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Protein

Serpin A11

Gene

Serpina11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A11
Gene namesi
Name:Serpina11
Synonyms:Gm895
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2685741. Serpina11.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 424403Serpin A11PRO_0000041974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CIE0.
PRIDEiQ8CIE0.

PTM databases

PhosphoSiteiQ8CIE0.

Expressioni

Gene expression databases

GenevestigatoriQ8CIE0.

Structurei

3D structure databases

ProteinModelPortaliQ8CIE0.
SMRiQ8CIE0. Positions 57-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ8CIE0.
PhylomeDBiQ8CIE0.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CIE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPVWLWLWL LVAEVLLPVH CQPFSAHGDK SLGASQPASH QSLEPAPAYH
60 70 80 90 100
KVTPTITNFA LRLYKQLAEE VAGNILFSPV SLSSSLALLS LGAHADTQTQ
110 120 130 140 150
ILESLGFNLT ETPAADVHRG FQSLLHTLDL PSPKLELKLG HSLFLDRQLK
160 170 180 190 200
PQQRFLDSAK ELYGALAFSA NFTEAAATGQ QINDLVRKQT YGQVVGCLPE
210 220 230 240 250
FSHDTLMVLL NYIFFKAKWK HPFDRYQTRK QESFSLDQRT PLRIPMMRQK
260 270 280 290 300
EMHRFLYDQE ASCTVLQIEY SGTALLLLVL PDPGKMQQVE AALQPETLRR
310 320 330 340 350
WGQRFLPSLL DLHLPRFSIS ATYNLEEILP LIGLGNLFDM EADLSGIMGQ
360 370 380 390 400
LNKTVSRVSH KAIVDMNEKG TEAAAASGLL SQPPALNMTS APQAHYNRPF
410 420
LLLLWEVTTQ SLLFLGKVVN PAAG
Length:424
Mass (Da):47,188
Last modified:March 1, 2003 - v1
Checksum:iD176AAF8D5A06D34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024087 mRNA. Translation: AAH24087.1.
BC096585 mRNA. Translation: AAH96585.1.
RefSeqiNP_955018.2. NM_199314.2.
UniGeneiMm.201338.

Genome annotation databases

GeneIDi380780.
KEGGimmu:380780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024087 mRNA. Translation: AAH24087.1.
BC096585 mRNA. Translation: AAH96585.1.
RefSeqiNP_955018.2. NM_199314.2.
UniGeneiMm.201338.

3D structure databases

ProteinModelPortaliQ8CIE0.
SMRiQ8CIE0. Positions 57-421.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.029.

PTM databases

PhosphoSiteiQ8CIE0.

Proteomic databases

PaxDbiQ8CIE0.
PRIDEiQ8CIE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi380780.
KEGGimmu:380780.

Organism-specific databases

CTDi256394.
MGIiMGI:2685741. Serpina11.

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ8CIE0.
PhylomeDBiQ8CIE0.

Miscellaneous databases

NextBioi401226.
PROiQ8CIE0.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8CIE0.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiSPA11_MOUSE
AccessioniPrimary (citable) accession number: Q8CIE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.