Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 26 member 6

Gene

Slc26a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.17 Publications

Enzyme regulationi

Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by DIDS (By similarity). Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and oxalate secretion in the duodenum are inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).By similarity6 Publications

Kineticsi

  1. KM=0.3 mM for oxalate, PubMed:121192872 Publications
  2. KM=0.314 mM for oxalate, PubMed:152039032 Publications
  3. KM=3.87 mM for formate, PubMed:152039032 Publications

    GO - Molecular functioni

    • anion:anion antiporter activity Source: UniProtKB
    • bicarbonate transmembrane transporter activity Source: UniProtKB
    • chloride channel activity Source: UniProtKB-KW
    • chloride transmembrane transporter activity Source: UniProtKB
    • efflux transmembrane transporter activity Source: UniProtKB
    • formate efflux transmembrane transporter activity Source: UniProtKB
    • formate transmembrane transporter activity Source: UniProtKB
    • formate uptake transmembrane transporter activity Source: UniProtKB
    • oxalate transmembrane transporter activity Source: UniProtKB
    • PDZ domain binding Source: UniProtKB
    • secondary active sulfate transmembrane transporter activity Source: InterPro
    • sulfate transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    • angiotensin-activated signaling pathway Source: UniProtKB
    • anion transmembrane transport Source: GOC
    • bicarbonate transport Source: UniProtKB
    • cellular response to cAMP Source: UniProtKB
    • cellular response to fructose stimulus Source: UniProtKB
    • cellular response to interferon-gamma Source: MGI
    • chloride transmembrane transport Source: GOC
    • chloride transport Source: UniProtKB
    • epithelial fluid transport Source: UniProtKB
    • formate transport Source: UniProtKB
    • intestinal absorption Source: UniProtKB
    • intracellular pH elevation Source: UniProtKB
    • mannitol transport Source: UniProtKB
    • oxalate transport Source: UniProtKB
    • oxalic acid secretion Source: UniProtKB
    • positive regulation of dipeptide transmembrane transport Source: UniProtKB
    • protein kinase C signaling Source: UniProtKB
    • regulation of intracellular pH Source: UniProtKB
    • sperm capacitation Source: UniProtKB
    • sulfate transmembrane transport Source: GOC
    • sulfate transport Source: UniProtKB
    • transepithelial chloride transport Source: UniProtKB
    • transepithelial transport Source: UniProtKB
    • transmembrane transport Source: GOC
    Complete GO annotation...

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_350869. Multifunctional anion exchangers.

    Protein family/group databases

    TCDBi2.A.53.2.8. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 26 member 6
    Alternative name(s):
    Anion exchange transporter
    Chloride-formate exchanger
    Pendrin-L1
    Pendrin-like protein 1
    Putative anion transporter-1
    Short name:
    Pat-1
    Gene namesi
    Name:Slc26a6Imported
    Synonyms:Cfex, Pat1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589 Componenti: Unplaced

    Organism-specific databases

    MGIiMGI:2159728. Slc26a6.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Topological domaini139 – 18749ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST
    Topological domaini209 – 26355CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Topological domaini285 – 2928ExtracellularSequence Analysis
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST
    Topological domaini314 – 34027CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei341 – 36121HelicalSequence AnalysisAdd
    BLAST
    Topological domaini362 – 38019ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Topological domaini402 – 41716CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Topological domaini439 – 48547ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST
    Topological domaini507 – 758252CytoplasmicSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    • apical plasma membrane Source: UniProtKB
    • basolateral plasma membrane Source: MGI
    • brush border membrane Source: UniProtKB
    • chloride channel complex Source: UniProtKB-KW
    • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    • endoplasmic reticulum Source: UniProtKB-KW
    • integral component of membrane Source: MGI
    • integral component of plasma membrane Source: MGI
    • intracellular Source: GOC
    • membrane Source: UniProtKB
    • membrane-bounded vesicle Source: UniProtKB
    • plasma membrane Source: UniProtKB
    • sperm midpiece Source: UniProtKB
    • vesicle membrane Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Disruption phenotypei

    Mice show an important decrease in salt absorption in the intestine and failed to develop hypertension on a high-fructose diet. Show a reduction in pancreatic duct fluid and bicarbonate secretion. Show enhanced oxalate absorption in the intestine leading to hyperoxalemia and hyperoxaluria with high incidence of calcium-oxalate stones formation.3 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi575 – 5751T → A: Does not inhibit formate transport in PMA-induced cells. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 758758Solute carrier family 26 member 6PRO_0000423423Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei603 – 6031Phosphoserine; by PKCBy similarity
    Modified residuei751 – 7511PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8CIW6.

    PTM databases

    PhosphoSiteiQ8CIW6.

    Expressioni

    Tissue specificityi

    Expressed in kidney (at protein level). Highly expressed in stomach, kidney, heart and small intestine, low in the lung, liver, testis, brain, skeletal muscle and colon. Expressed in spermatogenic cells. Isoform 1 is expressed in intestine, kidney, testis, brain, muscle, heart, and stomach.5 Publications

    Inductioni

    Up-regulated by dietary fructose intake (at protein level).1 Publication

    Interactioni

    Subunit structurei

    Interacts (via C-terminal cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange activity. Interacts with SLC9A3R1 (via the PDZ domains). Interacts with SLC9A3R2 (via the PDZ domains) (By similarity). Interacts (via C-terminal domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces chloride and oxalate exchange transport. Interacts with CFTR, SLC26A3 and SLC9A3R1. Interacts with AHCYL1; the interaction increases SLC26A6 activity (PubMed:23542070).By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CftrP263613EBI-6895517,EBI-6115317
    Slc26a3Q9WVC82EBI-6895517,EBI-6895537
    Slc9a3r1P704412EBI-6895517,EBI-1184085

    Protein-protein interaction databases

    IntActiQ8CIW6. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CIW6.
    SMRiQ8CIW6. Positions 512-561, 668-738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini531 – 741211STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    KOiK14704.
    OrthoDBiEOG76T9QT.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR030323. SLC26A6.
    IPR002645. STAS_dom.
    IPR001902. Sul_anion_transpt.
    IPR030402. Sulfate_tra_GLY.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PANTHERiPTHR11814. PTHR11814. 1 hit.
    PTHR11814:SF18. PTHR11814:SF18. 1 hit.
    PfamiPF01740. STAS. 1 hit.
    PF13792. Sulfate_tra_GLY. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q8CIW6-1) [UniParc]FASTAAdd to basket

    Also known as: Slc26a6a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MGLPDGSDQG THQTQALLSA AQEMELQRRD YHVERPLLNQ EQLEDLGHWG
    60 70 80 90 100
    PAAKTHQWRT WFRCSRARAH SLLLQHVPVL GWLPRYPVRE WLLGDLLSGL
    110 120 130 140 150
    SVAIMQLPQG LAYALLAGLP PMFGLYSSFY PVFIYFLFGT SRHISVGTFA
    160 170 180 190 200
    VMSVMVGSVT ESLTADKAFV QGLNATADDA RVQVAYTLSF LVGLFQVGLG
    210 220 230 240 250
    LVHFGFVVTY LSEPLVRSYT TAASVQVLVS QLKYVFGIKL SSHSGPLSVI
    260 270 280 290 300
    YTVLEVCAQL PETVPGTVVT AIVAGVALVL VKLLNEKLHR RLPLPIPGEL
    310 320 330 340 350
    LTLIGATGIS YGVKLNDRFK VDVVGNITTG LIPPVAPKTE LFATLVGNAF
    360 370 380 390 400
    AIAVVGFAIA ISLGKIFALR HGYRVDSNQE LVALGLSNLI GGFFQCFPVS
    410 420 430 440 450
    CSMSRSLVQE STGGNTQVAG AVSSLFILLI IVKLGELFRD LPKAVLAAVI
    460 470 480 490 500
    IVNLKGMMKQ FSDICSLWKA NRVDLLIWLV TFVATILLNL DIGLAVSIVF
    510 520 530 540 550
    SLLLVVVRMQ LPHYSVLGQV PDTDIYRDVA EYSGAKEVPG VKVFRSSATL
    560 570 580 590 600
    YFANAELYSD SLKEKCGVDV DRLITQKKKR IKKQEMKLKR MKKAKKSQKQ
    610 620 630 640 650
    DASSKISSVS VNVNTNLEDV KSNDVEGSEA KVHQGEELQD VVSSNQEDAK
    660 670 680 690 700
    APTMTSLKSL GLPQPGFHSL ILDLSTLSFV DTVCIKSLKN IFRDFREIEV
    710 720 730 740 750
    EVYIAACYSP VVAQLEAGHF FDESITKQHV FASVHDAVTF ALSHRKSVPK

    SPVLATKL
    Length:758
    Mass (Da):82,834
    Last modified:September 18, 2013 - v2
    Checksum:i1512CC3A417D037B
    GO
    Isoform 2 (identifier: Q8CIW6-2) [UniParc]FASTAAdd to basket

    Also known as: Slc26a6b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: Missing.

    Show »
    Length:735
    Mass (Da):80,496
    Checksum:i391DA011CB54C00A
    GO
    Isoform 3 (identifier: Q8CIW6-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: Missing.
         691-758: IFRDFREIEV...PKSPVLATKL → VRDCRQARAP...PALFVAADFP

    Show »
    Length:726
    Mass (Da):79,108
    Checksum:i8390F9A703F8EE94
    GO

    Sequence cautioni

    The sequence AC168054 differs from that shown. Reason: Erroneous gene model prediction. Curated
    The sequence CAAA01111125 differs from that shown. Reason: Erroneous gene model prediction. Curated
    The sequence CAAA01200220 differs from that shown. Reason: Erroneous gene model prediction. Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251E → G in AAK51131 (PubMed:11459928).Curated
    Sequence conflicti25 – 251E → G in BAC55182 (PubMed:15203903).Curated
    Sequence conflicti572 – 5721R → P in AAL13129 (PubMed:12217875).Curated
    Sequence conflicti572 – 5721R → P in AAN07089 (PubMed:12217875).Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2323Missing in isoform 2 and isoform 3. 5 PublicationsVSP_047853Add
    BLAST
    Alternative sequencei691 – 75868IFRDF…LATKL → VRDCRQARAPQAFMLILPLA SHLLATPPPNKPSPLSSPTK PCPIAASLRPALFVAADFP in isoform 3. 1 PublicationVSP_047854Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY032863 mRNA. Translation: AAK51131.1.
    AF248494 mRNA. Translation: AAN07089.1.
    AY049076 mRNA. Translation: AAL13129.1.
    AB099881 mRNA. Translation: BAC55182.1.
    AK163670 mRNA. Translation: BAE37450.1.
    AK163671 mRNA. Translation: BAE37451.1.
    AC168054 Genomic DNA. No translation available.
    CAAA01111125 Genomic DNA. No translation available.
    CAAA01200220 Genomic DNA. No translation available.
    CH466560 Genomic DNA. Translation: EDL21319.1.
    BC028856 mRNA. Translation: AAH28856.1.
    RefSeqiNP_599252.2. NM_134420.4. [Q8CIW6-2]
    UniGeneiMm.45201.

    Genome annotation databases

    GeneIDi171429.
    KEGGimmu:171429.
    UCSCiuc009rrd.1. mouse. [Q8CIW6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY032863 mRNA. Translation: AAK51131.1.
    AF248494 mRNA. Translation: AAN07089.1.
    AY049076 mRNA. Translation: AAL13129.1.
    AB099881 mRNA. Translation: BAC55182.1.
    AK163670 mRNA. Translation: BAE37450.1.
    AK163671 mRNA. Translation: BAE37451.1.
    AC168054 Genomic DNA. No translation available.
    CAAA01111125 Genomic DNA. No translation available.
    CAAA01200220 Genomic DNA. No translation available.
    CH466560 Genomic DNA. Translation: EDL21319.1.
    BC028856 mRNA. Translation: AAH28856.1.
    RefSeqiNP_599252.2. NM_134420.4. [Q8CIW6-2]
    UniGeneiMm.45201.

    3D structure databases

    ProteinModelPortaliQ8CIW6.
    SMRiQ8CIW6. Positions 512-561, 668-738.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ8CIW6. 3 interactions.

    Protein family/group databases

    TCDBi2.A.53.2.8. the sulfate permease (sulp) family.

    PTM databases

    PhosphoSiteiQ8CIW6.

    Proteomic databases

    PRIDEiQ8CIW6.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    GeneIDi171429.
    KEGGimmu:171429.
    UCSCiuc009rrd.1. mouse. [Q8CIW6-1]

    Organism-specific databases

    CTDi65010.
    MGIiMGI:2159728. Slc26a6.

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    KOiK14704.
    OrthoDBiEOG76T9QT.
    TreeFamiTF313784.

    Enzyme and pathway databases

    ReactomeiREACT_350869. Multifunctional anion exchangers.

    Miscellaneous databases

    NextBioi35555101.
    PROiQ8CIW6.
    SOURCEiSearch...

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR030323. SLC26A6.
    IPR002645. STAS_dom.
    IPR001902. Sul_anion_transpt.
    IPR030402. Sulfate_tra_GLY.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PANTHERiPTHR11814. PTHR11814. 1 hit.
    PTHR11814:SF18. PTHR11814:SF18. 1 hit.
    PfamiPF01740. STAS. 1 hit.
    PF13792. Sulfate_tra_GLY. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells."
      Knauf F., Yang C.L., Thomson R.B., Mentone S.A., Giebisch G., Aronson P.S.
      Proc. Natl. Acad. Sci. U.S.A. 98:9425-9430(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: BALB/c.
    2. "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1."
      Xie Q., Welch R., Mercado A., Romero M.F., Mount D.B.
      Am. J. Physiol. 283:F826-F838(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY.
      Strain: C57BL/6J.
    3. "Role of anion exchange transporter PAT1 (SLC26A6) in intestinal absorption of organic anions."
      Nozawa T., Sugiura S., Hashino Y., Tsuji A., Tamai I.
      J. Drug. Target. 12:97-104(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
      Strain: BALB/c.
      Tissue: Kidney.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Medulla oblongata.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Salivary gland.
    8. "Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine."
      Wang Z., Petrovic S., Mann E., Soleimani M.
      Am. J. Physiol. 282:G573-G579(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "Specificity of anion exchange mediated by mouse Slc26a6."
      Jiang Z., Grichtchenko I.I., Boron W.F., Aronson P.S.
      J. Biol. Chem. 277:33963-33967(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
    10. Cited for: FUNCTION, INTERACTION WITH PDZK1, SUBCELLULAR LOCATION.
    11. "Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3-secretion: relevance to cystic fibrosis."
      Wang Y., Soyombo A.A., Shcheynikov N., Zeng W., Dorwart M., Marino C.R., Thomas P.J., Muallem S.
      EMBO J. 25:5049-5057(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    12. "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6."
      Shcheynikov N., Wang Y., Park M., Ko S.B., Dorwart M., Naruse S., Thomas P.J., Muallem S.
      J. Gen. Physiol. 127:511-524(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6."
      Jiang Z., Asplin J.R., Evan A.P., Rajendran V.M., Velazquez H., Nottoli T.P., Binder H.J., Aronson P.S.
      Nat. Genet. 38:474-478(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    14. "PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3-exchanger in the upper villous epithelium of the murine duodenum."
      Simpson J.E., Schweinfest C.W., Shull G.E., Gawenis L.R., Walker N.M., Boyle K.T., Soleimani M., Clarke L.L.
      Am. J. Physiol. 292:G1079-G1088(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    15. Cited for: FUNCTION (ISOFORM 2), SUBCELLULAR LOCATION, MUTAGENESIS OF THR-575.
    16. "Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule."
      Petrovic S., Barone S., Wang Z., McDonough A.A., Amlal H., Soleimani M.
      Am. J. Nephrol. 28:330-338(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5."
      Singh A.K., Amlal H., Haas P.J., Dringenberg U., Fussell S., Barone S.L., Engelhardt R., Zuo J., Seidler U., Soleimani M.
      Kidney Int. 74:438-447(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, DISRUPTION PHENOTYPE.
    18. "Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium."
      Simpson J.E., Walker N.M., Supuran C.T., Soleimani M., Clarke L.L.
      Am. J. Physiol. 298:G683-G691(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    19. "Functional activity of Pat-1 (Slc26a6) Cl(-)/HCO(3)(-) exchange in the lower villus epithelium of murine duodenum."
      Walker N.M., Simpson J.E., Hoover E.E., Brazill J.M., Schweinfest C.W., Soleimani M., Clarke L.L.
      Acta Physiol. 201:21-31(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    20. "Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion."
      Knauf F., Ko N., Jiang Z., Robertson W.G., Van Itallie C.M., Anderson J.M., Aronson P.S.
      J. Am. Soc. Nephrol. 22:2247-2255(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION.
    21. "Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct."
      Song Y., Yamamoto A., Steward M.C., Ko S.B., Stewart A.K., Soleimani M., Liu B.C., Kondo T., Jin C.X., Ishiguro H.
      Am. J. Physiol. 303:C815-C824(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION.
    22. "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
      Chavez J.C., Hernandez-Gonzalez E.O., Wertheimer E., Visconti P.E., Darszon A., Trevino C.L.
      Biol. Reprod. 86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CFTR; SLC26A3 AND SLC9A3R1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    23. "Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice."
      Park S., Shcheynikov N., Hong J.H., Zheng C., Suh S.H., Kawaai K., Ando H., Mizutani A., Abe T., Kiyonari H., Seki G., Yule D., Mikoshiba K., Muallem S.
      Gastroenterology 145:232-241(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AHCYL1.

    Entry informationi

    Entry nameiS26A6_MOUSE
    AccessioniPrimary (citable) accession number: Q8CIW6
    Secondary accession number(s): E9Q4D3
    , Q3TQD3, Q812E2, Q8CJD0, Q8K142, Q923J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 18, 2013
    Last sequence update: September 18, 2013
    Last modified: July 22, 2015
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.