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Protein

Regulating synaptic membrane exocytosis protein 4

Gene

Rims4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates synaptic membrane exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • neurotransmitter secretion Source: RGD
  • regulation of membrane potential Source: ParkinsonsUK-UCL
  • regulation of synaptic vesicle exocytosis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 4
Alternative name(s):
RIM4 gamma
Rab3-interacting molecule 4
Short name:
RIM 4
Gene namesi
Name:Rims4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628695. Rims4.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • presynapse Source: GOC
  • synaptic membrane Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Regulating synaptic membrane exocytosis protein 4PRO_0000190209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei254 – 2541PhosphoserineBy similarity
Modified residuei257 – 2571PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CIX1.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Interactioni

Subunit structurei

Binds PPFIA3.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014499.

Structurei

3D structure databases

ProteinModelPortaliQ8CIX1.
SMRiQ8CIX1. Positions 99-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 217103C2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2060. Eukaryota.
ENOG410ZNB1. LUCA.
HOVERGENiHBG056381.
InParanoidiQ8CIX1.
KOiK15299.
PhylomeDBiQ8CIX1.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSQSRLSL SASFEALAIY FPCMNSFDDE DAADSRRLKG AIQRSTETGL
60 70 80 90 100
AVEMPSRTLR QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM
110 120 130 140 150
GPAQFVGRQT LATTPMGGVE IGLQERNGQL EVDIIQARGL TAKPGSKTLP
160 170 180 190 200
AAYIKAYLLE NGVCIAKKKT KVARKSLDPL YNQVLLFPES PQGKVLQVIV
210 220 230 240 250
WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS MVDPATGPLL
260
RQASQLSLES TVGPCGERS
Length:269
Mass (Da):29,271
Last modified:March 1, 2003 - v1
Checksum:i21ACDB643A9FDC9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548739 mRNA. Translation: AAN59931.1.
RefSeqiNP_733766.1. NM_170666.1.
UniGeneiRn.86957.

Genome annotation databases

GeneIDi266976.
KEGGirno:266976.
UCSCiRGD:628695. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548739 mRNA. Translation: AAN59931.1.
RefSeqiNP_733766.1. NM_170666.1.
UniGeneiRn.86957.

3D structure databases

ProteinModelPortaliQ8CIX1.
SMRiQ8CIX1. Positions 99-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014499.

Proteomic databases

PaxDbiQ8CIX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266976.
KEGGirno:266976.
UCSCiRGD:628695. rat.

Organism-specific databases

CTDi140730.
RGDi628695. Rims4.

Phylogenomic databases

eggNOGiKOG2060. Eukaryota.
ENOG410ZNB1. LUCA.
HOVERGENiHBG056381.
InParanoidiQ8CIX1.
KOiK15299.
PhylomeDBiQ8CIX1.

Miscellaneous databases

PROiQ8CIX1.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins."
    Wang Y., Suedhof T.C.
    Genomics 81:126-137(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PPFIA3, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRIMS4_RAT
AccessioniPrimary (citable) accession number: Q8CIX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.