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Protein

Tubulin-specific chaperone E

Gene

Tbce

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation.2 Publications

GO - Molecular functioni

  • unfolded protein binding Source: MGI

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • axonogenesis Source: MGI
  • developmental growth Source: MGI
  • microtubule cytoskeleton organization Source: MGI
  • muscle atrophy Source: MGI
  • peripheral nervous system neuron axonogenesis Source: MGI
  • post-chaperonin tubulin folding pathway Source: UniProtKB
  • post-embryonic development Source: MGI
  • protein folding Source: MGI
  • tubulin complex assembly Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone E
Alternative name(s):
Tubulin-folding cofactor E
Gene namesi
Name:Tbce
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1917680. Tbce.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000835392 – 524Tubulin-specific chaperone EAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei460N6-acetyllysineBy similarity1
Modified residuei492PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CIV8.
MaxQBiQ8CIV8.
PaxDbiQ8CIV8.
PeptideAtlasiQ8CIV8.
PRIDEiQ8CIV8.

PTM databases

PhosphoSitePlusiQ8CIV8.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000039233.
CleanExiMM_TBCE.
ExpressionAtlasiQ8CIV8. baseline and differential.
GenevisibleiQ8CIV8. MM.

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers.1 Publication

GO - Molecular functioni

  • unfolded protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047880.

Structurei

Secondary structure

1524
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi442 – 451Combined sources10
Beta strandi453 – 455Combined sources3
Beta strandi458 – 463Combined sources6
Helixi468 – 476Combined sources9
Turni477 – 480Combined sources4
Turni483 – 485Combined sources3
Beta strandi487 – 491Combined sources5
Beta strandi499 – 501Combined sources3
Beta strandi505 – 509Combined sources5
Helixi510 – 512Combined sources3
Beta strandi519 – 523Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJNNMR-A441-524[»]
ProteinModelPortaliQ8CIV8.
SMRiQ8CIV8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CIV8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 71CAP-GlyPROSITE-ProRule annotationAdd BLAST45
Repeati154 – 175LRR 1Add BLAST22
Repeati180 – 201LRR 2Add BLAST22
Repeati206 – 227LRR 3Add BLAST22
Repeati231 – 253LRR 4Add BLAST23
Repeati254 – 275LRR 5Add BLAST22
Repeati279 – 300LRR 6Add BLAST22
Repeati309 – 330LRR 7Add BLAST22
Domaini343 – 381LRRCTAdd BLAST39

Sequence similaritiesi

Belongs to the TBCE family.Curated
Contains 1 CAP-Gly domain.PROSITE-ProRule annotation
Contains 7 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3207. Eukaryota.
ENOG410YS3M. LUCA.
GeneTreeiENSGT00530000063405.
HOGENOMiHOG000154513.
HOVERGENiHBG084170.
InParanoidiQ8CIV8.
OMAiVSLRNCA.
OrthoDBiEOG091G07V5.
PhylomeDBiQ8CIV8.
TreeFamiTF313455.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR032675. L_dom-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
PF14560. Ubiquitin_2. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CIV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDILPLDVI GRRVEVNGEY ATVRFCGAVP PVAGLWLGVE WDNPERGKHD
60 70 80 90 100
GSHEGTMYFK CRHPTGGSFV RPSKVNFGDD FLTALKKRYV LEDGPDDDEN
110 120 130 140 150
SCSLKVGSKQ VQTIGFEHIT KKQSQLRALQ DISLWNCAVS HAGEQGRIAE
160 170 180 190 200
ACPNIRVVNL SKNLLSTWDE VVLIAEQLKD LEALDLSENK LQFPSDSPTL
210 220 230 240 250
TRTFSTLKTL VLNKTGITWT EVLHCAPSWP VLEELYLKSN NISISERPVN
260 270 280 290 300
VLQKMRLLDL SSNPSIDESQ LSLIADLPRL EHLVLSDIGL SSIHFPDAEI
310 320 330 340 350
GCKTSMFPAL KYLIVNDNQI SEWSFINELD KLQSLQALSC TRNPLSKADK
360 370 380 390 400
AEEIIIAKIA QLRTLNRCQI LPEERRGAEL DYRKAFGNEW RKAGGHPDPD
410 420 430 440 450
KNRPNAAFLS AHPRYQLLCC KYGAPEDEEL KTQQPFMLKK QLLTLKIKCS
460 470 480 490 500
NQPERQILEK QLPDSMTVQK VKGLLSRLLK VPVSELLLSY ESSKMPGREI
510 520
ELENDLQPLQ FYSVENGDCL LVRW
Length:524
Mass (Da):59,086
Last modified:March 1, 2003 - v1
Checksum:iE95280086D80FEF8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti348A → V.1 Publication1
Natural varianti524W → G.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082332 mRNA. Translation: AAL92570.1.
AK167383 mRNA. Translation: BAE39475.1.
BC050206 mRNA. Translation: AAH50206.1.
CCDSiCCDS26247.1.
RefSeqiNP_848027.1. NM_178337.3.
UniGeneiMm.260209.

Genome annotation databases

EnsembliENSMUST00000039894; ENSMUSP00000047880; ENSMUSG00000039233.
GeneIDi70430.
KEGGimmu:70430.
UCSCiuc007pmq.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082332 mRNA. Translation: AAL92570.1.
AK167383 mRNA. Translation: BAE39475.1.
BC050206 mRNA. Translation: AAH50206.1.
CCDSiCCDS26247.1.
RefSeqiNP_848027.1. NM_178337.3.
UniGeneiMm.260209.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJNNMR-A441-524[»]
ProteinModelPortaliQ8CIV8.
SMRiQ8CIV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047880.

PTM databases

PhosphoSitePlusiQ8CIV8.

Proteomic databases

EPDiQ8CIV8.
MaxQBiQ8CIV8.
PaxDbiQ8CIV8.
PeptideAtlasiQ8CIV8.
PRIDEiQ8CIV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039894; ENSMUSP00000047880; ENSMUSG00000039233.
GeneIDi70430.
KEGGimmu:70430.
UCSCiuc007pmq.2. mouse.

Organism-specific databases

CTDi6905.
MGIiMGI:1917680. Tbce.

Phylogenomic databases

eggNOGiKOG3207. Eukaryota.
ENOG410YS3M. LUCA.
GeneTreeiENSGT00530000063405.
HOGENOMiHOG000154513.
HOVERGENiHBG084170.
InParanoidiQ8CIV8.
OMAiVSLRNCA.
OrthoDBiEOG091G07V5.
PhylomeDBiQ8CIV8.
TreeFamiTF313455.

Miscellaneous databases

EvolutionaryTraceiQ8CIV8.
PROiQ8CIV8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039233.
CleanExiMM_TBCE.
ExpressionAtlasiQ8CIV8. baseline and differential.
GenevisibleiQ8CIV8. MM.

Family and domain databases

Gene3Di2.30.30.190. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR000938. CAP-Gly_domain.
IPR032675. L_dom-like.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF01302. CAP_GLY. 1 hit.
PF14560. Ubiquitin_2. 1 hit.
[Graphical view]
SMARTiSM01052. CAP_GLY. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF74924. SSF74924. 1 hit.
PROSITEiPS00845. CAP_GLY_1. 1 hit.
PS50245. CAP_GLY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBCE_MOUSE
AccessioniPrimary (citable) accession number: Q8CIV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.