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Q8CIP3 (MRGX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mas-related G-protein coupled receptor member X1
Alternative name(s):
Mas-related G-protein coupled receptor member C11
Sensory neuron-specific G-protein coupled receptor 1
Gene names
Name:Mrgprx1
Synonyms:Mrgc11, Mrgprc11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G11 proteins. May regulate the function of nociceptive neurons by modulation of pain perception. Ref.1 UniProtKB Q96LB2

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Mas-related G-protein coupled receptor member X1
PRO_0000283731

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 598Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 10020Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14221Cytoplasmic Potential
Transmembrane143 – 16321Helical; Name=4; Potential
Topological domain164 – 17916Extracellular Potential
Transmembrane180 – 20021Helical; Name=5; Potential
Topological domain201 – 22323Cytoplasmic Potential
Transmembrane224 – 24421Helical; Name=6; Potential
Topological domain245 – 25713Extracellular Potential
Transmembrane258 – 27821Helical; Name=7; Potential
Topological domain279 – 32244Cytoplasmic Potential

Amino acid modifications

Glycosylation161N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8CIP3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 1E03ECD5A4AF88DC

FASTA32236,810
        10         20         30         40         50         60 
MDPTISSHDT ESTPLNETGH PNCTPILTLS FLVLITTLVG LAGNTIVLWL LGFRMRRKAI 

        70         80         90        100        110        120 
SVYILNLALA DSFFLCCHFI DSLLRIIDFY GLYAHKLSKD ILGNAAIIPY ISGLSILSAI 

       130        140        150        160        170        180 
STERCLCVLW PIWYHCHRPR NMSAIICALI WVLSFLMGIL DWFSGFLGET HHHLWKNVDF 

       190        200        210        220        230        240 
IITAFLIFLF MLLSGSSLAL LLRILCGPRR KPLSRLYVTI ALTVMVYLIC GLPLGLYLFL 

       250        260        270        280        290        300 
LYWFGVHLHY PFCHIYQVTA VLSCVNSSAN PIIYFLVGSF RQHRKHRSLK RVLKRALEDT 

       310        320 
PEEDEYTDSH LHKTTEISES RY 

« Hide

References

[1]"Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway."
Han S.-K., Dong X., Hwang J.-I., Zylka M.J., Anderson D.J., Simon M.I.
Proc. Natl. Acad. Sci. U.S.A. 99:14740-14745(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY152435 mRNA. Translation: AAN64385.1.
RefSeqNP_997423.1. NM_207540.3.
UniGeneMm.354955.

3D structure databases

ProteinModelPortalQ8CIP3.
SMRQ8CIP3. Positions 25-292.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ8CIP3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000094390; ENSMUSP00000091954; ENSMUSG00000070552.
GeneID404242.
KEGGmmu:404242.
UCSCuc009hal.1. mouse.

Organism-specific databases

CTD259249.
MGIMGI:3033139. Mrgprx1.

Phylogenomic databases

eggNOGNOG146549.
GeneTreeENSGT00550000074531.
HOVERGENHBG003592.
InParanoidQ8CIP3.
KOK08396.
OMADEYTDSH.
OrthoDBEOG7TF79R.
PhylomeDBQ8CIP3.
TreeFamTF336336.

Gene expression databases

CleanExMM_MRGPRX1.
GenevestigatorQ8CIP3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio406450.
PROQ8CIP3.
SOURCESearch...

Entry information

Entry nameMRGX1_MOUSE
AccessionPrimary (citable) accession number: Q8CIP3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries