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Q8CIW6

- S26A6_MOUSE

UniProt

Q8CIW6 - S26A6_MOUSE

Protein

Solute carrier family 26 member 6

Gene

Slc26a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.17 Publications

    Enzyme regulationi

    Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by DIDS By similarity. Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and oxalate secretion in the duodenum are inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).By similarity6 Publications

    Kineticsi

    1. KM=0.3 mM for oxalate, PubMed:121192872 Publications
    2. KM=0.314 mM for oxalate, PubMed:152039032 Publications
    3. KM=3.87 mM for formate, PubMed:152039032 Publications

    GO - Molecular functioni

    1. anion:anion antiporter activity Source: UniProtKB
    2. bicarbonate transmembrane transporter activity Source: UniProtKB
    3. chloride channel activity Source: UniProtKB-KW
    4. chloride transmembrane transporter activity Source: UniProtKB
    5. efflux transmembrane transporter activity Source: UniProtKB
    6. formate efflux transmembrane transporter activity Source: UniProtKB
    7. formate transmembrane transporter activity Source: MGI
    8. formate uptake transmembrane transporter activity Source: UniProtKB
    9. oxalate transmembrane transporter activity Source: UniProtKB
    10. PDZ domain binding Source: UniProtKB
    11. protein binding Source: UniProtKB
    12. secondary active sulfate transmembrane transporter activity Source: InterPro
    13. sulfate transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. angiotensin-activated signaling pathway Source: UniProtKB
    2. bicarbonate transport Source: UniProtKB
    3. cellular response to cAMP Source: UniProtKB
    4. cellular response to fructose stimulus Source: UniProtKB
    5. chloride transmembrane transport Source: GOC
    6. chloride transport Source: UniProtKB
    7. epithelial fluid transport Source: UniProtKB
    8. formate transport Source: UniProtKB
    9. intestinal absorption Source: UniProtKB
    10. intracellular pH elevation Source: UniProtKB
    11. mannitol transport Source: UniProtKB
    12. oxalate transport Source: UniProtKB
    13. oxalic acid secretion Source: UniProtKB
    14. positive regulation of dipeptide transmembrane transport Source: UniProtKB
    15. protein kinase C signaling Source: UniProtKB
    16. regulation of intracellular pH Source: UniProtKB
    17. sperm capacitation Source: UniProtKB
    18. sulfate transmembrane transport Source: GOC
    19. sulfate transport Source: UniProtKB
    20. transepithelial chloride transport Source: UniProtKB
    21. transepithelial transport Source: UniProtKB
    22. transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Chloride channel, Ion channel

    Keywords - Biological processi

    Anion exchange, Antiport, Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    TCDBi2.A.53.2.8. the sulfate permease (sulp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 26 member 6
    Alternative name(s):
    Anion exchange transporter
    Chloride-formate exchanger
    Pendrin-L1
    Pendrin-like protein 1
    Putative anion transporter-1
    Short name:
    Pat-1
    Gene namesi
    Name:Slc26a6
    Synonyms:Cfex, Pat1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2159728. Slc26a6.

    Subcellular locationi

    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome
    Note: Colocalized with CA2 at the surface of the cell membrane in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate (PMA)-induced cells By similarity. Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. May be translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol myristate acetate (PMA)-induced cells.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. brush border membrane Source: UniProtKB
    3. chloride channel complex Source: UniProtKB-KW
    4. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    5. endoplasmic reticulum Source: UniProtKB-KW
    6. integral component of plasma membrane Source: MGI
    7. membrane Source: UniProtKB
    8. membrane-bounded vesicle Source: UniProtKB
    9. plasma membrane Source: UniProtKB
    10. sperm midpiece Source: UniProtKB
    11. vesicle membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Disruption phenotypei

    Mice show an important decrease in salt absorption in the intestine and failed to develop hypertension on a high-fructose diet. Show a reduction in pancreatic duct fluid and bicarbonate secretion. Show enhanced oxalate absorption in the intestine leading to hyperoxalemia and hyperoxaluria with high incidence of calcium-oxalate stones formation.3 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi575 – 5751T → A: Does not inhibit formate transport in PMA-induced cells. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 758758Solute carrier family 26 member 6PRO_0000423423Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei603 – 6031Phosphoserine; by PKCBy similarity
    Modified residuei751 – 7511PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8CIW6.

    PTM databases

    PhosphoSiteiQ8CIW6.

    Expressioni

    Tissue specificityi

    Expressed in kidney (at protein level). Highly expressed in stomach, kidney, heart and small intestine, low in the lung, liver, testis, brain, skeletal muscle and colon. Expressed in spermatogenic cells. Isoform 1 is expressed in intestine, kidney, testis, brain, muscle, heart, and stomach.5 Publications

    Inductioni

    Up-regulated by dietary fructose intake (at protein level).1 Publication

    Gene expression databases

    GenevestigatoriQ8CIW6.

    Interactioni

    Subunit structurei

    Interacts (via C-terminal cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange activity. Interacts with SLC9A3R1 (via the PDZ domains). Interacts with SLC9A3R2 (via the PDZ domains) By similarity. Interacts (via C-terminal domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces chloride and oxalate exchange transport. Interacts with CFTR, SLC26A3 and SLC9A3R1.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CftrP263613EBI-6895517,EBI-6115317
    Slc26a3Q9WVC82EBI-6895517,EBI-6895537
    Slc9a3r1P704412EBI-6895517,EBI-1184085

    Protein-protein interaction databases

    IntActiQ8CIW6. 3 interactions.
    STRINGi10090.ENSMUSP00000095979.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CIW6.
    SMRiQ8CIW6. Positions 512-561, 668-738.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 18749ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 26355CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 2928ExtracellularSequence Analysis
    Topological domaini314 – 34027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini362 – 38019ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini402 – 41716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini439 – 48547ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini507 – 758252CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei341 – 36121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini531 – 741211STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    InParanoidiQ8CIW6.
    KOiK14704.
    OrthoDBiEOG76T9QT.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CIW6-1) [UniParc]FASTAAdd to Basket

    Also known as: Slc26a6a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLPDGSDQG THQTQALLSA AQEMELQRRD YHVERPLLNQ EQLEDLGHWG    50
    PAAKTHQWRT WFRCSRARAH SLLLQHVPVL GWLPRYPVRE WLLGDLLSGL 100
    SVAIMQLPQG LAYALLAGLP PMFGLYSSFY PVFIYFLFGT SRHISVGTFA 150
    VMSVMVGSVT ESLTADKAFV QGLNATADDA RVQVAYTLSF LVGLFQVGLG 200
    LVHFGFVVTY LSEPLVRSYT TAASVQVLVS QLKYVFGIKL SSHSGPLSVI 250
    YTVLEVCAQL PETVPGTVVT AIVAGVALVL VKLLNEKLHR RLPLPIPGEL 300
    LTLIGATGIS YGVKLNDRFK VDVVGNITTG LIPPVAPKTE LFATLVGNAF 350
    AIAVVGFAIA ISLGKIFALR HGYRVDSNQE LVALGLSNLI GGFFQCFPVS 400
    CSMSRSLVQE STGGNTQVAG AVSSLFILLI IVKLGELFRD LPKAVLAAVI 450
    IVNLKGMMKQ FSDICSLWKA NRVDLLIWLV TFVATILLNL DIGLAVSIVF 500
    SLLLVVVRMQ LPHYSVLGQV PDTDIYRDVA EYSGAKEVPG VKVFRSSATL 550
    YFANAELYSD SLKEKCGVDV DRLITQKKKR IKKQEMKLKR MKKAKKSQKQ 600
    DASSKISSVS VNVNTNLEDV KSNDVEGSEA KVHQGEELQD VVSSNQEDAK 650
    APTMTSLKSL GLPQPGFHSL ILDLSTLSFV DTVCIKSLKN IFRDFREIEV 700
    EVYIAACYSP VVAQLEAGHF FDESITKQHV FASVHDAVTF ALSHRKSVPK 750
    SPVLATKL 758
    Length:758
    Mass (Da):82,834
    Last modified:September 18, 2013 - v2
    Checksum:i1512CC3A417D037B
    GO
    Isoform 2 (identifier: Q8CIW6-2) [UniParc]FASTAAdd to Basket

    Also known as: Slc26a6b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: Missing.

    Show »
    Length:735
    Mass (Da):80,496
    Checksum:i391DA011CB54C00A
    GO
    Isoform 3 (identifier: Q8CIW6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: Missing.
         691-758: IFRDFREIEV...PKSPVLATKL → VRDCRQARAP...PALFVAADFP

    Show »
    Length:726
    Mass (Da):79,108
    Checksum:i8390F9A703F8EE94
    GO

    Sequence cautioni

    The sequence AC168054 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAAA01111125 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAAA01200220 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251E → G in AAK51131. (PubMed:11459928)Curated
    Sequence conflicti25 – 251E → G in BAC55182. (PubMed:15203903)Curated
    Sequence conflicti572 – 5721R → P in AAL13129. (PubMed:12217875)Curated
    Sequence conflicti572 – 5721R → P in AAN07089. (PubMed:12217875)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2323Missing in isoform 2 and isoform 3. 5 PublicationsVSP_047853Add
    BLAST
    Alternative sequencei691 – 75868IFRDF…LATKL → VRDCRQARAPQAFMLILPLA SHLLATPPPNKPSPLSSPTK PCPIAASLRPALFVAADFP in isoform 3. 1 PublicationVSP_047854Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032863 mRNA. Translation: AAK51131.1.
    AF248494 mRNA. Translation: AAN07089.1.
    AY049076 mRNA. Translation: AAL13129.1.
    AB099881 mRNA. Translation: BAC55182.1.
    AK163670 mRNA. Translation: BAE37450.1.
    AK163671 mRNA. Translation: BAE37451.1.
    AC168054 Genomic DNA. No translation available.
    CAAA01111125 Genomic DNA. No translation available.
    CAAA01200220 Genomic DNA. No translation available.
    CH466560 Genomic DNA. Translation: EDL21319.1.
    BC028856 mRNA. Translation: AAH28856.1.
    RefSeqiNP_599252.2. NM_134420.4. [Q8CIW6-2]
    UniGeneiMm.45201.

    Genome annotation databases

    GeneIDi171429.
    KEGGimmu:171429.
    UCSCiuc029xge.1. mouse.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032863 mRNA. Translation: AAK51131.1 .
    AF248494 mRNA. Translation: AAN07089.1 .
    AY049076 mRNA. Translation: AAL13129.1 .
    AB099881 mRNA. Translation: BAC55182.1 .
    AK163670 mRNA. Translation: BAE37450.1 .
    AK163671 mRNA. Translation: BAE37451.1 .
    AC168054 Genomic DNA. No translation available.
    CAAA01111125 Genomic DNA. No translation available.
    CAAA01200220 Genomic DNA. No translation available.
    CH466560 Genomic DNA. Translation: EDL21319.1 .
    BC028856 mRNA. Translation: AAH28856.1 .
    RefSeqi NP_599252.2. NM_134420.4. [Q8CIW6-2 ]
    UniGenei Mm.45201.

    3D structure databases

    ProteinModelPortali Q8CIW6.
    SMRi Q8CIW6. Positions 512-561, 668-738.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CIW6. 3 interactions.
    STRINGi 10090.ENSMUSP00000095979.

    Protein family/group databases

    TCDBi 2.A.53.2.8. the sulfate permease (sulp) family.

    PTM databases

    PhosphoSitei Q8CIW6.

    Proteomic databases

    PRIDEi Q8CIW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 171429.
    KEGGi mmu:171429.
    UCSCi uc029xge.1. mouse.

    Organism-specific databases

    CTDi 65010.
    MGIi MGI:2159728. Slc26a6.

    Phylogenomic databases

    eggNOGi COG0659.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    InParanoidi Q8CIW6.
    KOi K14704.
    OrthoDBi EOG76T9QT.
    TreeFami TF313784.

    Miscellaneous databases

    NextBioi 35555101.
    PROi E9Q4D3.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8CIW6.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells."
      Knauf F., Yang C.L., Thomson R.B., Mentone S.A., Giebisch G., Aronson P.S.
      Proc. Natl. Acad. Sci. U.S.A. 98:9425-9430(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: BALB/c.
    2. "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1."
      Xie Q., Welch R., Mercado A., Romero M.F., Mount D.B.
      Am. J. Physiol. 283:F826-F838(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY.
      Strain: C57BL/6J.
    3. "Role of anion exchange transporter PAT1 (SLC26A6) in intestinal absorption of organic anions."
      Nozawa T., Sugiura S., Hashino Y., Tsuji A., Tamai I.
      J. Drug. Target. 12:97-104(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
      Strain: BALB/c.
      Tissue: Kidney.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Medulla oblongata.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Salivary gland.
    8. "Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine."
      Wang Z., Petrovic S., Mann E., Soleimani M.
      Am. J. Physiol. 282:G573-G579(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "Specificity of anion exchange mediated by mouse Slc26a6."
      Jiang Z., Grichtchenko I.I., Boron W.F., Aronson P.S.
      J. Biol. Chem. 277:33963-33967(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
    10. Cited for: FUNCTION, INTERACTION WITH PDZK1, SUBCELLULAR LOCATION.
    11. "Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3-secretion: relevance to cystic fibrosis."
      Wang Y., Soyombo A.A., Shcheynikov N., Zeng W., Dorwart M., Marino C.R., Thomas P.J., Muallem S.
      EMBO J. 25:5049-5057(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    12. "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6."
      Shcheynikov N., Wang Y., Park M., Ko S.B., Dorwart M., Naruse S., Thomas P.J., Muallem S.
      J. Gen. Physiol. 127:511-524(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6."
      Jiang Z., Asplin J.R., Evan A.P., Rajendran V.M., Velazquez H., Nottoli T.P., Binder H.J., Aronson P.S.
      Nat. Genet. 38:474-478(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    14. "PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3-exchanger in the upper villous epithelium of the murine duodenum."
      Simpson J.E., Schweinfest C.W., Shull G.E., Gawenis L.R., Walker N.M., Boyle K.T., Soleimani M., Clarke L.L.
      Am. J. Physiol. 292:G1079-G1088(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    15. Cited for: FUNCTION (ISOFORM 2), SUBCELLULAR LOCATION, MUTAGENESIS OF THR-575.
    16. "Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule."
      Petrovic S., Barone S., Wang Z., McDonough A.A., Amlal H., Soleimani M.
      Am. J. Nephrol. 28:330-338(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5."
      Singh A.K., Amlal H., Haas P.J., Dringenberg U., Fussell S., Barone S.L., Engelhardt R., Zuo J., Seidler U., Soleimani M.
      Kidney Int. 74:438-447(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, DISRUPTION PHENOTYPE.
    18. "Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium."
      Simpson J.E., Walker N.M., Supuran C.T., Soleimani M., Clarke L.L.
      Am. J. Physiol. 298:G683-G691(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    19. "Functional activity of Pat-1 (Slc26a6) Cl(-)/HCO(3)(-) exchange in the lower villus epithelium of murine duodenum."
      Walker N.M., Simpson J.E., Hoover E.E., Brazill J.M., Schweinfest C.W., Soleimani M., Clarke L.L.
      Acta Physiol. 201:21-31(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    20. "Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion."
      Knauf F., Ko N., Jiang Z., Robertson W.G., Van Itallie C.M., Anderson J.M., Aronson P.S.
      J. Am. Soc. Nephrol. 22:2247-2255(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION.
    21. "Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct."
      Song Y., Yamamoto A., Steward M.C., Ko S.B., Stewart A.K., Soleimani M., Liu B.C., Kondo T., Jin C.X., Ishiguro H.
      Am. J. Physiol. 303:C815-C824(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION.
    22. "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
      Chavez J.C., Hernandez-Gonzalez E.O., Wertheimer E., Visconti P.E., Darszon A., Trevino C.L.
      Biol. Reprod. 86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CFTR; SLC26A3 AND SLC9A3R1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS26A6_MOUSE
    AccessioniPrimary (citable) accession number: Q8CIW6
    Secondary accession number(s): E9Q4D3
    , Q3TQD3, Q812E2, Q8CJD0, Q8K142, Q923J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 18, 2013
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3