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Q8CIR4

- TRPM6_MOUSE

UniProt

Q8CIR4 - TRPM6_MOUSE

Protein

Transient receptor potential cation channel subfamily M member 6

Gene

Trpm6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1786 – 17861ATPBy similarity
    Binding sitei1810 – 18101ATPBy similarity
    Binding sitei1882 – 18821ATPBy similarity
    Metal bindingi1915 – 19151ZincBy similarity
    Active sitei1929 – 19291Proton acceptorBy similarity
    Binding sitei1931 – 19311ATPBy similarity
    Binding sitei1939 – 19391ATPBy similarity
    Metal bindingi1972 – 19721ZincBy similarity
    Metal bindingi1974 – 19741ZincBy similarity
    Metal bindingi1978 – 19781ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1956 – 19627ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium channel activity Source: UniProtKB-KW
    3. cation channel activity Source: MGI
    4. metal ion binding Source: UniProtKB-KW
    5. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. metal ion transport Source: MGI
    2. response to toxic substance Source: Ensembl

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_227861. TRP channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily M member 6 (EC:2.7.11.1)
    Alternative name(s):
    Channel kinase 2
    Melastatin-related TRP cation channel 6
    Gene namesi
    Name:Trpm6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:2675603. Trpm6.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. brush border membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20282028Transient receptor potential cation channel subfamily M member 6PRO_0000215330Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1857 – 18571Phosphothreonine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8CIR4.

    PTM databases

    PhosphoSiteiQ8CIR4.

    Expressioni

    Gene expression databases

    BgeeiQ8CIR4.
    GenevestigatoriQ8CIR4.

    Interactioni

    Subunit structurei

    Forms heterodimers with TRPM7. Interacts (via kinase domain) with GNB2L1/RACK1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000037443.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CIR4.
    SMRiQ8CIR4. Positions 1180-1229, 1713-1992.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 747747CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini769 – 84779ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini869 – 91042CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini932 – 94514ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini967 – 97812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1000 – 101819ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1040 – 105314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1075 – 2028954CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei1019 – 103921Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei748 – 76821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei848 – 86821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei911 – 93121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei946 – 96621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei979 – 99921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1054 – 107421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1756 – 1986231Alpha-type protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated
    Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253824.
    GeneTreeiENSGT00650000093139.
    HOGENOMiHOG000230920.
    HOVERGENiHBG055663.
    InParanoidiQ8CIR4.
    KOiK04981.
    OMAiLMECMVH.
    OrthoDBiEOG7NPFSC.
    PhylomeDBiQ8CIR4.
    TreeFamiTF314204.

    Family and domain databases

    InterProiIPR005821. Ion_trans_dom.
    IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    IPR029597. TRPM6.
    [Graphical view]
    PANTHERiPTHR13800:SF15. PTHR13800:SF15. 1 hit.
    PfamiPF02816. Alpha_kinase. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    SMARTiSM00811. Alpha_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51158. ALPHA_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CIR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVKKSWIEG VFYKRECNKF IPSSKDPHRC TPGCQICHNL VRCYCGRLIE     50
    EHHGLDRAWN LSVTEGHGDE QWSVEKHTVK SPTDTFGTIN FQDGEHIHHS 100
    KYIRTSWDTK SDHLLHLMLK EWNMELPKLV ISVHGGLQNF KISSKLKETF 150
    SQGLVKAAET TGAWIITEGI NSGVSKHVGD ALKAHSSKSL RKIWTVGIPP 200
    WGVIENQREL VGKDVVCMYQ TLGNPLSKLT TLNCMHSHFI LCDDGTVGMY 250
    GNEEKLRRNL EKHLSMQKIH TCSRQGVPVV GLVMEGGPNV ILWVWETVKN 300
    KEPVVVCEGT GRAADLLAFT YKHLEDGGIL RPQVKEELFC LIQNMFNFSL 350
    RQSKHLFQIL MECMVHKDSI TIFDADSEEH QDLDLAILTA LLKGTSLSIS 400
    EQLNLAMAWD RMDIAKKHIL TYGQHWKPGA LEQAMLDALV MDRVDFVKLL 450
    IENGVNLHRF LTIPRLEELY NTKQGPTNKF LRHLVQDVKQ HTLLSSYRIT 500
    LIDIGLVIEY LIGGAYRSSY TRKSFRILYN NLYRKHKSVS SFAQGLSQHS 550
    LHQRHSLRNR KESSESTLHS QFFRTAQPYK SKEKPEDSQK SKKKSKERQS 600
    LSEEPEAAGF IYPYNDLLVW AVLMKRQNMA MFFWQHGEEA TVKAVIASIL 650
    YRAMAREAKE SNMVDDTSEE LKNYSEQFGQ LALDVLEKAF KQNEPMAMKL 700
    LTYELKNWSN STCLKLAVSG GLRPFVSHSC TQMLLTDMWM GRLKMRKNSW 750
    LKIIISILLP PMILTLEFKS KAEMSHVPQS QDFQFTWNYS DQGLSNTKES 800
    ACVKDYDLER GPDEKPDEPL HLDLRNVPQS LPWTRRVYEF YSAPFVKFWF 850
    YTMAYLAFLM LFTYTVLVEM QPQPSVHEWL VIIYIFTNAI EKVREICISE 900
    PSKFKQKVKM WLSEYWNLME TVAIGLFAVG FGLRWGHPPL QTAGRLIYCI 950
    DIIFWFSRLM DFFAVNQHAG PYVTMIAKMA ANMFYIVIIM AIVLLSFGVA 1000
    RKAILSPKEP PSWRLARDIV FEPYWMMYGE VYASDIDVCS NETSCPPGSF 1050
    LTPFLQAVYL FVQYIIMVNL LIACFNNIYL DIKSISNKLW KYNRYRYIMT 1100
    YHQKPWLPPP FILLNHLCLL LRGLCCRPAP QDQEEGDGGL KLYLTKDDLK 1150
    KLHDFEEQCV EKYFHEKTEG LNCSFEEQIR MTSERVSEMF FQLKEMNEKV 1200
    SFIKDSLLSL DSQVGHLQDL SAITVDTLKV LSAVDTLQED EILLANRKHS 1250
    TCRKRPHSWT NVICAKVLSD MESCGKKKLQ YYSMPPSLLR SLARSQLPPS 1300
    VQRGALVEVT HSKREASHVR EEQEEREMEQ RTTASGISHV RQAHSKYGQF 1350
    LLVPSSGKQV PLSLETPPHL FRSSEEAGID GLVLEHIHQS DLTTHLPQQT 1400
    PAASHQALVA EHKDQHEAVT QMSDKPAKAE QDLLAFSGTP APMTVTSLPS 1450
    RAISMQDEGG YVNWAFSEND ETGVFSFKKK WKTCLASTCN SDSNPGGDYF 1500
    LHTGGRSGLD NSRRLAQSCE CPAGPWTQAR RSFWINPLCR DKALIKSHSF 1550
    RFHKEEKLRK TWKNNSHSKS LETRSTWLKA KLLTKTRSLS KKKRKTQGLQ 1600
    VPVITVNACY QSDQLNAEPG ETNTTEEFSK KWLSVSNFSQ IGLEPYIYQK 1650
    MKMKEIKRHT TQASDHLRQP QENRDKTPTW NSGSTSLSRS FLTRSPNEVH 1700
    KISTSLKSPQ EPHHHYSAIE RNNLMRLSQT IPFTPIQLFT GEEVTIYKLE 1750
    ESSPLTLDKS MSSWSQHGRA AMIQVLSQEE MDGGLRKAMR VISTWSEDDV 1800
    LKPGQVFIVK SFLPEVVQTW YKIFQESTVL HLCLREIQQQ RAAQKLIYTF 1850
    NQVKPQTIPY TPRFLEVSLV YCHSANQWLT IEKYMTGEFR KYNNNNGDEI 1900
    APTNTLEELM LAFSHWTYEY TRGELLVLDL QGVGENLTDP SVIKPEDKQS 1950
    RGMVFGPANL GEDAIRSFIA KHRCNSCCGK LRLPDLKRND YSLSRTHCNL 2000
    GFGQTIEPTE ELPERDKNRS SLEDHTRL 2028
    Length:2,028
    Mass (Da):232,888
    Last modified:March 1, 2003 - v1
    Checksum:i3060C1D70DC9A20E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY135644 mRNA. Translation: AAN15217.1.
    CCDSiCCDS29691.1.
    RefSeqiNP_700466.1. NM_153417.1.
    UniGeneiMm.215171.

    Genome annotation databases

    EnsembliENSMUST00000040489; ENSMUSP00000037443; ENSMUSG00000024727.
    GeneIDi225997.
    KEGGimmu:225997.
    UCSCiuc008gya.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY135644 mRNA. Translation: AAN15217.1 .
    CCDSi CCDS29691.1.
    RefSeqi NP_700466.1. NM_153417.1.
    UniGenei Mm.215171.

    3D structure databases

    ProteinModelPortali Q8CIR4.
    SMRi Q8CIR4. Positions 1180-1229, 1713-1992.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000037443.

    PTM databases

    PhosphoSitei Q8CIR4.

    Proteomic databases

    PRIDEi Q8CIR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040489 ; ENSMUSP00000037443 ; ENSMUSG00000024727 .
    GeneIDi 225997.
    KEGGi mmu:225997.
    UCSCi uc008gya.1. mouse.

    Organism-specific databases

    CTDi 140803.
    MGIi MGI:2675603. Trpm6.

    Phylogenomic databases

    eggNOGi NOG253824.
    GeneTreei ENSGT00650000093139.
    HOGENOMi HOG000230920.
    HOVERGENi HBG055663.
    InParanoidi Q8CIR4.
    KOi K04981.
    OMAi LMECMVH.
    OrthoDBi EOG7NPFSC.
    PhylomeDBi Q8CIR4.
    TreeFami TF314204.

    Enzyme and pathway databases

    Reactomei REACT_227861. TRP channels.

    Miscellaneous databases

    NextBioi 377907.
    PROi Q8CIR4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CIR4.
    Genevestigatori Q8CIR4.

    Family and domain databases

    InterProi IPR005821. Ion_trans_dom.
    IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    IPR029597. TRPM6.
    [Graphical view ]
    PANTHERi PTHR13800:SF15. PTHR13800:SF15. 1 hit.
    Pfami PF02816. Alpha_kinase. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    SMARTi SM00811. Alpha_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51158. ALPHA_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ryazanova L.V., Ryazanov A.G.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Kidney.

    Entry informationi

    Entry nameiTRPM6_MOUSE
    AccessioniPrimary (citable) accession number: Q8CIR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3