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Q8CIP3

- MRGX1_MOUSE

UniProt

Q8CIP3 - MRGX1_MOUSE

Protein

Mas-related G-protein coupled receptor member X1

Gene

Mrgprx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception.By similarity1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. chemosensory behavior Source: MGI
    2. hematopoietic progenitor cell differentiation Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mas-related G-protein coupled receptor member X1
    Alternative name(s):
    Mas-related G-protein coupled receptor member C11
    Sensory neuron-specific G-protein coupled receptor 1
    Gene namesi
    Name:Mrgprx1Imported
    Synonyms:Mrgc11Imported, Mrgprc11Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:3033139. Mrgprx1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Mas-related G-protein coupled receptor member X1PRO_0000283731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8CIP3.

    Expressioni

    Tissue specificityi

    Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons.1 Publication

    Gene expression databases

    CleanExiMM_MRGPRX1.
    GenevestigatoriQ8CIP3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CIP3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 598CytoplasmicSequence Analysis
    Topological domaini81 – 10020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17916ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini201 – 22323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini245 – 25713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini279 – 32244CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146549.
    GeneTreeiENSGT00550000074531.
    HOVERGENiHBG003592.
    InParanoidiQ8CIP3.
    KOiK08396.
    OMAiDEYTDSH.
    OrthoDBiEOG7TF79R.
    PhylomeDBiQ8CIP3.
    TreeFamiTF336336.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    [Graphical view]
    PANTHERiPTHR11334. PTHR11334. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR02108. MRGPCRFAMILY.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CIP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPTISSHDT ESTPLNETGH PNCTPILTLS FLVLITTLVG LAGNTIVLWL    50
    LGFRMRRKAI SVYILNLALA DSFFLCCHFI DSLLRIIDFY GLYAHKLSKD 100
    ILGNAAIIPY ISGLSILSAI STERCLCVLW PIWYHCHRPR NMSAIICALI 150
    WVLSFLMGIL DWFSGFLGET HHHLWKNVDF IITAFLIFLF MLLSGSSLAL 200
    LLRILCGPRR KPLSRLYVTI ALTVMVYLIC GLPLGLYLFL LYWFGVHLHY 250
    PFCHIYQVTA VLSCVNSSAN PIIYFLVGSF RQHRKHRSLK RVLKRALEDT 300
    PEEDEYTDSH LHKTTEISES RY 322
    Length:322
    Mass (Da):36,810
    Last modified:March 1, 2003 - v1
    Checksum:i1E03ECD5A4AF88DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY152435 mRNA. Translation: AAN64385.1.
    CCDSiCCDS21299.1.
    RefSeqiNP_997423.1. NM_207540.3.
    UniGeneiMm.354955.

    Genome annotation databases

    EnsembliENSMUST00000094390; ENSMUSP00000091954; ENSMUSG00000070552.
    GeneIDi404242.
    KEGGimmu:404242.
    UCSCiuc009hal.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY152435 mRNA. Translation: AAN64385.1 .
    CCDSi CCDS21299.1.
    RefSeqi NP_997423.1. NM_207540.3.
    UniGenei Mm.354955.

    3D structure databases

    ProteinModelPortali Q8CIP3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q8CIP3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094390 ; ENSMUSP00000091954 ; ENSMUSG00000070552 .
    GeneIDi 404242.
    KEGGi mmu:404242.
    UCSCi uc009hal.1. mouse.

    Organism-specific databases

    CTDi 259249.
    MGIi MGI:3033139. Mrgprx1.

    Phylogenomic databases

    eggNOGi NOG146549.
    GeneTreei ENSGT00550000074531.
    HOVERGENi HBG003592.
    InParanoidi Q8CIP3.
    KOi K08396.
    OMAi DEYTDSH.
    OrthoDBi EOG7TF79R.
    PhylomeDBi Q8CIP3.
    TreeFami TF336336.

    Miscellaneous databases

    NextBioi 406450.
    PROi Q8CIP3.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MRGPRX1.
    Genevestigatori Q8CIP3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    [Graphical view ]
    PANTHERi PTHR11334. PTHR11334. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR02108. MRGPCRFAMILY.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway."
      Han S.-K., Dong X., Hwang J.-I., Zylka M.J., Anderson D.J., Simon M.I.
      Proc. Natl. Acad. Sci. U.S.A. 99:14740-14745(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6Imported.

    Entry informationi

    Entry nameiMRGX1_MOUSE
    AccessioniPrimary (citable) accession number: Q8CIP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3