Q8CIP3 (MRGX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mas-related G-protein coupled receptor member X1

Alternative name(s):
Mas-related G-protein coupled receptor member C11
Sensory neuron-specific G-protein coupled receptor 1

Gene names

Name:	Mrgprx1
Synonyms:	Mrgc11, Mrgprc11

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G11 proteins. May regulate the function of nociceptive neurons by modulation of pain perception. Ref.1 UniProtKB Q96LB2
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Mas-related G-protein coupled receptor member X1		PRO_0000283731
Regions
	Topological domain	1 – 30	30	Extracellular Potential
	Transmembrane	31 – 51	21	Helical; Name=1; Potential
	Topological domain	52 – 59	8	Cytoplasmic Potential
	Transmembrane	60 – 80	21	Helical; Name=2; Potential
	Topological domain	81 – 100	20	Extracellular Potential
	Transmembrane	101 – 121	21	Helical; Name=3; Potential
	Topological domain	122 – 142	21	Cytoplasmic Potential
	Transmembrane	143 – 163	21	Helical; Name=4; Potential
	Topological domain	164 – 179	16	Extracellular Potential
	Transmembrane	180 – 200	21	Helical; Name=5; Potential
	Topological domain	201 – 223	23	Cytoplasmic Potential
	Transmembrane	224 – 244	21	Helical; Name=6; Potential
	Topological domain	245 – 257	13	Extracellular Potential
	Transmembrane	258 – 278	21	Helical; Name=7; Potential
	Topological domain	279 – 322	44	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	16	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8CIP3 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1E03ECD5A4AF88DC	FASTA	322	36,810
	10 20 30 40 50 60 MDPTISSHDT ESTPLNETGH PNCTPILTLS FLVLITTLVG LAGNTIVLWL LGFRMRRKAI 70 80 90 100 110 120 SVYILNLALA DSFFLCCHFI DSLLRIIDFY GLYAHKLSKD ILGNAAIIPY ISGLSILSAI 130 140 150 160 170 180 STERCLCVLW PIWYHCHRPR NMSAIICALI WVLSFLMGIL DWFSGFLGET HHHLWKNVDF 190 200 210 220 230 240 IITAFLIFLF MLLSGSSLAL LLRILCGPRR KPLSRLYVTI ALTVMVYLIC GLPLGLYLFL 250 260 270 280 290 300 LYWFGVHLHY PFCHIYQVTA VLSCVNSSAN PIIYFLVGSF RQHRKHRSLK RVLKRALEDT 310 320 PEEDEYTDSH LHKTTEISES RY

References

[1]	"Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway." Han S.-K., Dong X., Hwang J.-I., Zylka M.J., Anderson D.J., Simon M.I. Proc. Natl. Acad. Sci. U.S.A. 99:14740-14745(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY152435 mRNA. Translation: AAN64385.1.
IPI	IPI00407757.
RefSeq	NP_997423.1. NM_207540.3.
UniGene	Mm.354955.
3D structure databases
ProteinModelPortal	Q8CIP3.
SMR	Q8CIP3. Positions 25-291.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q8CIP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000094390; ENSMUSP00000091954; ENSMUSG00000070552.
GeneID	404242.
KEGG	mmu:404242.
UCSC	uc009hal.1. mouse.
Organism-specific databases
CTD	259249.
MGI	MGI:3033139. Mrgprx1.
Phylogenomic databases
eggNOG	NOG146549.
GeneTree	ENSGT00550000074531.
HOVERGEN	HBG003592.
InParanoid	Q8CIP3.
KO	K08396.
OMA	PEEDEYT.
OrthoDB	EOG4MW86R.
Gene expression databases
CleanEx	MM_MRGPRX1.
Genevestigator	Q8CIP3.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR026234. MRGPCRFAMILY. [Graphical view]
PANTHER	PTHR11334. PTHR11334. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR02108. MRGPCRFAMILY.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	406450.
SOURCE	Search...

Entry information

Entry name

MRGX1_MOUSE

Accession

Primary (citable) accession number: Q8CIP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program