Reviewed, UniProtKB/Swiss-Prot Q8CIN7 (IMPA2_RAT)

Names and origin

Protein names

Recommended name:
    Inositol monophosphatase 2
      Short name=IMPase 2
      Short name=IMP 2
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase 2
    Myo-inositol monophosphatase A2

Gene names

Name:

Impa2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain By similarity.
Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Pathway	Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Lithium Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Molecular function	inositol-1(or 4)-monophosphatase activity Inferred from electronic annotation. Source: EC lithium ion binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Inositol monophosphatase 2		PRO_0000142522
Regions
	Region	105 – 108	4	Substrate binding By similarity
	Region	207 – 209	3	Substrate binding By similarity
Sites
	Metal binding	83	1	Magnesium 1 By similarity
	Metal binding	103	1	Magnesium 1 By similarity
	Metal binding	103	1	Magnesium 2 By similarity
	Metal binding	105	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	106	1	Magnesium 2 By similarity
	Metal binding	233	1	Magnesium 2 By similarity
	Binding site	83	1	Substrate By similarity
	Binding site	226	1	Substrate By similarity
	Binding site	233	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8CIN7-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 6DF985B2BD99F266	FASTA	290	31,796
	10 20 30 40 50 60 MKPNSEEEEE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKHVSTKT SAADLVTETD 70 80 90 100 110 120 HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW IIDPIDGTCN FVHRFPTVAV 130 140 150 160 170 180 SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR 190 200 210 220 230 240 DPDTLKVFLS NMERLLHAKA HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI 250 260 270 280 290 IREAGGIVID TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and sequencing of rat Impa2." Parthasarathy L., Seelan R., Parthasarathy R. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY160191 mRNA. Translation: AAN47010.1. BC083544 mRNA. Translation: AAH83544.1.
IPI	IPI00194003.
RefSeq	NP_757378.1.
UniGene	Rn.856
3D structure databases
SMR	Q8CIN7. Positions 17-284.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CIN7.
Genome annotation databases
Ensembl	ENSRNOT00000025147; ENSRNOP00000025147; ENSRNOG00000018516; Rattus norvegicus. [Genome view]
GeneID	282636.
KEGG	rno:282636.
UCSC	NM_172224. rat.
Organism-specific databases
CTD	282636.
RGD	628692. Impa2.
Phylogenomic databases
eggNOG	roNOG09523.
HOVERGEN	Q8CIN7.
InParanoid	Q8CIN7.
OMA	AAGTREM.
OrthoDB	EOG9STVQS.
PhylomeDB	Q8CIN7.
Enzyme and pathway databases
BRENDA	3.1.3.25. 248.
Gene expression databases
ArrayExpress	Q8CIN7.
Genevestigator	Q8CIN7.
GermOnline	ENSRNOG00000018516. Rattus norvegicus.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR020552. Inositol_monoPase_Li-sen. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00377. IMPHPHTASES. PR00378. LIIMPHPHTASE.
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	624837.

Entry information

Entry name

IMPA2_RAT

Accession

Primary (citable) accession number: Q8CIN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)