Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mas-related G-protein coupled receptor member X1

Gene

Mrgprx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception.By similarity1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. chemosensory behavior Source: MGI
  2. hematopoietic progenitor cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member X1
Alternative name(s):
Mas-related G-protein coupled receptor member C11
Sensory neuron-specific G-protein coupled receptor 1
Gene namesi
Name:Mrgprx1Imported
Synonyms:Mrgc11Imported, Mrgprc11Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3033139. Mrgprx1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini52 – 598CytoplasmicSequence Analysis
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini164 – 17916ExtracellularSequence AnalysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini201 – 22323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini245 – 25713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini279 – 32244CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Mas-related G-protein coupled receptor member X1PRO_0000283731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8CIP3.

Expressioni

Tissue specificityi

Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons.1 Publication

Gene expression databases

CleanExiMM_MRGPRX1.
GenevestigatoriQ8CIP3.

Structurei

3D structure databases

ProteinModelPortaliQ8CIP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146549.
GeneTreeiENSGT00550000074531.
HOVERGENiHBG003592.
InParanoidiQ8CIP3.
KOiK08396.
OMAiDEYTDSH.
OrthoDBiEOG7TF79R.
PhylomeDBiQ8CIP3.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTISSHDT ESTPLNETGH PNCTPILTLS FLVLITTLVG LAGNTIVLWL
60 70 80 90 100
LGFRMRRKAI SVYILNLALA DSFFLCCHFI DSLLRIIDFY GLYAHKLSKD
110 120 130 140 150
ILGNAAIIPY ISGLSILSAI STERCLCVLW PIWYHCHRPR NMSAIICALI
160 170 180 190 200
WVLSFLMGIL DWFSGFLGET HHHLWKNVDF IITAFLIFLF MLLSGSSLAL
210 220 230 240 250
LLRILCGPRR KPLSRLYVTI ALTVMVYLIC GLPLGLYLFL LYWFGVHLHY
260 270 280 290 300
PFCHIYQVTA VLSCVNSSAN PIIYFLVGSF RQHRKHRSLK RVLKRALEDT
310 320
PEEDEYTDSH LHKTTEISES RY
Length:322
Mass (Da):36,810
Last modified:March 1, 2003 - v1
Checksum:i1E03ECD5A4AF88DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152435 mRNA. Translation: AAN64385.1.
CCDSiCCDS21299.1.
RefSeqiNP_997423.1. NM_207540.3.
UniGeneiMm.354955.

Genome annotation databases

EnsembliENSMUST00000094390; ENSMUSP00000091954; ENSMUSG00000070552.
GeneIDi404242.
KEGGimmu:404242.
UCSCiuc009hal.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152435 mRNA. Translation: AAN64385.1.
CCDSiCCDS21299.1.
RefSeqiNP_997423.1. NM_207540.3.
UniGeneiMm.354955.

3D structure databases

ProteinModelPortaliQ8CIP3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ8CIP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094390; ENSMUSP00000091954; ENSMUSG00000070552.
GeneIDi404242.
KEGGimmu:404242.
UCSCiuc009hal.1. mouse.

Organism-specific databases

CTDi259249.
MGIiMGI:3033139. Mrgprx1.

Phylogenomic databases

eggNOGiNOG146549.
GeneTreeiENSGT00550000074531.
HOVERGENiHBG003592.
InParanoidiQ8CIP3.
KOiK08396.
OMAiDEYTDSH.
OrthoDBiEOG7TF79R.
PhylomeDBiQ8CIP3.
TreeFamiTF336336.

Miscellaneous databases

NextBioi406450.
PROiQ8CIP3.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MRGPRX1.
GenevestigatoriQ8CIP3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway."
    Han S.-K., Dong X., Hwang J.-I., Zylka M.J., Anderson D.J., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 99:14740-14745(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6Imported.

Entry informationi

Entry nameiMRGX1_MOUSE
AccessioniPrimary (citable) accession number: Q8CIP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.