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Protein

Inositol monophosphatase 2

Gene

Impa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain (By similarity).By similarity

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactori

Mg2+By similarity

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase 1 (Isyna1)
  2. Inositol monophosphatase 3 (Impad1), Inositol monophosphatase 1 (Impa1), Inositol monophosphatase 2 (Impa2)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Magnesium 1By similarity
Binding sitei83 – 831SubstrateBy similarity
Metal bindingi103 – 1031Magnesium 1By similarity
Metal bindingi103 – 1031Magnesium 2By similarity
Metal bindingi105 – 1051Magnesium 1; via carbonyl oxygenBy similarity
Metal bindingi106 – 1061Magnesium 2By similarity
Binding sitei226 – 2261SubstrateBy similarity
Metal bindingi233 – 2331Magnesium 2By similarity
Binding sitei233 – 2331SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Lithium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
UniPathwayiUPA00823; UER00788.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol monophosphatase 2 (EC:3.1.3.25)
Short name:
IMP 2
Short name:
IMPase 2
Alternative name(s):
Inositol-1(or 4)-monophosphatase 2
Myo-inositol monophosphatase A2
Gene namesi
Name:Impa2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi628692. Impa2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Inositol monophosphatase 2PRO_0000142522Add
BLAST

Proteomic databases

PaxDbiQ8CIN7.
PRIDEiQ8CIN7.

Expressioni

Gene expression databases

ExpressionAtlasiQ8CIN7. baseline and differential.
GenevisibleiQ8CIN7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025147.

Structurei

3D structure databases

ProteinModelPortaliQ8CIN7.
SMRiQ8CIN7. Positions 17-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1084Substrate bindingBy similarity
Regioni207 – 2093Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiKOG2951. Eukaryota.
COG0483. LUCA.
GeneTreeiENSGT00390000014699.
HOGENOMiHOG000282238.
HOVERGENiHBG052123.
InParanoidiQ8CIN7.
KOiK01092.
OMAiREMAMFI.
OrthoDBiEOG7RJPS8.
PhylomeDBiQ8CIN7.
TreeFamiTF313194.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPNSEEEEE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKHVSTKT
60 70 80 90 100
SAADLVTETD HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW
110 120 130 140 150
IIDPIDGTCN FVHRFPTVAV SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ
160 170 180 190 200
GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR DPDTLKVFLS NMERLLHAKA
210 220 230 240 250
HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI IREAGGIVID
260 270 280 290
TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK
Length:290
Mass (Da):31,796
Last modified:March 1, 2003 - v1
Checksum:i6DF985B2BD99F266
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY160191 mRNA. Translation: AAN47010.1.
BC083544 mRNA. Translation: AAH83544.1.
RefSeqiNP_757378.1. NM_172224.1.
UniGeneiRn.856.

Genome annotation databases

EnsembliENSRNOT00000025147; ENSRNOP00000025147; ENSRNOG00000018516.
ENSRNOT00000081432; ENSRNOP00000069287; ENSRNOG00000018516.
GeneIDi282636.
KEGGirno:282636.
UCSCiRGD:628692. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY160191 mRNA. Translation: AAN47010.1.
BC083544 mRNA. Translation: AAH83544.1.
RefSeqiNP_757378.1. NM_172224.1.
UniGeneiRn.856.

3D structure databases

ProteinModelPortaliQ8CIN7.
SMRiQ8CIN7. Positions 17-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025147.

Proteomic databases

PaxDbiQ8CIN7.
PRIDEiQ8CIN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025147; ENSRNOP00000025147; ENSRNOG00000018516.
ENSRNOT00000081432; ENSRNOP00000069287; ENSRNOG00000018516.
GeneIDi282636.
KEGGirno:282636.
UCSCiRGD:628692. rat.

Organism-specific databases

CTDi3613.
RGDi628692. Impa2.

Phylogenomic databases

eggNOGiKOG2951. Eukaryota.
COG0483. LUCA.
GeneTreeiENSGT00390000014699.
HOGENOMiHOG000282238.
HOVERGENiHBG052123.
InParanoidiQ8CIN7.
KOiK01092.
OMAiREMAMFI.
OrthoDBiEOG7RJPS8.
PhylomeDBiQ8CIN7.
TreeFamiTF313194.

Enzyme and pathway databases

UniPathwayiUPA00823; UER00788.
ReactomeiR-RNO-1855183. Synthesis of IP2, IP, and Ins in the cytosol.

Miscellaneous databases

PROiQ8CIN7.

Gene expression databases

ExpressionAtlasiQ8CIN7. baseline and differential.
GenevisibleiQ8CIN7. RN.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSiPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequencing of rat Impa2."
    Parthasarathy L., Seelan R., Parthasarathy R.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiIMPA2_RAT
AccessioniPrimary (citable) accession number: Q8CIN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.