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Q8CIR4

- TRPM6_MOUSE

UniProt

Q8CIR4 - TRPM6_MOUSE

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Protein
Transient receptor potential cation channel subfamily M member 6
Gene
Trpm6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1786 – 17861ATP By similarity
Binding sitei1810 – 18101ATP By similarity
Binding sitei1882 – 18821ATP By similarity
Metal bindingi1915 – 19151Zinc By similarity
Active sitei1929 – 19291Proton acceptor By similarity
Binding sitei1931 – 19311ATP By similarity
Binding sitei1939 – 19391ATP By similarity
Metal bindingi1972 – 19721Zinc By similarity
Metal bindingi1974 – 19741Zinc By similarity
Metal bindingi1978 – 19781Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1956 – 19627ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium channel activity Source: UniProtKB-KW
  3. cation channel activity Source: MGI
  4. metal ion binding Source: UniProtKB-KW
  5. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. metal ion transport Source: MGI
  2. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 6 (EC:2.7.11.1)
Alternative name(s):
Channel kinase 2
Melastatin-related TRP cation channel 6
Gene namesi
Name:Trpm6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2675603. Trpm6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 747747Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei748 – 76821Helical; Reviewed prediction
Add
BLAST
Topological domaini769 – 84779Extracellular Reviewed prediction
Add
BLAST
Transmembranei848 – 86821Helical; Reviewed prediction
Add
BLAST
Topological domaini869 – 91042Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei911 – 93121Helical; Reviewed prediction
Add
BLAST
Topological domaini932 – 94514Extracellular Reviewed prediction
Add
BLAST
Transmembranei946 – 96621Helical; Reviewed prediction
Add
BLAST
Topological domaini967 – 97812Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei979 – 99921Helical; Reviewed prediction
Add
BLAST
Topological domaini1000 – 101819Extracellular Reviewed prediction
Add
BLAST
Intramembranei1019 – 103921Pore-forming; Reviewed prediction
Add
BLAST
Topological domaini1040 – 105314Extracellular Reviewed prediction
Add
BLAST
Transmembranei1054 – 107421Helical; Reviewed prediction
Add
BLAST
Topological domaini1075 – 2028954Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. brush border membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20282028Transient receptor potential cation channel subfamily M member 6
PRO_0000215330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1857 – 18571Phosphothreonine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8CIR4.

PTM databases

PhosphoSiteiQ8CIR4.

Expressioni

Gene expression databases

BgeeiQ8CIR4.
GenevestigatoriQ8CIR4.

Interactioni

Subunit structurei

Forms heterodimers with TRPM7. Interacts (via kinase domain) with GNB2L1/RACK1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037443.

Structurei

3D structure databases

ProteinModelPortaliQ8CIR4.
SMRiQ8CIR4. Positions 1180-1229, 1713-1992.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1756 – 1986231Alpha-type protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253824.
GeneTreeiENSGT00650000093139.
HOGENOMiHOG000230920.
HOVERGENiHBG055663.
InParanoidiQ8CIR4.
KOiK04981.
OMAiLMECMVH.
OrthoDBiEOG7NPFSC.
PhylomeDBiQ8CIR4.
TreeFamiTF314204.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
IPR029597. TRPM6.
[Graphical view]
PANTHERiPTHR13800:SF15. PTHR13800:SF15. 1 hit.
PfamiPF02816. Alpha_kinase. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIR4-1 [UniParc]FASTAAdd to Basket

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MQVKKSWIEG VFYKRECNKF IPSSKDPHRC TPGCQICHNL VRCYCGRLIE     50
EHHGLDRAWN LSVTEGHGDE QWSVEKHTVK SPTDTFGTIN FQDGEHIHHS 100
KYIRTSWDTK SDHLLHLMLK EWNMELPKLV ISVHGGLQNF KISSKLKETF 150
SQGLVKAAET TGAWIITEGI NSGVSKHVGD ALKAHSSKSL RKIWTVGIPP 200
WGVIENQREL VGKDVVCMYQ TLGNPLSKLT TLNCMHSHFI LCDDGTVGMY 250
GNEEKLRRNL EKHLSMQKIH TCSRQGVPVV GLVMEGGPNV ILWVWETVKN 300
KEPVVVCEGT GRAADLLAFT YKHLEDGGIL RPQVKEELFC LIQNMFNFSL 350
RQSKHLFQIL MECMVHKDSI TIFDADSEEH QDLDLAILTA LLKGTSLSIS 400
EQLNLAMAWD RMDIAKKHIL TYGQHWKPGA LEQAMLDALV MDRVDFVKLL 450
IENGVNLHRF LTIPRLEELY NTKQGPTNKF LRHLVQDVKQ HTLLSSYRIT 500
LIDIGLVIEY LIGGAYRSSY TRKSFRILYN NLYRKHKSVS SFAQGLSQHS 550
LHQRHSLRNR KESSESTLHS QFFRTAQPYK SKEKPEDSQK SKKKSKERQS 600
LSEEPEAAGF IYPYNDLLVW AVLMKRQNMA MFFWQHGEEA TVKAVIASIL 650
YRAMAREAKE SNMVDDTSEE LKNYSEQFGQ LALDVLEKAF KQNEPMAMKL 700
LTYELKNWSN STCLKLAVSG GLRPFVSHSC TQMLLTDMWM GRLKMRKNSW 750
LKIIISILLP PMILTLEFKS KAEMSHVPQS QDFQFTWNYS DQGLSNTKES 800
ACVKDYDLER GPDEKPDEPL HLDLRNVPQS LPWTRRVYEF YSAPFVKFWF 850
YTMAYLAFLM LFTYTVLVEM QPQPSVHEWL VIIYIFTNAI EKVREICISE 900
PSKFKQKVKM WLSEYWNLME TVAIGLFAVG FGLRWGHPPL QTAGRLIYCI 950
DIIFWFSRLM DFFAVNQHAG PYVTMIAKMA ANMFYIVIIM AIVLLSFGVA 1000
RKAILSPKEP PSWRLARDIV FEPYWMMYGE VYASDIDVCS NETSCPPGSF 1050
LTPFLQAVYL FVQYIIMVNL LIACFNNIYL DIKSISNKLW KYNRYRYIMT 1100
YHQKPWLPPP FILLNHLCLL LRGLCCRPAP QDQEEGDGGL KLYLTKDDLK 1150
KLHDFEEQCV EKYFHEKTEG LNCSFEEQIR MTSERVSEMF FQLKEMNEKV 1200
SFIKDSLLSL DSQVGHLQDL SAITVDTLKV LSAVDTLQED EILLANRKHS 1250
TCRKRPHSWT NVICAKVLSD MESCGKKKLQ YYSMPPSLLR SLARSQLPPS 1300
VQRGALVEVT HSKREASHVR EEQEEREMEQ RTTASGISHV RQAHSKYGQF 1350
LLVPSSGKQV PLSLETPPHL FRSSEEAGID GLVLEHIHQS DLTTHLPQQT 1400
PAASHQALVA EHKDQHEAVT QMSDKPAKAE QDLLAFSGTP APMTVTSLPS 1450
RAISMQDEGG YVNWAFSEND ETGVFSFKKK WKTCLASTCN SDSNPGGDYF 1500
LHTGGRSGLD NSRRLAQSCE CPAGPWTQAR RSFWINPLCR DKALIKSHSF 1550
RFHKEEKLRK TWKNNSHSKS LETRSTWLKA KLLTKTRSLS KKKRKTQGLQ 1600
VPVITVNACY QSDQLNAEPG ETNTTEEFSK KWLSVSNFSQ IGLEPYIYQK 1650
MKMKEIKRHT TQASDHLRQP QENRDKTPTW NSGSTSLSRS FLTRSPNEVH 1700
KISTSLKSPQ EPHHHYSAIE RNNLMRLSQT IPFTPIQLFT GEEVTIYKLE 1750
ESSPLTLDKS MSSWSQHGRA AMIQVLSQEE MDGGLRKAMR VISTWSEDDV 1800
LKPGQVFIVK SFLPEVVQTW YKIFQESTVL HLCLREIQQQ RAAQKLIYTF 1850
NQVKPQTIPY TPRFLEVSLV YCHSANQWLT IEKYMTGEFR KYNNNNGDEI 1900
APTNTLEELM LAFSHWTYEY TRGELLVLDL QGVGENLTDP SVIKPEDKQS 1950
RGMVFGPANL GEDAIRSFIA KHRCNSCCGK LRLPDLKRND YSLSRTHCNL 2000
GFGQTIEPTE ELPERDKNRS SLEDHTRL 2028
Length:2,028
Mass (Da):232,888
Last modified:March 1, 2003 - v1
Checksum:i3060C1D70DC9A20E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135644 mRNA. Translation: AAN15217.1.
CCDSiCCDS29691.1.
RefSeqiNP_700466.1. NM_153417.1.
UniGeneiMm.215171.

Genome annotation databases

EnsembliENSMUST00000040489; ENSMUSP00000037443; ENSMUSG00000024727.
GeneIDi225997.
KEGGimmu:225997.
UCSCiuc008gya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135644 mRNA. Translation: AAN15217.1 .
CCDSi CCDS29691.1.
RefSeqi NP_700466.1. NM_153417.1.
UniGenei Mm.215171.

3D structure databases

ProteinModelPortali Q8CIR4.
SMRi Q8CIR4. Positions 1180-1229, 1713-1992.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000037443.

PTM databases

PhosphoSitei Q8CIR4.

Proteomic databases

PRIDEi Q8CIR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040489 ; ENSMUSP00000037443 ; ENSMUSG00000024727 .
GeneIDi 225997.
KEGGi mmu:225997.
UCSCi uc008gya.1. mouse.

Organism-specific databases

CTDi 140803.
MGIi MGI:2675603. Trpm6.

Phylogenomic databases

eggNOGi NOG253824.
GeneTreei ENSGT00650000093139.
HOGENOMi HOG000230920.
HOVERGENi HBG055663.
InParanoidi Q8CIR4.
KOi K04981.
OMAi LMECMVH.
OrthoDBi EOG7NPFSC.
PhylomeDBi Q8CIR4.
TreeFami TF314204.

Enzyme and pathway databases

Reactomei REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 377907.
PROi Q8CIR4.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIR4.
Genevestigatori Q8CIR4.

Family and domain databases

InterProi IPR005821. Ion_trans_dom.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
IPR029597. TRPM6.
[Graphical view ]
PANTHERi PTHR13800:SF15. PTHR13800:SF15. 1 hit.
Pfami PF02816. Alpha_kinase. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
SMARTi SM00811. Alpha_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51158. ALPHA_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Ryazanova L.V., Ryazanov A.G.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Kidney.

Entry informationi

Entry nameiTRPM6_MOUSE
AccessioniPrimary (citable) accession number: Q8CIR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi