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Protein

F-box/LRR-repeat protein 8

Gene

Fbxl8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 8
Alternative name(s):
F-box and leucine-rich repeat protein 8
F-box protein FBL8
Gene namesi
Name:Fbxl8
Synonyms:Fbl8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1354697. Fbxl8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374F-box/LRR-repeat protein 8PRO_0000119851Add
BLAST

Proteomic databases

EPDiQ8CIG9.
MaxQBiQ8CIG9.
PaxDbiQ8CIG9.
PRIDEiQ8CIG9.

Expressioni

Tissue specificityi

Widely expressed during embryogenesis and in adult tissues.1 Publication

Gene expression databases

BgeeiQ8CIG9.
CleanExiMM_FBXL8.
ExpressionAtlasiQ8CIG9. baseline and differential.
GenevisibleiQ8CIG9. MM.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi206120. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8CIG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4847F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKPE. Eukaryota.
ENOG4111K6I. LUCA.
GeneTreeiENSGT00420000029943.
HOGENOMiHOG000112553.
HOVERGENiHBG051592.
InParanoidiQ8CIG9.
KOiK10274.
OMAiNHALVNS.
OrthoDBiEOG72JWGS.
PhylomeDBiQ8CIG9.
TreeFamiTF321665.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CIG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGELVDNLPE EVLALIFRDL PLRDLAVATR VCRAWAAAAA NSTVWSDKSI
60 70 80 90 100
SCDCELEDLL PPYLSSCLDH IHNLRLEYEP SKKPSRGTAT ELLTALASRA
110 120 130 140 150
PRLRGLRLEC RGEKPLFDAG QDILGAVHAV CGAAHQLRHL DLRHLPYTLD
160 170 180 190 200
DTLVLKAAAG CPELRSLFLD NHALVNSVQP TSVLKLLEAC PHLRALGLHL
210 220 230 240 250
ASMSRAALEL LAAPHRSPFA LLALRCACPE DARASPLPDE AWATLSCRHP
260 270 280 290 300
GLEVELELEP VLPDEAVTRI LQPAVPVAVL RLNLSGDTVG PVRFATRHYA
310 320 330 340 350
ETLRALEVRA SASPELHTAL EELAARCAGL REIHCFCVVR PSVLDAFRAH
360 370
CPRLRSYTLK LKREPHPWRP TLVR
Length:374
Mass (Da):41,145
Last modified:March 1, 2003 - v1
Checksum:iCBDFBF5B6656BEE4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881T → N in AAF09132 (PubMed:10531037).Curated
Sequence conflicti300 – 3001A → D in AAF09132 (PubMed:10531037).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176523 mRNA. Translation: AAF09132.1.
BC023902 mRNA. Translation: AAH23902.1.
CCDSiCCDS22595.1.
RefSeqiNP_056636.2. NM_015821.2.
UniGeneiMm.334764.

Genome annotation databases

EnsembliENSMUST00000036221; ENSMUSP00000038638; ENSMUSG00000033313.
GeneIDi50788.
KEGGimmu:50788.
UCSCiuc009nbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176523 mRNA. Translation: AAF09132.1.
BC023902 mRNA. Translation: AAH23902.1.
CCDSiCCDS22595.1.
RefSeqiNP_056636.2. NM_015821.2.
UniGeneiMm.334764.

3D structure databases

ProteinModelPortaliQ8CIG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206120. 1 interaction.

Proteomic databases

EPDiQ8CIG9.
MaxQBiQ8CIG9.
PaxDbiQ8CIG9.
PRIDEiQ8CIG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036221; ENSMUSP00000038638; ENSMUSG00000033313.
GeneIDi50788.
KEGGimmu:50788.
UCSCiuc009nbz.2. mouse.

Organism-specific databases

CTDi55336.
MGIiMGI:1354697. Fbxl8.

Phylogenomic databases

eggNOGiENOG410IKPE. Eukaryota.
ENOG4111K6I. LUCA.
GeneTreeiENSGT00420000029943.
HOGENOMiHOG000112553.
HOVERGENiHBG051592.
InParanoidiQ8CIG9.
KOiK10274.
OMAiNHALVNS.
OrthoDBiEOG72JWGS.
PhylomeDBiQ8CIG9.
TreeFamiTF321665.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ8CIG9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CIG9.
CleanExiMM_FBXL8.
ExpressionAtlasiQ8CIG9. baseline and differential.
GenevisibleiQ8CIG9. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SKP1, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.

Entry informationi

Entry nameiFBXL8_MOUSE
AccessioniPrimary (citable) accession number: Q8CIG9
Secondary accession number(s): Q9QZN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

While the gene symbol and protein names are indicative of the presence of LRR repeats, such repeats are not present in this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.