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Protein

Regulating synaptic membrane exocytosis protein 4

Gene

Rims4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates synaptic membrane exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
  • neurotransmitter secretion Source: RGD
  • regulation of membrane potential Source: ParkinsonsUK-UCL
  • regulation of synaptic vesicle exocytosis Source: MGI

Keywordsi

Biological processExocytosis, Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 4
Alternative name(s):
RIM4 gamma
Rab3-interacting molecule 4
Short name:
RIM 4
Gene namesi
Name:Rims4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628695 Rims4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902091 – 269Regulating synaptic membrane exocytosis protein 4Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei254PhosphoserineBy similarity1
Modified residuei257PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CIX1
PRIDEiQ8CIX1

Expressioni

Tissue specificityi

Brain specific.1 Publication

Interactioni

Subunit structurei

Binds PPFIA3.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014499

Structurei

3D structure databases

ProteinModelPortaliQ8CIX1
SMRiQ8CIX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 217C2PROSITE-ProRule annotationAdd BLAST103

Phylogenomic databases

eggNOGiKOG2060 Eukaryota
ENOG410ZNB1 LUCA
HOVERGENiHBG056381
InParanoidiQ8CIX1
KOiK15299
PhylomeDBiQ8CIX1

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CIX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSQSRLSL SASFEALAIY FPCMNSFDDE DAADSRRLKG AIQRSTETGL
60 70 80 90 100
AVEMPSRTLR QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM
110 120 130 140 150
GPAQFVGRQT LATTPMGGVE IGLQERNGQL EVDIIQARGL TAKPGSKTLP
160 170 180 190 200
AAYIKAYLLE NGVCIAKKKT KVARKSLDPL YNQVLLFPES PQGKVLQVIV
210 220 230 240 250
WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS MVDPATGPLL
260
RQASQLSLES TVGPCGERS
Length:269
Mass (Da):29,271
Last modified:March 1, 2003 - v1
Checksum:i21ACDB643A9FDC9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548739 mRNA Translation: AAN59931.1
RefSeqiNP_733766.1, NM_170666.1
UniGeneiRn.86957

Genome annotation databases

GeneIDi266976
KEGGirno:266976
UCSCiRGD:628695 rat

Similar proteinsi

Entry informationi

Entry nameiRIMS4_RAT
AccessioniPrimary (citable) accession number: Q8CIX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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