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Q8CIS0

- CAR11_MOUSE

UniProt

Q8CIS0 - CAR11_MOUSE

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Protein
Caspase recruitment domain-containing protein 11
Gene
Card11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10 By similarity.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. T cell costimulation Source: UniProtKB
  2. positive regulation of B cell proliferation Source: MGI
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  4. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  5. positive regulation of T cell activation Source: MGI
  6. positive regulation of T cell proliferation Source: MGI
  7. positive regulation of cytokine production Source: Ensembl
  8. positive regulation of interleukin-2 biosynthetic process Source: MGI
  9. regulation of B cell differentiation Source: MGI
  10. regulation of T cell differentiation Source: MGI
  11. regulation of apoptotic process Source: InterPro
  12. regulation of immune response Source: MGI
  13. signal transduction Source: MGI
  14. thymic T cell selection Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_199121. Activation of NF-kappaB in B cells.
REACT_205561. FCERI mediated NF-kB activation.
REACT_225145. Downstream TCR signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 11
Gene namesi
Name:Card11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1916978. Card11.

Subcellular locationi

Cytoplasm By similarity. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts By similarity.

GO - Cellular componenti

  1. T cell receptor complex Source: Ensembl
  2. cytoplasm Source: UniProtKB-SubCell
  3. immunological synapse Source: MGI
  4. membrane raft Source: UniProtKB-SubCell
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11591159Caspase recruitment domain-containing protein 11
PRO_0000320102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei466 – 4661Phosphoserine By similarity
Modified residuei564 – 5641Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication
Modified residuei598 – 5981Phosphoserine By similarity
Modified residuei649 – 6491Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication
Modified residuei657 – 6571Phosphoserine; by PKC/PRKCB and PKC/PRKCQ1 Publication
Modified residuei930 – 9301Phosphoserine By similarity

Post-translational modificationi

Phosphorylation at Ser-564, Ser-649 and Ser-657 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CIS0.
PRIDEiQ8CIS0.

Expressioni

Gene expression databases

BgeeiQ8CIS0.
CleanExiMM_CARD11.
GenevestigatoriQ8CIS0.

Interactioni

Subunit structurei

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail) By similarity.

Protein-protein interaction databases

BioGridi224389. 2 interactions.
DIPiDIP-49692N.
IntActiQ8CIS0. 4 interactions.
MINTiMINT-1764942.
STRINGi10090.ENSMUSP00000082941.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 274
Helixi30 – 367
Helixi39 – 4810
Helixi54 – 618
Turni70 – 734
Helixi74 – 807
Helixi84 – 9815
Helixi100 – 1078

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I16X-ray1.75A18-110[»]
ProteinModelPortaliQ8CIS0.
SMRiQ8CIS0. Positions 21-109, 685-850.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 11093CARD
Add
BLAST
Domaini672 – 76089PDZ
Add
BLAST
Domaini978 – 1145168Guanylate kinase-like
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili176 – 449274 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi623 – 6275Poly-Ser

Sequence similaritiesi

Contains 1 CARD domain.
Contains 1 PDZ (DHR) domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG47732.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000111299.
HOVERGENiHBG099790.
InParanoidiQ8CIS0.
KOiK07367.
OMAiEALPCLY.
OrthoDBiEOG747PH5.
PhylomeDBiQ8CIS0.
TreeFamiTF351139.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CIS0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPGGGPAMDD YMETLKDEEE ALWDNVECNR HMLSRYINPA KLTPYLRQCK     50
VIDEQDEDEV LNAPMLPSKI NRAGRLLDIL HTKGQRGYVV FLESLEFYYP 100
ELYKLVTGKE PTRRFSTIVV EEGHEGLTHF LMNEVIKLQQ QVKAKDLQRC 150
ELLAKSRQLE DEKKQLSLIR VELLTFQERY YKMKEERDSY NDELVKVKDD 200
NYNLAMRYAQ LSEEKNMAVM RSRDLQLEID QLKHRLNKME EECKLERNQS 250
LKLKNDIENR PRKEQVLELE RENEMLKTKI QELQSIIQAG KRSLPDSDKA 300
ILDILEHDRK EALEDRQELV NKIYNLQEEV RQAEELRDKY LEEKEDLELK 350
CSTLGKDCEM YKHRMNTVML QLEEVERERD QAFHSRDEAQ TQYSQCLIEK 400
DKYRKQIREL EEKNDEMRIE MVRREACIVN LESKLRRLSK DNGSLDQSLP 450
RHLPATIISQ NLGDTSPRTN GQEADDSSTS EESPEDSKYF LPYHPPRRRM 500
NLKGIQLQRA KSPISMKQAS EFQALMRTVK GHEEDFTDGS PSSSRSLPVT 550
SSFSKMQPHR SRSSIMSITA EPPGNDSIVR RCKEDAPHRS TVEEDNDSCG 600
FDALDLDDEN HERYSFGPPS IHSSSSSHQS EGLDAYDLEQ VNLMLRKFSL 650
ERPFRPSVTS GGHVRGTGPL VQHTTLNGDG LITQLTLLGG NARGSFIHSV 700
KPGSLAERAG LREGHQLLLL EGCIRGERQS VPLDACTKEE ARWTIQRCSG 750
LITLHYKVNH EGYRKLLKEM EDGLITSGDS FYIRLNLNIS SQLDACSMSL 800
KCDDVVHVLD TMYQDRHEWL CARVDPFTDQ DLDTGTIPSY SRAQQLLLVK 850
LQRLVHRGNR EEADSAHHTL RSLRNTLQPE EMLSTSDPRV SPRLSRASFF 900
FGQLLQFVSR SENKYKRMNS NERVRIISGS PLGSLSRSSL DATKLLTEKH 950
EELDPENELS RNLTLIPYSL VRAFHCERRR PVLFTPTMLA KTLVQKLLNS 1000
GGAMEFTICK SDIVTRDEFL RKQKTETIIY SREKNPNTFE CIVPANIEAV 1050
AAKNKHCLLE AGIGCVRDLI KCKVYPIVLL IRVSEKNIKR FRKLLPRPET 1100
EEEFLRVCRL KEKELEALPC LYATVEAEMW SSVEELLRVL KDKIVEEQRK 1150
TIWVDEDQL 1159
Length:1,159
Mass (Da):134,040
Last modified:February 26, 2008 - v2
Checksum:i2ED53905B99DD94E
GO
Isoform 2 (identifier: Q8CIS0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     524-528: Missing.

Show »
Length:1,154
Mass (Da):133,468
Checksum:iCE5FA71361B2EB19
GO

Sequence cautioni

The sequence BAD21384.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei524 – 5285Missing in isoform 2.
VSP_031595

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581E → Q in AAN10150. 1 Publication
Sequence conflicti860 – 8601R → L in BAC29910. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135367 mRNA. Translation: AAN10150.1.
AK131134 mRNA. Translation: BAD21384.1. Different initiation.
BC096592 mRNA. Translation: AAH96592.1.
AK037968 mRNA. Translation: BAC29910.1.
CCDSiCCDS51686.1. [Q8CIS0-2]
RefSeqiNP_780571.2. NM_175362.2. [Q8CIS0-2]
UniGeneiMm.46187.

Genome annotation databases

EnsembliENSMUST00000085786; ENSMUSP00000082941; ENSMUSG00000036526. [Q8CIS0-2]
GeneIDi108723.
KEGGimmu:108723.
UCSCiuc009aik.2. mouse. [Q8CIS0-2]
uc012egd.1. mouse. [Q8CIS0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135367 mRNA. Translation: AAN10150.1 .
AK131134 mRNA. Translation: BAD21384.1 . Different initiation.
BC096592 mRNA. Translation: AAH96592.1 .
AK037968 mRNA. Translation: BAC29910.1 .
CCDSi CCDS51686.1. [Q8CIS0-2 ]
RefSeqi NP_780571.2. NM_175362.2. [Q8CIS0-2 ]
UniGenei Mm.46187.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I16 X-ray 1.75 A 18-110 [» ]
ProteinModelPortali Q8CIS0.
SMRi Q8CIS0. Positions 21-109, 685-850.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 224389. 2 interactions.
DIPi DIP-49692N.
IntActi Q8CIS0. 4 interactions.
MINTi MINT-1764942.
STRINGi 10090.ENSMUSP00000082941.

Proteomic databases

PaxDbi Q8CIS0.
PRIDEi Q8CIS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085786 ; ENSMUSP00000082941 ; ENSMUSG00000036526 . [Q8CIS0-2 ]
GeneIDi 108723.
KEGGi mmu:108723.
UCSCi uc009aik.2. mouse. [Q8CIS0-2 ]
uc012egd.1. mouse. [Q8CIS0-1 ]

Organism-specific databases

CTDi 84433.
MGIi MGI:1916978. Card11.

Phylogenomic databases

eggNOGi NOG47732.
GeneTreei ENSGT00530000063108.
HOGENOMi HOG000111299.
HOVERGENi HBG099790.
InParanoidi Q8CIS0.
KOi K07367.
OMAi EALPCLY.
OrthoDBi EOG747PH5.
PhylomeDBi Q8CIS0.
TreeFami TF351139.

Enzyme and pathway databases

Reactomei REACT_199121. Activation of NF-kappaB in B cells.
REACT_205561. FCERI mediated NF-kB activation.
REACT_225145. Downstream TCR signaling.

Miscellaneous databases

ChiTaRSi CARD11. mouse.
NextBioi 361261.
PROi Q8CIS0.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIS0.
CleanExi MM_CARD11.
Genevestigatori Q8CIS0.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex."
    Pomerantz J.L., Denny E.M., Baltimore D.
    EMBO J. 21:5184-5194(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Thymus.
  2. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
    DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: 129.
    Tissue: Mammary tumor.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 611-1159.
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. Cited for: FUNCTION, PHOSPHORYLATION AT SER-564; SER-649 AND SER-657.

Entry informationi

Entry nameiCAR11_MOUSE
AccessioniPrimary (citable) accession number: Q8CIS0
Secondary accession number(s): Q4VA14, Q6KAS3, Q8BYV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 3, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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