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Protein

Melatonin receptor type 1B

Gene

Mtnr1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1B
Short name:
Mel-1B-R
Short name:
Mel1b receptor
Gene namesi
Name:Mtnr1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2181726. Mtnr1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242ExtracellularSequence analysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 7613CytoplasmicSequence analysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini98 – 11518ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15519CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini177 – 20024ExtracellularSequence analysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini222 – 25332CytoplasmicSequence analysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini275 – 28713ExtracellularSequence analysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini309 – 36456CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Melatonin receptor type 1BPRO_0000069871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi113 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CIQ6.
PRIDEiQ8CIQ6.

Expressioni

Gene expression databases

CleanExiMM_MTNR1B.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053086.

Structurei

3D structure databases

ProteinModelPortaliQ8CIQ6.
SMRiQ8CIQ6. Positions 55-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiQ8CIQ6.
PhylomeDBiQ8CIQ6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027459. Mel_rcpt_1B.
IPR000025. Melatonin_rcpt.
[Graphical view]
PANTHERiPTHR24242:SF262. PTHR24242:SF262. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPENSSIPNC CEASGLAARP SWSGSAGARP PVTARAPWVA PMLSTVVVVT
60 70 80 90 100
TAVDFVGNLL VILSVLRNRK LRNAGNLFVV SLALADLVIA LYPYPLILVA
110 120 130 140 150
IIRDGWVLGE AHCKASAFVM GLSVIGSVFN ITAIAINRYC CICHSTTYHR
160 170 180 190 200
VCSHWYTPIY ISLVWLLTLV ALVPNFFVGS LEYDPRIYSC TFIQTASTQY
210 220 230 240 250
TAAVVAIHFL LPMAVVSFCY LRIWVLVLQA RRKAKATRKL RLRPSDLRSF
260 270 280 290 300
LTMFAVFVVF AICWAPLNCI GLAVAINPEA MALQVPEGLF VTSYFLAYFN
310 320 330 340 350
SCLNAIVYGL LNQNFRREYK RILLAIWNTR RCIQHASKHC LTEERQGPTP
360
PAARATVPVK EGAL
Length:364
Mass (Da):40,261
Last modified:March 1, 2003 - v1
Checksum:i62DDA46BB59FEE7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371T → E in AAL85489 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145850 mRNA. Translation: AAN46105.1.
AY078982 mRNA. Translation: AAL85489.3.
AY255608 mRNA. Translation: AAO85120.1.
CCDSiCCDS22841.1.
UniGeneiMm.222631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145850 mRNA. Translation: AAN46105.1.
AY078982 mRNA. Translation: AAL85489.3.
AY255608 mRNA. Translation: AAO85120.1.
CCDSiCCDS22841.1.
UniGeneiMm.222631.

3D structure databases

ProteinModelPortaliQ8CIQ6.
SMRiQ8CIQ6. Positions 55-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053086.

Chemistry

GuidetoPHARMACOLOGYi288.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ8CIQ6.
PRIDEiQ8CIQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2181726. Mtnr1b.

Phylogenomic databases

eggNOGiENOG410IHFY. Eukaryota.
ENOG4111ZZV. LUCA.
HOGENOMiHOG000037953.
HOVERGENiHBG052528.
InParanoidiQ8CIQ6.
PhylomeDBiQ8CIQ6.

Miscellaneous databases

PROiQ8CIQ6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MTNR1B.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027459. Mel_rcpt_1B.
IPR000025. Melatonin_rcpt.
[Graphical view]
PANTHERiPTHR24242:SF262. PTHR24242:SF262. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00857. MELATONINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Targeted disruption of the mouse Mel1b melatonin receptor."
    Jin X., von Gall C., Pieschl R.L., Gribkoff V.K., Stehle J.H., Reppert S.M., Weaver D.R.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. Resuehr D., Olcese J.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 142-364.
    Strain: C57BL/6 X C3H.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-253.

Entry informationi

Entry nameiMTR1B_MOUSE
AccessioniPrimary (citable) accession number: Q8CIQ6
Secondary accession number(s): Q80T38, Q8K3K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.