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Q8CIT0

- CRF_MOUSE

UniProt

Q8CIT0 - CRF_MOUSE

Protein

Corticoliberin

Gene

Crh

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

    GO - Biological processi

    1. adrenal gland development Source: MGI
    2. associative learning Source: Ensembl
    3. cellular response to cocaine Source: Ensembl
    4. cellular response to dexamethasone stimulus Source: Ensembl
    5. diterpenoid metabolic process Source: Ensembl
    6. feeding behavior Source: Ensembl
    7. female pregnancy Source: Ensembl
    8. ferulate metabolic process Source: Ensembl
    9. glucocorticoid biosynthetic process Source: MGI
    10. hormone-mediated apoptotic signaling pathway Source: Ensembl
    11. hypothalamus development Source: Ensembl
    12. inflammatory response Source: MGI
    13. ion homeostasis Source: Ensembl
    14. locomotory exploration behavior Source: MGI
    15. long-term memory Source: Ensembl
    16. long-term synaptic potentiation Source: Ensembl
    17. lung development Source: MGI
    18. negative regulation of blood pressure Source: Ensembl
    19. negative regulation of cell death Source: Ensembl
    20. negative regulation of epinephrine secretion Source: Ensembl
    21. negative regulation of gene expression Source: Ensembl
    22. negative regulation of glucagon secretion Source: Ensembl
    23. negative regulation of luteinizing hormone secretion Source: Ensembl
    24. negative regulation of norepinephrine secretion Source: Ensembl
    25. positive regulation of behavioral fear response Source: Ensembl
    26. positive regulation of calcium ion import Source: Ensembl
    27. positive regulation of cAMP biosynthetic process Source: Ensembl
    28. positive regulation of cell death Source: Ensembl
    29. positive regulation of cell proliferation Source: Ensembl
    30. positive regulation of corticosterone secretion Source: Ensembl
    31. positive regulation of corticotropin secretion Source: Ensembl
    32. positive regulation of cortisol secretion Source: Ensembl
    33. positive regulation of digestive system process Source: Ensembl
    34. positive regulation of gene expression Source: Ensembl
    35. positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
    36. positive regulation of protein phosphorylation Source: Ensembl
    37. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
    38. regulation of serotonin secretion Source: Ensembl
    39. response to corticosterone Source: Ensembl
    40. response to drug Source: Ensembl
    41. response to estrogen Source: Ensembl
    42. response to ethanol Source: Ensembl
    43. response to ether Source: Ensembl
    44. response to immobilization stress Source: Ensembl
    45. response to pain Source: Ensembl
    46. synaptic transmission, dopaminergic Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Corticoliberin
    Alternative name(s):
    Corticotropin-releasing factor
    Short name:
    CRF
    Corticotropin-releasing hormone
    Gene namesi
    Name:Crh
    Synonyms:Gm1347
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:88496. Crh.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl
    3. perikaryon Source: Ensembl
    4. varicosity Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 144125By similarityPRO_0000006214Add
    BLAST
    Peptidei145 – 18541CorticoliberinPRO_0000006215Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei185 – 1851Isoleucine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PRIDEiQ8CIT0.

    Expressioni

    Gene expression databases

    BgeeiQ8CIT0.
    CleanExiMM_CRH.
    GenevestigatoriQ8CIT0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CIT0.
    SMRiQ8CIT0. Positions 145-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38852.
    GeneTreeiENSGT00510000048573.
    HOGENOMiHOG000004762.
    HOVERGENiHBG001951.
    InParanoidiQ14AA2.
    KOiK05256.
    OMAiSALGGHQ.
    OrthoDBiEOG7NSB43.
    PhylomeDBiQ8CIT0.
    TreeFamiTF332956.

    Family and domain databases

    InterProiIPR018446. Corticotropin-releasing_fac_CS.
    IPR000187. Corticotropin-releasing_factor.
    IPR003620. Urocortin_CRF.
    [Graphical view]
    PANTHERiPTHR15035. PTHR15035. 1 hit.
    PfamiPF00473. CRF. 1 hit.
    [Graphical view]
    PRINTSiPR01612. CRFFAMILY.
    SMARTiSM00039. CRF. 1 hit.
    [Graphical view]
    PROSITEiPS00511. CRF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CIT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLRLLVSAG MLLVALSSCL PCRALLSRGS VPRAPRAPQP LNFLQPEQPQ    50
    QPQPVLIRMG EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA 100
    NFFRVLLQQL QMPQRSLDSR AEPAERGAED ALGGHQGALE RERRSEEPPI 150
    SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK LMEIIGK 187
    Length:187
    Mass (Da):20,778
    Last modified:March 1, 2003 - v1
    Checksum:i5E51665291FAA998
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY128673 Genomic DNA. Translation: AAN07905.1.
    BC116921 mRNA. Translation: AAI16922.1.
    BC119036 mRNA. Translation: AAI19037.1.
    CCDSiCCDS17258.1.
    RefSeqiNP_991338.1. NM_205769.2.
    UniGeneiMm.290689.

    Genome annotation databases

    EnsembliENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796.
    GeneIDi12918.
    KEGGimmu:12918.
    UCSCiuc008orx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY128673 Genomic DNA. Translation: AAN07905.1 .
    BC116921 mRNA. Translation: AAI16922.1 .
    BC119036 mRNA. Translation: AAI19037.1 .
    CCDSi CCDS17258.1.
    RefSeqi NP_991338.1. NM_205769.2.
    UniGenei Mm.290689.

    3D structure databases

    ProteinModelPortali Q8CIT0.
    SMRi Q8CIT0. Positions 145-185.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8CIT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061294 ; ENSMUSP00000061185 ; ENSMUSG00000049796 .
    GeneIDi 12918.
    KEGGi mmu:12918.
    UCSCi uc008orx.2. mouse.

    Organism-specific databases

    CTDi 1392.
    MGIi MGI:88496. Crh.

    Phylogenomic databases

    eggNOGi NOG38852.
    GeneTreei ENSGT00510000048573.
    HOGENOMi HOG000004762.
    HOVERGENi HBG001951.
    InParanoidi Q14AA2.
    KOi K05256.
    OMAi SALGGHQ.
    OrthoDBi EOG7NSB43.
    PhylomeDBi Q8CIT0.
    TreeFami TF332956.

    Miscellaneous databases

    NextBioi 282564.
    PROi Q8CIT0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CIT0.
    CleanExi MM_CRH.
    Genevestigatori Q8CIT0.

    Family and domain databases

    InterProi IPR018446. Corticotropin-releasing_fac_CS.
    IPR000187. Corticotropin-releasing_factor.
    IPR003620. Urocortin_CRF.
    [Graphical view ]
    PANTHERi PTHR15035. PTHR15035. 1 hit.
    Pfami PF00473. CRF. 1 hit.
    [Graphical view ]
    PRINTSi PR01612. CRFFAMILY.
    SMARTi SM00039. CRF. 1 hit.
    [Graphical view ]
    PROSITEi PS00511. CRF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene."
      Seasholtz A.F., Bourbonais F.J., Harnden C.E., Camper S.A.
      Mol. Cell. Neurosci. 2:266-273(1991)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCRF_MOUSE
    AccessioniPrimary (citable) accession number: Q8CIT0
    Secondary accession number(s): Q14AA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3