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Q8CIS0

- CAR11_MOUSE

UniProt

Q8CIS0 - CAR11_MOUSE

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Protein

Caspase recruitment domain-containing protein 11

Gene

Card11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 (By similarity).By similarity

GO - Biological processi

  1. positive regulation of B cell proliferation Source: MGI
  2. positive regulation of cytokine production Source: Ensembl
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  4. positive regulation of interleukin-2 biosynthetic process Source: MGI
  5. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  6. positive regulation of T cell activation Source: MGI
  7. positive regulation of T cell proliferation Source: MGI
  8. regulation of apoptotic process Source: InterPro
  9. regulation of B cell differentiation Source: MGI
  10. regulation of immune response Source: MGI
  11. regulation of T cell differentiation Source: MGI
  12. signal transduction Source: MGI
  13. T cell costimulation Source: UniProtKB
  14. thymic T cell selection Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_199121. Activation of NF-kappaB in B cells.
REACT_205561. FCERI mediated NF-kB activation.
REACT_225145. Downstream TCR signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 11
Gene namesi
Name:Card11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1916978. Card11.

Subcellular locationi

Cytoplasm By similarity. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. immunological synapse Source: MGI
  3. membrane raft Source: Ensembl
  4. plasma membrane Source: MGI
  5. T cell receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11591159Caspase recruitment domain-containing protein 11PRO_0000320102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei466 – 4661PhosphoserineBy similarity
Modified residuei564 – 5641Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication
Modified residuei598 – 5981PhosphoserineBy similarity
Modified residuei649 – 6491Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication
Modified residuei657 – 6571Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication
Modified residuei930 – 9301PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-564, Ser-649 and Ser-657 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CIS0.
PRIDEiQ8CIS0.

Expressioni

Gene expression databases

BgeeiQ8CIS0.
CleanExiMM_CARD11.
ExpressionAtlasiQ8CIS0. baseline and differential.
GenevestigatoriQ8CIS0.

Interactioni

Subunit structurei

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail) (By similarity).By similarity

Protein-protein interaction databases

BioGridi224389. 2 interactions.
DIPiDIP-49692N.
IntActiQ8CIS0. 4 interactions.
MINTiMINT-1764942.
STRINGi10090.ENSMUSP00000082941.

Structurei

Secondary structure

1
1159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 274
Helixi30 – 367
Helixi39 – 4810
Helixi54 – 618
Turni70 – 734
Helixi74 – 807
Helixi84 – 9815
Helixi100 – 1078

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I16X-ray1.75A18-110[»]
ProteinModelPortaliQ8CIS0.
SMRiQ8CIS0. Positions 21-109, 685-850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 11093CARDPROSITE-ProRule annotationAdd
BLAST
Domaini672 – 76089PDZAdd
BLAST
Domaini978 – 1145168Guanylate kinase-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili176 – 449274Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi623 – 6275Poly-Ser

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation
Contains 1 guanylate kinase-like domain.Curated
Contains 1 PDZ (DHR) domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG47732.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000111299.
HOVERGENiHBG099790.
InParanoidiQ8CIS0.
KOiK07367.
OMAiEALPCLY.
OrthoDBiEOG747PH5.
PhylomeDBiQ8CIS0.
TreeFamiTF351139.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CIS0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGGGPAMDD YMETLKDEEE ALWDNVECNR HMLSRYINPA KLTPYLRQCK
60 70 80 90 100
VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP
110 120 130 140 150
ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QVKAKDLQRC
160 170 180 190 200
ELLAKSRQLE DEKKQLSLIR VELLTFQERY YKMKEERDSY NDELVKVKDD
210 220 230 240 250
NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS
260 270 280 290 300
LKLKNDIENR PRKEQVLELE RENEMLKTKI QELQSIIQAG KRSLPDSDKA
310 320 330 340 350
ILDILEHDRK EALEDRQELV NKIYNLQEEV RQAEELRDKY LEEKEDLELK
360 370 380 390 400
CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK
410 420 430 440 450
DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DNGSLDQSLP
460 470 480 490 500
RHLPATIISQ NLGDTSPRTN GQEADDSSTS EESPEDSKYF LPYHPPRRRM
510 520 530 540 550
NLKGIQLQRA KSPISMKQAS EFQALMRTVK GHEEDFTDGS PSSSRSLPVT
560 570 580 590 600
SSFSKMQPHR SRSSIMSITA EPPGNDSIVR RCKEDAPHRS TVEEDNDSCG
610 620 630 640 650
FDALDLDDEN HERYSFGPPS IHSSSSSHQS EGLDAYDLEQ VNLMLRKFSL
660 670 680 690 700
ERPFRPSVTS GGHVRGTGPL VQHTTLNGDG LITQLTLLGG NARGSFIHSV
710 720 730 740 750
KPGSLAERAG LREGHQLLLL EGCIRGERQS VPLDACTKEE ARWTIQRCSG
760 770 780 790 800
LITLHYKVNH EGYRKLLKEM EDGLITSGDS FYIRLNLNIS SQLDACSMSL
810 820 830 840 850
KCDDVVHVLD TMYQDRHEWL CARVDPFTDQ DLDTGTIPSY SRAQQLLLVK
860 870 880 890 900
LQRLVHRGNR EEADSAHHTL RSLRNTLQPE EMLSTSDPRV SPRLSRASFF
910 920 930 940 950
FGQLLQFVSR SENKYKRMNS NERVRIISGS PLGSLSRSSL DATKLLTEKH
960 970 980 990 1000
EELDPENELS RNLTLIPYSL VRAFHCERRR PVLFTPTMLA KTLVQKLLNS
1010 1020 1030 1040 1050
GGAMEFTICK SDIVTRDEFL RKQKTETIIY SREKNPNTFE CIVPANIEAV
1060 1070 1080 1090 1100
AAKNKHCLLE AGIGCVRDLI KCKVYPIVLL IRVSEKNIKR FRKLLPRPET
1110 1120 1130 1140 1150
EEEFLRVCRL KEKELEALPC LYATVEAEMW SSVEELLRVL KDKIVEEQRK

TIWVDEDQL
Length:1,159
Mass (Da):134,040
Last modified:February 26, 2008 - v2
Checksum:i2ED53905B99DD94E
GO
Isoform 2 (identifier: Q8CIS0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-528: Missing.

Show »
Length:1,154
Mass (Da):133,468
Checksum:iCE5FA71361B2EB19
GO

Sequence cautioni

The sequence BAD21384.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581E → Q in AAN10150. (PubMed:12356734)Curated
Sequence conflicti860 – 8601R → L in BAC29910. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei524 – 5285Missing in isoform 2. 2 PublicationsVSP_031595

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135367 mRNA. Translation: AAN10150.1.
AK131134 mRNA. Translation: BAD21384.1. Different initiation.
BC096592 mRNA. Translation: AAH96592.1.
AK037968 mRNA. Translation: BAC29910.1.
CCDSiCCDS51686.1. [Q8CIS0-2]
RefSeqiNP_780571.2. NM_175362.2. [Q8CIS0-2]
UniGeneiMm.46187.

Genome annotation databases

EnsembliENSMUST00000085786; ENSMUSP00000082941; ENSMUSG00000036526. [Q8CIS0-2]
GeneIDi108723.
KEGGimmu:108723.
UCSCiuc009aik.2. mouse. [Q8CIS0-2]
uc012egd.1. mouse. [Q8CIS0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135367 mRNA. Translation: AAN10150.1 .
AK131134 mRNA. Translation: BAD21384.1 . Different initiation.
BC096592 mRNA. Translation: AAH96592.1 .
AK037968 mRNA. Translation: BAC29910.1 .
CCDSi CCDS51686.1. [Q8CIS0-2 ]
RefSeqi NP_780571.2. NM_175362.2. [Q8CIS0-2 ]
UniGenei Mm.46187.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I16 X-ray 1.75 A 18-110 [» ]
ProteinModelPortali Q8CIS0.
SMRi Q8CIS0. Positions 21-109, 685-850.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 224389. 2 interactions.
DIPi DIP-49692N.
IntActi Q8CIS0. 4 interactions.
MINTi MINT-1764942.
STRINGi 10090.ENSMUSP00000082941.

Proteomic databases

PaxDbi Q8CIS0.
PRIDEi Q8CIS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085786 ; ENSMUSP00000082941 ; ENSMUSG00000036526 . [Q8CIS0-2 ]
GeneIDi 108723.
KEGGi mmu:108723.
UCSCi uc009aik.2. mouse. [Q8CIS0-2 ]
uc012egd.1. mouse. [Q8CIS0-1 ]

Organism-specific databases

CTDi 84433.
MGIi MGI:1916978. Card11.

Phylogenomic databases

eggNOGi NOG47732.
GeneTreei ENSGT00530000063108.
HOGENOMi HOG000111299.
HOVERGENi HBG099790.
InParanoidi Q8CIS0.
KOi K07367.
OMAi EALPCLY.
OrthoDBi EOG747PH5.
PhylomeDBi Q8CIS0.
TreeFami TF351139.

Enzyme and pathway databases

Reactomei REACT_199121. Activation of NF-kappaB in B cells.
REACT_205561. FCERI mediated NF-kB activation.
REACT_225145. Downstream TCR signaling.

Miscellaneous databases

ChiTaRSi CARD11. mouse.
NextBioi 361261.
PROi Q8CIS0.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIS0.
CleanExi MM_CARD11.
ExpressionAtlasi Q8CIS0. baseline and differential.
Genevestigatori Q8CIS0.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex."
    Pomerantz J.L., Denny E.M., Baltimore D.
    EMBO J. 21:5184-5194(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Thymus.
  2. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
    DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: 129.
    Tissue: Mammary tumor.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 611-1159.
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. Cited for: FUNCTION, PHOSPHORYLATION AT SER-564; SER-649 AND SER-657.

Entry informationi

Entry nameiCAR11_MOUSE
AccessioniPrimary (citable) accession number: Q8CIS0
Secondary accession number(s): Q4VA14, Q6KAS3, Q8BYV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3