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Q8CID3 (FA20A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM20A
Gene names
Name:Fam20a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Ref.2.

Tissue specificity

Observed throughout the tissues of the mandibular incisor, including the secretory and maturation stage ameloblasts, the suprabasal layers of the gingival epithelium and the odontoblasts. Weak expression in the enamel matrix. Ref.3

Developmental stage

In EML and MPRO cell lines, low levels in undifferentiated cells. Induced during maturation to promyelocyte stage of neutrophil differentiation. Decreased during neutrophil terminal differentiation. Ref.2

Induction

By all-trans retinoic acid (atRA) and IL3 in EML cell line.

Post-translational modification

N-glycosylated. Ref.2

Sequence similarities

Belongs to the FAM20 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processenamel mineralization

Inferred from mutant phenotype PubMed 22732358. Source: MGI

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 23468644. Source: UniProt

cell

Inferred from direct assay Ref.3. Source: UniProt

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 541508Protein FAM20A
PRO_0000008744

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Glycosylation2871N-linked (GlcNAc...) Potential
Glycosylation3881N-linked (GlcNAc...) Potential
Glycosylation5381N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis14 – 152LL → DE: Not secreted; nuclear localization. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8CID3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2F6B2DCF9A447CDA

FASTA54161,526
        10         20         30         40         50         60 
MPGLRRDRLL ALLLLGALFS ADLYFHLWPQ VQRQLRPGER PAACPCSGRA PSASLHSAAA 

        70         80         90        100        110        120 
SRDLGTASHN FSGALPRVEH PSRGHPAPRS KLQALFAHSL YQVLEDPPLL GPEDWLLASQ 

       130        140        150        160        170        180 
EALRYYRRKV ARWNRRHKIY KEQFNLTSLD PPLQFRPEAS WVQFHLGINS HGLYSRSSLA 

       190        200        210        220        230        240 
ISKLLHDMRH FPTISADYSQ DEKALLGACD CSQIVKPSGV HLKLVLRFSD FGKAMFKPMR 

       250        260        270        280        290        300 
QQREEETPED FFYFIDFQRH NAEIAAFHLD RILDFRRVPP TVGRLVNVTK EILEVTKNEI 

       310        320        330        340        350        360 
LQSVFFVSPA NNVCFFAKCP YMCKTEYAVC GNPHLLEGSL SAFLPSLNLA PRLSVPNPWI 

       370        380        390        400        410        420 
RSYSLSGKEE WELNPLYCDT VKQIYPYNSS NRLLGIIDMA VFDFLIGNMD RHHYEMFTKF 

       430        440        450        460        470        480 
GDDGYLIHLD NARGFGRHSQ DEISILAPLA QCCMIKRKTL LHLQLLAQAD YRLSDVMRES 

       490        500        510        520        530        540 
LLEDQLSPVL TEPHLLALDR RLQIILKTVE DCIEAHGERR VIAEGSAQRS APDSGQANLT 


S 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
[2]"FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells."
Nalbant D., Youn H., Nalbant S.I., Sharma S., Cobos E., Beale E.G., Du Y., Williams S.C.
BMC Genomics 6:11-11(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF 14-LEU-LEU-15.
[3]"Whole-exome sequencing identifies FAM20A mutations as a cause of amelogenesis imperfecta and gingival hyperplasia syndrome."
O'Sullivan J., Bitu C.C., Daly S.B., Urquhart J.E., Barron M.J., Bhaskar S.S., Martelli-Junior H., dos Santos Neto P.E., Mansilla M.A., Murray J.C., Coletta R.D., Black G.C., Dixon M.J.
Am. J. Hum. Genet. 88:616-620(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC029169 mRNA. Translation: AAH29169.1.
CCDSCCDS25584.1.
RefSeqNP_722477.1. NM_153782.1.
UniGeneMm.208662.

3D structure databases

ProteinModelPortalQ8CID3.
SMRQ8CID3. Positions 160-533.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8CID3.

Proteomic databases

PaxDbQ8CID3.
PRIDEQ8CID3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020938; ENSMUSP00000020938; ENSMUSG00000020614.
ENSMUST00000155559; ENSMUSP00000116687; ENSMUSG00000020614.
GeneID208659.
KEGGmmu:208659.
UCSCuc007mcw.1. mouse.

Organism-specific databases

CTD54757.
MGIMGI:2388266. Fam20a.

Phylogenomic databases

eggNOGNOG238678.
GeneTreeENSGT00390000007484.
HOGENOMHOG000231437.
HOVERGENHBG051635.
InParanoidQ8CID3.
OMAHGLYSRS.
OrthoDBEOG7JX33T.
PhylomeDBQ8CID3.
TreeFamTF313276.

Gene expression databases

BgeeQ8CID3.
GenevestigatorQ8CID3.

Family and domain databases

InterProIPR009581. DUF1193.
IPR024869. FAM20.
[Graphical view]
PANTHERPTHR12450. PTHR12450. 1 hit.
PfamPF06702. DUF1193. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio372371.
PROQ8CID3.
SOURCESearch...

Entry information

Entry nameFA20A_MOUSE
AccessionPrimary (citable) accession number: Q8CID3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot