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Reviewed, UniProtKB/Swiss-Prot Q8CIN7 (IMPA2_RAT)

Last modified February 9, 2010. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Inositol monophosphatase 2
      Short name=IMPase 2
      Short name=IMP 2
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase 2
    Myo-inositol monophosphatase A2
Gene names
Name: Impa2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li+ action in brain By similarity.

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Sequence similarities

Belongs to the inositol monophosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Inositol monophosphatase 2
PRO_0000142522

Regions

Region105 – 1084Substrate binding By similarity
Region207 – 2093Substrate binding By similarity

Sites

Metal binding831Magnesium 1 By similarity
Metal binding1031Magnesium 1 By similarity
Metal binding1031Magnesium 2 By similarity
Metal binding1051Magnesium 1; via carbonyl oxygen By similarity
Metal binding1061Magnesium 2 By similarity
Metal binding2331Magnesium 2 By similarity
Binding site831Substrate By similarity
Binding site2261Substrate By similarity
Binding site2331Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CIN7-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6DF985B2BD99F266

FASTA29031,796
        10         20         30         40         50         60 
MKPNSEEEEE LVQGVGPWDE CFEVAVQLAL RAGQIIRKAL TEEKHVSTKT SAADLVTETD 

        70         80         90        100        110        120 
HRVEDLIVSE LRKRFPSHRF IAEEATASGA KCVLTHSPTW IIDPIDGTCN FVHRFPTVAV 

       130        140        150        160        170        180 
SIGFAVHQEL EFGVIHHCTE ERLYTGRRGQ GAFCNGQRLQ VSRETDLAKA LVLTEIGPKR 

       190        200        210        220        230        240 
DPDTLKVFLS NMERLLHAKA HGVRVIGSST LALCYLASGA ADAYYQFGLH CWDLAAATVI 

       250        260        270        280        290 
IREAGGIVID TSGGPLDLMS CRVVAAGTRE MAVLIAQALQ TINYGRDDEK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequencing of rat Impa2."
Parthasarathy L., Seelan R., Parthasarathy R.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY160191 mRNA. Translation: AAN47010.1.
BC083544 mRNA. Translation: AAH83544.1.
IPIIPI00194003.
RefSeqNP_757378.1.
UniGeneRn.856

3D structure databases

SMRQ8CIN7. Positions 17-284.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CIN7.

Genome annotation databases

EnsemblENSRNOT00000025147; ENSRNOP00000025147; ENSRNOG00000018516; Rattus norvegicus. [Genome view]
GeneID282636.
KEGGrno:282636.
UCSCNM_172224. rat.

Organism-specific databases

CTD282636.
RGD628692. Impa2.

Phylogenomic databases

eggNOGroNOG09523.
HOVERGENQ8CIN7.
InParanoidQ8CIN7.
OMAAAGTREM.
OrthoDBEOG9STVQS.
PhylomeDBQ8CIN7.

Enzyme and pathway databases

BRENDA3.1.3.25. 248.

Gene expression databases

ArrayExpressQ8CIN7.
GenevestigatorQ8CIN7.
GermOnlineENSRNOG00000018516. Rattus norvegicus.

Family and domain databases

InterProIPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio624837.

Entry information

Entry nameIMPA2_RAT
AccessionPrimary (citable) accession number: Q8CIN7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents