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Protein

Cytochrome P450 2D26

Gene

Cyp2d26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D26 (EC:1.14.14.1)
Alternative name(s):
CYPIID26
Gene namesi
Name:Cyp2d26Imported
Synonyms:Cyp2d-26By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923529. Cyp2d26.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517461 – 500Cytochrome P450 2D26Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CIM7.
PaxDbiQ8CIM7.
PeptideAtlasiQ8CIM7.
PRIDEiQ8CIM7.

PTM databases

iPTMnetiQ8CIM7.
PhosphoSitePlusiQ8CIM7.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.Curated

Interactioni

Protein-protein interaction databases

IntActiQ8CIM7. 6 interactors.
MINTiMINT-1862922.
STRINGi10090.ENSMUSP00000006094.

Structurei

3D structure databases

ProteinModelPortaliQ8CIM7.
SMRiQ8CIM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ8CIM7.
KOiK07414.
PhylomeDBiQ8CIM7.
TreeFamiTF352043.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CIM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLVGDDLW AVVIFTAIFL LLVDLVHRRQ RWTACYPPGP VPFPGLGNLL
60 70 80 90 100
QVDFENIPYS FYKLQNRYGN VFSLQMAWKP VVVVNGLKAV RELLVTYGED
110 120 130 140 150
TSDRPLMPIY NHIGYGHKSK GVILAPYGPE WREQRRFSVS TLRDFGLGKK
160 170 180 190 200
SLEQWVTEEA GHLCDAFTKE AEHPFNPSPL LSKAVSNVIA SLIYARRFEY
210 220 230 240 250
EDPFFNRMLK TLKESLGEDT GFVGEVLNAI PMLLHIPGLP DKAFPKLNSF
260 270 280 290 300
IALVNKMLIE HDLTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDKNLRI
310 320 330 340 350
VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHQEIDE VIGHVRHPEM
360 370 380 390 400
ADQARMPYTN AVIHEVQRFA DIVPTNLPHM TSRDIKFQDF FIPKGTTLIP
410 420 430 440 450
NLSSVLKDET VWEKPLRFYP EHFLDAQGHF VKHEAFMPFS AGRRSCLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPDGQPRPSD YGIYTMPVTP EPYQLCAVAR
Length:500
Mass (Da):56,976
Last modified:March 1, 2003 - v1
Checksum:iB3DDCD88DFA3F265
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263L → S in BAB23666 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004915 mRNA. Translation: BAB23666.1.
BC023241 mRNA. Translation: AAH23241.1.
CCDSiCCDS37163.1.
RefSeqiNP_083838.1. NM_029562.2.
UniGeneiMm.439931.

Genome annotation databases

GeneIDi76279.
KEGGimmu:76279.
UCSCiuc007wzn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCP2DQ_MOUSE
AccessioniPrimary (citable) accession number: Q8CIM7
Secondary accession number(s): Q9DBJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families