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Protein

G-protein coupled receptor 84

Gene

Gpr84

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 84
Gene namesi
Name:Gpr84
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1934129. Gpr84.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence analysisAdd
BLAST
Transmembranei22 – 4221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini43 – 5715CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9416ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini116 – 13520CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 18024ExtracellularSequence analysisAdd
BLAST
Transmembranei181 – 20121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini202 – 320119CytoplasmicSequence analysisAdd
BLAST
Transmembranei321 – 34121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini342 – 35211ExtracellularSequence analysisAdd
BLAST
Transmembranei353 – 37321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini374 – 39623CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396G-protein coupled receptor 84PRO_0000069590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Modified residuei221 – 2211PhosphoserineCombined sources
Modified residuei224 – 2241PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8CIM5.
PaxDbiQ8CIM5.
PRIDEiQ8CIM5.

PTM databases

iPTMnetiQ8CIM5.
PhosphoSiteiQ8CIM5.

Expressioni

Tissue specificityi

Expressed predominantly in hematopoietic tissues. Expressed mainly in the bone marrow with transcripts also detected in spleen, the lymph node, liver and the lung.2 Publications

Inductioni

By lipopolysaccharide in the monocyte/macrophage cell lines.1 Publication

Gene expression databases

BgeeiQ8CIM5.
CleanExiMM_GPR84.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078753.

Structurei

3D structure databases

ProteinModelPortaliQ8CIM5.
SMRiQ8CIM5. Positions 30-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000077772.
HOVERGENiHBG051820.
InParanoidiQ8CIM5.
KOiK08421.
OrthoDBiEOG7M6D7X.
PhylomeDBiQ8CIM5.
TreeFamiTF333474.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWNSSDANFS CYHESVLGYR YFAVIWGVAV AVTGTVGNVL TLLALAIRPK
60 70 80 90 100
LRTRFNLLIA NLTLADLLYC TLLQPFSVDT YLHLHWRTGA VFCRIFGLLL
110 120 130 140 150
FTSNSVSILT LCLIALGRYL LIAHPKLFPQ VFSAKGIVLA LVGSWVVGVT
160 170 180 190 200
SFAPLWNVFV LVPVVCTCSF DRMRGRPYTT ILMGIYFVLG LSSVGVFYCL
210 220 230 240 250
IHRQVKRAAR ALDQYGLHQA SIRSHQVAGT QEAMPGHFQE LDSGVASRGP
260 270 280 290 300
SEGISSEPVS AATTQTLEGD SSEAGGQGIR KAAQQIAERS LPEVHRKPRE
310 320 330 340 350
TAGARRATDA PSEFGKVTRM CFAVFLCFAL SYIPFLLLNI LDARGRAPRV
360 370 380 390
VHMVAANLTW LNSCINPVLY AAMNRQFRHA YGSILKRGPQ SFRRFH
Length:396
Mass (Da):43,717
Last modified:March 1, 2003 - v1
Checksum:i80F0601CBB4B1B03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241V → I in AAK01859 (PubMed:11273702).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272948 mRNA. Translation: AAK01859.1.
BC023249 mRNA. Translation: AAH23249.1.
CCDSiCCDS27902.1.
RefSeqiNP_109645.1. NM_030720.1.
UniGeneiMm.160369.

Genome annotation databases

GeneIDi80910.
KEGGimmu:80910.
UCSCiuc007xxy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272948 mRNA. Translation: AAK01859.1.
BC023249 mRNA. Translation: AAH23249.1.
CCDSiCCDS27902.1.
RefSeqiNP_109645.1. NM_030720.1.
UniGeneiMm.160369.

3D structure databases

ProteinModelPortaliQ8CIM5.
SMRiQ8CIM5. Positions 30-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078753.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8CIM5.
PhosphoSiteiQ8CIM5.

Proteomic databases

MaxQBiQ8CIM5.
PaxDbiQ8CIM5.
PRIDEiQ8CIM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80910.
KEGGimmu:80910.
UCSCiuc007xxy.1. mouse.

Organism-specific databases

CTDi53831.
MGIiMGI:1934129. Gpr84.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000077772.
HOVERGENiHBG051820.
InParanoidiQ8CIM5.
KOiK08421.
OrthoDBiEOG7M6D7X.
PhylomeDBiQ8CIM5.
TreeFamiTF333474.

Miscellaneous databases

NextBioi350278.
PROiQ8CIM5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CIM5.
CleanExiMM_GPR84.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors."
    Wittenberger T., Schaller H.C., Hellebrand S.
    J. Mol. Biol. 307:799-813(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. "Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84."
    Wang J., Wu X., Simonavicius N., Tian H., Ling L.
    J. Biol. Chem. 281:34457-34464(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221 AND SER-224, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPR84_MOUSE
AccessioniPrimary (citable) accession number: Q8CIM5
Secondary accession number(s): Q99MX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.