BLAST
Domaini2580 – 264566VWFC 3Add
BLAST
Domaini2724 – 281289CTCKAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni764 – 78724Amino-terminalAdd
BLAST
Regioni788 – 83346E1Add
BLAST
Regioni826 – 85328CXAdd
BLAST
Regioni2216 – 226146E2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2507 – 25093Cell attachment site By similarityBy similarity

Domaini

The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules By similarity.

Sequence similaritiesi

Contains 3 VWFA domains.
Contains 3 VWFC domains.
Contains 4 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000110607.
HOGENOMiHOG000169747.
HOVERGENiHBG004380.
InParanoidiQ8CIZ8.
KOiK03900.
PhylomeDBiQ8CIZ8.

Family and domain databases

Gene3Di3.40.50.410. 3 hits.
InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR012011. VWF.
IPR002035. VWF_A.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF01826. TIL. 5 hits.
PF00092. VWA. 3 hits.
PF00093. VWC. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view]
PIRSFiPIRSF002495. VWF. 1 hit.
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00327. VWA. 3 hits.
SM00214. VWC. 5 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 3 hits.
SSF57567. SSF57567. 5 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50234. VWFA. 3 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8CIZ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNPFRYEICL LVLALTWPGT LCTEKPRDRP STARCSLFGD DFINTFDETM     50
YSFAGGCSYL LAGDCQKRSF SILGNFQDGK RMSLSVYLGE FFDIHLFANG 100
TVMQGDQSIS MPYASQGLYL ELEAGYYKLS SETFGFAARI DGNGNFQVLM 150
SDRHFNKTCG LCGDFNIFAE DDFRTQEGTL TSDPYDFANS WALSSEEQRC 200
KRASPPSRNC ESSSGDMHQA MWEQCQLLKT ASVFARCHPL VDPESFVALC 250
EKILCTCATG PECACPVLLE YARTCAQEGM VLYGWTDHSA CRPACPAGME 300
YKECVSPCPR TCQSLSINEV CQQQCVDGCS CPEGELLDED RCVQSSDCPC 350
VHAGKRYPPG TSLSQDCNTC ICRNSLWICS NEECPGECLV TGQSHFKSFD 400
NRYFTFSGIC QYLLARDCED HTFSIVIETM QCADDPDAVC TRSVSVRLSA 450
LHNSLVKLKH GGAVGIDGQD VQLPFLQGDL RIQHTVMASV RLSYAEDLQM 500
DWDGRGRLLV KLSPVYSGKT CGLCGNYNGN KGDDFLTPAG LVEPLVVDFG 550
NAWKLQGDCS DLRRQHSDPC SLNPRLTRFA EEACALLTSS KFEACHHAVS 600
PLPYLQNCRY DVCSCSDSRD CLCNAVANYA AECARKGVHI GWREPGFCAL 650
GCPQGQVYLQ CGNSCNLTCR SLSLPDEECS EVCLEGCYCP PGLYQDERGD 700
CVPKAQCPCY YDGELFQPAD IFSDHHTMCY CEDGFMHCTT SGTLGSLLPD 750
TVLSSPLSHR SKRSLSCRPP MVKLVCPADN PRAQGLECAK TCQNYDLERM 800
SLGCVSGCLC PPGMVRHENK CVALERCPCF HQGAEYAPGD TVKIGCNTCV 850
CRERKWNCTN HVCDATRSAI GMAHYLTFDG LKYLFPGECQ YVLVYDYCGS 900
NPGTFQILVG NEGCSYPSVK CRKRVTILVD GGELELFDGE VNVKRPLRDE 950
SHFEVVESGR YVILLLGQAL SVVWDHHLSI SVVLKHTYQE QVCGLCGNFD 1000
GIQNNDSTTS SLQVEEDPVN FGNSWKVSSQ CADTRKLSLD VSPATCHNNI 1050
MKQTMVDSAC RILTSDVFQG CNRLVDPEPY LDICIYDTCS CESIGDCACF 1100
CDTIAAYAHV CAQHGQVVAW RTPTLCPQSC EEKNVRENGY ECEWRYNSCA 1150
PACPVTCQHP EPLACPVQCV EGCHAHCPPG RILDELLQTC VDPQDCPVCE 1200
VAGRRLAPGK KITLSPDDPA HCQNCHCDGV NLTCEACQEP GGLVAPPTDA 1250
PVSSTTPYVE DTPEPPLHNF YCSKLLDLVF LLDGSSMLSE AEFEVLKAFV 1300
VGMMERLHIS QKRIRVAVVE YHDGSRAYLE LKARKRPSEL RRITSQIKYT 1350
GSQVASTSEV LKYTLFQIFG KIDRPEASHI TLLLTASQEP PRMARNLVRY 1400
VQGLKKKKVI VIPVGIGPHA SLKQIRLIEK QAPENKAFLL SGVDELEQRR 1450
DEIVSYLCDL APEAPAPTQP PQVAHVTVSP GIAGISSPGP KRKSMVLDVV 1500
FVLEGSDEVG EANFNKSKEF VEEVIQRMDV SPDATRISVL QYSYTVTMEY 1550
AFNGAQSKEE VLRHVREIRY QGGNRTNTGQ ALQYLSEHSF SPSQGDRVEA 1600
PNLVYMVTGN PASDEIKRLP GDIQVVPIGV GPHANMQELE RISRPIAPIF 1650
IRDFETLPRE APDLVLQTCC SKEGLQLPTL PPLPDCSQPL DVVLLLDGSS 1700
SLPESSFDKM KSFAKAFISK ANIGPHLTQV SVIQYGSINT IDVPWNVVQE 1750
KAHLQSLVDL MQQEGGPSQI GDALAFAVRY VTSQIHGARP GASKAVVIII 1800
MDTSLDPVDT AADAARSNRV AVFPVGVGDR YDEAQLRILA GPGASSNVVK 1850
LQQVEDLSTM ATLGNSFFHK LCSGFSGVCV DEDGNEKRPG DVWTLPDQCH 1900
TVTCLANGQT LLQSHRVNCD HGPRPSCANS QSPVRVEETC GCRWTCPCVC 1950
TGSSTRHIVT FDGQNFKLTG SCSYVIFQNK EQDLEVLLHN GACSPGAKQA 2000
CMKSIEIKHA GVSAELHSNM EMAVDGRLVL APYVGENMEV SIYGAIMYEV 2050
RFTHLGHILT YTPQNNEFQL QLSPKTFASK MHGLCGICDE NGANDFTLRD 2100
GTVTTDWKRL VQEWTVQQPG YTCQAVPEEQ CPVSDSSHCQ VLLSASFAEC 2150
HKVIAPATFH TICQQDSCHQ ERVCEVIASY AHLCRTSGVC VDWRTTDFCA 2200
MSCPPSLVYN HCERGCPRHC DGNTSFCGDH PSEGCFCPQH QVFLEGSCVP 2250
EEACTQCVGE DGVRHQFLET WVPDHQPCQI CMCLSGRKIN CTAQPCPTAR 2300
APTCGPCEVA RLKQSTNLCC PEYECVCDLF NCNLPPVPPC EGGLQPTLTN 2350
PGECRPTFTC DCRKEECKRV SPPSCPPHRT PTLRKTQCCD EYECACSCVN 2400
STLSCPLGYL ASATTNDCGC TTTTCLPDKV CVHRGTVYPV GQFWEEGCDT 2450
CTCTDMEDTV VGLRVVQCSQ RPCEDSCQPG FSYVLHEGEC CGRCLPSACK 2500
VVAGSLRGDS HSSWKSVGSR WAVPENPCLV NECVRVEDAV FVQQRNISCP 2550
QLAVPTCPTG FQLNCETSEC CPSCHCEPVE ACLLNGTIIG PGKSVMVDLC 2600
TTCRCIVQTD AISRFKLECR KTTCEACPMG YREEKSQGEC CGRCLPTACT 2650
IQLRGGRIMT LKQDETFQDG CDSHLCRVNE RGEYIWEKRV TGCPPFDEHK 2700
CLAEGGKIVK IPGTCCDTCE EPDCKDITAK VQYIKVGDCK SQEEVDIHYC 2750
QGKCASKAVY SIDIEDVQEQ CSCCLPSRTE PMRVPLHCTN GSVVYHEVIN 2800
AMQCRCSPRN CSK 2813
Length:2,813
Mass (Da):309,269
Last modified:October 1, 2003 - v2
Checksum:i3EE2C7D8FF21FFA6
GO
Isoform 2 (identifier: Q8CIZ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-402: ECLVTGQSHFKSFDNR → RLGTFSPFLPVLCGEV
     403-2813: Missing.

Note: No experimental confirmation available.

Show »
Length:402
Mass (Da):44,467
Checksum:i36201FC93F1EE915
GO

Sequence cautioni

The sequence BAC38822.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei387 – 40216ECLVT…SFDNR → RLGTFSPFLPVLCGEV in isoform 2. VSP_051618Add
BLAST
Alternative sequencei403 – 28132411Missing in isoform 2. VSP_051619Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031M → T in AAP41950. 1 Publication
Sequence conflicti122 – 1221L → R in AAP41950. 1 Publication
Sequence conflicti799 – 7991R → C in AAP41950. 1 Publication
Sequence conflicti867 – 8671R → C in AAP41950. 1 Publication
Sequence conflicti895 – 8951Y → Q in AAP41950. 1 Publication
Sequence conflicti1007 – 10071S → F in AAP41950. 1 Publication
Sequence conflicti1245 – 12451A → V in CAB86200. 1 Publication
Sequence conflicti1421 – 14211S → D in AAA82929. 1 Publication
Sequence conflicti1485 – 14862IS → TL in AAA82929. 1 Publication
Sequence conflicti2361 – 23611D → A in AAP41950. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY208897 mRNA. Translation: AAP41950.1.
AY162409 mRNA. Translation: AAN73055.1.
AF539800 mRNA. Translation: AAN07781.2.
AK083237 mRNA. Translation: BAC38822.1. Different initiation.
AJ238390 Genomic DNA. Translation: CAB86200.1.
U27810 Genomic DNA. Translation: AAA82929.1.
CCDSiCCDS20552.1. [Q8CIZ8-1]
RefSeqiNP_035838.3. NM_011708.4.
UniGeneiMm.22339.

Genome annotation databases

EnsembliENSMUST00000001995; ENSMUSP00000001995; ENSMUSG00000001930.
GeneIDi22371.
KEGGimmu:22371.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY208897 mRNA. Translation: AAP41950.1 .
AY162409 mRNA. Translation: AAN73055.1 .
AF539800 mRNA. Translation: AAN07781.2 .
AK083237 mRNA. Translation: BAC38822.1 . Different initiation.
AJ238390 Genomic DNA. Translation: CAB86200.1 .
U27810 Genomic DNA. Translation: AAA82929.1 .
CCDSi CCDS20552.1. [Q8CIZ8-1 ]
RefSeqi NP_035838.3. NM_011708.4.
UniGenei Mm.22339.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1U0O X-ray 2.70 C 1261-1468 [» ]
ProteinModelPortali Q8CIZ8.
SMRi Q8CIZ8. Positions 1270-1464, 1494-1671, 1685-1873, 2721-2813.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CIZ8. 1 interaction.
MINTi MINT-4140177.

Protein family/group databases

MEROPSi I08.950.

PTM databases

PhosphoSitei Q8CIZ8.

Proteomic databases

MaxQBi Q8CIZ8.
PaxDbi Q8CIZ8.
PRIDEi Q8CIZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001995 ; ENSMUSP00000001995 ; ENSMUSG00000001930 .
GeneIDi 22371.
KEGGi mmu:22371.

Organism-specific databases

CTDi 7450.
MGIi MGI:98941. Vwf.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000110607.
HOGENOMi HOG000169747.
HOVERGENi HBG004380.
InParanoidi Q8CIZ8.
KOi K03900.
PhylomeDBi Q8CIZ8.

Enzyme and pathway databases

Reactomei REACT_216309. Integrin cell surface interactions.
REACT_225107. Platelet Adhesion to exposed collagen.

Miscellaneous databases

ChiTaRSi VWF. mouse.
EvolutionaryTracei Q8CIZ8.
NextBioi 302707.
PROi Q8CIZ8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8CIZ8.
Bgeei Q8CIZ8.
CleanExi MM_VWF.
Genevestigatori Q8CIZ8.

Family and domain databases

Gene3Di 3.40.50.410. 3 hits.
InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR012011. VWF.
IPR002035. VWF_A.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 4 hits.
PF01826. TIL. 5 hits.
PF00092. VWA. 3 hits.
PF00093. VWC. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view ]
PIRSFi PIRSF002495. VWF. 1 hit.
SMARTi SM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00327. VWA. 3 hits.
SM00214. VWC. 5 hits.
SM00216. VWD. 4 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 3 hits.
SSF57567. SSF57567. 5 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50234. VWFA. 3 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
PS51233. VWFD. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of full-length murine von Willebrand factor cDNA."
    Chitta M.S., Duhe R.J., Kermode J.C.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Lung.
  2. "Murine von Willebrand factor."
    Lenting P.J., Westein E., de Groot P.G., Denis C.V.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  4. "Variance of molecular datings, evolution of rodents and the phylogenetic affinities between Ctenodactylidae and Hystricognathi."
    Huchon D., Catzeflis F.M., Douzery E.J.P.
    Proc. R. Soc. B 267:393-402(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1238-1658 (ISOFORM 1).
  5. "von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene."
    Nichols W.C., Cooney K.A., Mohlke K.L., Ballew J.D., Yang A., Bruck M.E., Reddington M., Novak E.K., Swank R.T., Ginsburg D.
    Blood 83:3225-3231(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1298-1684 (ISOFORM 1).
    Strain: BALB/c.
  6. "An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation."
    Lenting P.J., Westein E., Terraube V., Ribba A.-S., Huizinga E.G., Meyer D., de Groot P.G., Denis C.V.
    J. Biol. Chem. 279:12102-12109(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-1205, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  7. "von Willebrand factor, platelets and endothelial cell interactions."
    Ruggeri Z.M.
    J. Thromb. Haemost. 1:1335-1342(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation."
    Fukuda K., Doggett T., Laurenzi I.J., Liddington R.C., Diacovo T.G.
    Nat. Struct. Mol. Biol. 12:152-159(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1261-1468 IN COMPLEX WITH SNAKE VENOM BOTROCETIN, DISULFIDE BOND.

Entry informationi

Entry nameiVWF_MOUSE
AccessioniPrimary (citable) accession number: Q8CIZ8
Secondary accession number(s): Q60863
, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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