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Protein

D-2-hydroxyglutarate dehydrogenase, mitochondrial

Gene

D2hgdh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.By similarity

Catalytic activityi

(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

Cofactori

FADCurated

Enzyme regulationi

Activated by zinc and cobalt.By similarity

GO - Molecular functioni

  • (R)-2-hydroxyglutarate dehydrogenase activity Source: HGNC
  • flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  • cellular protein metabolic process Source: HGNC
  • response to cobalt ion Source: HGNC
  • response to manganese ion Source: HGNC
  • response to zinc ion Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-880009. Interconversion of 2-oxoglutarate and 2-hydroxyglutarate.

Names & Taxonomyi

Protein namesi
Recommended name:
D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC:1.1.99.-)
Gene namesi
Name:D2hgdh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138209. D2hgdh.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5050MitochondrionSequence analysisAdd
BLAST
Chaini51 – 535485D-2-hydroxyglutarate dehydrogenase, mitochondrialPRO_0000231675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151N6-succinyllysineCombined sources

Proteomic databases

MaxQBiQ8CIM3.
PaxDbiQ8CIM3.
PeptideAtlasiQ8CIM3.
PRIDEiQ8CIM3.

PTM databases

iPTMnetiQ8CIM3.
PhosphoSiteiQ8CIM3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000073609.
CleanExiMM_D2HGDH.
ExpressionAtlasiQ8CIM3. baseline and differential.
GenevisibleiQ8CIM3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095235.

Structurei

3D structure databases

ProteinModelPortaliQ8CIM3.
SMRiQ8CIM3. Positions 75-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 289180FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1232. Eukaryota.
COG0277. LUCA.
GeneTreeiENSGT00550000075086.
HOGENOMiHOG000230997.
HOVERGENiHBG079809.
InParanoidiQ8CIM3.
TreeFamiTF323342.

Family and domain databases

Gene3Di1.10.45.10. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view]
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CIM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLPLVSRWS ARVLWASPGW RRTYTQRACV GLKRLGCPRG VYSPLAHRAY
60 70 80 90 100
SVVAGGPEVT LTPERYPVQR LPFSTVSEED LAAFECIIPG RVITDPEQLQ
110 120 130 140 150
TCNVDWLKTV RGCSKVLLRP QTSEEVSQIL RHCYKRNLAV NPQGGNTGMV
160 170 180 190 200
GGSVPVFDEV ILSTALMNQV ISFHDVSGIL VCQAGCVLEE LSRYVQERDF
210 220 230 240 250
IMPLDLGAKG SCHIGGNVAT NAGGLRFLRY GSLRGTVLGL EVVLADGTIL
260 270 280 290 300
NCLTSLRKDN TGYDLKQMFI GSEGTLGVIT AVSIVCPPRP KAVNVAFLGC
310 320 330 340 350
PGFAEVLQTF RTCRGMLGEI LSAFEFMDTE CMQLVGQHLQ LTNPVQESPF
360 370 380 390 400
YVLVETSGSS AGHDAEKLTN VLEQVLNSGL VTDGTMATDQ RKVQMLWALR
410 420 430 440 450
ERITEALSRD GYVFKYDLSL PVERLYDLVI DLRTRLGPRA KHVVGYGHLG
460 470 480 490 500
DGNLHLNVTA EAFSRELLGA LEPYVYAWTA EQRGSVSAEH GLGFKKKDVL
510 520 530
GYSKPPVAVT LMQQLKAMLD PEGILNPYKT LPAQA
Length:535
Mass (Da):58,576
Last modified:October 3, 2012 - v3
Checksum:i1056007386DE4043
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561G → S in AAH23277 (PubMed:15489334).Curated
Sequence conflicti451 – 4511D → G in BAE41647 (PubMed:16141072).Curated
Sequence conflicti522 – 5221E → K in BAE41647 (PubMed:16141072).Curated
Sequence conflicti522 – 5221E → K in BAC40205 (PubMed:16141072).Curated
Sequence conflicti522 – 5221E → K in AAH23277 (PubMed:15489334).Curated
Sequence conflicti522 – 5221E → K in AAI17795 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088200 mRNA. Translation: BAC40205.1.
AK170226 mRNA. Translation: BAE41647.1.
AC167139 Genomic DNA. No translation available.
BC023277 mRNA. Translation: AAH23277.1.
BC117794 mRNA. Translation: AAI17795.1.
CCDSiCCDS15196.1.
RefSeqiNP_849213.2. NM_178882.4.
UniGeneiMm.383401.

Genome annotation databases

EnsembliENSMUST00000097633; ENSMUSP00000095235; ENSMUSG00000073609.
GeneIDi98314.
KEGGimmu:98314.
UCSCiuc007cep.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088200 mRNA. Translation: BAC40205.1.
AK170226 mRNA. Translation: BAE41647.1.
AC167139 Genomic DNA. No translation available.
BC023277 mRNA. Translation: AAH23277.1.
BC117794 mRNA. Translation: AAI17795.1.
CCDSiCCDS15196.1.
RefSeqiNP_849213.2. NM_178882.4.
UniGeneiMm.383401.

3D structure databases

ProteinModelPortaliQ8CIM3.
SMRiQ8CIM3. Positions 75-531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095235.

PTM databases

iPTMnetiQ8CIM3.
PhosphoSiteiQ8CIM3.

Proteomic databases

MaxQBiQ8CIM3.
PaxDbiQ8CIM3.
PeptideAtlasiQ8CIM3.
PRIDEiQ8CIM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097633; ENSMUSP00000095235; ENSMUSG00000073609.
GeneIDi98314.
KEGGimmu:98314.
UCSCiuc007cep.2. mouse.

Organism-specific databases

CTDi728294.
MGIiMGI:2138209. D2hgdh.

Phylogenomic databases

eggNOGiKOG1232. Eukaryota.
COG0277. LUCA.
GeneTreeiENSGT00550000075086.
HOGENOMiHOG000230997.
HOVERGENiHBG079809.
InParanoidiQ8CIM3.
TreeFamiTF323342.

Enzyme and pathway databases

ReactomeiR-MMU-880009. Interconversion of 2-oxoglutarate and 2-hydroxyglutarate.

Miscellaneous databases

PROiQ8CIM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073609.
CleanExiMM_D2HGDH.
ExpressionAtlasiQ8CIM3. baseline and differential.
GenevisibleiQ8CIM3. MM.

Family and domain databases

Gene3Di1.10.45.10. 1 hit.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR016164. FAD-linked_Oxase-like_C.
IPR004113. FAD-linked_oxidase_C.
IPR006094. Oxid_FAD_bind_N.
IPR016171. Vanillyl_alc_oxidase_C-sub2.
[Graphical view]
PfamiPF02913. FAD-oxidase_C. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
SUPFAMiSSF55103. SSF55103. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD2HDH_MOUSE
AccessioniPrimary (citable) accession number: Q8CIM3
Secondary accession number(s): E9QLL1
, Q149H0, Q3TDF5, Q8BU06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.