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Q8CIV3

- LIPH_MOUSE

UniProt

Q8CIV3 - LIPH_MOUSE

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Protein

Lipase member H

Gene

Liph

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541NucleophileBy similarity
Active sitei178 – 1781Charge relay systemBy similarity
Active sitei248 – 2481Charge relay systemBy similarity

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. phospholipase activity Source: Ensembl

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member H (EC:3.1.1.-)
Gene namesi
Name:Liph
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2388029. Liph.

Subcellular locationi

Secreted. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 451435Lipase member HPRO_0000273322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi233 ↔ 246By similarity
Disulfide bondi270 ↔ 281By similarity
Disulfide bondi284 ↔ 292By similarity
Disulfide bondi427 ↔ 446By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8CIV3.

PTM databases

PhosphoSiteiQ8CIV3.

Expressioni

Tissue specificityi

Expressed in placenta and colon. Weakly expressed in small intestine.1 Publication

Gene expression databases

BgeeiQ8CIV3.
CleanExiMM_LIPH.
GenevestigatoriQ8CIV3.

Structurei

3D structure databases

ProteinModelPortaliQ8CIV3.
SMRiQ8CIV3. Positions 39-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39787.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000234386.
HOVERGENiHBG080640.
InParanoidiQ8CIV3.
OMAiITAYPCD.
OrthoDBiEOG79PJP2.
PhylomeDBiQ8CIV3.
TreeFamiTF324997.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CIV3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRLCFFISF MCLVKSDTDE TCPSFTRLSF HSAVVGTGLS VRLMLYTQRD
60 70 80 90 100
QTCAQIINST ALGSLNVTKK TTFIIHGFRP TGSPPVWIEE LVQSLISVQE
110 120 130 140 150
MNVVVVDWNR GATTVIYPHA SSKTRQVASI LKEFIDQMLV KGASLDNIYM
160 170 180 190 200
IGVSLGAHIA GFVGESYEGK LGRVTGLDPA GPLFNGRPPE ERLDPSDALF
210 220 230 240 250
VDVIHSDTDA LGYKEALGHI DFYPNGGLDQ PGCPKTIFGG IKYFKCDHQM
260 270 280 290 300
SVYLYLASLQ NNCSITAYPC DSYRDYRNGK CVSCGAGQIV PCPRVGYYAD
310 320 330 340 350
SWKEYLWDRD PPMTKAFFDT AETKPYCMYH YFVDIVSWNK SVRRGFITIK
360 370 380 390 400
LRGEDGNITE SKIDHEPSAF EKYHQVSLLA RFNRDLDKVA EISLLFSTGS
410 420 430 440 450
VVGPKYKLRV LQMKLRSLAH PDRPHLCRYD LVLMENVETS FQPILCSQQQ

M
Length:451
Mass (Da):50,675
Last modified:January 23, 2007 - v2
Checksum:iDBB7F5311A08D70A
GO
Isoform 2 (identifier: Q8CIV3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: Missing.

Note: No experimental confirmation available.

Show »
Length:449
Mass (Da):50,491
Checksum:iB3312ECF3950A2B7
GO
Isoform 3 (identifier: Q8CIV3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-239: Missing.

Note: No experimental confirmation available.

Show »
Length:421
Mass (Da):47,514
Checksum:i127552E1012959DC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291S → N in BAE36182. (PubMed:16141072)Curated
Sequence conflicti146 – 1461D → N in BAE23014. (PubMed:16141072)Curated
Sequence conflicti251 – 2511S → Y in BAE36182. (PubMed:16141072)Curated
Sequence conflicti395 – 3951L → M in AAM18804. (PubMed:12213196)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei210 – 23930Missing in isoform 3. 1 PublicationVSP_022505Add
BLAST
Alternative sequencei210 – 2112Missing in isoform 2. 1 PublicationVSP_022506

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093499 mRNA. Translation: AAM18804.1.
AK048150 mRNA. Translation: BAC33259.1.
AK134352 mRNA. Translation: BAE22108.1.
AK136503 mRNA. Translation: BAE23014.1.
AK161067 mRNA. Translation: BAE36182.1.
AK162492 mRNA. Translation: BAE36944.1.
BC037489 mRNA. Translation: AAH37489.1.
CCDSiCCDS37295.1. [Q8CIV3-3]
CCDS37296.1. [Q8CIV3-1]
RefSeqiNP_001077363.1. NM_001083894.1. [Q8CIV3-1]
NP_001276511.1. NM_001289582.1. [Q8CIV3-2]
NP_700453.1. NM_153404.3. [Q8CIV3-3]
UniGeneiMm.33192.

Genome annotation databases

EnsembliENSMUST00000060673; ENSMUSP00000062310; ENSMUSG00000044626. [Q8CIV3-1]
ENSMUST00000074230; ENSMUSP00000073853; ENSMUSG00000044626. [Q8CIV3-3]
GeneIDi239759.
KEGGimmu:239759.
UCSCiuc007yru.1. mouse. [Q8CIV3-1]
uc007yrv.1. mouse. [Q8CIV3-3]
uc012adk.1. mouse. [Q8CIV3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093499 mRNA. Translation: AAM18804.1 .
AK048150 mRNA. Translation: BAC33259.1 .
AK134352 mRNA. Translation: BAE22108.1 .
AK136503 mRNA. Translation: BAE23014.1 .
AK161067 mRNA. Translation: BAE36182.1 .
AK162492 mRNA. Translation: BAE36944.1 .
BC037489 mRNA. Translation: AAH37489.1 .
CCDSi CCDS37295.1. [Q8CIV3-3 ]
CCDS37296.1. [Q8CIV3-1 ]
RefSeqi NP_001077363.1. NM_001083894.1. [Q8CIV3-1 ]
NP_001276511.1. NM_001289582.1. [Q8CIV3-2 ]
NP_700453.1. NM_153404.3. [Q8CIV3-3 ]
UniGenei Mm.33192.

3D structure databases

ProteinModelPortali Q8CIV3.
SMRi Q8CIV3. Positions 39-443.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8CIV3.

Proteomic databases

PRIDEi Q8CIV3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060673 ; ENSMUSP00000062310 ; ENSMUSG00000044626 . [Q8CIV3-1 ]
ENSMUST00000074230 ; ENSMUSP00000073853 ; ENSMUSG00000044626 . [Q8CIV3-3 ]
GeneIDi 239759.
KEGGi mmu:239759.
UCSCi uc007yru.1. mouse. [Q8CIV3-1 ]
uc007yrv.1. mouse. [Q8CIV3-3 ]
uc012adk.1. mouse. [Q8CIV3-2 ]

Organism-specific databases

CTDi 200879.
MGIi MGI:2388029. Liph.

Phylogenomic databases

eggNOGi NOG39787.
GeneTreei ENSGT00760000119069.
HOGENOMi HOG000234386.
HOVERGENi HBG080640.
InParanoidi Q8CIV3.
OMAi ITAYPCD.
OrthoDBi EOG79PJP2.
PhylomeDBi Q8CIV3.
TreeFami TF324997.

Miscellaneous databases

NextBioi 384267.
PROi Q8CIV3.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIV3.
CleanExi MM_LIPH.
Genevestigatori Q8CIV3.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR013818. Lipase_N.
IPR016272. Lipoprotein_lipase_LIPH.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
Pfami PF00151. Lipase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSi PR00821. TAGLIPASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Lipase h, a new member of the triglyceride lipase family synthesized by the intestine."
    Jin W., Broedl U., Monajemi H., Glick J., Rader D.
    Genomics 80:268-273(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: CD-1.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cecum, Head, Testis and Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiLIPH_MOUSE
AccessioniPrimary (citable) accession number: Q8CIV3
Secondary accession number(s): Q3TRT3
, Q3TTZ0, Q3UWA2, Q8BXB5, Q8CI45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3