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Protein

Corticoliberin

Gene

Crh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (PubMed:23470617).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:Crh
Synonyms:Gm1347
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88496. Crh.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000621420 – 144By similarityAdd BLAST125
PeptideiPRO_0000006215145 – 185CorticoliberinAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185Isoleucine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8CIT0.
PRIDEiQ8CIT0.

PTM databases

PhosphoSitePlusiQ8CIT0.

Expressioni

Tissue specificityi

Expressed in parvocellular paraventricular nucleus of the hypothalamus and in medial accessory olivary nucleus.1 Publication

Inductioni

Up-regulated during water-avoidance stress.1 Publication

Gene expression databases

BgeeiENSMUSG00000049796.
CleanExiMM_CRH.
GenevisibleiQ8CIT0. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061185.

Structurei

3D structure databases

ProteinModelPortaliQ8CIT0.
SMRiQ8CIT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiQ8CIT0.
KOiK05256.
OMAiYFIRLGN.
OrthoDBiEOG091G0QDI.
PhylomeDBiQ8CIT0.
TreeFamiTF332956.

Family and domain databases

InterProiView protein in InterPro
IPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiView protein in Pfam
PF00473. CRF. 1 hit.
PRINTSiPR01612. CRFFAMILY.
SMARTiView protein in SMART
SM00039. CRF. 1 hit.
PROSITEiView protein in PROSITE
PS00511. CRF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CIT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRLLVSAG MLLVALSSCL PCRALLSRGS VPRAPRAPQP LNFLQPEQPQ
60 70 80 90 100
QPQPVLIRMG EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA
110 120 130 140 150
NFFRVLLQQL QMPQRSLDSR AEPAERGAED ALGGHQGALE RERRSEEPPI
160 170 180
SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK LMEIIGK
Length:187
Mass (Da):20,778
Last modified:March 1, 2003 - v1
Checksum:i5E51665291FAA998
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128673 Genomic DNA. Translation: AAN07905.1.
BC116921 mRNA. Translation: AAI16922.1.
BC119036 mRNA. Translation: AAI19037.1.
CCDSiCCDS17258.1.
RefSeqiNP_991338.1. NM_205769.3.
UniGeneiMm.290689.

Genome annotation databases

EnsembliENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796.
GeneIDi12918.
KEGGimmu:12918.
UCSCiuc008orx.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCRF_MOUSE
AccessioniPrimary (citable) accession number: Q8CIT0
Secondary accession number(s): Q14AA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families