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Q8CIT0

- CRF_MOUSE

UniProt

Q8CIT0 - CRF_MOUSE

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Protein
Corticoliberin
Gene
Crh, Gm1347
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. associative learning Source: Ensembl
  3. cellular response to cocaine Source: Ensembl
  4. cellular response to dexamethasone stimulus Source: Ensembl
  5. diterpenoid metabolic process Source: Ensembl
  6. feeding behavior Source: Ensembl
  7. female pregnancy Source: Ensembl
  8. ferulate metabolic process Source: Ensembl
  9. glucocorticoid biosynthetic process Source: MGI
  10. hormone-mediated apoptotic signaling pathway Source: Ensembl
  11. hypothalamus development Source: Ensembl
  12. inflammatory response Source: MGI
  13. ion homeostasis Source: Ensembl
  14. locomotory exploration behavior Source: MGI
  15. long-term memory Source: Ensembl
  16. long-term synaptic potentiation Source: Ensembl
  17. lung development Source: MGI
  18. negative regulation of blood pressure Source: Ensembl
  19. negative regulation of cell death Source: Ensembl
  20. negative regulation of epinephrine secretion Source: Ensembl
  21. negative regulation of gene expression Source: Ensembl
  22. negative regulation of glucagon secretion Source: Ensembl
  23. negative regulation of luteinizing hormone secretion Source: Ensembl
  24. negative regulation of norepinephrine secretion Source: Ensembl
  25. positive regulation of behavioral fear response Source: Ensembl
  26. positive regulation of cAMP biosynthetic process Source: Ensembl
  27. positive regulation of calcium ion import Source: Ensembl
  28. positive regulation of cell death Source: Ensembl
  29. positive regulation of cell proliferation Source: Ensembl
  30. positive regulation of corticosterone secretion Source: Ensembl
  31. positive regulation of corticotropin secretion Source: Ensembl
  32. positive regulation of cortisol secretion Source: Ensembl
  33. positive regulation of digestive system process Source: Ensembl
  34. positive regulation of gene expression Source: Ensembl
  35. positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  36. positive regulation of protein phosphorylation Source: Ensembl
  37. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl
  38. regulation of serotonin secretion Source: Ensembl
  39. response to corticosterone Source: Ensembl
  40. response to drug Source: Ensembl
  41. response to estrogen Source: Ensembl
  42. response to ethanol Source: Ensembl
  43. response to ether Source: Ensembl
  44. response to immobilization stress Source: Ensembl
  45. response to pain Source: Ensembl
  46. synaptic transmission, dopaminergic Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:Crh
Synonyms:Gm1347
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88496. Crh.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
  3. perikaryon Source: Ensembl
  4. varicosity Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 144125 By similarity
PRO_0000006214Add
BLAST
Peptidei145 – 18541Corticoliberin
PRO_0000006215Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851Isoleucine amide By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiQ8CIT0.

Expressioni

Gene expression databases

BgeeiQ8CIT0.
CleanExiMM_CRH.
GenevestigatoriQ8CIT0.

Structurei

3D structure databases

ProteinModelPortaliQ8CIT0.
SMRiQ8CIT0. Positions 145-185.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38852.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiQ14AA2.
KOiK05256.
OMAiSALGGHQ.
OrthoDBiEOG7NSB43.
PhylomeDBiQ8CIT0.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CIT0-1 [UniParc]FASTAAdd to Basket

« Hide

MRLRLLVSAG MLLVALSSCL PCRALLSRGS VPRAPRAPQP LNFLQPEQPQ    50
QPQPVLIRMG EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA 100
NFFRVLLQQL QMPQRSLDSR AEPAERGAED ALGGHQGALE RERRSEEPPI 150
SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK LMEIIGK 187
Length:187
Mass (Da):20,778
Last modified:March 1, 2003 - v1
Checksum:i5E51665291FAA998
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY128673 Genomic DNA. Translation: AAN07905.1.
BC116921 mRNA. Translation: AAI16922.1.
BC119036 mRNA. Translation: AAI19037.1.
CCDSiCCDS17258.1.
RefSeqiNP_991338.1. NM_205769.2.
UniGeneiMm.290689.

Genome annotation databases

EnsembliENSMUST00000061294; ENSMUSP00000061185; ENSMUSG00000049796.
GeneIDi12918.
KEGGimmu:12918.
UCSCiuc008orx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY128673 Genomic DNA. Translation: AAN07905.1 .
BC116921 mRNA. Translation: AAI16922.1 .
BC119036 mRNA. Translation: AAI19037.1 .
CCDSi CCDS17258.1.
RefSeqi NP_991338.1. NM_205769.2.
UniGenei Mm.290689.

3D structure databases

ProteinModelPortali Q8CIT0.
SMRi Q8CIT0. Positions 145-185.
ModBasei Search...

Proteomic databases

PRIDEi Q8CIT0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061294 ; ENSMUSP00000061185 ; ENSMUSG00000049796 .
GeneIDi 12918.
KEGGi mmu:12918.
UCSCi uc008orx.2. mouse.

Organism-specific databases

CTDi 1392.
MGIi MGI:88496. Crh.

Phylogenomic databases

eggNOGi NOG38852.
GeneTreei ENSGT00510000048573.
HOGENOMi HOG000004762.
HOVERGENi HBG001951.
InParanoidi Q14AA2.
KOi K05256.
OMAi SALGGHQ.
OrthoDBi EOG7NSB43.
PhylomeDBi Q8CIT0.
TreeFami TF332956.

Miscellaneous databases

NextBioi 282564.
PROi Q8CIT0.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIT0.
CleanExi MM_CRH.
Genevestigatori Q8CIT0.

Family and domain databases

InterProi IPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view ]
PANTHERi PTHR15035. PTHR15035. 1 hit.
Pfami PF00473. CRF. 1 hit.
[Graphical view ]
PRINTSi PR01612. CRFFAMILY.
SMARTi SM00039. CRF. 1 hit.
[Graphical view ]
PROSITEi PS00511. CRF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene."
    Seasholtz A.F., Bourbonais F.J., Harnden C.E., Camper S.A.
    Mol. Cell. Neurosci. 2:266-273(1991)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCRF_MOUSE
AccessioniPrimary (citable) accession number: Q8CIT0
Secondary accession number(s): Q14AA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi