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Protein

Corticoliberin

Gene

Crh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (PubMed:23470617).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:Crh
Synonyms:Gm1347
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88496. Crh.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 144125By similarityPRO_0000006214Add
BLAST
Peptidei145 – 18541CorticoliberinPRO_0000006215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851Isoleucine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MaxQBiQ8CIT0.
PaxDbiQ8CIT0.
PRIDEiQ8CIT0.

Expressioni

Tissue specificityi

Expressed in parvocellular paraventricular nucleus of the hypothalamus and in medial accessory olivary nucleus.1 Publication

Inductioni

Up-regulated during water-avoidance stress.1 Publication

Gene expression databases

BgeeiQ8CIT0.
CleanExiMM_CRH.
GenevisibleiQ8CIT0. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061185.

Structurei

3D structure databases

ProteinModelPortaliQ8CIT0.
SMRiQ8CIT0. Positions 145-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiQ8CIT0.
KOiK05256.
OMAiSALGGHQ.
OrthoDBiEOG7NSB43.
PhylomeDBiQ8CIT0.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CIT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRLLVSAG MLLVALSSCL PCRALLSRGS VPRAPRAPQP LNFLQPEQPQ
60 70 80 90 100
QPQPVLIRMG EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA
110 120 130 140 150
NFFRVLLQQL QMPQRSLDSR AEPAERGAED ALGGHQGALE RERRSEEPPI
160 170 180
SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK LMEIIGK
Length:187
Mass (Da):20,778
Last modified:March 1, 2003 - v1
Checksum:i5E51665291FAA998
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128673 Genomic DNA. Translation: AAN07905.1.
BC116921 mRNA. Translation: AAI16922.1.
BC119036 mRNA. Translation: AAI19037.1.
CCDSiCCDS17258.1.
RefSeqiNP_991338.1. NM_205769.3.
UniGeneiMm.290689.

Genome annotation databases

EnsembliENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796.
GeneIDi12918.
KEGGimmu:12918.
UCSCiuc008orx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128673 Genomic DNA. Translation: AAN07905.1.
BC116921 mRNA. Translation: AAI16922.1.
BC119036 mRNA. Translation: AAI19037.1.
CCDSiCCDS17258.1.
RefSeqiNP_991338.1. NM_205769.3.
UniGeneiMm.290689.

3D structure databases

ProteinModelPortaliQ8CIT0.
SMRiQ8CIT0. Positions 145-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061185.

Proteomic databases

MaxQBiQ8CIT0.
PaxDbiQ8CIT0.
PRIDEiQ8CIT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796.
GeneIDi12918.
KEGGimmu:12918.
UCSCiuc008orx.2. mouse.

Organism-specific databases

CTDi1392.
MGIiMGI:88496. Crh.

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiQ8CIT0.
KOiK05256.
OMAiSALGGHQ.
OrthoDBiEOG7NSB43.
PhylomeDBiQ8CIT0.
TreeFamiTF332956.

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

NextBioi282564.
PROiQ8CIT0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CIT0.
CleanExiMM_CRH.
GenevisibleiQ8CIT0. MM.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene."
    Seasholtz A.F., Bourbonais F.J., Harnden C.E., Camper S.A.
    Mol. Cell. Neurosci. 2:266-273(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: BALB/cJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice."
    Sun Y., Zhang M., Chen C.C., Gillilland M. III, Sun X., El-Zaatari M., Huffnagle G.B., Young V.B., Zhang J., Hong S.C., Chang Y.M., Gumucio D.L., Owyang C., Kao J.Y.
    Gastroenterology 144:1478-1487(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY STRESS.

Entry informationi

Entry nameiCRF_MOUSE
AccessioniPrimary (citable) accession number: Q8CIT0
Secondary accession number(s): Q14AA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.