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Protein
Submitted name:

Polyductin

Gene

Pkhd1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PolyductinImported
Gene namesi
Name:Pkhd1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2155808. Pkhd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3852 – 387524HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 40594041Sequence analysisPRO_5004304482Add
BLAST

Proteomic databases

PaxDbiQ8CIS7.
PRIDEiQ8CIS7.

Expressioni

Gene expression databases

GenevisibleiQ8CIS7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085794.

Structurei

3D structure databases

ProteinModelPortaliQ8CIS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1928 – 2049122G8InterPro annotationAdd
BLAST
Domaini2741 – 2867127G8InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEIF. Eukaryota.
ENOG410XQ01. LUCA.
HOGENOMiHOG000115555.
HOVERGENiHBG053604.
KOiK19865.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
2.60.40.10. 6 hits.
InterProiIPR019316. G8_domain.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR028839. PKHD1.
[Graphical view]
PANTHERiPTHR11915:SF299. PTHR11915:SF299. 1 hit.
PfamiPF10162. G8. 2 hits.
PF01833. TIG. 6 hits.
[Graphical view]
SMARTiSM01225. G8. 2 hits.
SM00429. IPT. 6 hits.
SM00710. PbH1. 8 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 5 hits.
SSF81296. SSF81296. 6 hits.
PROSITEiPS51484. G8. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLAWLVSLL SMEVLLLAKP YSSFQIEPAE GSLAGGTWIT VVFDGLDRSI
60 70 80 90 100
LYPNNGSQLQ IDLVSVAIPT LRIPCDVSPA FVDLPVVTCQ TRSLPSEADA
110 120 130 140 150
GPYSLEIRSG EQVLGTPCPG SLDSCTFKFS KDQTPVLYQV YPASGVPGEV
160 170 180 190 200
VSVYGRVITT WLETFDPDVD YIESPLILEA REDKWLTPCS LINRQTGSCF
210 220 230 240 250
PIQEEHGLGN VQCRVEGDYI GSQNVSFSVF NKGRSMVHKE AWLISAKQEL
260 270 280 290 300
FLYQTYPEIL SVFPKVGSLG GRTDIIITGD FFDPSARVTI AGIPCDIRYV
310 320 330 340 350
SPRKIECTTR APGNEARLTA PQAGNRGLRF EVGDATKDVE LTEATPGYRW
360 370 380 390 400
QIVPNASSPS GFWSKEGRPF RARLSGFFVA PQTNNYTFWI QADSQASLCF
410 420 430 440 450
SSSEEPRTKV EVASVGVGTA DWFDSWEQIG NEGSWHQKTT KLELQGGAKY
460 470 480 490 500
YLEAEQHGIA PSRGMRIGVQ IHNTWLNPDV VNTYLLEKHQ IRARAQRLPE
510 520 530 540 550
IQVLHVSGKG NFFLTWGNVS SQPVPANATA QQIQTTIEEL LVVKCNLAPF
560 570 580 590 600
SARVLLRLGF EQGLEGSRSD GVLTSSTEPF CGRFSLGQLG HLILIPEAAD
610 620 630 640 650
KGYQPDRYPY LCLAYRGHMN KTLDMTVSFL FGFQNIMKNI TCDWSLTNPH
660 670 680 690 700
PESWQFTCIN LWDTCLCHSE DLQSSLANTP LLVHRIDIRP VVPEAGLLYV
710 720 730 740 750
DEIILADTNV TVSQADSGRA CPGGNVVESV SVVGVPPVYS ISSWLAGCGS
760 770 780 790 800
ELPLITACSV STEGTGDGSE LIEVTAQRLQ RTSPPLGGHF FLYLSDTVIT
810 820 830 840 850
DVPVRMSARQ LHKLLQDSAD ESTSGYLNAG DFTVTEDLNS CYEHVWTLSW
860 870 880 890 900
TTQTGDLPNF IRVSDQNLTG VNPTVTARVV YDGGVFLGPI FGDMLATANQ
910 920 930 940 950
QTQVAVQVND IPAYCSGSCS FQYQQESTPS VDHVWYSLGS DVNLLVHFTG
960 970 980 990 1000
TGFPRDTQFL QVTVNKTSCE VLFSNETNVA CELALLPVGV HQIFMLVIPS
1010 1020 1030 1040 1050
GLAVNASGED LLLHVEPRLD AVEPSTAAEI GGRWVTLRGS SLEGVSLVLF
1060 1070 1080 1090 1100
GTQSCVIDAI RSNSQQIQCK VPPRGKVGYT VNVTVISGDH STVLARAFTY
1110 1120 1130 1140 1150
VSSLNPVIVS LSRNRSSIAG GEILFLGMSL LVNYTDLDVQ IHVQDTSAQV
1160 1170 1180 1190 1200
LSQTAWGLEV VLPPLVPGIH AISAFINGVS IRSQGVDLYI QYLTEVFSVE
1210 1220 1230 1240 1250
PCSGSLLGGT LLNLLGTGLG RDPALIRVLV DNHPCDIVNL TEVNIWCETP
1260 1270 1280 1290 1300
PAVLPPRADV LTVPASVEIW AGNTSFFHGP SLVGKGFTFT YEAAATPVVT
1310 1320 1330 1340 1350
AMWGEFRNNS VRFYVEGSNI SDSVILLGSL KCELEVQFFG DSMNLFGCFF
1360 1370 1380 1390 1400
PLHSLEAGVY TLQVRHKRMG FANMSVVPQK FELSPQIIAI FPTHGSKCGG
1410 1420 1430 1440 1450
TVLTVKGMAF SSRKRSVHVD ISGPFACMIL SLEDHTVLCQ TRFVGDQFSE
1460 1470 1480 1490 1500
ASLALNITVL VNGLTSKCKG NCTLFIEEAA TPNVDALTIS ISGSLTMVLM
1510 1520 1530 1540 1550
RGRRLATTAD EPIAFVDDQL PCHTTFFNTS HVACQIRDLA PGFHYLSAVH
1560 1570 1580 1590 1600
TSAGYACLNS VSRNFFIVPQ VLDYFPKDFS IHGGSLLMIK GTALRGWKAT
1610 1620 1630 1640 1650
VVYVGRQACL TVNISSDFIQ CIVPAGNGSA ALEIDVDGVL YHIGLVDYSS
1660 1670 1680 1690 1700
IFTPELLSVS RSQDILTFTV ARISGAANVD IFIGTSPCLG VAGNRTVLQC
1710 1720 1730 1740 1750
MVPLLPAGEY LVTGYDHSRG WASSTLILVL RATVTSVTKN YGCLGGRLLH
1760 1770 1780 1790 1800
VLGAGFSPGN ISAAVCGAPC QVLANATVSA FSCLVLPLDV SLAFLCDLRH
1810 1820 1830 1840 1850
AEDSCKVRSS TYLQCDLTVS MGTERLPGSW PYVYLCEESS LCLFEPDHWT
1860 1870 1880 1890 1900
ESVFPSFSGL FLSPKVERDE VLIYNSSCNI TMETEAEMEC EMPNQPITAK
1910 1920 1930 1940 1950
ITEIQKSWGQ NTQGNFSFQF CRRWSRPHSW FPQRVPHDGD SVTVETGHLL
1960 1970 1980 1990 2000
LLDANTSFLN SLHIKGGKLI FMDPGPIELR AHSILITDGG ELHIGSEEKP
2010 2020 2030 2040 2050
FQGKARIKIY GSVHSTPFFP YGVKFLAVRN GTLSLHGSVP EVTVTYLQAA
2060 2070 2080 2090 2100
AHAGDKVLTL GEAVDWKPGD EAVITSGMTV AGAEATEVVV VETVHNADLH
2110 2120 2130 2140 2150
LRNPLRYSYD FRENWVAGEN PILKPTVALL SRNIIIQGNF TLERVKLLNS
2160 2170 2180 2190 2200
CQEANTAKGN LKHCLYSKSE KMLGARDLGA RVIIQSFPEE PSFVKLKGVQ
2210 2220 2230 2240 2250
FRDLGQAFHK HLSSLALVGA MRGSYIQSCS VWNSFSRGLS MHRTWGLKVD
2260 2270 2280 2290 2300
SNVFYKIVGH ALLLGSYLDG RFSTSETVTG RKNGWWEQGS TIRNNVIISV
2310 2320 2330 2340 2350
SAAEGLSGSE MLAPAGIYTF SPTNVMEGNR VCAAGYGYVF HLVTSQTLQA
2360 2370 2380 2390 2400
PLLSFNWNTA HSCTRYGLLV YPKFQPPWNN DTGFTLFQNF MVWGSAGGAQ
2410 2420 2430 2440 2450
IFRSNNLHLK NFQVYACRDF GIDILESDAN TLITDSFLLG HFTHKGSLCM
2460 2470 2480 2490 2500
SAGIKTPQRW ELTISNTTFV NFDGNCVAIR TCSGCFQGQG GYTVKTRQLK
2510 2520 2530 2540 2550
FVNSSNLVAF PFPHAAVLED LDGSLSGKNG SHVLASMETL SDTCLTNASF
2560 2570 2580 2590 2600
SQIVPGSVCG EAVLFHRMSI ALANSLDVPK NLTITDISNK TITVNYVEDT
2610 2620 2630 2640 2650
LSNYYGWMAL LLDQETYSLQ FESPWMNRSL QYSATFDSFA PGNYLLIMHR
2660 2670 2680 2690 2700
DLPPYPDILL RCGSQVGHSL PFHPLPSQDR ACDWFFNRQL RQLTYLVSGE
2710 2720 2730 2740 2750
GQVKVFLQLK PGVPPSVSAS TSVPESASRW SLPETWQDVE KGWGGYNHTI
2760 2770 2780 2790 2800
PGPGDDVLIL PNKTVLVDTD LPVLRCLYVM GTLEFPVDRS NVLSVACLLI
2810 2820 2830 2840 2850
AGGELKVGTL ENPLEKDQRL LIFLRASEEV VCDYFEGIHV DPGTIGVYGK
2860 2870 2880 2890 2900
LRLHSAYPKK SWVHLGADIA PGNERIIVHN AVDWQPHDTI VLSSSSYEAH
2910 2920 2930 2940 2950
EAEVLTVKEV KGHHIRIYER LKHRHIGSTH TMEDGQQVHL AAEVGLLTRN
2960 2970 2980 2990 3000
IRIQPDSSCR GRLLVGSFRK SSGEDFSGVL QLLNVEIQNM GLPLYSSIEF
3010 3020 3030 3040 3050
TGVSAGSWVI SSTVHQSCSV GIHASSSHGV ILTDNVVFGT NGHGIDVEGQ
3060 3070 3080 3090 3100
NYSLTNNLVI LTMQSANSSP WVAGIKVNYA EDIILHGNVV AGSERLGFHV
3110 3120 3130 3140 3150
GGHGCSSEVL WSDNVVHSSL HGLHLYKKHE SNNCTGVSGF MAFKNFDYGA
3160 3170 3180 3190 3200
MVQTENSVDI QNITLVDNTV GLLAITYVSS ALLSSVSTVQ ITLRNSVIVA
3210 3220 3230 3240 3250
TSSSFDCIHD RKAPQSANWT STDRAPSNPR GGRIGILWPV SASEPNAWPQ
3260 3270 3280 3290 3300
EPWHKVRSHH SVPGIMKLQD VTFSSFVKSC YSNDLDVCIL PNEYSTGVMY
3310 3320 3330 3340 3350
PITAERTRML GIKDKNKFYF PVLQSSKDLV GTICPTLVCE YPRKYLFTDL
3360 3370 3380 3390 3400
DGRTLGLPPP VSVFPRTEEE WTGSFLNTGI FREEQKCTFR AMNQGFFCKQ
3410 3420 3430 3440 3450
TEHAVLILDN VDATWTIPKS HPLVSVTNGF VDTFSIVKDS DLCPPTSSLS
3460 3470 3480 3490 3500
TFYSILPTRQ MTKVCFPEQT PPFLRFLLLG NQRASKLILA VFYNEIQSPH
3510 3520 3530 3540 3550
VFLDKSFIPP TPLESAFSLL AEPSGANYFD IMNNLLYVVL QGEEPVEIHS
3560 3570 3580 3590 3600
SVSIHLALTV TFSVLEKGWE RAMLESLSDF FQIDPNQIRL TLEMPGNKET
3610 3620 3630 3640 3650
LEAIANSERK RKRNCPSVTC GGPSIRYGQR RPLMAEMTSL KITPATTLET
3660 3670 3680 3690 3700
FSKVIVIEVG DLPNIRNSEP IQSLPSNRLQ RLVNQVITAQ QTGALENVLG
3710 3720 3730 3740 3750
MTVGALLVTQ SKGVTGYRNA SSLITGNLIY TRPSELSILV QPSDGEVGIE
3760 3770 3780 3790 3800
LPVQPRLVFL DEKNERVESL GLPSEPWIIS VSLEGASESV LKGCTLAETR
3810 3820 3830 3840 3850
DGYVTFSRLA VLISGSNWHL FFTVISPPGT NFTARSRTFV VLPVASKERS
3860 3870 3880 3890 3900
TIILALSLCS VASWVALSCL VCCWFKKSKT RKIKPEDISE SQAKEQKKNT
3910 3920 3930 3940 3950
HNSSKPRGLQ AKTAKENTLM GEDMRMKVMQ GMQSQFPQHS MDGVSKRKVS
3960 3970 3980 3990 4000
RLAVTGERTA TPAPKIPRIT CVPGSLAQQL TLQEPGNWQE AQQQLLRYQL
4010 4020 4030 4040 4050
AGRNQLLLLR PDLRQERKQG QEPSQLDKGS DCTGLSQEKA TCIPTETFGL

HTTPPETIQ
Length:4,059
Mass (Da):444,665
Last modified:March 1, 2003 - v1
Checksum:i2429E4314ACB54EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130764 mRNA. Translation: AAN05018.1.
RefSeqiNP_694819.2. NM_153179.3.
UniGeneiMm.249253.

Genome annotation databases

GeneIDi241035.
KEGGimmu:241035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130764 mRNA. Translation: AAN05018.1.
RefSeqiNP_694819.2. NM_153179.3.
UniGeneiMm.249253.

3D structure databases

ProteinModelPortaliQ8CIS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085794.

Proteomic databases

PaxDbiQ8CIS7.
PRIDEiQ8CIS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi241035.
KEGGimmu:241035.

Organism-specific databases

CTDi5314.
MGIiMGI:2155808. Pkhd1.

Phylogenomic databases

eggNOGiENOG410IEIF. Eukaryota.
ENOG410XQ01. LUCA.
HOGENOMiHOG000115555.
HOVERGENiHBG053604.
KOiK19865.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevisibleiQ8CIS7. MM.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
2.60.40.10. 6 hits.
InterProiIPR019316. G8_domain.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR028839. PKHD1.
[Graphical view]
PANTHERiPTHR11915:SF299. PTHR11915:SF299. 1 hit.
PfamiPF10162. G8. 2 hits.
PF01833. TIG. 6 hits.
[Graphical view]
SMARTiSM01225. G8. 2 hits.
SM00429. IPT. 6 hits.
SM00710. PbH1. 8 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 5 hits.
SSF81296. SSF81296. 6 hits.
PROSITEiPS51484. G8. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene."
    Nagasawa Y., Matthiesen S., Onuchic L.F., Hou X., Bergmann C., Esquivel E., Senderek J., Ren Z., Zeltner R., Furu L., Avner E., Moser M., Somlo S., Guay-Woodford L., Buttner R., Zerres K., Germino G.G.
    J. Am. Soc. Nephrol. 13:2246-2258(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8CIS7_MOUSE
AccessioniPrimary (citable) accession number: Q8CIS7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.