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Protein

Keratin, type I cytoskeletal 9

Gene

Krt9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity). May be involved in spermatid nuclear shaping and sperm development.By similarity1 Publication

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).Curated

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: RGD

GO - Biological processi

  • intermediate filament organization Source: UniProtKB
  • skin development Source: UniProtKB
  • spermatogenesis Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 9
Alternative name(s):
Cytokeratin-9
Short name:
CK-9
Keratin-9
Short name:
K9
Spermatid perinuclear ring manchette protein K9
Gene namesi
Name:Krt9
Synonyms:Krt1-9Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628785 Krt9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083731 – 618Keratin, type I cytoskeletal 9Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei17PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8CIS9

Expressioni

Tissue specificityi

Expressed in the perinuclear ring of spermatid manchettes within testis and in keratinocytes of the suprabasal layer of footpad epidermis (at protein level).1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Structurei

3D structure databases

ProteinModelPortaliQ8CIS9
SMRiQ8CIS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 450IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 137HeadSequence analysisAdd BLAST137
Regioni138 – 173Coil 1ASequence analysisAdd BLAST36
Regioni174 – 192Linker 1Sequence analysisAdd BLAST19
Regioni193 – 284Coil 1BSequence analysisAdd BLAST92
Regioni285 – 307Linker 12Sequence analysisAdd BLAST23
Regioni308 – 446Coil 2Sequence analysisAdd BLAST139
Regioni447 – 609TailSequence analysisAdd BLAST163

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 131Gly-richSequence analysisAdd BLAST117
Compositional biasi470 – 612Ser-richSequence analysisAdd BLAST143

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ8CIS9
KOiK07604
PhylomeDBiQ8CIS9

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 5 hits
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CIS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRQISSSF RSSSGSSCGG GGGRGASRGS MRSSFGRSSR AGGESRFGSS
60 70 80 90 100
SGFGGGGFSA CGTGGGGSFG SSYGGGYGRG FSAGSSSGMF GGSSRGCFGG
110 120 130 140 150
GSGGGFGGGS GGGFGGGFGG GFGGGSGGGE GSILNTNEKV VMQNLNSRLA
160 170 180 190 200
SYMDKVQELE EDNANLEKQI QEWYSRKGNR VFQKDYSHYY NTIEDLKDRI
210 220 230 240 250
VDLTARNNKA LIDMDNTRMT LGDFRVKLEM EQSLPQGVDA DINGLQKVLD
260 270 280 290 300
DINMEKSDLE IQFDSLDDEL KALKKSHKEE MNQLTGLNDG DVNVEINVAP
310 320 330 340 350
STDLTQVLND MREEYEHLIS KNRQDIEQHY ESQMTQIEHQ LTNSGPEMET
360 370 380 390 400
NMKQVSQLQH SVQELNIELQ TQLTTKSALE KALEDTKNRY CGQLQQIREQ
410 420 430 440 450
ISEMEAQLAQ VRAETECQNQ EYGLLLSIKT RLEKEIETYR KLLEGGQQDF
460 470 480 490 500
ESSGAGQIGF GSGKGGQRGS GGSYGGGSGD SYEGESGGSY GGGSGGSHGG
510 520 530 540 550
KSGGSYGGGS SSGGGSGGSY GGGSGGSHGG KSGGSHGGGS GGSYGGGSGS
560 570 580 590 600
GGESGGSYGG GSGGSHGGQK GGSGGSYEGG SGGSYGGGSG SGGGSGGSYG
610
GGNTRPSQSQ SSQIPRLR
Length:618
Mass (Da):63,009
Last modified:March 1, 2003 - v1
Checksum:iB0140A0E34E2A28F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY128946 mRNA Translation: AAN05455.1
RefSeqiNP_703206.1, NM_153476.1
UniGeneiRn.145135

Genome annotation databases

GeneIDi266717
KEGGirno:266717
UCSCiRGD:628785 rat

Similar proteinsi

Entry informationi

Entry nameiK1C9_RAT
AccessioniPrimary (citable) accession number: Q8CIS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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