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Q8CIW6

- S26A6_MOUSE

UniProt

Q8CIW6 - S26A6_MOUSE

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Protein

Solute carrier family 26 member 6

Gene

Slc26a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.17 Publications

Enzyme regulationi

Apical membrane chloride-bicarbonate exchange activity of the pancreatic duct is inhibited by DIDS (By similarity). Apical membrane chloride-formate exchange activity in the proximal tubules of the kidney and oxalate secretion in the duodenum are inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).By similarity6 Publications

Kineticsi

  1. KM=0.3 mM for oxalate, PubMed:121192872 Publications
  2. KM=0.314 mM for oxalate, PubMed:152039032 Publications
  3. KM=3.87 mM for formate, PubMed:152039032 Publications

GO - Molecular functioni

  1. anion:anion antiporter activity Source: UniProtKB
  2. bicarbonate transmembrane transporter activity Source: UniProtKB
  3. chloride channel activity Source: UniProtKB-KW
  4. chloride transmembrane transporter activity Source: UniProtKB
  5. efflux transmembrane transporter activity Source: UniProtKB
  6. formate efflux transmembrane transporter activity Source: UniProtKB
  7. formate transmembrane transporter activity Source: MGI
  8. formate uptake transmembrane transporter activity Source: UniProtKB
  9. oxalate transmembrane transporter activity Source: UniProtKB
  10. PDZ domain binding Source: UniProtKB
  11. secondary active sulfate transmembrane transporter activity Source: InterPro
  12. sulfate transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. angiotensin-activated signaling pathway Source: UniProtKB
  2. bicarbonate transport Source: UniProtKB
  3. cellular response to cAMP Source: UniProtKB
  4. cellular response to fructose stimulus Source: UniProtKB
  5. chloride transmembrane transport Source: GOC
  6. chloride transport Source: UniProtKB
  7. epithelial fluid transport Source: UniProtKB
  8. formate transport Source: UniProtKB
  9. intestinal absorption Source: UniProtKB
  10. intracellular pH elevation Source: UniProtKB
  11. mannitol transport Source: UniProtKB
  12. oxalate transport Source: UniProtKB
  13. oxalic acid secretion Source: UniProtKB
  14. positive regulation of dipeptide transmembrane transport Source: UniProtKB
  15. protein kinase C signaling Source: UniProtKB
  16. regulation of intracellular pH Source: UniProtKB
  17. sperm capacitation Source: UniProtKB
  18. sulfate transmembrane transport Source: GOC
  19. sulfate transport Source: UniProtKB
  20. transepithelial chloride transport Source: UniProtKB
  21. transepithelial transport Source: UniProtKB
  22. transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Keywords - Ligandi

Chloride

Protein family/group databases

TCDBi2.A.53.2.8. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 26 member 6
Alternative name(s):
Anion exchange transporter
Chloride-formate exchanger
Pendrin-L1
Pendrin-like protein 1
Putative anion transporter-1
Short name:
Pat-1
Gene namesi
Name:Slc26a6
Synonyms:Cfex, Pat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2159728. Slc26a6.

Subcellular locationi

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome
Note: Colocalized with CA2 at the surface of the cell membrane in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate (PMA)-induced cells (By similarity). Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. May be translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol myristate acetate (PMA)-induced cells.By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. brush border membrane Source: UniProtKB
  3. chloride channel complex Source: UniProtKB-KW
  4. cytoplasmic vesicle Source: UniProtKB-KW
  5. endoplasmic reticulum Source: UniProtKB-KW
  6. integral component of plasma membrane Source: MGI
  7. membrane Source: UniProtKB
  8. membrane-bounded vesicle Source: UniProtKB
  9. plasma membrane Source: UniProtKB
  10. sperm midpiece Source: UniProtKB
  11. vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Disruption phenotypei

Mice show an important decrease in salt absorption in the intestine and failed to develop hypertension on a high-fructose diet. Show a reduction in pancreatic duct fluid and bicarbonate secretion. Show enhanced oxalate absorption in the intestine leading to hyperoxalemia and hyperoxaluria with high incidence of calcium-oxalate stones formation.3 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi575 – 5751T → A: Does not inhibit formate transport in PMA-induced cells. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Solute carrier family 26 member 6PRO_0000423423Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei603 – 6031Phosphoserine; by PKCBy similarity
Modified residuei751 – 7511PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on serine residues by PKC; the phosphorylation disrupts interaction with carbonic anhydrase CA2 and reduces bicarbonate transport activity in a phorbol myristate acetate (PMA)-induced manner.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8CIW6.

PTM databases

PhosphoSiteiQ8CIW6.

Expressioni

Tissue specificityi

Expressed in kidney (at protein level). Highly expressed in stomach, kidney, heart and small intestine, low in the lung, liver, testis, brain, skeletal muscle and colon. Expressed in spermatogenic cells. Isoform 1 is expressed in intestine, kidney, testis, brain, muscle, heart, and stomach.5 Publications

Inductioni

Up-regulated by dietary fructose intake (at protein level).1 Publication

Gene expression databases

GenevestigatoriQ8CIW6.

Interactioni

Subunit structurei

Interacts (via C-terminal cytoplasmic domain) with CA2; the interaction stimulates chloride-bicarbonate exchange activity. Interacts with SLC9A3R1 (via the PDZ domains). Interacts with SLC9A3R2 (via the PDZ domains) (By similarity). Interacts (via C-terminal domain) with PDZK1 (via C-terminal PDZ domain); the interaction induces chloride and oxalate exchange transport. Interacts with CFTR, SLC26A3 and SLC9A3R1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CftrP263613EBI-6895517,EBI-6115317
Slc26a3Q9WVC82EBI-6895517,EBI-6895537
Slc9a3r1P704412EBI-6895517,EBI-1184085

Protein-protein interaction databases

IntActiQ8CIW6. 3 interactions.
STRINGi10090.ENSMUSP00000095979.

Structurei

3D structure databases

ProteinModelPortaliQ8CIW6.
SMRiQ8CIW6. Positions 512-561, 668-738.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini139 – 18749ExtracellularSequence AnalysisAdd
BLAST
Topological domaini209 – 26355CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini285 – 2928ExtracellularSequence Analysis
Topological domaini314 – 34027CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini362 – 38019ExtracellularSequence AnalysisAdd
BLAST
Topological domaini402 – 41716CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini439 – 48547ExtracellularSequence AnalysisAdd
BLAST
Topological domaini507 – 758252CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence AnalysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence AnalysisAdd
BLAST
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini531 – 741211STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
KOiK14704.
OrthoDBiEOG76T9QT.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CIW6-1) [UniParc]FASTAAdd to Basket

Also known as: Slc26a6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLPDGSDQG THQTQALLSA AQEMELQRRD YHVERPLLNQ EQLEDLGHWG
60 70 80 90 100
PAAKTHQWRT WFRCSRARAH SLLLQHVPVL GWLPRYPVRE WLLGDLLSGL
110 120 130 140 150
SVAIMQLPQG LAYALLAGLP PMFGLYSSFY PVFIYFLFGT SRHISVGTFA
160 170 180 190 200
VMSVMVGSVT ESLTADKAFV QGLNATADDA RVQVAYTLSF LVGLFQVGLG
210 220 230 240 250
LVHFGFVVTY LSEPLVRSYT TAASVQVLVS QLKYVFGIKL SSHSGPLSVI
260 270 280 290 300
YTVLEVCAQL PETVPGTVVT AIVAGVALVL VKLLNEKLHR RLPLPIPGEL
310 320 330 340 350
LTLIGATGIS YGVKLNDRFK VDVVGNITTG LIPPVAPKTE LFATLVGNAF
360 370 380 390 400
AIAVVGFAIA ISLGKIFALR HGYRVDSNQE LVALGLSNLI GGFFQCFPVS
410 420 430 440 450
CSMSRSLVQE STGGNTQVAG AVSSLFILLI IVKLGELFRD LPKAVLAAVI
460 470 480 490 500
IVNLKGMMKQ FSDICSLWKA NRVDLLIWLV TFVATILLNL DIGLAVSIVF
510 520 530 540 550
SLLLVVVRMQ LPHYSVLGQV PDTDIYRDVA EYSGAKEVPG VKVFRSSATL
560 570 580 590 600
YFANAELYSD SLKEKCGVDV DRLITQKKKR IKKQEMKLKR MKKAKKSQKQ
610 620 630 640 650
DASSKISSVS VNVNTNLEDV KSNDVEGSEA KVHQGEELQD VVSSNQEDAK
660 670 680 690 700
APTMTSLKSL GLPQPGFHSL ILDLSTLSFV DTVCIKSLKN IFRDFREIEV
710 720 730 740 750
EVYIAACYSP VVAQLEAGHF FDESITKQHV FASVHDAVTF ALSHRKSVPK

SPVLATKL
Length:758
Mass (Da):82,834
Last modified:September 18, 2013 - v2
Checksum:i1512CC3A417D037B
GO
Isoform 2 (identifier: Q8CIW6-2) [UniParc]FASTAAdd to Basket

Also known as: Slc26a6b

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:735
Mass (Da):80,496
Checksum:i391DA011CB54C00A
GO
Isoform 3 (identifier: Q8CIW6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.
     691-758: IFRDFREIEV...PKSPVLATKL → VRDCRQARAP...PALFVAADFP

Show »
Length:726
Mass (Da):79,108
Checksum:i8390F9A703F8EE94
GO

Sequence cautioni

The sequence AC168054 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAAA01111125 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAAA01200220 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251E → G in AAK51131. (PubMed:11459928)Curated
Sequence conflicti25 – 251E → G in BAC55182. (PubMed:15203903)Curated
Sequence conflicti572 – 5721R → P in AAL13129. (PubMed:12217875)Curated
Sequence conflicti572 – 5721R → P in AAN07089. (PubMed:12217875)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 2 and isoform 3. 5 PublicationsVSP_047853Add
BLAST
Alternative sequencei691 – 75868IFRDF…LATKL → VRDCRQARAPQAFMLILPLA SHLLATPPPNKPSPLSSPTK PCPIAASLRPALFVAADFP in isoform 3. 1 PublicationVSP_047854Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032863 mRNA. Translation: AAK51131.1.
AF248494 mRNA. Translation: AAN07089.1.
AY049076 mRNA. Translation: AAL13129.1.
AB099881 mRNA. Translation: BAC55182.1.
AK163670 mRNA. Translation: BAE37450.1.
AK163671 mRNA. Translation: BAE37451.1.
AC168054 Genomic DNA. No translation available.
CAAA01111125 Genomic DNA. No translation available.
CAAA01200220 Genomic DNA. No translation available.
CH466560 Genomic DNA. Translation: EDL21319.1.
BC028856 mRNA. Translation: AAH28856.1.
RefSeqiNP_599252.2. NM_134420.4. [Q8CIW6-2]
UniGeneiMm.45201.

Genome annotation databases

GeneIDi171429.
KEGGimmu:171429.
UCSCiuc029xge.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032863 mRNA. Translation: AAK51131.1 .
AF248494 mRNA. Translation: AAN07089.1 .
AY049076 mRNA. Translation: AAL13129.1 .
AB099881 mRNA. Translation: BAC55182.1 .
AK163670 mRNA. Translation: BAE37450.1 .
AK163671 mRNA. Translation: BAE37451.1 .
AC168054 Genomic DNA. No translation available.
CAAA01111125 Genomic DNA. No translation available.
CAAA01200220 Genomic DNA. No translation available.
CH466560 Genomic DNA. Translation: EDL21319.1 .
BC028856 mRNA. Translation: AAH28856.1 .
RefSeqi NP_599252.2. NM_134420.4. [Q8CIW6-2 ]
UniGenei Mm.45201.

3D structure databases

ProteinModelPortali Q8CIW6.
SMRi Q8CIW6. Positions 512-561, 668-738.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8CIW6. 3 interactions.
STRINGi 10090.ENSMUSP00000095979.

Protein family/group databases

TCDBi 2.A.53.2.8. the sulfate permease (sulp) family.

PTM databases

PhosphoSitei Q8CIW6.

Proteomic databases

PRIDEi Q8CIW6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 171429.
KEGGi mmu:171429.
UCSCi uc029xge.1. mouse.

Organism-specific databases

CTDi 65010.
MGIi MGI:2159728. Slc26a6.

Phylogenomic databases

eggNOGi COG0659.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
KOi K14704.
OrthoDBi EOG76T9QT.
TreeFami TF313784.

Miscellaneous databases

NextBioi 35555101.
PROi E9Q4D3.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8CIW6.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells."
    Knauf F., Yang C.L., Thomson R.B., Mentone S.A., Giebisch G., Aronson P.S.
    Proc. Natl. Acad. Sci. U.S.A. 98:9425-9430(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/c.
  2. "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1."
    Xie Q., Welch R., Mercado A., Romero M.F., Mount D.B.
    Am. J. Physiol. 283:F826-F838(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  3. "Role of anion exchange transporter PAT1 (SLC26A6) in intestinal absorption of organic anions."
    Nozawa T., Sugiura S., Hashino Y., Tsuji A., Tamai I.
    J. Drug. Target. 12:97-104(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
    Strain: BALB/c.
    Tissue: Kidney.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Medulla oblongata.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Salivary gland.
  8. "Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine."
    Wang Z., Petrovic S., Mann E., Soleimani M.
    Am. J. Physiol. 282:G573-G579(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Specificity of anion exchange mediated by mouse Slc26a6."
    Jiang Z., Grichtchenko I.I., Boron W.F., Aronson P.S.
    J. Biol. Chem. 277:33963-33967(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
  10. Cited for: FUNCTION, INTERACTION WITH PDZK1, SUBCELLULAR LOCATION.
  11. "Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3-secretion: relevance to cystic fibrosis."
    Wang Y., Soyombo A.A., Shcheynikov N., Zeng W., Dorwart M., Marino C.R., Thomas P.J., Muallem S.
    EMBO J. 25:5049-5057(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  12. "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6."
    Shcheynikov N., Wang Y., Park M., Ko S.B., Dorwart M., Naruse S., Thomas P.J., Muallem S.
    J. Gen. Physiol. 127:511-524(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6."
    Jiang Z., Asplin J.R., Evan A.P., Rajendran V.M., Velazquez H., Nottoli T.P., Binder H.J., Aronson P.S.
    Nat. Genet. 38:474-478(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  14. "PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3-exchanger in the upper villous epithelium of the murine duodenum."
    Simpson J.E., Schweinfest C.W., Shull G.E., Gawenis L.R., Walker N.M., Boyle K.T., Soleimani M., Clarke L.L.
    Am. J. Physiol. 292:G1079-G1088(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  15. Cited for: FUNCTION (ISOFORM 2), SUBCELLULAR LOCATION, MUTAGENESIS OF THR-575.
  16. "Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule."
    Petrovic S., Barone S., Wang Z., McDonough A.A., Amlal H., Soleimani M.
    Am. J. Nephrol. 28:330-338(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5."
    Singh A.K., Amlal H., Haas P.J., Dringenberg U., Fussell S., Barone S.L., Engelhardt R., Zuo J., Seidler U., Soleimani M.
    Kidney Int. 74:438-447(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, DISRUPTION PHENOTYPE.
  18. "Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium."
    Simpson J.E., Walker N.M., Supuran C.T., Soleimani M., Clarke L.L.
    Am. J. Physiol. 298:G683-G691(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "Functional activity of Pat-1 (Slc26a6) Cl(-)/HCO(3)(-) exchange in the lower villus epithelium of murine duodenum."
    Walker N.M., Simpson J.E., Hoover E.E., Brazill J.M., Schweinfest C.W., Soleimani M., Clarke L.L.
    Acta Physiol. 201:21-31(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion."
    Knauf F., Ko N., Jiang Z., Robertson W.G., Van Itallie C.M., Anderson J.M., Aronson P.S.
    J. Am. Soc. Nephrol. 22:2247-2255(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION.
  21. "Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO-3 exchange in mouse pancreatic duct."
    Song Y., Yamamoto A., Steward M.C., Ko S.B., Stewart A.K., Soleimani M., Liu B.C., Kondo T., Jin C.X., Ishiguro H.
    Am. J. Physiol. 303:C815-C824(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION.
  22. "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
    Chavez J.C., Hernandez-Gonzalez E.O., Wertheimer E., Visconti P.E., Darszon A., Trevino C.L.
    Biol. Reprod. 86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CFTR; SLC26A3 AND SLC9A3R1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS26A6_MOUSE
AccessioniPrimary (citable) accession number: Q8CIW6
Secondary accession number(s): E9Q4D3
, Q3TQD3, Q812E2, Q8CJD0, Q8K142, Q923J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: September 18, 2013
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3