Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 8B

Gene

Zbtb8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri331 – 353C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri359 – 382C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 8B
Gene namesi
Name:Zbtb8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2387181. Zbtb8b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477221 – 484Zinc finger and BTB domain-containing protein 8BAdd BLAST484

Proteomic databases

PaxDbiQ8CII0.
PRIDEiQ8CII0.

PTM databases

PhosphoSitePlusiQ8CII0.

Interactioni

Protein-protein interaction databases

BioGridi229641. 1 interactor.
STRINGi10090.ENSMUSP00000058157.

Structurei

3D structure databases

ProteinModelPortaliQ8CII0.
SMRiQ8CII0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 92BTBPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 149Ala-richAdd BLAST18

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri331 – 353C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri359 – 382C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000124661.
InParanoidiQ8CII0.
KOiK10495.
PhylomeDBiQ8CII0.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF57667. SSF57667. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8CII0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAQSYCAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR
60 70 80 90 100
ALLLHYIQDS GRHSTASLDI VTSDAFSTIL DFLYSGKLDL CGENVIEVMS
110 120 130 140 150
AASYLQMNEV VNFCKTYIRS SLDICRKMEK EAAVAAAMAA AAAAAAAAAH
160 170 180 190 200
QIDSESPSSG LEGTSCGTKS FVSSPVDGEG SLDCTISSCD DCHPLELVAK
210 220 230 240 250
DSQGSGVSDN DLCVVPRRVE PKVEFDVARV EVEADEQLQQ YAAPLAHMEE
260 270 280 290 300
GLPSNQALDL TYSSYHVKQF LEALLRNGAV QSKDDLDCHS SRGLEGRLEG
310 320 330 340 350
PGVAMSSVMD VQNDWYREDA GDVLVVPIKL HRCPFCPYTA KQKGILKRHI
360 370 380 390 400
RSHTGERPYP CETCGKRFTR QEHLRSHALS VHRSSRPIIC KGCRRTFTSH
410 420 430 440 450
LSQGLRRFGL CDSCTCVTDP QEEEDDLMPV NLSLVEASSE SHEKSDTDDW
460 470 480
PIYIESGEEN DPTAEDSDDK PHIRPNLPAP ETLT
Length:484
Mass (Da):53,387
Last modified:March 1, 2003 - v1
Checksum:iB4FF082555B0CA1A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263S → N in BAE37541 (PubMed:16141072).Curated1
Sequence conflicti263S → N in BAE24519 (PubMed:16141072).Curated1
Sequence conflicti263S → N in BAE20999 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132152 mRNA. Translation: BAE20999.1.
AK140914 mRNA. Translation: BAE24519.1.
AK163930 mRNA. Translation: BAE37541.1.
BC023839 mRNA. Translation: AAH23839.1.
CCDSiCCDS18691.1.
RefSeqiNP_705769.2. NM_153541.3.
UniGeneiMm.428660.
Mm.458339.

Genome annotation databases

GeneIDi215627.
KEGGimmu:215627.

Similar proteinsi

Entry informationi

Entry nameiZBT8B_MOUSE
AccessioniPrimary (citable) accession number: Q8CII0
Secondary accession number(s): Q3US18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot