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Q8CID3

- FA20A_MOUSE

UniProt

Q8CID3 - FA20A_MOUSE

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Protein
Protein FAM20A
Gene
Fam20a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. enamel mineralization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM20A
Gene namesi
Name:Fam20a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2388266. Fam20a.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProt
  2. cell Source: UniProt
  3. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi14 – 152LL → DE: Not secreted; nuclear localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 541508Protein FAM20A
PRO_0000008744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi287 – 2871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi388 – 3881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8CID3.
PRIDEiQ8CID3.

PTM databases

PhosphoSiteiQ8CID3.

Expressioni

Tissue specificityi

Observed throughout the tissues of the mandibular incisor, including the secretory and maturation stage ameloblasts, the suprabasal layers of the gingival epithelium and the odontoblasts. Weak expression in the enamel matrix.1 Publication

Developmental stagei

In EML and MPRO cell lines, low levels in undifferentiated cells. Induced during maturation to promyelocyte stage of neutrophil differentiation. Decreased during neutrophil terminal differentiation.1 Publication

Inductioni

By all-trans retinoic acid (atRA) and IL3 in EML cell line.

Gene expression databases

BgeeiQ8CID3.
GenevestigatoriQ8CID3.

Structurei

3D structure databases

ProteinModelPortaliQ8CID3.
SMRiQ8CID3. Positions 160-533.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM20 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG238678.
GeneTreeiENSGT00390000007484.
HOGENOMiHOG000231437.
HOVERGENiHBG051635.
InParanoidiQ8CID3.
OMAiHGLYSRS.
OrthoDBiEOG7JX33T.
PhylomeDBiQ8CID3.
TreeFamiTF313276.

Family and domain databases

InterProiIPR009581. DUF1193.
IPR024869. FAM20.
[Graphical view]
PANTHERiPTHR12450. PTHR12450. 1 hit.
PfamiPF06702. DUF1193. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CID3-1 [UniParc]FASTAAdd to Basket

« Hide

MPGLRRDRLL ALLLLGALFS ADLYFHLWPQ VQRQLRPGER PAACPCSGRA    50
PSASLHSAAA SRDLGTASHN FSGALPRVEH PSRGHPAPRS KLQALFAHSL 100
YQVLEDPPLL GPEDWLLASQ EALRYYRRKV ARWNRRHKIY KEQFNLTSLD 150
PPLQFRPEAS WVQFHLGINS HGLYSRSSLA ISKLLHDMRH FPTISADYSQ 200
DEKALLGACD CSQIVKPSGV HLKLVLRFSD FGKAMFKPMR QQREEETPED 250
FFYFIDFQRH NAEIAAFHLD RILDFRRVPP TVGRLVNVTK EILEVTKNEI 300
LQSVFFVSPA NNVCFFAKCP YMCKTEYAVC GNPHLLEGSL SAFLPSLNLA 350
PRLSVPNPWI RSYSLSGKEE WELNPLYCDT VKQIYPYNSS NRLLGIIDMA 400
VFDFLIGNMD RHHYEMFTKF GDDGYLIHLD NARGFGRHSQ DEISILAPLA 450
QCCMIKRKTL LHLQLLAQAD YRLSDVMRES LLEDQLSPVL TEPHLLALDR 500
RLQIILKTVE DCIEAHGERR VIAEGSAQRS APDSGQANLT S 541
Length:541
Mass (Da):61,526
Last modified:March 1, 2003 - v1
Checksum:i2F6B2DCF9A447CDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC029169 mRNA. Translation: AAH29169.1.
CCDSiCCDS25584.1.
RefSeqiNP_722477.1. NM_153782.1.
UniGeneiMm.208662.

Genome annotation databases

EnsembliENSMUST00000020938; ENSMUSP00000020938; ENSMUSG00000020614.
ENSMUST00000155559; ENSMUSP00000116687; ENSMUSG00000020614.
GeneIDi208659.
KEGGimmu:208659.
UCSCiuc007mcw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC029169 mRNA. Translation: AAH29169.1 .
CCDSi CCDS25584.1.
RefSeqi NP_722477.1. NM_153782.1.
UniGenei Mm.208662.

3D structure databases

ProteinModelPortali Q8CID3.
SMRi Q8CID3. Positions 160-533.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8CID3.

Proteomic databases

PaxDbi Q8CID3.
PRIDEi Q8CID3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020938 ; ENSMUSP00000020938 ; ENSMUSG00000020614 .
ENSMUST00000155559 ; ENSMUSP00000116687 ; ENSMUSG00000020614 .
GeneIDi 208659.
KEGGi mmu:208659.
UCSCi uc007mcw.1. mouse.

Organism-specific databases

CTDi 54757.
MGIi MGI:2388266. Fam20a.

Phylogenomic databases

eggNOGi NOG238678.
GeneTreei ENSGT00390000007484.
HOGENOMi HOG000231437.
HOVERGENi HBG051635.
InParanoidi Q8CID3.
OMAi HGLYSRS.
OrthoDBi EOG7JX33T.
PhylomeDBi Q8CID3.
TreeFami TF313276.

Miscellaneous databases

NextBioi 372371.
PROi Q8CID3.
SOURCEi Search...

Gene expression databases

Bgeei Q8CID3.
Genevestigatori Q8CID3.

Family and domain databases

InterProi IPR009581. DUF1193.
IPR024869. FAM20.
[Graphical view ]
PANTHERi PTHR12450. PTHR12450. 1 hit.
Pfami PF06702. DUF1193. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
  2. "FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells."
    Nalbant D., Youn H., Nalbant S.I., Sharma S., Cobos E., Beale E.G., Du Y., Williams S.C.
    BMC Genomics 6:11-11(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF 14-LEU-LEU-15.
  3. "Whole-exome sequencing identifies FAM20A mutations as a cause of amelogenesis imperfecta and gingival hyperplasia syndrome."
    O'Sullivan J., Bitu C.C., Daly S.B., Urquhart J.E., Barron M.J., Bhaskar S.S., Martelli-Junior H., dos Santos Neto P.E., Mansilla M.A., Murray J.C., Coletta R.D., Black G.C., Dixon M.J.
    Am. J. Hum. Genet. 88:616-620(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFA20A_MOUSE
AccessioniPrimary (citable) accession number: Q8CID3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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