ID   IMPA2_RAT               Reviewed;         290 AA.
AC   Q8CIN7;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   16-JUN-2009, entry version 43.
DE   RecName: Full=Inositol monophosphatase 2;
DE            EC=3.1.3.25;
DE   AltName: Full=Inositol-1(or 4)-monophosphatase 2;
DE            Short=IMPase 2;
DE            Short=IMP 2;
DE   AltName: Full=Myo-inositol monophosphatase A2;
GN   Name=Impa2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Parthasarathy L., Seelan R., Parthasarathy R.;
RT   "Molecular cloning and sequencing of rat Impa2.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: Myo-inositol phosphate + H(2)O = myo-inositol
CC       + phosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-
CC       inositol from D-glucose 6-phosphate: step 2/2.
CC   -!- SIMILARITY: Belongs to the inositol monophosphatase family.
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DR   EMBL; AY160191; AAN47010.1; -; mRNA.
DR   EMBL; BC083544; AAH83544.1; -; mRNA.
DR   IPI; IPI00194003; -.
DR   RefSeq; NP_757378.1; -.
DR   UniGene; Rn.856; -.
DR   HSSP; P29218; 1IMF.
DR   SMR; Q8CIN7; 17-283.
DR   Ensembl; ENSRNOG00000018516; Rattus norvegicus.
DR   GeneID; 282636; -.
DR   KEGG; rno:282636; -.
DR   RGD; 628692; Impa2.
DR   HOVERGEN; Q8CIN7; -.
DR   OMA; Q8CIN7; PLEITEK.
DR   BRENDA; 3.1.3.25; 248.
DR   NextBio; 624837; -.
DR   ArrayExpress; Q8CIN7; -.
DR   GermOnline; ENSRNOG00000018516; Rattus norvegicus.
DR   GO; GO:0008934; F:inositol-1(or 4)-monophosphatase activity; IEA:EC.
DR   GO; GO:0031403; F:lithium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR000760; Inositol_P.
DR   PANTHER; PTHR20854; Inositol_P; 1.
DR   Pfam; PF00459; Inositol_P; 1.
DR   PRINTS; PR00378; INOSPHPHTASE.
DR   ProDom; PD023420; Inositol_P; 1.
DR   PROSITE; PS00629; IMP_1; 1.
DR   PROSITE; PS00630; IMP_2; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Lithium; Magnesium; Metal-binding.
FT   CHAIN         1    290       Inositol monophosphatase 2.
FT                                /FTId=PRO_0000142522.
FT   METAL        83     83       Magnesium 1 (By similarity).
FT   METAL       103    103       Magnesium 1 (By similarity).
FT   METAL       103    103       Magnesium 2 (By similarity).
FT   METAL       105    105       Magnesium 1; via carbonyl oxygen (By
FT                                similarity).
FT   METAL       106    106       Magnesium 2 (By similarity).
FT   METAL       233    233       Magnesium 2 (By similarity).
SQ   SEQUENCE   290 AA;  31796 MW;  6DF985B2BD99F266 CRC64;
     MKPNSEEEEE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKHVSTKT SAADLVTETD
     HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW IIDPIDGTCN FVHRFPTVAV
     SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR
     DPDTLKVFLS NMERLLHAKA HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI
     IREAGGIVID TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK
//