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Protein

Lipase member H

Gene

Liph

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei154NucleophileBy similarity1
Active sitei178Charge relay systemBy similarity1
Active sitei248Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-1483166. Synthesis of PA.

Protein family/group databases

ESTHERimouse-LIPH. Phospholipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase member H (EC:3.1.1.-)
Gene namesi
Name:Liph
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2388029. Liph.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000027332217 – 451Lipase member HAdd BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi233 ↔ 246By similarity
Disulfide bondi270 ↔ 281By similarity
Disulfide bondi284 ↔ 292By similarity
Disulfide bondi427 ↔ 446By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CIV3.
PRIDEiQ8CIV3.

PTM databases

PhosphoSitePlusiQ8CIV3.

Expressioni

Tissue specificityi

Expressed in placenta and colon. Weakly expressed in small intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000044626.
CleanExiMM_LIPH.
GenevisibleiQ8CIV3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062310.

Structurei

3D structure databases

ProteinModelPortaliQ8CIV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKYJ. Eukaryota.
ENOG4111AHY. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000234386.
HOVERGENiHBG080640.
InParanoidiQ8CIV3.
KOiK19404.
OMAiSFHSAVV.
OrthoDBiEOG091G0680.
PhylomeDBiQ8CIV3.
TreeFamiTF324997.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR000734. TAG_lipase.
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiView protein in Pfam
PF00151. Lipase. 1 hit.
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CIV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRLCFFISF MCLVKSDTDE TCPSFTRLSF HSAVVGTGLS VRLMLYTQRD
60 70 80 90 100
QTCAQIINST ALGSLNVTKK TTFIIHGFRP TGSPPVWIEE LVQSLISVQE
110 120 130 140 150
MNVVVVDWNR GATTVIYPHA SSKTRQVASI LKEFIDQMLV KGASLDNIYM
160 170 180 190 200
IGVSLGAHIA GFVGESYEGK LGRVTGLDPA GPLFNGRPPE ERLDPSDALF
210 220 230 240 250
VDVIHSDTDA LGYKEALGHI DFYPNGGLDQ PGCPKTIFGG IKYFKCDHQM
260 270 280 290 300
SVYLYLASLQ NNCSITAYPC DSYRDYRNGK CVSCGAGQIV PCPRVGYYAD
310 320 330 340 350
SWKEYLWDRD PPMTKAFFDT AETKPYCMYH YFVDIVSWNK SVRRGFITIK
360 370 380 390 400
LRGEDGNITE SKIDHEPSAF EKYHQVSLLA RFNRDLDKVA EISLLFSTGS
410 420 430 440 450
VVGPKYKLRV LQMKLRSLAH PDRPHLCRYD LVLMENVETS FQPILCSQQQ

M
Length:451
Mass (Da):50,675
Last modified:January 23, 2007 - v2
Checksum:iDBB7F5311A08D70A
GO
Isoform 2 (identifier: Q8CIV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: Missing.

Note: No experimental confirmation available.
Show »
Length:449
Mass (Da):50,491
Checksum:iB3312ECF3950A2B7
GO
Isoform 3 (identifier: Q8CIV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-239: Missing.

Note: No experimental confirmation available.
Show »
Length:421
Mass (Da):47,514
Checksum:i127552E1012959DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29S → N in BAE36182 (PubMed:16141072).Curated1
Sequence conflicti146D → N in BAE23014 (PubMed:16141072).Curated1
Sequence conflicti251S → Y in BAE36182 (PubMed:16141072).Curated1
Sequence conflicti395L → M in AAM18804 (PubMed:12213196).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022505210 – 239Missing in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_022506210 – 211Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY093499 mRNA. Translation: AAM18804.1.
AK048150 mRNA. Translation: BAC33259.1.
AK134352 mRNA. Translation: BAE22108.1.
AK136503 mRNA. Translation: BAE23014.1.
AK161067 mRNA. Translation: BAE36182.1.
AK162492 mRNA. Translation: BAE36944.1.
BC037489 mRNA. Translation: AAH37489.1.
CCDSiCCDS37295.1. [Q8CIV3-3]
CCDS37296.1. [Q8CIV3-1]
RefSeqiNP_001077363.1. NM_001083894.1. [Q8CIV3-1]
NP_001276511.1. NM_001289582.1. [Q8CIV3-2]
NP_700453.1. NM_153404.3. [Q8CIV3-3]
UniGeneiMm.33192.

Genome annotation databases

EnsembliENSMUST00000060673; ENSMUSP00000062310; ENSMUSG00000044626. [Q8CIV3-1]
ENSMUST00000074230; ENSMUSP00000073853; ENSMUSG00000044626. [Q8CIV3-3]
GeneIDi239759.
KEGGimmu:239759.
UCSCiuc007yru.1. mouse. [Q8CIV3-1]
uc007yrv.1. mouse. [Q8CIV3-3]
uc012adk.1. mouse. [Q8CIV3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLIPH_MOUSE
AccessioniPrimary (citable) accession number: Q8CIV3
Secondary accession number(s): Q3TRT3
, Q3TTZ0, Q3UWA2, Q8BXB5, Q8CI45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families