Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8CIM7

- CP2DQ_MOUSE

UniProt

Q8CIM7 - CP2DQ_MOUSE

Protein

Cytochrome P450 2D26

Gene

Cyp2d26

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. female pregnancy Source: Ensembl
    2. response to drug Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D26 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID26
    Gene namesi
    Name:Cyp2d26Imported
    Synonyms:Cyp2d-26By similarity
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1923529. Cyp2d26.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cytochrome P450 2D26PRO_0000051746Add
    BLAST

    Proteomic databases

    MaxQBiQ8CIM7.
    PaxDbiQ8CIM7.
    PRIDEiQ8CIM7.

    PTM databases

    PhosphoSiteiQ8CIM7.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

    Gene expression databases

    BgeeiQ8CIM7.
    GenevestigatoriQ8CIM7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8CIM7. 6 interactions.
    MINTiMINT-1862922.
    STRINGi10090.ENSMUSP00000006094.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CIM7.
    SMRiQ8CIM7. Positions 51-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117392.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiQ8CIM7.
    KOiK07414.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ8CIM7.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CIM7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLVGDDLW AVVIFTAIFL LLVDLVHRRQ RWTACYPPGP VPFPGLGNLL    50
    QVDFENIPYS FYKLQNRYGN VFSLQMAWKP VVVVNGLKAV RELLVTYGED 100
    TSDRPLMPIY NHIGYGHKSK GVILAPYGPE WREQRRFSVS TLRDFGLGKK 150
    SLEQWVTEEA GHLCDAFTKE AEHPFNPSPL LSKAVSNVIA SLIYARRFEY 200
    EDPFFNRMLK TLKESLGEDT GFVGEVLNAI PMLLHIPGLP DKAFPKLNSF 250
    IALVNKMLIE HDLTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDKNLRI 300
    VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHQEIDE VIGHVRHPEM 350
    ADQARMPYTN AVIHEVQRFA DIVPTNLPHM TSRDIKFQDF FIPKGTTLIP 400
    NLSSVLKDET VWEKPLRFYP EHFLDAQGHF VKHEAFMPFS AGRRSCLGEP 450
    LARMELFLFF TCLLQRFSFS VPDGQPRPSD YGIYTMPVTP EPYQLCAVAR 500
    Length:500
    Mass (Da):56,976
    Last modified:March 1, 2003 - v1
    Checksum:iB3DDCD88DFA3F265
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti263 – 2631L → S in BAB23666. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004915 mRNA. Translation: BAB23666.1.
    BC023241 mRNA. Translation: AAH23241.1.
    CCDSiCCDS37163.1.
    RefSeqiNP_083838.1. NM_029562.2.
    UniGeneiMm.439931.

    Genome annotation databases

    EnsembliENSMUST00000006094; ENSMUSP00000006094; ENSMUSG00000022445.
    GeneIDi76279.
    KEGGimmu:76279.
    UCSCiuc007wzn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004915 mRNA. Translation: BAB23666.1 .
    BC023241 mRNA. Translation: AAH23241.1 .
    CCDSi CCDS37163.1.
    RefSeqi NP_083838.1. NM_029562.2.
    UniGenei Mm.439931.

    3D structure databases

    ProteinModelPortali Q8CIM7.
    SMRi Q8CIM7. Positions 51-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CIM7. 6 interactions.
    MINTi MINT-1862922.
    STRINGi 10090.ENSMUSP00000006094.

    PTM databases

    PhosphoSitei Q8CIM7.

    Proteomic databases

    MaxQBi Q8CIM7.
    PaxDbi Q8CIM7.
    PRIDEi Q8CIM7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006094 ; ENSMUSP00000006094 ; ENSMUSG00000022445 .
    GeneIDi 76279.
    KEGGi mmu:76279.
    UCSCi uc007wzn.1. mouse.

    Organism-specific databases

    CTDi 76279.
    MGIi MGI:1923529. Cyp2d26.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117392.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi Q8CIM7.
    KOi K07414.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q8CIM7.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 344895.
    PROi Q8CIM7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CIM7.
    Genevestigatori Q8CIM7.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: LiverImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiCP2DQ_MOUSE
    AccessioniPrimary (citable) accession number: Q8CIM7
    Secondary accession number(s): Q9DBJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3