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Q8CIE0

- SPA11_MOUSE

UniProt

Q8CIE0 - SPA11_MOUSE

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Protein

Serpin A11

Gene

Serpina11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A11
Gene namesi
Name:Serpina11
Synonyms:Gm895
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2685741. Serpina11.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 424403Serpin A11PRO_0000041974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CIE0.
PRIDEiQ8CIE0.

PTM databases

PhosphoSiteiQ8CIE0.

Expressioni

Gene expression databases

GenevestigatoriQ8CIE0.

Structurei

3D structure databases

ProteinModelPortaliQ8CIE0.
SMRiQ8CIE0. Positions 57-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ8CIE0.
PhylomeDBiQ8CIE0.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CIE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPVWLWLWL LVAEVLLPVH CQPFSAHGDK SLGASQPASH QSLEPAPAYH
60 70 80 90 100
KVTPTITNFA LRLYKQLAEE VAGNILFSPV SLSSSLALLS LGAHADTQTQ
110 120 130 140 150
ILESLGFNLT ETPAADVHRG FQSLLHTLDL PSPKLELKLG HSLFLDRQLK
160 170 180 190 200
PQQRFLDSAK ELYGALAFSA NFTEAAATGQ QINDLVRKQT YGQVVGCLPE
210 220 230 240 250
FSHDTLMVLL NYIFFKAKWK HPFDRYQTRK QESFSLDQRT PLRIPMMRQK
260 270 280 290 300
EMHRFLYDQE ASCTVLQIEY SGTALLLLVL PDPGKMQQVE AALQPETLRR
310 320 330 340 350
WGQRFLPSLL DLHLPRFSIS ATYNLEEILP LIGLGNLFDM EADLSGIMGQ
360 370 380 390 400
LNKTVSRVSH KAIVDMNEKG TEAAAASGLL SQPPALNMTS APQAHYNRPF
410 420
LLLLWEVTTQ SLLFLGKVVN PAAG
Length:424
Mass (Da):47,188
Last modified:March 1, 2003 - v1
Checksum:iD176AAF8D5A06D34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC024087 mRNA. Translation: AAH24087.1.
BC096585 mRNA. Translation: AAH96585.1.
RefSeqiNP_955018.2. NM_199314.2.
UniGeneiMm.201338.

Genome annotation databases

GeneIDi380780.
KEGGimmu:380780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC024087 mRNA. Translation: AAH24087.1 .
BC096585 mRNA. Translation: AAH96585.1 .
RefSeqi NP_955018.2. NM_199314.2.
UniGenei Mm.201338.

3D structure databases

ProteinModelPortali Q8CIE0.
SMRi Q8CIE0. Positions 57-421.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.029.

PTM databases

PhosphoSitei Q8CIE0.

Proteomic databases

PaxDbi Q8CIE0.
PRIDEi Q8CIE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 380780.
KEGGi mmu:380780.

Organism-specific databases

CTDi 256394.
MGIi MGI:2685741. Serpina11.

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238521.
HOVERGENi HBG005957.
InParanoidi Q8CIE0.
PhylomeDBi Q8CIE0.

Miscellaneous databases

NextBioi 401226.
PROi Q8CIE0.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8CIE0.

Family and domain databases

InterProi IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiSPA11_MOUSE
AccessioniPrimary (citable) accession number: Q8CIE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3