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Q8CID0

- CSR2B_MOUSE

UniProt

Q8CID0 - CSR2B_MOUSE

Protein

Cysteine-rich protein 2-binding protein

Gene

Csrp2bp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle By similarity.By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. G2/M transition of mitotic cell cycle Source: MGI
    2. histone acetylation Source: MGI
    3. histone H3 acetylation Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich protein 2-binding protein
    Short name:
    CSRP2-binding protein
    Alternative name(s):
    ADA2A-containing complex subunit 2
    Short name:
    ATAC2
    CRP2-binding partner
    Short name:
    CRP2BP
    Gene namesi
    Name:Csrp2bp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1917264. Csrp2bp.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Mainly nuclear.By similarity

    GO - Cellular componenti

    1. Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Early embryonic lethality. Severe growth retardation, increased apoptosis, and alterations in the cell cycle.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 779779Cysteine-rich protein 2-binding proteinPRO_0000304937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei230 – 2301N6-acetyllysine1 Publication
    Modified residuei291 – 2911N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ8CID0.

    PTM databases

    PhosphoSiteiQ8CID0.

    Expressioni

    Gene expression databases

    BgeeiQ8CID0.
    GenevestigatoriQ8CID0.

    Interactioni

    Subunit structurei

    Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.By similarity

    Protein-protein interaction databases

    BioGridi230756. 10 interactions.
    IntActiQ8CID0. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CID0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini635 – 779145N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG295186.
    GeneTreeiENSGT00390000001146.
    HOGENOMiHOG000230880.
    HOVERGENiHBG051142.
    InParanoidiQ8CID0.
    OMAiKEDICAF.
    OrthoDBiEOG7M6D6R.
    PhylomeDBiQ8CID0.
    TreeFamiTF324809.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CID0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSSIHLSGL LSRHDDDATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL    50
    SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN 100
    FFRFTCCDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE 150
    DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPVYFR SGAQEFGEPG 200
    WWKLVHNRPP TMRPEGEKLA ASTLKVKASK PTLDPIITVE GLRKRASRNP 250
    VESAMELKEK RSRTQEAKDI RRAQKEAAGL LDRSTSSTPV KFISRGRRPD 300
    LILEKGEVID FSSLSSSDRT PLTSPSPSPS LDFSAPGTPA SHSATPSLLS 350
    EADLIPDVMP PQALFHDDDE LEGDGVIDPG MEYIPPPAGS ASGLLGSRKK 400
    VRAPEQIKQE VDSEEEKPDR MDGDSEDTDS NISLHTRARE KRKPPLEKDM 450
    KPKGPRYTPV SIYEEKLLLK RLEACPGAVA MTPEARRLKR KLIVRQAKRD 500
    RGLPLFDLDE VVNAALLLVD GIYGAKDGGA SRLAAGQATY RTTCQDFRIL 550
    DRYQTALPAR KGFRHQTTRF LYRLVGSEDL AVDQSIISPY TSRILKPYIR 600
    RDYETKPPKL QLLSQIRSHL HRSDPHWTPG PDAPLDYCYV RPNHIPTINS 650
    MCQEFFWPGI DLSECLQYPD FSVVVLYKKV IVAFGFMVPD VKYNEAYISF 700
    LLVHPEWRRA GIATFMIYHL IQTCMGKDVT LHVSASNPAM LLYQKFGFKT 750
    EEYVLDFYDK YYPLESTECK HAFFLRLRR 779
    Length:779
    Mass (Da):88,217
    Last modified:October 2, 2007 - v2
    Checksum:i6750A26E6DF1B749
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti144 – 1441G → V in AAH31563. (PubMed:15489334)Curated
    Sequence conflicti497 – 4971A → L in AAH31563. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL808123 Genomic DNA. Translation: CAM26792.1.
    BC031563 mRNA. Translation: AAH31563.1.
    CCDSiCCDS16819.1.
    RefSeqiNP_852082.2. NM_181417.3.
    UniGeneiMm.227925.
    Mm.490976.

    Genome annotation databases

    EnsembliENSMUST00000028911; ENSMUSP00000028911; ENSMUSG00000027425.
    GeneIDi228714.
    KEGGimmu:228714.
    UCSCiuc008mqy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL808123 Genomic DNA. Translation: CAM26792.1 .
    BC031563 mRNA. Translation: AAH31563.1 .
    CCDSi CCDS16819.1.
    RefSeqi NP_852082.2. NM_181417.3.
    UniGenei Mm.227925.
    Mm.490976.

    3D structure databases

    ProteinModelPortali Q8CID0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230756. 10 interactions.
    IntActi Q8CID0. 2 interactions.

    PTM databases

    PhosphoSitei Q8CID0.

    Proteomic databases

    PRIDEi Q8CID0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028911 ; ENSMUSP00000028911 ; ENSMUSG00000027425 .
    GeneIDi 228714.
    KEGGi mmu:228714.
    UCSCi uc008mqy.2. mouse.

    Organism-specific databases

    CTDi 57325.
    MGIi MGI:1917264. Csrp2bp.

    Phylogenomic databases

    eggNOGi NOG295186.
    GeneTreei ENSGT00390000001146.
    HOGENOMi HOG000230880.
    HOVERGENi HBG051142.
    InParanoidi Q8CID0.
    OMAi KEDICAF.
    OrthoDBi EOG7M6D6R.
    PhylomeDBi Q8CID0.
    TreeFami TF324809.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    NextBioi 379084.
    PROi Q8CID0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CID0.
    Genevestigatori Q8CID0.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "The double-histone-acetyltransferase complex ATAC is essential for mammalian development."
      Guelman S., Kozuka K., Mao Y., Pham V., Solloway M.J., Wang J., Wu J., Lill J.R., Zha J.
      Mol. Cell. Biol. 29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-230 AND LYS-291, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiCSR2B_MOUSE
    AccessioniPrimary (citable) accession number: Q8CID0
    Secondary accession number(s): A2ANA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3