SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8CIM7

- CP2DQ_MOUSE

UniProt

Q8CIM7 - CP2DQ_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome P450 2D26
Gene
Cyp2d26, Cyp2d-26
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.By similarity

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. female pregnancy Source: Ensembl
  2. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D26 (EC:1.14.14.1)
Alternative name(s):
CYPIID26
Gene namesi
Name:Cyp2d26
Synonyms:Cyp2d-26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1923529. Cyp2d26.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Cytochrome P450 2D26
PRO_0000051746Add
BLAST

Proteomic databases

MaxQBiQ8CIM7.
PaxDbiQ8CIM7.
PRIDEiQ8CIM7.

PTM databases

PhosphoSiteiQ8CIM7.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiQ8CIM7.
GenevestigatoriQ8CIM7.

Interactioni

Protein-protein interaction databases

IntActiQ8CIM7. 6 interactions.
MINTiMINT-1862922.
STRINGi10090.ENSMUSP00000006094.

Structurei

3D structure databases

ProteinModelPortaliQ8CIM7.
SMRiQ8CIM7. Positions 51-500.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00750000117392.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ8CIM7.
KOiK07414.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ8CIM7.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIM7-1 [UniParc]FASTAAdd to Basket

« Hide

MGLLVGDDLW AVVIFTAIFL LLVDLVHRRQ RWTACYPPGP VPFPGLGNLL    50
QVDFENIPYS FYKLQNRYGN VFSLQMAWKP VVVVNGLKAV RELLVTYGED 100
TSDRPLMPIY NHIGYGHKSK GVILAPYGPE WREQRRFSVS TLRDFGLGKK 150
SLEQWVTEEA GHLCDAFTKE AEHPFNPSPL LSKAVSNVIA SLIYARRFEY 200
EDPFFNRMLK TLKESLGEDT GFVGEVLNAI PMLLHIPGLP DKAFPKLNSF 250
IALVNKMLIE HDLTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDKNLRI 300
VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHQEIDE VIGHVRHPEM 350
ADQARMPYTN AVIHEVQRFA DIVPTNLPHM TSRDIKFQDF FIPKGTTLIP 400
NLSSVLKDET VWEKPLRFYP EHFLDAQGHF VKHEAFMPFS AGRRSCLGEP 450
LARMELFLFF TCLLQRFSFS VPDGQPRPSD YGIYTMPVTP EPYQLCAVAR 500
Length:500
Mass (Da):56,976
Last modified:March 1, 2003 - v1
Checksum:iB3DDCD88DFA3F265
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631L → S in BAB23666. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004915 mRNA. Translation: BAB23666.1.
BC023241 mRNA. Translation: AAH23241.1.
CCDSiCCDS37163.1.
RefSeqiNP_083838.1. NM_029562.2.
UniGeneiMm.439931.

Genome annotation databases

EnsembliENSMUST00000006094; ENSMUSP00000006094; ENSMUSG00000022445.
GeneIDi76279.
KEGGimmu:76279.
UCSCiuc007wzn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004915 mRNA. Translation: BAB23666.1 .
BC023241 mRNA. Translation: AAH23241.1 .
CCDSi CCDS37163.1.
RefSeqi NP_083838.1. NM_029562.2.
UniGenei Mm.439931.

3D structure databases

ProteinModelPortali Q8CIM7.
SMRi Q8CIM7. Positions 51-500.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8CIM7. 6 interactions.
MINTi MINT-1862922.
STRINGi 10090.ENSMUSP00000006094.

PTM databases

PhosphoSitei Q8CIM7.

Proteomic databases

MaxQBi Q8CIM7.
PaxDbi Q8CIM7.
PRIDEi Q8CIM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006094 ; ENSMUSP00000006094 ; ENSMUSG00000022445 .
GeneIDi 76279.
KEGGi mmu:76279.
UCSCi uc007wzn.1. mouse.

Organism-specific databases

CTDi 76279.
MGIi MGI:1923529. Cyp2d26.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00750000117392.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi Q8CIM7.
KOi K07414.
OrthoDBi EOG7RBZ85.
PhylomeDBi Q8CIM7.
TreeFami TF352043.

Miscellaneous databases

NextBioi 344895.
PROi Q8CIM7.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIM7.
Genevestigatori Q8CIM7.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiCP2DQ_MOUSE
AccessioniPrimary (citable) accession number: Q8CIM7
Secondary accession number(s): Q9DBJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi