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Protein

CUGBP Elav-like family member 3

Gene

Celf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity).By similarity

GO - Molecular functioni

  • 7SK snRNA binding Source: MGI
  • nucleotide binding Source: InterPro
  • RNA binding Source: MGI

GO - Biological processi

  • flagellated sperm motility Source: MGI
  • mRNA processing Source: UniProtKB-KW
  • ncRNA transcription Source: MGI
  • nuclear body organization Source: MGI
  • positive regulation of mRNA splicing, via spliceosome Source: UniProtKB
  • regulation of alternative mRNA splicing, via spliceosome Source: MGI
  • RNA splicing Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CUGBP Elav-like family member 3
Short name:
CELF-3
Alternative name(s):
Bruno-like protein 1
CUG-BP- and ETR-3-like factor 3
ELAV-type RNA-binding protein 1
Short name:
ETR-1
RNA-binding protein BRUNOL-1
Trinucleotide repeat-containing gene 4 protein
Gene namesi
Name:Celf3
Synonyms:Tnrc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1926034. Celf3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nuclear body Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951991 – 465CUGBP Elav-like family member 3Add BLAST465

Proteomic databases

PaxDbiQ8CIN6.
PRIDEiQ8CIN6.

PTM databases

iPTMnetiQ8CIN6.
PhosphoSitePlusiQ8CIN6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028137.
CleanExiMM_TNRC4.
ExpressionAtlasiQ8CIN6. baseline and differential.
GenevisibleiQ8CIN6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8CIN6. 1 interactor.
MINTiMINT-4116444.
STRINGi10090.ENSMUSP00000029784.

Structurei

3D structure databases

ProteinModelPortaliQ8CIN6.
SMRiQ8CIN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 88RRM 1PROSITE-ProRule annotationAdd BLAST82
Domaini95 – 174RRM 2PROSITE-ProRule annotationAdd BLAST80
Domaini380 – 458RRM 3PROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi351 – 373Gln-richAdd BLAST23

Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0146. Eukaryota.
ENOG410XNTW. LUCA.
GeneTreeiENSGT00560000076837.
HOGENOMiHOG000004754.
HOVERGENiHBG107646.
InParanoidiQ8CIN6.
KOiK13207.
OMAiVWRGEVF.
OrthoDBiEOG091G19O1.
PhylomeDBiQ8CIN6.
TreeFamiTF314924.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CIN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEPDAIKLF VGQIPRHLEE KDLKPIFEQF GRIFELTVIK DKYTGLHKGC
60 70 80 90 100
AFLTYCARDS ALKAQSALHE QKTLPGMNRP IQVKPADSES RGDRKLFVGM
110 120 130 140 150
LGKQQTDEDV RKMFEPFGTI DECTVLRGPD GTSKGCAFVK FQTHAEAQAA
160 170 180 190 200
INTLHSSRTL PGASSSLVVK FADTEKERGL RRMQQVATQL GMFSPIALQF
210 220 230 240 250
GAYSAYTQAL MQQQAALVAA HSAYLSPMAT MAAVQMQHMA AISANGLIAT
260 270 280 290 300
PITPSSGTST PPAIAATPVS AIPAALGVNG YSPVPTQPTG QPAPDALYPN
310 320 330 340 350
GVHPYPAQSP AAPVDPLQQA YAGMQHYTAA YPAAYSLVAP AFPQPPALVA
360 370 380 390 400
QQPPPPPQQQ QQQQQQQQQQ QQQREGPDGC NIFIYHLPQE FTDSEILQMF
410 420 430 440 450
VPFGHVISAK VFVDRATNQS KCFGFVSFDN PASAQAAIQA MNGFQIGMKR
460
LKVQLKRPKD ANRPY
Length:465
Mass (Da):50,520
Last modified:March 1, 2003 - v1
Checksum:i542DF7AC60CCA705
GO
Isoform 2 (identifier: Q8CIN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-92: G → GE
     306-306: P → PDEALSAERSAGGVPIMSQAHSWLVMLSA

Show »
Length:494
Mass (Da):53,545
Checksum:i4B6E858580D4F28E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02682692G → GE in isoform 2. 1 Publication1
Alternative sequenceiVSP_026827306P → PDEALSAERSAGGVPIMSQA HSWLVMLSA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY165052 mRNA. Translation: AAN73885.1.
BC057553 mRNA. Translation: AAH57553.1.
CCDSiCCDS38536.1. [Q8CIN6-1]
CCDS79972.1. [Q8CIN6-2]
RefSeqiNP_001276542.1. NM_001289613.1. [Q8CIN6-2]
NP_001276545.1. NM_001289616.1.
NP_001276549.1. NM_001289620.1.
NP_766022.1. NM_172434.3. [Q8CIN6-1]
XP_006502386.1. XM_006502323.3. [Q8CIN6-2]
UniGeneiMm.44292.

Genome annotation databases

EnsembliENSMUST00000029784; ENSMUSP00000029784; ENSMUSG00000028137. [Q8CIN6-1]
ENSMUST00000200342; ENSMUSP00000143344; ENSMUSG00000028137. [Q8CIN6-2]
GeneIDi78784.
KEGGimmu:78784.
UCSCiuc008qgl.2. mouse. [Q8CIN6-1]
uc008qgm.2. mouse. [Q8CIN6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY165052 mRNA. Translation: AAN73885.1.
BC057553 mRNA. Translation: AAH57553.1.
CCDSiCCDS38536.1. [Q8CIN6-1]
CCDS79972.1. [Q8CIN6-2]
RefSeqiNP_001276542.1. NM_001289613.1. [Q8CIN6-2]
NP_001276545.1. NM_001289616.1.
NP_001276549.1. NM_001289620.1.
NP_766022.1. NM_172434.3. [Q8CIN6-1]
XP_006502386.1. XM_006502323.3. [Q8CIN6-2]
UniGeneiMm.44292.

3D structure databases

ProteinModelPortaliQ8CIN6.
SMRiQ8CIN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CIN6. 1 interactor.
MINTiMINT-4116444.
STRINGi10090.ENSMUSP00000029784.

PTM databases

iPTMnetiQ8CIN6.
PhosphoSitePlusiQ8CIN6.

Proteomic databases

PaxDbiQ8CIN6.
PRIDEiQ8CIN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029784; ENSMUSP00000029784; ENSMUSG00000028137. [Q8CIN6-1]
ENSMUST00000200342; ENSMUSP00000143344; ENSMUSG00000028137. [Q8CIN6-2]
GeneIDi78784.
KEGGimmu:78784.
UCSCiuc008qgl.2. mouse. [Q8CIN6-1]
uc008qgm.2. mouse. [Q8CIN6-2]

Organism-specific databases

CTDi11189.
MGIiMGI:1926034. Celf3.

Phylogenomic databases

eggNOGiKOG0146. Eukaryota.
ENOG410XNTW. LUCA.
GeneTreeiENSGT00560000076837.
HOGENOMiHOG000004754.
HOVERGENiHBG107646.
InParanoidiQ8CIN6.
KOiK13207.
OMAiVWRGEVF.
OrthoDBiEOG091G19O1.
PhylomeDBiQ8CIN6.
TreeFamiTF314924.

Miscellaneous databases

PROiQ8CIN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028137.
CleanExiMM_TNRC4.
ExpressionAtlasiQ8CIN6. baseline and differential.
GenevisibleiQ8CIN6. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCELF3_MOUSE
AccessioniPrimary (citable) accession number: Q8CIN6
Secondary accession number(s): Q6PFH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.