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Q8CIZ8

- VWF_MOUSE

UniProt

Q8CIZ8 - VWF_MOUSE

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Protein

von Willebrand factor

Gene

Vwf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.By similarity1 Publication

GO - Molecular functioni

  1. chaperone binding Source: UniProtKB
  2. collagen binding Source: UniProtKB
  3. glycoprotein binding Source: UniProtKB
  4. immunoglobulin binding Source: UniProtKB
  5. integrin binding Source: UniProtKB
  6. protease binding Source: UniProtKB
  7. protein homodimerization activity Source: UniProtKB
  8. protein N-terminus binding Source: UniProtKB

GO - Biological processi

  1. blood coagulation Source: UniProtKB
  2. cell adhesion Source: UniProtKB
  3. cell-substrate adhesion Source: UniProtKB
  4. hemostasis Source: UniProtKB
  5. liver development Source: MGI
  6. placenta development Source: MGI
  7. platelet activation Source: UniProtKB
  8. protein homooligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_216309. Integrin cell surface interactions.
REACT_225107. Platelet Adhesion to exposed collagen.

Protein family/group databases

MEROPSiI08.950.

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
Cleaved into the following chain:
Alternative name(s):
von Willebrand antigen II
Gene namesi
Name:VwfImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:98941. Vwf.

Subcellular locationi

Secreted By similarity. Secretedextracellular spaceextracellular matrix By similarity
Note: Localized to storage granules.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. external side of plasma membrane Source: MGI
  3. extracellular matrix Source: UniProtKB
  4. extracellular region Source: UniProtKB
  5. proteinaceous extracellular matrix Source: UniProtKB-KW
  6. Weibel-Palade body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Platelet deposition and thrombus formation is significantly delayed, but despite this small thrombi do eventually form. At later stages, thrombus growth frequently arrests leaving open channels within arterioles. In double knockouts of FGA and VWF, in addition to delayed platelet deposition, thrombi are fragile and frequently embolize.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1205 – 12051R → H: Accelerated clearance of VWF from blood plasma. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 763741von Willebrand antigen 2PRO_0000022684Add
BLAST
Chaini764 – 28132050von Willebrand factorPRO_0000022685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 2811By similarity
Disulfide bondi? ↔ 996By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi666 – 6661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi767 ↔ 808By similarity
Disulfide bondi776 ↔ 804By similarity
Disulfide bondi810 ↔ 821By similarity
Glycosylationi857 – 8571N-linked (GlcNAc...)By similarity
Disulfide bondi889 ↔ 1031By similarity
Disulfide bondi898 ↔ 993By similarity
Disulfide bondi914 ↔ 921By similarity
Glycosylationi1005 – 10051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1060 ↔ 1084By similarity
Disulfide bondi1071 ↔ 1111By similarity
Disulfide bondi1089 ↔ 1091By similarity
Disulfide bondi1126 ↔ 1130By similarity
Glycosylationi1147 – 11471N-linked (GlcNAc...); atypicalBy similarity
Disulfide bondi1149 ↔ 1169By similarity
Disulfide bondi1153 ↔ 1165By similarity
Disulfide bondi1196 ↔ 1199By similarity
Glycosylationi1231 – 12311N-linked (GlcNAc...)By similarity
Disulfide bondi1234 ↔ 1237By similarity
Glycosylationi1248 – 12481O-linked (GalNAc...)By similarityCurated
Glycosylationi1255 – 12551O-linked (GalNAc...)By similarityCurated
Glycosylationi1256 – 12561O-linked (GalNAc...)By similarityCurated
Disulfide bondi1272 ↔ 14581 Publication
Glycosylationi1468 – 14681O-linked (GalNAc...)By similarityCurated
Glycosylationi1477 – 14771O-linked (GalNAc...)By similarityCurated
Glycosylationi1486 – 14861O-linked (GalNAc...)By similarityCurated
Glycosylationi1515 – 15151N-linked (GlcNAc...)By similarity
Glycosylationi1574 – 15741N-linked (GlcNAc...)By similarity
Disulfide bondi1669 ↔ 1670By similarity
Glycosylationi1679 – 16791O-linked (GalNAc...)By similarityCurated
Disulfide bondi1686 ↔ 1872By similarity
Cross-linki1720 – 1720Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Disulfide bondi1879 ↔ 1904By similarity
Disulfide bondi1899 ↔ 1940Or C-1899 with C-1942By similarityPROSITE-ProRule annotation
Disulfide bondi1927 ↔ 2088By similarity
Disulfide bondi1950 ↔ 2085By similarity
Disulfide bondi1972 ↔ 2123By similarity
Disulfide bondi1993 ↔ 2001By similarity
Glycosylationi2223 – 22231N-linked (GlcNAc...)By similarity
Glycosylationi2290 – 22901N-linked (GlcNAc...)By similarity
Glycosylationi2298 – 22981O-linked (GalNAc...)By similarityCurated
Glycosylationi2400 – 24001N-linked (GlcNAc...)By similarity
Glycosylationi2546 – 25461N-linked (GlcNAc...)By similarity
Glycosylationi2585 – 25851N-linked (GlcNAc...)By similarity
Disulfide bondi2724 ↔ 2774By similarity
Disulfide bondi2739 ↔ 2788By similarity
Disulfide bondi2750 ↔ 2804By similarity
Disulfide bondi2754 ↔ 2806By similarity
Glycosylationi2790 – 27901N-linked (GlcNAc...)By similarity
Glycosylationi2810 – 28101N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

All cysteine residues are involved in intrachain or interchain disulfide bonds.By similarity
N- and O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8CIZ8.
PaxDbiQ8CIZ8.
PRIDEiQ8CIZ8.

PTM databases

PhosphoSiteiQ8CIZ8.

Expressioni

Tissue specificityi

Plasma. Expressed in liver.1 Publication

Gene expression databases

BgeeiQ8CIZ8.
CleanExiMM_VWF.
ExpressionAtlasiQ8CIZ8. baseline and differential.
GenevestigatoriQ8CIZ8.

Interactioni

Subunit structurei

Multimeric. Interacts with F8 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8CIZ8. 1 interaction.
MINTiMINT-4140177.

Structurei

Secondary structure

1
2813
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1274 – 128310
Beta strandi1285 – 12884
Helixi1290 – 130415
Beta strandi1311 – 132919
Helixi1337 – 13459
Helixi1357 – 136610
Turni1367 – 13693
Beta strandi1377 – 13859
Helixi1391 – 13944
Helixi1397 – 140610
Beta strandi1409 – 142012
Helixi1422 – 14309
Beta strandi1438 – 14425
Helixi1443 – 145816

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U0OX-ray2.70C1261-1468[»]
ProteinModelPortaliQ8CIZ8.
SMRiQ8CIZ8. Positions 766-864, 1270-1464, 1494-1671, 1685-1873, 2721-2813.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CIZ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 240207VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini295 – 34854TIL 1Add
BLAST
Domaini387 – 598212VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini652 – 70756TIL 2Add
BLAST
Domaini804 – 82724TIL 3Add
BLAST
Domaini866 – 1074209VWFD 3PROSITE-ProRule annotationAdd
BLAST
Domaini1146 – 119651TIL 4Add
BLAST
Domaini1277 – 1453177VWFA 1; binding site for platelet glycoprotein IbPROSITE-ProRule annotationAdd
BLAST
Domaini1498 – 1665168VWFA 2PROSITE-ProRule annotationAdd
BLAST
Domaini1691 – 1871181VWFA 3; principal binding site for collagens type I and IIIPROSITE-ProRule annotationAdd
BLAST
Domaini1949 – 2153205VWFD 4PROSITE-ProRule annotationAdd
BLAST
Domaini2255 – 232874VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini2429 – 249567VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini2580 – 264566VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini2724 – 281289CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni764 – 78724Amino-terminalAdd
BLAST
Regioni788 – 83346E1Add
BLAST
Regioni826 – 85328CXAdd
BLAST
Regioni2216 – 226146E2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2507 – 25093Cell attachment siteBy similarity

Domaini

The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.By similarity

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 3 VWFA domains.PROSITE-ProRule annotation
Contains 3 VWFC domains.PROSITE-ProRule annotation
Contains 4 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118896.
HOGENOMiHOG000169747.
HOVERGENiHBG004380.
InParanoidiQ8CIZ8.
KOiK03900.
PhylomeDBiQ8CIZ8.

Family and domain databases

Gene3Di3.40.50.410. 3 hits.
InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR012011. VWF.
IPR002035. VWF_A.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 4 hits.
PF01826. TIL. 5 hits.
PF00092. VWA. 3 hits.
PF00093. VWC. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view]
PIRSFiPIRSF002495. VWF. 1 hit.
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00327. VWA. 3 hits.
SM00214. VWC. 5 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 3 hits.
SSF57567. SSF57567. 5 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50234. VWFA. 3 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8CIZ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPFRYEICL LVLALTWPGT LCTEKPRDRP STARCSLFGD DFINTFDETM
60 70 80 90 100
YSFAGGCSYL LAGDCQKRSF SILGNFQDGK RMSLSVYLGE FFDIHLFANG
110 120 130 140 150
TVMQGDQSIS MPYASQGLYL ELEAGYYKLS SETFGFAARI DGNGNFQVLM
160 170 180 190 200
SDRHFNKTCG LCGDFNIFAE DDFRTQEGTL TSDPYDFANS WALSSEEQRC
210 220 230 240 250
KRASPPSRNC ESSSGDMHQA MWEQCQLLKT ASVFARCHPL VDPESFVALC
260 270 280 290 300
EKILCTCATG PECACPVLLE YARTCAQEGM VLYGWTDHSA CRPACPAGME
310 320 330 340 350
YKECVSPCPR TCQSLSINEV CQQQCVDGCS CPEGELLDED RCVQSSDCPC
360 370 380 390 400
VHAGKRYPPG TSLSQDCNTC ICRNSLWICS NEECPGECLV TGQSHFKSFD
410 420 430 440 450
NRYFTFSGIC QYLLARDCED HTFSIVIETM QCADDPDAVC TRSVSVRLSA
460 470 480 490 500
LHNSLVKLKH GGAVGIDGQD VQLPFLQGDL RIQHTVMASV RLSYAEDLQM
510 520 530 540 550
DWDGRGRLLV KLSPVYSGKT CGLCGNYNGN KGDDFLTPAG LVEPLVVDFG
560 570 580 590 600
NAWKLQGDCS DLRRQHSDPC SLNPRLTRFA EEACALLTSS KFEACHHAVS
610 620 630 640 650
PLPYLQNCRY DVCSCSDSRD CLCNAVANYA AECARKGVHI GWREPGFCAL
660 670 680 690 700
GCPQGQVYLQ CGNSCNLTCR SLSLPDEECS EVCLEGCYCP PGLYQDERGD
710 720 730 740 750
CVPKAQCPCY YDGELFQPAD IFSDHHTMCY CEDGFMHCTT SGTLGSLLPD
760 770 780 790 800
TVLSSPLSHR SKRSLSCRPP MVKLVCPADN PRAQGLECAK TCQNYDLERM
810 820 830 840 850
SLGCVSGCLC PPGMVRHENK CVALERCPCF HQGAEYAPGD TVKIGCNTCV
860 870 880 890 900
CRERKWNCTN HVCDATRSAI GMAHYLTFDG LKYLFPGECQ YVLVYDYCGS
910 920 930 940 950
NPGTFQILVG NEGCSYPSVK CRKRVTILVD GGELELFDGE VNVKRPLRDE
960 970 980 990 1000
SHFEVVESGR YVILLLGQAL SVVWDHHLSI SVVLKHTYQE QVCGLCGNFD
1010 1020 1030 1040 1050
GIQNNDSTTS SLQVEEDPVN FGNSWKVSSQ CADTRKLSLD VSPATCHNNI
1060 1070 1080 1090 1100
MKQTMVDSAC RILTSDVFQG CNRLVDPEPY LDICIYDTCS CESIGDCACF
1110 1120 1130 1140 1150
CDTIAAYAHV CAQHGQVVAW RTPTLCPQSC EEKNVRENGY ECEWRYNSCA
1160 1170 1180 1190 1200
PACPVTCQHP EPLACPVQCV EGCHAHCPPG RILDELLQTC VDPQDCPVCE
1210 1220 1230 1240 1250
VAGRRLAPGK KITLSPDDPA HCQNCHCDGV NLTCEACQEP GGLVAPPTDA
1260 1270 1280 1290 1300
PVSSTTPYVE DTPEPPLHNF YCSKLLDLVF LLDGSSMLSE AEFEVLKAFV
1310 1320 1330 1340 1350
VGMMERLHIS QKRIRVAVVE YHDGSRAYLE LKARKRPSEL RRITSQIKYT
1360 1370 1380 1390 1400
GSQVASTSEV LKYTLFQIFG KIDRPEASHI TLLLTASQEP PRMARNLVRY
1410 1420 1430 1440 1450
VQGLKKKKVI VIPVGIGPHA SLKQIRLIEK QAPENKAFLL SGVDELEQRR
1460 1470 1480 1490 1500
DEIVSYLCDL APEAPAPTQP PQVAHVTVSP GIAGISSPGP KRKSMVLDVV
1510 1520 1530 1540 1550
FVLEGSDEVG EANFNKSKEF VEEVIQRMDV SPDATRISVL QYSYTVTMEY
1560 1570 1580 1590 1600
AFNGAQSKEE VLRHVREIRY QGGNRTNTGQ ALQYLSEHSF SPSQGDRVEA
1610 1620 1630 1640 1650
PNLVYMVTGN PASDEIKRLP GDIQVVPIGV GPHANMQELE RISRPIAPIF
1660 1670 1680 1690 1700
IRDFETLPRE APDLVLQTCC SKEGLQLPTL PPLPDCSQPL DVVLLLDGSS
1710 1720 1730 1740 1750
SLPESSFDKM KSFAKAFISK ANIGPHLTQV SVIQYGSINT IDVPWNVVQE
1760 1770 1780 1790 1800
KAHLQSLVDL MQQEGGPSQI GDALAFAVRY VTSQIHGARP GASKAVVIII
1810 1820 1830 1840 1850
MDTSLDPVDT AADAARSNRV AVFPVGVGDR YDEAQLRILA GPGASSNVVK
1860 1870 1880 1890 1900
LQQVEDLSTM ATLGNSFFHK LCSGFSGVCV DEDGNEKRPG DVWTLPDQCH
1910 1920 1930 1940 1950
TVTCLANGQT LLQSHRVNCD HGPRPSCANS QSPVRVEETC GCRWTCPCVC
1960 1970 1980 1990 2000
TGSSTRHIVT FDGQNFKLTG SCSYVIFQNK EQDLEVLLHN GACSPGAKQA
2010 2020 2030 2040 2050
CMKSIEIKHA GVSAELHSNM EMAVDGRLVL APYVGENMEV SIYGAIMYEV
2060 2070 2080 2090 2100
RFTHLGHILT YTPQNNEFQL QLSPKTFASK MHGLCGICDE NGANDFTLRD
2110 2120 2130 2140 2150
GTVTTDWKRL VQEWTVQQPG YTCQAVPEEQ CPVSDSSHCQ VLLSASFAEC
2160 2170 2180 2190 2200
HKVIAPATFH TICQQDSCHQ ERVCEVIASY AHLCRTSGVC VDWRTTDFCA
2210 2220 2230 2240 2250
MSCPPSLVYN HCERGCPRHC DGNTSFCGDH PSEGCFCPQH QVFLEGSCVP
2260 2270 2280 2290 2300
EEACTQCVGE DGVRHQFLET WVPDHQPCQI CMCLSGRKIN CTAQPCPTAR
2310 2320 2330 2340 2350
APTCGPCEVA RLKQSTNLCC PEYECVCDLF NCNLPPVPPC EGGLQPTLTN
2360 2370 2380 2390 2400
PGECRPTFTC DCRKEECKRV SPPSCPPHRT PTLRKTQCCD EYECACSCVN
2410 2420 2430 2440 2450
STLSCPLGYL ASATTNDCGC TTTTCLPDKV CVHRGTVYPV GQFWEEGCDT
2460 2470 2480 2490 2500
CTCTDMEDTV VGLRVVQCSQ RPCEDSCQPG FSYVLHEGEC CGRCLPSACK
2510 2520 2530 2540 2550
VVAGSLRGDS HSSWKSVGSR WAVPENPCLV NECVRVEDAV FVQQRNISCP
2560 2570 2580 2590 2600
QLAVPTCPTG FQLNCETSEC CPSCHCEPVE ACLLNGTIIG PGKSVMVDLC
2610 2620 2630 2640 2650
TTCRCIVQTD AISRFKLECR KTTCEACPMG YREEKSQGEC CGRCLPTACT
2660 2670 2680 2690 2700
IQLRGGRIMT LKQDETFQDG CDSHLCRVNE RGEYIWEKRV TGCPPFDEHK
2710 2720 2730 2740 2750
CLAEGGKIVK IPGTCCDTCE EPDCKDITAK VQYIKVGDCK SQEEVDIHYC
2760 2770 2780 2790 2800
QGKCASKAVY SIDIEDVQEQ CSCCLPSRTE PMRVPLHCTN GSVVYHEVIN
2810
AMQCRCSPRN CSK
Length:2,813
Mass (Da):309,269
Last modified:October 1, 2003 - v2
Checksum:i3EE2C7D8FF21FFA6
GO
Isoform 2Curated (identifier: Q8CIZ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-402: ECLVTGQSHFKSFDNR → RLGTFSPFLPVLCGEV
     403-2813: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:402
Mass (Da):44,467
Checksum:i36201FC93F1EE915
GO

Sequence cautioni

The sequence BAC38822.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031M → T in AAP41950. 1 PublicationCurated
Sequence conflicti122 – 1221L → R in AAP41950. 1 PublicationCurated
Sequence conflicti799 – 7991R → C in AAP41950. 1 PublicationCurated
Sequence conflicti867 – 8671R → C in AAP41950. 1 PublicationCurated
Sequence conflicti895 – 8951Y → Q in AAP41950. 1 PublicationCurated
Sequence conflicti1007 – 10071S → F in AAP41950. 1 PublicationCurated
Sequence conflicti1245 – 12451A → V in CAB86200. (PubMed:10722222)Curated
Sequence conflicti1421 – 14211S → D in AAA82929. (PubMed:8193357)Curated
Sequence conflicti1485 – 14862IS → TL in AAA82929. (PubMed:8193357)Curated
Sequence conflicti2361 – 23611D → A in AAP41950. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei387 – 40216ECLVT…SFDNR → RLGTFSPFLPVLCGEV in isoform 2. 1 PublicationVSP_051618Add
BLAST
Alternative sequencei403 – 28132411Missing in isoform 2. 1 PublicationVSP_051619Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY208897 mRNA. Translation: AAP41950.1.
AY162409 mRNA. Translation: AAN73055.1.
AF539800 mRNA. Translation: AAN07781.2.
AK083237 mRNA. Translation: BAC38822.1. Different initiation.
AJ238390 Genomic DNA. Translation: CAB86200.1.
U27810 Genomic DNA. Translation: AAA82929.1.
CCDSiCCDS20552.1. [Q8CIZ8-1]
RefSeqiNP_035838.3. NM_011708.4.
UniGeneiMm.22339.

Genome annotation databases

EnsembliENSMUST00000001995; ENSMUSP00000001995; ENSMUSG00000001930.
GeneIDi22371.
KEGGimmu:22371.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY208897 mRNA. Translation: AAP41950.1 .
AY162409 mRNA. Translation: AAN73055.1 .
AF539800 mRNA. Translation: AAN07781.2 .
AK083237 mRNA. Translation: BAC38822.1 . Different initiation.
AJ238390 Genomic DNA. Translation: CAB86200.1 .
U27810 Genomic DNA. Translation: AAA82929.1 .
CCDSi CCDS20552.1. [Q8CIZ8-1 ]
RefSeqi NP_035838.3. NM_011708.4.
UniGenei Mm.22339.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1U0O X-ray 2.70 C 1261-1468 [» ]
ProteinModelPortali Q8CIZ8.
SMRi Q8CIZ8. Positions 766-864, 1270-1464, 1494-1671, 1685-1873, 2721-2813.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CIZ8. 1 interaction.
MINTi MINT-4140177.

Protein family/group databases

MEROPSi I08.950.

PTM databases

PhosphoSitei Q8CIZ8.

Proteomic databases

MaxQBi Q8CIZ8.
PaxDbi Q8CIZ8.
PRIDEi Q8CIZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001995 ; ENSMUSP00000001995 ; ENSMUSG00000001930 .
GeneIDi 22371.
KEGGi mmu:22371.

Organism-specific databases

CTDi 7450.
MGIi MGI:98941. Vwf.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118896.
HOGENOMi HOG000169747.
HOVERGENi HBG004380.
InParanoidi Q8CIZ8.
KOi K03900.
PhylomeDBi Q8CIZ8.

Enzyme and pathway databases

Reactomei REACT_216309. Integrin cell surface interactions.
REACT_225107. Platelet Adhesion to exposed collagen.

Miscellaneous databases

ChiTaRSi VWF. mouse.
EvolutionaryTracei Q8CIZ8.
NextBioi 302707.
PROi Q8CIZ8.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIZ8.
CleanExi MM_VWF.
ExpressionAtlasi Q8CIZ8. baseline and differential.
Genevestigatori Q8CIZ8.

Family and domain databases

Gene3Di 3.40.50.410. 3 hits.
InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR012011. VWF.
IPR002035. VWF_A.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 4 hits.
PF01826. TIL. 5 hits.
PF00092. VWA. 3 hits.
PF00093. VWC. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view ]
PIRSFi PIRSF002495. VWF. 1 hit.
SMARTi SM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00327. VWA. 3 hits.
SM00214. VWC. 5 hits.
SM00216. VWD. 4 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 3 hits.
SSF57567. SSF57567. 5 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS50234. VWFA. 3 hits.
PS01208. VWFC_1. 3 hits.
PS50184. VWFC_2. 3 hits.
PS51233. VWFD. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of full-length murine von Willebrand factor cDNA."
    Chitta M.S., Duhe R.J., Kermode J.C.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6Imported.
    Tissue: LungImported.
  2. "Murine von Willebrand factor."
    Lenting P.J., Westein E., de Groot P.G., Denis C.V.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/cImported.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  4. "Variance of molecular datings, evolution of rodents and the phylogenetic affinities between Ctenodactylidae and Hystricognathi."
    Huchon D., Catzeflis F.M., Douzery E.J.P.
    Proc. R. Soc. B 267:393-402(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1238-1658 (ISOFORM 1).
  5. "von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene."
    Nichols W.C., Cooney K.A., Mohlke K.L., Ballew J.D., Yang A., Bruck M.E., Reddington M., Novak E.K., Swank R.T., Ginsburg D.
    Blood 83:3225-3231(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1298-1684 (ISOFORM 1).
    Strain: BALB/cImported.
  6. "Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen."
    Ni H., Denis C.V., Subbarao S., Degen J.L., Sato T.N., Hynes R.O., Wagner D.D.
    J. Clin. Invest. 106:385-392(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation."
    Lenting P.J., Westein E., Terraube V., Ribba A.-S., Huizinga E.G., Meyer D., de Groot P.G., Denis C.V.
    J. Biol. Chem. 279:12102-12109(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-1205, TISSUE SPECIFICITY.
    Strain: C57BL/6J1 Publication.
  8. "von Willebrand factor, platelets and endothelial cell interactions."
    Ruggeri Z.M.
    J. Thromb. Haemost. 1:1335-1342(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation."
    Fukuda K., Doggett T., Laurenzi I.J., Liddington R.C., Diacovo T.G.
    Nat. Struct. Mol. Biol. 12:152-159(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1261-1468 IN COMPLEX WITH SNAKE VENOM BOTROCETIN, DISULFIDE BOND.

Entry informationi

Entry nameiVWF_MOUSE
AccessioniPrimary (citable) accession number: Q8CIZ8
Secondary accession number(s): Q60863
, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3