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Q8CIR4

- TRPM6_MOUSE

UniProt

Q8CIR4 - TRPM6_MOUSE

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Protein

Transient receptor potential cation channel subfamily M member 6

Gene

Trpm6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Essential ion channel and kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1786 – 17861ATPBy similarity
Binding sitei1810 – 18101ATPBy similarity
Binding sitei1882 – 18821ATPBy similarity
Metal bindingi1915 – 19151ZincBy similarity
Active sitei1929 – 19291Proton acceptorBy similarity
Binding sitei1931 – 19311ATPBy similarity
Binding sitei1939 – 19391ATPBy similarity
Metal bindingi1972 – 19721ZincBy similarity
Metal bindingi1974 – 19741ZincBy similarity
Metal bindingi1978 – 19781ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1956 – 19627ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium channel activity Source: UniProtKB-KW
  3. cation channel activity Source: MGI
  4. metal ion binding Source: UniProtKB-KW
  5. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. metal ion transport Source: MGI
  2. response to toxic substance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 6 (EC:2.7.11.1)
Alternative name(s):
Channel kinase 2
Melastatin-related TRP cation channel 6
Gene namesi
Name:Trpm6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2675603. Trpm6.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 747747CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei748 – 76821HelicalSequence AnalysisAdd
BLAST
Topological domaini769 – 84779ExtracellularSequence AnalysisAdd
BLAST
Transmembranei848 – 86821HelicalSequence AnalysisAdd
BLAST
Topological domaini869 – 91042CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei911 – 93121HelicalSequence AnalysisAdd
BLAST
Topological domaini932 – 94514ExtracellularSequence AnalysisAdd
BLAST
Transmembranei946 – 96621HelicalSequence AnalysisAdd
BLAST
Topological domaini967 – 97812CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei979 – 99921HelicalSequence AnalysisAdd
BLAST
Topological domaini1000 – 101819ExtracellularSequence AnalysisAdd
BLAST
Intramembranei1019 – 103921Pore-formingSequence AnalysisAdd
BLAST
Topological domaini1040 – 105314ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1054 – 107421HelicalSequence AnalysisAdd
BLAST
Topological domaini1075 – 2028954CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. brush border membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20282028Transient receptor potential cation channel subfamily M member 6PRO_0000215330Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1857 – 18571Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8CIR4.

PTM databases

PhosphoSiteiQ8CIR4.

Expressioni

Gene expression databases

BgeeiQ8CIR4.
GenevestigatoriQ8CIR4.

Interactioni

Subunit structurei

Forms heterodimers with TRPM7. Interacts (via kinase domain) with GNB2L1/RACK1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037443.

Structurei

3D structure databases

ProteinModelPortaliQ8CIR4.
SMRiQ8CIR4. Positions 1180-1229, 1713-1992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1756 – 1986231Alpha-type protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated
Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253824.
GeneTreeiENSGT00760000119127.
HOGENOMiHOG000230920.
HOVERGENiHBG055663.
InParanoidiQ8CIR4.
KOiK04981.
OMAiLMECMVH.
OrthoDBiEOG7NPFSC.
PhylomeDBiQ8CIR4.
TreeFamiTF314204.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
IPR029597. TRPM6.
[Graphical view]
PANTHERiPTHR13800:SF15. PTHR13800:SF15. 1 hit.
PfamiPF02816. Alpha_kinase. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIR4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVKKSWIEG VFYKRECNKF IPSSKDPHRC TPGCQICHNL VRCYCGRLIE
60 70 80 90 100
EHHGLDRAWN LSVTEGHGDE QWSVEKHTVK SPTDTFGTIN FQDGEHIHHS
110 120 130 140 150
KYIRTSWDTK SDHLLHLMLK EWNMELPKLV ISVHGGLQNF KISSKLKETF
160 170 180 190 200
SQGLVKAAET TGAWIITEGI NSGVSKHVGD ALKAHSSKSL RKIWTVGIPP
210 220 230 240 250
WGVIENQREL VGKDVVCMYQ TLGNPLSKLT TLNCMHSHFI LCDDGTVGMY
260 270 280 290 300
GNEEKLRRNL EKHLSMQKIH TCSRQGVPVV GLVMEGGPNV ILWVWETVKN
310 320 330 340 350
KEPVVVCEGT GRAADLLAFT YKHLEDGGIL RPQVKEELFC LIQNMFNFSL
360 370 380 390 400
RQSKHLFQIL MECMVHKDSI TIFDADSEEH QDLDLAILTA LLKGTSLSIS
410 420 430 440 450
EQLNLAMAWD RMDIAKKHIL TYGQHWKPGA LEQAMLDALV MDRVDFVKLL
460 470 480 490 500
IENGVNLHRF LTIPRLEELY NTKQGPTNKF LRHLVQDVKQ HTLLSSYRIT
510 520 530 540 550
LIDIGLVIEY LIGGAYRSSY TRKSFRILYN NLYRKHKSVS SFAQGLSQHS
560 570 580 590 600
LHQRHSLRNR KESSESTLHS QFFRTAQPYK SKEKPEDSQK SKKKSKERQS
610 620 630 640 650
LSEEPEAAGF IYPYNDLLVW AVLMKRQNMA MFFWQHGEEA TVKAVIASIL
660 670 680 690 700
YRAMAREAKE SNMVDDTSEE LKNYSEQFGQ LALDVLEKAF KQNEPMAMKL
710 720 730 740 750
LTYELKNWSN STCLKLAVSG GLRPFVSHSC TQMLLTDMWM GRLKMRKNSW
760 770 780 790 800
LKIIISILLP PMILTLEFKS KAEMSHVPQS QDFQFTWNYS DQGLSNTKES
810 820 830 840 850
ACVKDYDLER GPDEKPDEPL HLDLRNVPQS LPWTRRVYEF YSAPFVKFWF
860 870 880 890 900
YTMAYLAFLM LFTYTVLVEM QPQPSVHEWL VIIYIFTNAI EKVREICISE
910 920 930 940 950
PSKFKQKVKM WLSEYWNLME TVAIGLFAVG FGLRWGHPPL QTAGRLIYCI
960 970 980 990 1000
DIIFWFSRLM DFFAVNQHAG PYVTMIAKMA ANMFYIVIIM AIVLLSFGVA
1010 1020 1030 1040 1050
RKAILSPKEP PSWRLARDIV FEPYWMMYGE VYASDIDVCS NETSCPPGSF
1060 1070 1080 1090 1100
LTPFLQAVYL FVQYIIMVNL LIACFNNIYL DIKSISNKLW KYNRYRYIMT
1110 1120 1130 1140 1150
YHQKPWLPPP FILLNHLCLL LRGLCCRPAP QDQEEGDGGL KLYLTKDDLK
1160 1170 1180 1190 1200
KLHDFEEQCV EKYFHEKTEG LNCSFEEQIR MTSERVSEMF FQLKEMNEKV
1210 1220 1230 1240 1250
SFIKDSLLSL DSQVGHLQDL SAITVDTLKV LSAVDTLQED EILLANRKHS
1260 1270 1280 1290 1300
TCRKRPHSWT NVICAKVLSD MESCGKKKLQ YYSMPPSLLR SLARSQLPPS
1310 1320 1330 1340 1350
VQRGALVEVT HSKREASHVR EEQEEREMEQ RTTASGISHV RQAHSKYGQF
1360 1370 1380 1390 1400
LLVPSSGKQV PLSLETPPHL FRSSEEAGID GLVLEHIHQS DLTTHLPQQT
1410 1420 1430 1440 1450
PAASHQALVA EHKDQHEAVT QMSDKPAKAE QDLLAFSGTP APMTVTSLPS
1460 1470 1480 1490 1500
RAISMQDEGG YVNWAFSEND ETGVFSFKKK WKTCLASTCN SDSNPGGDYF
1510 1520 1530 1540 1550
LHTGGRSGLD NSRRLAQSCE CPAGPWTQAR RSFWINPLCR DKALIKSHSF
1560 1570 1580 1590 1600
RFHKEEKLRK TWKNNSHSKS LETRSTWLKA KLLTKTRSLS KKKRKTQGLQ
1610 1620 1630 1640 1650
VPVITVNACY QSDQLNAEPG ETNTTEEFSK KWLSVSNFSQ IGLEPYIYQK
1660 1670 1680 1690 1700
MKMKEIKRHT TQASDHLRQP QENRDKTPTW NSGSTSLSRS FLTRSPNEVH
1710 1720 1730 1740 1750
KISTSLKSPQ EPHHHYSAIE RNNLMRLSQT IPFTPIQLFT GEEVTIYKLE
1760 1770 1780 1790 1800
ESSPLTLDKS MSSWSQHGRA AMIQVLSQEE MDGGLRKAMR VISTWSEDDV
1810 1820 1830 1840 1850
LKPGQVFIVK SFLPEVVQTW YKIFQESTVL HLCLREIQQQ RAAQKLIYTF
1860 1870 1880 1890 1900
NQVKPQTIPY TPRFLEVSLV YCHSANQWLT IEKYMTGEFR KYNNNNGDEI
1910 1920 1930 1940 1950
APTNTLEELM LAFSHWTYEY TRGELLVLDL QGVGENLTDP SVIKPEDKQS
1960 1970 1980 1990 2000
RGMVFGPANL GEDAIRSFIA KHRCNSCCGK LRLPDLKRND YSLSRTHCNL
2010 2020
GFGQTIEPTE ELPERDKNRS SLEDHTRL
Length:2,028
Mass (Da):232,888
Last modified:March 1, 2003 - v1
Checksum:i3060C1D70DC9A20E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135644 mRNA. Translation: AAN15217.1.
CCDSiCCDS29691.1.
RefSeqiNP_700466.1. NM_153417.1.
UniGeneiMm.215171.

Genome annotation databases

EnsembliENSMUST00000040489; ENSMUSP00000037443; ENSMUSG00000024727.
GeneIDi225997.
KEGGimmu:225997.
UCSCiuc008gya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135644 mRNA. Translation: AAN15217.1 .
CCDSi CCDS29691.1.
RefSeqi NP_700466.1. NM_153417.1.
UniGenei Mm.215171.

3D structure databases

ProteinModelPortali Q8CIR4.
SMRi Q8CIR4. Positions 1180-1229, 1713-1992.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000037443.

PTM databases

PhosphoSitei Q8CIR4.

Proteomic databases

PRIDEi Q8CIR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040489 ; ENSMUSP00000037443 ; ENSMUSG00000024727 .
GeneIDi 225997.
KEGGi mmu:225997.
UCSCi uc008gya.1. mouse.

Organism-specific databases

CTDi 140803.
MGIi MGI:2675603. Trpm6.

Phylogenomic databases

eggNOGi NOG253824.
GeneTreei ENSGT00760000119127.
HOGENOMi HOG000230920.
HOVERGENi HBG055663.
InParanoidi Q8CIR4.
KOi K04981.
OMAi LMECMVH.
OrthoDBi EOG7NPFSC.
PhylomeDBi Q8CIR4.
TreeFami TF314204.

Enzyme and pathway databases

Reactomei REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 377907.
PROi Q8CIR4.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIR4.
Genevestigatori Q8CIR4.

Family and domain databases

InterProi IPR005821. Ion_trans_dom.
IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
IPR029597. TRPM6.
[Graphical view ]
PANTHERi PTHR13800:SF15. PTHR13800:SF15. 1 hit.
Pfami PF02816. Alpha_kinase. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
SMARTi SM00811. Alpha_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51158. ALPHA_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Ryazanova L.V., Ryazanov A.G.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Kidney.

Entry informationi

Entry nameiTRPM6_MOUSE
AccessioniPrimary (citable) accession number: Q8CIR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3