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Q8CIM7 (CP2DQ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D26

EC=1.14.14.1
Alternative name(s):
CYPIID26
Gene names
Name:Cyp2d26
Synonyms:Cyp2d-26
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity. UniProtKB P10634

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. UniProtKB P10634

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Cytochrome P450 2D26
PRO_0000051746

Sites

Metal binding4461Iron (heme axial ligand) UniProtKB P10634

Experimental info

Sequence conflict2631L → S in BAB23666. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8CIM7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B3DDCD88DFA3F265

FASTA50056,976
        10         20         30         40         50         60 
MGLLVGDDLW AVVIFTAIFL LLVDLVHRRQ RWTACYPPGP VPFPGLGNLL QVDFENIPYS 

        70         80         90        100        110        120 
FYKLQNRYGN VFSLQMAWKP VVVVNGLKAV RELLVTYGED TSDRPLMPIY NHIGYGHKSK 

       130        140        150        160        170        180 
GVILAPYGPE WREQRRFSVS TLRDFGLGKK SLEQWVTEEA GHLCDAFTKE AEHPFNPSPL 

       190        200        210        220        230        240 
LSKAVSNVIA SLIYARRFEY EDPFFNRMLK TLKESLGEDT GFVGEVLNAI PMLLHIPGLP 

       250        260        270        280        290        300 
DKAFPKLNSF IALVNKMLIE HDLTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDKNLRI 

       310        320        330        340        350        360 
VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHQEIDE VIGHVRHPEM ADQARMPYTN 

       370        380        390        400        410        420 
AVIHEVQRFA DIVPTNLPHM TSRDIKFQDF FIPKGTTLIP NLSSVLKDET VWEKPLRFYP 

       430        440        450        460        470        480 
EHFLDAQGHF VKHEAFMPFS AGRRSCLGEP LARMELFLFF TCLLQRFSFS VPDGQPRPSD 

       490        500 
YGIYTMPVTP EPYQLCAVAR 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004915 mRNA. Translation: BAB23666.1.
BC023241 mRNA. Translation: AAH23241.1.
CCDSCCDS37163.1.
RefSeqNP_083838.1. NM_029562.2.
UniGeneMm.439931.

3D structure databases

ProteinModelPortalQ8CIM7.
SMRQ8CIM7. Positions 51-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8CIM7. 6 interactions.
MINTMINT-1862922.
STRING10090.ENSMUSP00000006094.

PTM databases

PhosphoSiteQ8CIM7.

Proteomic databases

MaxQBQ8CIM7.
PaxDbQ8CIM7.
PRIDEQ8CIM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006094; ENSMUSP00000006094; ENSMUSG00000022445.
GeneID76279.
KEGGmmu:76279.
UCSCuc007wzn.1. mouse.

Organism-specific databases

CTD76279.
MGIMGI:1923529. Cyp2d26.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117392.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidQ8CIM7.
KOK07414.
OrthoDBEOG7RBZ85.
PhylomeDBQ8CIM7.
TreeFamTF352043.

Gene expression databases

BgeeQ8CIM7.
GenevestigatorQ8CIM7.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio344895.
PROQ8CIM7.
SOURCESearch...

Entry information

Entry nameCP2DQ_MOUSE
AccessionPrimary (citable) accession number: Q8CIM7
Secondary accession number(s): Q9DBJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot