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Protein

Cysteine-rich protein 2-binding protein

Gene

Kat14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • G2/M transition of mitotic cell cycle Source: MGI
  • histone acetylation Source: MGI
  • histone H3 acetylation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2-binding protein
Short name:
CSRP2-binding protein
Alternative name(s):
ADA2A-containing complex subunit 2
Short name:
ATAC2
CRP2-binding partner
Short name:
CRP2BP
Lysine acetyltransferase 14By similarity
Gene namesi
Name:Kat14By similarity
Synonyms:Csrp2bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1917264 Kat14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Early embryonic lethality. Severe growth retardation, increased apoptosis, and alterations in the cell cycle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049371 – 779Cysteine-rich protein 2-binding proteinAdd BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei230N6-acetyllysineCombined sources1
Modified residuei284PhosphoserineBy similarity1
Modified residuei291N6-acetyllysineCombined sources1
Modified residuei413PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8CID0
PaxDbiQ8CID0
PRIDEiQ8CID0

PTM databases

iPTMnetiQ8CID0
PhosphoSitePlusiQ8CID0

Expressioni

Gene expression databases

BgeeiENSMUSG00000027425
ExpressionAtlasiQ8CID0 baseline and differential
GenevisibleiQ8CID0 MM

Interactioni

Subunit structurei

Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.By similarity

Protein-protein interaction databases

BioGridi230756, 9 interactors
ComplexPortaliCPX-1025 GCN5-containing ATAC complex
CPX-1029 PCAF-containing ATAC complex
IntActiQ8CID0, 2 interactors
MINTiQ8CID0
STRINGi10090.ENSMUSP00000028911

Structurei

3D structure databases

ProteinModelPortaliQ8CID0
SMRiQ8CID0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini635 – 779N-acetyltransferasePROSITE-ProRule annotationAdd BLAST145

Phylogenomic databases

eggNOGiENOG410IQJZ Eukaryota
ENOG410Y6C7 LUCA
GeneTreeiENSGT00390000001146
HOGENOMiHOG000230880
HOVERGENiHBG051142
InParanoidiQ8CID0
OMAiTWWSTVA
OrthoDBiEOG091G0CJX
PhylomeDBiQ8CID0
TreeFamiTF324809

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR037829 KAT14
PANTHERiPTHR20916:SF0 PTHR20916:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CID0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSIHLSGL LSRHDDDATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL
60 70 80 90 100
SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN
110 120 130 140 150
FFRFTCCDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE
160 170 180 190 200
DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPVYFR SGAQEFGEPG
210 220 230 240 250
WWKLVHNRPP TMRPEGEKLA ASTLKVKASK PTLDPIITVE GLRKRASRNP
260 270 280 290 300
VESAMELKEK RSRTQEAKDI RRAQKEAAGL LDRSTSSTPV KFISRGRRPD
310 320 330 340 350
LILEKGEVID FSSLSSSDRT PLTSPSPSPS LDFSAPGTPA SHSATPSLLS
360 370 380 390 400
EADLIPDVMP PQALFHDDDE LEGDGVIDPG MEYIPPPAGS ASGLLGSRKK
410 420 430 440 450
VRAPEQIKQE VDSEEEKPDR MDGDSEDTDS NISLHTRARE KRKPPLEKDM
460 470 480 490 500
KPKGPRYTPV SIYEEKLLLK RLEACPGAVA MTPEARRLKR KLIVRQAKRD
510 520 530 540 550
RGLPLFDLDE VVNAALLLVD GIYGAKDGGA SRLAAGQATY RTTCQDFRIL
560 570 580 590 600
DRYQTALPAR KGFRHQTTRF LYRLVGSEDL AVDQSIISPY TSRILKPYIR
610 620 630 640 650
RDYETKPPKL QLLSQIRSHL HRSDPHWTPG PDAPLDYCYV RPNHIPTINS
660 670 680 690 700
MCQEFFWPGI DLSECLQYPD FSVVVLYKKV IVAFGFMVPD VKYNEAYISF
710 720 730 740 750
LLVHPEWRRA GIATFMIYHL IQTCMGKDVT LHVSASNPAM LLYQKFGFKT
760 770
EEYVLDFYDK YYPLESTECK HAFFLRLRR
Length:779
Mass (Da):88,217
Last modified:October 2, 2007 - v2
Checksum:i6750A26E6DF1B749
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144G → V in AAH31563 (PubMed:15489334).Curated1
Sequence conflicti497A → L in AAH31563 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808123 Genomic DNA No translation available.
BC031563 mRNA Translation: AAH31563.1
CCDSiCCDS16819.1
RefSeqiNP_852082.2, NM_181417.3
UniGeneiMm.227925
Mm.490976

Genome annotation databases

EnsembliENSMUST00000028911; ENSMUSP00000028911; ENSMUSG00000027425
GeneIDi228714
KEGGimmu:228714
UCSCiuc008mqy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCSR2B_MOUSE
AccessioniPrimary (citable) accession number: Q8CID0
Secondary accession number(s): A2ANA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 20, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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