Reviewed, UniProtKB/Swiss-Prot Q8CIS0 (CAR11_MOUSE)

Names and origin

Protein names

Recommended name:
    Caspase recruitment domain-containing protein 11

Gene names

Name:

Card11

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 By similarity.
Subunit structure	CARD11 and BCL10 bind to each other by CARD-CARD interaction By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 CARD domain. Contains 1 guanylate kinase-like domain. Contains 1 PDZ (DHR) domain.
Caution	Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Gene Ontology (GO)
Biological process	positive regulation of B cell proliferation Inferred from mutant phenotype. Source: MGI positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: MGI positive regulation of T cell proliferation Inferred from mutant phenotype. Source: MGI positive regulation of interleukin-2 biosynthetic process Inferred from mutant phenotype. Source: MGI regulation of B cell differentiation Inferred from mutant phenotype. Source: MGI regulation of T cell differentiation Inferred from mutant phenotype. Source: MGI regulation of apoptosis Inferred from electronic annotation. Source: InterPro regulation of immune response Inferred from mutant phenotype. Source: MGI signal transduction Ref.1 Inferred from direct assay. Source: MGI thymic T cell selection Inferred from mutant phenotype. Source: MGI
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: MGI
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8CIS0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8CIS0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     524-528: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1159	1159	Caspase recruitment domain-containing protein 11		PRO_0000320102
Regions
	Domain	18 – 110	93	CARD
	Domain	672 – 760	89	PDZ
	Domain	978 – 1145	168	Guanylate kinase-like
	Coiled coil	176 – 449	274	Potential
	Compositional bias	623 – 627	5	Poly-Ser
Natural variations
	Alternative sequence	524 – 528	5	Missing in isoform 2.		VSP_031595
Experimental info
	Sequence conflict	258	1	E → Q in AAN10150. Ref.1
	Sequence conflict	860	1	R → L in BAC29910. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 2ED53905B99DD94E	FASTA	1,159	134,040
	10 20 30 40 50 60 MPGGGPAMDD YMETLKDEEE ALWDNVECNR HMLSRYINPA KLTPYLRQCK VIDEQDEDEV 70 80 90 100 110 120 LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP ELYKLVTGKE PTRRFSTIVV 130 140 150 160 170 180 EEGHEGLTHF LMNEVIKLQQ QVKAKDLQRC ELLAKSRQLE DEKKQLSLIR VELLTFQERY 190 200 210 220 230 240 YKMKEERDSY NDELVKVKDD NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME 250 260 270 280 290 300 EECKLERNQS LKLKNDIENR PRKEQVLELE RENEMLKTKI QELQSIIQAG KRSLPDSDKA 310 320 330 340 350 360 ILDILEHDRK EALEDRQELV NKIYNLQEEV RQAEELRDKY LEEKEDLELK CSTLGKDCEM 370 380 390 400 410 420 YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK DKYRKQIREL EEKNDEMRIE 430 440 450 460 470 480 MVRREACIVN LESKLRRLSK DNGSLDQSLP RHLPATIISQ NLGDTSPRTN GQEADDSSTS 490 500 510 520 530 540 EESPEDSKYF LPYHPPRRRM NLKGIQLQRA KSPISMKQAS EFQALMRTVK GHEEDFTDGS 550 560 570 580 590 600 PSSSRSLPVT SSFSKMQPHR SRSSIMSITA EPPGNDSIVR RCKEDAPHRS TVEEDNDSCG 610 620 630 640 650 660 FDALDLDDEN HERYSFGPPS IHSSSSSHQS EGLDAYDLEQ VNLMLRKFSL ERPFRPSVTS 670 680 690 700 710 720 GGHVRGTGPL VQHTTLNGDG LITQLTLLGG NARGSFIHSV KPGSLAERAG LREGHQLLLL 730 740 750 760 770 780 EGCIRGERQS VPLDACTKEE ARWTIQRCSG LITLHYKVNH EGYRKLLKEM EDGLITSGDS 790 800 810 820 830 840 FYIRLNLNIS SQLDACSMSL KCDDVVHVLD TMYQDRHEWL CARVDPFTDQ DLDTGTIPSY 850 860 870 880 890 900 SRAQQLLLVK LQRLVHRGNR EEADSAHHTL RSLRNTLQPE EMLSTSDPRV SPRLSRASFF 910 920 930 940 950 960 FGQLLQFVSR SENKYKRMNS NERVRIISGS PLGSLSRSSL DATKLLTEKH EELDPENELS 970 980 990 1000 1010 1020 RNLTLIPYSL VRAFHCERRR PVLFTPTMLA KTLVQKLLNS GGAMEFTICK SDIVTRDEFL 1030 1040 1050 1060 1070 1080 RKQKTETIIY SREKNPNTFE CIVPANIEAV AAKNKHCLLE AGIGCVRDLI KCKVYPIVLL 1090 1100 1110 1120 1130 1140 IRVSEKNIKR FRKLLPRPET EEEFLRVCRL KEKELEALPC LYATVEAEMW SSVEELLRVL 1150 KDKIVEEQRK TIWVDEDQL
	Isoform 2. Checksum: CE5FA71361B2EB19	FASTA	1,154	133,468
	10 20 30 40 50 60 MPGGGPAMDD YMETLKDEEE ALWDNVECNR HMLSRYINPA KLTPYLRQCK VIDEQDEDEV 70 80 90 100 110 120 LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP ELYKLVTGKE PTRRFSTIVV 130 140 150 160 170 180 EEGHEGLTHF LMNEVIKLQQ QVKAKDLQRC ELLAKSRQLE DEKKQLSLIR VELLTFQERY 190 200 210 220 230 240 YKMKEERDSY NDELVKVKDD NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME 250 260 270 280 290 300 EECKLERNQS LKLKNDIENR PRKEQVLELE RENEMLKTKI QELQSIIQAG KRSLPDSDKA 310 320 330 340 350 360 ILDILEHDRK EALEDRQELV NKIYNLQEEV RQAEELRDKY LEEKEDLELK CSTLGKDCEM 370 380 390 400 410 420 YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK DKYRKQIREL EEKNDEMRIE 430 440 450 460 470 480 MVRREACIVN LESKLRRLSK DNGSLDQSLP RHLPATIISQ NLGDTSPRTN GQEADDSSTS 490 500 510 520 530 540 EESPEDSKYF LPYHPPRRRM NLKGIQLQRA KSPISMKQAS EFQVKGHEED FTDGSPSSSR 550 560 570 580 590 600 SLPVTSSFSK MQPHRSRSSI MSITAEPPGN DSIVRRCKED APHRSTVEED NDSCGFDALD 610 620 630 640 650 660 LDDENHERYS FGPPSIHSSS SSHQSEGLDA YDLEQVNLML RKFSLERPFR PSVTSGGHVR 670 680 690 700 710 720 GTGPLVQHTT LNGDGLITQL TLLGGNARGS FIHSVKPGSL AERAGLREGH QLLLLEGCIR 730 740 750 760 770 780 GERQSVPLDA CTKEEARWTI QRCSGLITLH YKVNHEGYRK LLKEMEDGLI TSGDSFYIRL 790 800 810 820 830 840 NLNISSQLDA CSMSLKCDDV VHVLDTMYQD RHEWLCARVD PFTDQDLDTG TIPSYSRAQQ 850 860 870 880 890 900 LLLVKLQRLV HRGNREEADS AHHTLRSLRN TLQPEEMLST SDPRVSPRLS RASFFFGQLL 910 920 930 940 950 960 QFVSRSENKY KRMNSNERVR IISGSPLGSL SRSSLDATKL LTEKHEELDP ENELSRNLTL 970 980 990 1000 1010 1020 IPYSLVRAFH CERRRPVLFT PTMLAKTLVQ KLLNSGGAME FTICKSDIVT RDEFLRKQKT 1030 1040 1050 1060 1070 1080 ETIIYSREKN PNTFECIVPA NIEAVAAKNK HCLLEAGIGC VRDLIKCKVY PIVLLIRVSE 1090 1100 1110 1120 1130 1140 KNIKRFRKLL PRPETEEEFL RVCRLKEKEL EALPCLYATV EAEMWSSVEE LLRVLKDKIV 1150 EEQRKTIWVD EDQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex." Pomerantz J.L., Denny E.M., Baltimore D. EMBO J. 21:5184-5194(2002) [PubMed: 12356734] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Thymus.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed: 14621295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Thymus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: 129. Tissue: Mammary tumor.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 611-1159. Strain: C57BL/6J. Tissue: Thymus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY135367 mRNA. Translation: AAN10150.1. AK131134 mRNA. Translation: BAD21384.1. Different initiation. BC096592 mRNA. Translation: AAH96592.1. AK037968 mRNA. Translation: BAC29910.1.
IPI	IPI00229908. IPI00885270.
RefSeq	NP_780571.2.
UniGene	Mm.46187
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8CIS0. 2 interactions.
STRING	Q8CIS0.
Genome annotation databases
Ensembl	ENSMUST00000085786; ENSMUSP00000082941; ENSMUSG00000036526; Mus musculus. [Genome view]
GeneID	108723.
KEGG	mmu:108723.
UCSC	uc009aij.1. mouse. uc009aik.1. mouse.
Organism-specific databases
CTD	108723.
MGI	MGI:1916978. Card11.
Phylogenomic databases
HOVERGEN	Q8CIS0.
OMA	DEMRIEM.
Gene expression databases
ArrayExpress	Q8CIS0.
Bgee	Q8CIS0.
CleanEx	MM_CARD11.
Genevestigator	Q8CIS0.
Family and domain databases
InterPro	IPR001315. CARD. IPR020590. Guanylate_kinase_CS. IPR001478. PDZ/DHR/GLGF. [Graphical view]
Pfam	PF00619. CARD. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. [Graphical view]
PROSITE	PS50209. CARD. 1 hit. PS00856. GUANYLATE_KINASE_1. False negative. PS50052. GUANYLATE_KINASE_2. False negative. PS50106. PDZ. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	361261.
SOURCE	Search...

Entry information

Entry name

CAR11_MOUSE

Accession

Primary (citable) accession number: Q8CIS0
Secondary accession number(s): Q4VA14, Q6KAS3, Q8BYV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)