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Q8CIT0 (CRF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name=CRF
Corticotropin-releasing hormone
Gene names
Name:Crh
Synonyms:Gm1347
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

Subcellular location

Secreted.

Sequence similarities

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadrenal gland development

Inferred from mutant phenotype PubMed 10861000. Source: MGI

associative learning

Inferred from electronic annotation. Source: Ensembl

cellular response to cocaine

Inferred from electronic annotation. Source: Ensembl

cellular response to dexamethasone stimulus

Inferred from electronic annotation. Source: Ensembl

diterpenoid metabolic process

Inferred from electronic annotation. Source: Ensembl

feeding behavior

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

ferulate metabolic process

Inferred from electronic annotation. Source: Ensembl

glucocorticoid biosynthetic process

Inferred from mutant phenotype PubMed 10861000. Source: MGI

hormone-mediated apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

hypothalamus development

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from mutant phenotype PubMed 15159534. Source: MGI

ion homeostasis

Inferred from electronic annotation. Source: Ensembl

locomotory exploration behavior

Inferred from genetic interaction PubMed 17908177. Source: MGI

long-term memory

Inferred from electronic annotation. Source: Ensembl

long-term synaptic potentiation

Inferred from electronic annotation. Source: Ensembl

lung development

Inferred from mutant phenotype PubMed 10861000. Source: MGI

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell death

Inferred from electronic annotation. Source: Ensembl

negative regulation of epinephrine secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

negative regulation of glucagon secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of luteinizing hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of norepinephrine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of behavioral fear response

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion import

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell death

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of corticosterone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of corticotropin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of cortisol secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of digestive system process

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of insulin secretion involved in cellular response to glucose stimulus

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

regulation of N-methyl-D-aspartate selective glutamate receptor activity

Inferred from electronic annotation. Source: Ensembl

regulation of serotonin secretion

Inferred from electronic annotation. Source: Ensembl

response to corticosterone

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to ether

Inferred from electronic annotation. Source: Ensembl

response to immobilization stress

Inferred from electronic annotation. Source: Ensembl

response to pain

Inferred from electronic annotation. Source: Ensembl

synaptic transmission, dopaminergic

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

perikaryon

Inferred from electronic annotation. Source: Ensembl

varicosity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 144125 By similarity
PRO_0000006214
Peptide145 – 18541Corticoliberin
PRO_0000006215

Amino acid modifications

Modified residue1851Isoleucine amide By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CIT0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5E51665291FAA998

FASTA18720,778
        10         20         30         40         50         60 
MRLRLLVSAG MLLVALSSCL PCRALLSRGS VPRAPRAPQP LNFLQPEQPQ QPQPVLIRMG 

        70         80         90        100        110        120 
EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA NFFRVLLQQL QMPQRSLDSR 

       130        140        150        160        170        180 
AEPAERGAED ALGGHQGALE RERRSEEPPI SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK 


LMEIIGK 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene."
Seasholtz A.F., Bourbonais F.J., Harnden C.E., Camper S.A.
Mol. Cell. Neurosci. 2:266-273(1991)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY128673 Genomic DNA. Translation: AAN07905.1.
BC116921 mRNA. Translation: AAI16922.1.
BC119036 mRNA. Translation: AAI19037.1.
CCDSCCDS17258.1.
RefSeqNP_991338.1. NM_205769.2.
UniGeneMm.290689.

3D structure databases

ProteinModelPortalQ8CIT0.
SMRQ8CIT0. Positions 145-185.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8CIT0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796.
GeneID12918.
KEGGmmu:12918.
UCSCuc008orx.2. mouse.

Organism-specific databases

CTD1392.
MGIMGI:88496. Crh.

Phylogenomic databases

eggNOGNOG38852.
GeneTreeENSGT00510000048573.
HOGENOMHOG000004762.
HOVERGENHBG001951.
InParanoidQ14AA2.
KOK05256.
OMASALGGHQ.
OrthoDBEOG7NSB43.
PhylomeDBQ8CIT0.
TreeFamTF332956.

Gene expression databases

BgeeQ8CIT0.
CleanExMM_CRH.
GenevestigatorQ8CIT0.

Family and domain databases

InterProIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERPTHR15035. PTHR15035. 1 hit.
PfamPF00473. CRF. 1 hit.
[Graphical view]
PRINTSPR01612. CRFFAMILY.
SMARTSM00039. CRF. 1 hit.
[Graphical view]
PROSITEPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282564.
PROQ8CIT0.
SOURCESearch...

Entry information

Entry nameCRF_MOUSE
AccessionPrimary (citable) accession number: Q8CIT0
Secondary accession number(s): Q14AA2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot