Q8CIT0 (CRF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Corticoliberin

Alternative name(s):
Corticotropin-releasing factor
Short name=CRF
Corticotropin-releasing hormone

Gene names

Name:	Crh
Synonyms:	Gm1347

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.
Subcellular location	Secreted.
Sequence similarities	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adrenal gland development Inferred from mutant phenotype PubMed 10861000. Source: MGI associative learning Inferred from electronic annotation. Source: Compara cellular response to cocaine Inferred from electronic annotation. Source: Compara cellular response to dexamethasone stimulus Inferred from electronic annotation. Source: Compara diterpenoid metabolic process Inferred from electronic annotation. Source: Compara feeding behavior Inferred from electronic annotation. Source: Compara female pregnancy Inferred from electronic annotation. Source: Compara ferulate metabolic process Inferred from electronic annotation. Source: Compara glucocorticoid biosynthetic process Inferred from mutant phenotype PubMed 10861000. Source: MGI hormone-mediated apoptotic signaling pathway Inferred from electronic annotation. Source: Compara hypothalamus development Inferred from electronic annotation. Source: Compara inflammatory response Inferred from mutant phenotype PubMed 15159534. Source: MGI ion homeostasis Inferred from electronic annotation. Source: Compara locomotory exploration behavior Inferred from genetic interaction PubMed 17908177. Source: MGI long-term memory Inferred from electronic annotation. Source: Compara lung development Inferred from mutant phenotype PubMed 10861000. Source: MGI negative regulation of blood pressure Inferred from electronic annotation. Source: Compara negative regulation of cell death Inferred from electronic annotation. Source: Compara negative regulation of epinephrine secretion Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara negative regulation of glucagon secretion Inferred from electronic annotation. Source: Compara negative regulation of luteinizing hormone secretion Inferred from electronic annotation. Source: Compara negative regulation of norepinephrine secretion Inferred from electronic annotation. Source: Compara positive regulation of behavioral fear response Inferred from electronic annotation. Source: Compara positive regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of calcium ion import Inferred from electronic annotation. Source: Compara positive regulation of cell death Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of corticosterone secretion Inferred from electronic annotation. Source: Compara positive regulation of corticotropin secretion Inferred from electronic annotation. Source: Compara positive regulation of cortisol secretion Inferred from electronic annotation. Source: Compara positive regulation of digestive system process Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of insulin secretion involved in cellular response to glucose stimulus Inferred from electronic annotation. Source: Compara positive regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara regulation of N-methyl-D-aspartate selective glutamate receptor activity Inferred from electronic annotation. Source: Compara regulation of serotonin secretion Inferred from electronic annotation. Source: Compara response to corticosterone stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to estrogen stimulus Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to ether Inferred from electronic annotation. Source: Compara response to immobilization stress Inferred from electronic annotation. Source: Compara response to pain Inferred from electronic annotation. Source: Compara synaptic transmission, dopaminergic Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara perikaryon Inferred from electronic annotation. Source: Compara varicosity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 144	125	By similarity		PRO_0000006214
	Peptide	145 – 185	41	Corticoliberin		PRO_0000006215
Amino acid modifications
	Modified residue	185	1	Isoleucine amide By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CIT0 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5E51665291FAA998	FASTA	187	20,778
	10 20 30 40 50 60 MRLRLLVSAG MLLVALSSCL PCRALLSRGS VPRAPRAPQP LNFLQPEQPQ QPQPVLIRMG 70 80 90 100 110 120 EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA NFFRVLLQQL QMPQRSLDSR 130 140 150 160 170 180 AEPAERGAED ALGGHQGALE RERRSEEPPI SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK LMEIIGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene." Seasholtz A.F., Bourbonais F.J., Harnden C.E., Camper S.A. Mol. Cell. Neurosci. 2:266-273(1991) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY128673 Genomic DNA. Translation: AAN07905.1. BC116921 mRNA. Translation: AAI16922.1. BC119036 mRNA. Translation: AAI19037.1.
IPI	IPI00379277.
RefSeq	NP_991338.1. NM_205769.2.
UniGene	Mm.290689.
3D structure databases
ProteinModelPortal	Q8CIT0.
SMR	Q8CIT0. Positions 145-185.
ModBase	Search...
Proteomic databases
PRIDE	Q8CIT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796.
GeneID	12918.
KEGG	mmu:12918.
UCSC	uc008orx.2. mouse.
Organism-specific databases
CTD	1392.
MGI	MGI:88496. Crh.
Phylogenomic databases
eggNOG	NOG38852.
GeneTree	ENSGT00510000048573.
HOGENOM	HOG000004762.
HOVERGEN	HBG001951.
InParanoid	Q14AA2.
KO	K05256.
OMA	AANFFRV.
OrthoDB	EOG4P2Q3Q.
Gene expression databases
Bgee	Q8CIT0.
CleanEx	MM_CRH.
Genevestigator	Q8CIT0.
GermOnline	ENSMUSG00000049796. Mus musculus.
Family and domain databases
InterPro	IPR018446. Corticotropin-releasing_fac_CS. IPR000187. Corticotropin-releasing_factor. IPR003620. Urocortin_CRF. [Graphical view]
PANTHER	PTHR15035. PTHR15035. 1 hit.
Pfam	PF00473. CRF. 1 hit. [Graphical view]
PRINTS	PR01612. CRFFAMILY.
SMART	SM00039. CRF. 1 hit. [Graphical view]
PROSITE	PS00511. CRF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	282564.
SOURCE	Search...

Entry information

Entry name

CRF_MOUSE

Accession

Primary (citable) accession number: Q8CIT0
Secondary accession number(s): Q14AA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program