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Q8CID3

- FA20A_MOUSE

UniProt

Q8CID3 - FA20A_MOUSE

Protein

Protein FAM20A

Gene

Fam20a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. enamel mineralization Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM20A
    Gene namesi
    Name:Fam20a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2388266. Fam20a.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. cell Source: UniProt
    2. extracellular region Source: UniProtKB-SubCell
    3. Golgi apparatus Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi14 – 152LL → DE: Not secreted; nuclear localization. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 541508Protein FAM20APRO_0000008744Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8CID3.
    PRIDEiQ8CID3.

    PTM databases

    PhosphoSiteiQ8CID3.

    Expressioni

    Tissue specificityi

    Observed throughout the tissues of the mandibular incisor, including the secretory and maturation stage ameloblasts, the suprabasal layers of the gingival epithelium and the odontoblasts. Weak expression in the enamel matrix.1 Publication

    Developmental stagei

    In EML and MPRO cell lines, low levels in undifferentiated cells. Induced during maturation to promyelocyte stage of neutrophil differentiation. Decreased during neutrophil terminal differentiation.1 Publication

    Inductioni

    By all-trans retinoic acid (atRA) and IL3 in EML cell line.

    Gene expression databases

    BgeeiQ8CID3.
    GenevestigatoriQ8CID3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CID3.
    SMRiQ8CID3. Positions 160-533.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM20 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG238678.
    GeneTreeiENSGT00390000007484.
    HOGENOMiHOG000231437.
    HOVERGENiHBG051635.
    InParanoidiQ8CID3.
    OMAiHGLYSRS.
    OrthoDBiEOG7JX33T.
    PhylomeDBiQ8CID3.
    TreeFamiTF313276.

    Family and domain databases

    InterProiIPR009581. DUF1193.
    IPR024869. FAM20.
    [Graphical view]
    PANTHERiPTHR12450. PTHR12450. 1 hit.
    PfamiPF06702. DUF1193. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CID3-1 [UniParc]FASTAAdd to Basket

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    MPGLRRDRLL ALLLLGALFS ADLYFHLWPQ VQRQLRPGER PAACPCSGRA    50
    PSASLHSAAA SRDLGTASHN FSGALPRVEH PSRGHPAPRS KLQALFAHSL 100
    YQVLEDPPLL GPEDWLLASQ EALRYYRRKV ARWNRRHKIY KEQFNLTSLD 150
    PPLQFRPEAS WVQFHLGINS HGLYSRSSLA ISKLLHDMRH FPTISADYSQ 200
    DEKALLGACD CSQIVKPSGV HLKLVLRFSD FGKAMFKPMR QQREEETPED 250
    FFYFIDFQRH NAEIAAFHLD RILDFRRVPP TVGRLVNVTK EILEVTKNEI 300
    LQSVFFVSPA NNVCFFAKCP YMCKTEYAVC GNPHLLEGSL SAFLPSLNLA 350
    PRLSVPNPWI RSYSLSGKEE WELNPLYCDT VKQIYPYNSS NRLLGIIDMA 400
    VFDFLIGNMD RHHYEMFTKF GDDGYLIHLD NARGFGRHSQ DEISILAPLA 450
    QCCMIKRKTL LHLQLLAQAD YRLSDVMRES LLEDQLSPVL TEPHLLALDR 500
    RLQIILKTVE DCIEAHGERR VIAEGSAQRS APDSGQANLT S 541
    Length:541
    Mass (Da):61,526
    Last modified:March 1, 2003 - v1
    Checksum:i2F6B2DCF9A447CDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC029169 mRNA. Translation: AAH29169.1.
    CCDSiCCDS25584.1.
    RefSeqiNP_722477.1. NM_153782.1.
    UniGeneiMm.208662.

    Genome annotation databases

    EnsembliENSMUST00000020938; ENSMUSP00000020938; ENSMUSG00000020614.
    ENSMUST00000155559; ENSMUSP00000116687; ENSMUSG00000020614.
    GeneIDi208659.
    KEGGimmu:208659.
    UCSCiuc007mcw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC029169 mRNA. Translation: AAH29169.1 .
    CCDSi CCDS25584.1.
    RefSeqi NP_722477.1. NM_153782.1.
    UniGenei Mm.208662.

    3D structure databases

    ProteinModelPortali Q8CID3.
    SMRi Q8CID3. Positions 160-533.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8CID3.

    Proteomic databases

    PaxDbi Q8CID3.
    PRIDEi Q8CID3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020938 ; ENSMUSP00000020938 ; ENSMUSG00000020614 .
    ENSMUST00000155559 ; ENSMUSP00000116687 ; ENSMUSG00000020614 .
    GeneIDi 208659.
    KEGGi mmu:208659.
    UCSCi uc007mcw.1. mouse.

    Organism-specific databases

    CTDi 54757.
    MGIi MGI:2388266. Fam20a.

    Phylogenomic databases

    eggNOGi NOG238678.
    GeneTreei ENSGT00390000007484.
    HOGENOMi HOG000231437.
    HOVERGENi HBG051635.
    InParanoidi Q8CID3.
    OMAi HGLYSRS.
    OrthoDBi EOG7JX33T.
    PhylomeDBi Q8CID3.
    TreeFami TF313276.

    Miscellaneous databases

    NextBioi 372371.
    PROi Q8CID3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CID3.
    Genevestigatori Q8CID3.

    Family and domain databases

    InterProi IPR009581. DUF1193.
    IPR024869. FAM20.
    [Graphical view ]
    PANTHERi PTHR12450. PTHR12450. 1 hit.
    Pfami PF06702. DUF1193. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
    2. "FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells."
      Nalbant D., Youn H., Nalbant S.I., Sharma S., Cobos E., Beale E.G., Du Y., Williams S.C.
      BMC Genomics 6:11-11(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF 14-LEU-LEU-15.
    3. "Whole-exome sequencing identifies FAM20A mutations as a cause of amelogenesis imperfecta and gingival hyperplasia syndrome."
      O'Sullivan J., Bitu C.C., Daly S.B., Urquhart J.E., Barron M.J., Bhaskar S.S., Martelli-Junior H., dos Santos Neto P.E., Mansilla M.A., Murray J.C., Coletta R.D., Black G.C., Dixon M.J.
      Am. J. Hum. Genet. 88:616-620(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFA20A_MOUSE
    AccessioniPrimary (citable) accession number: Q8CID3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3