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Q8CID0

- CSR2B_MOUSE

UniProt

Q8CID0 - CSR2B_MOUSE

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Protein

Cysteine-rich protein 2-binding protein

Gene

Csrp2bp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (By similarity).By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: MGI

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: MGI
  2. histone acetylation Source: MGI
  3. histone H3 acetylation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_226917. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2-binding protein
Short name:
CSRP2-binding protein
Alternative name(s):
ADA2A-containing complex subunit 2
Short name:
ATAC2
CRP2-binding partner
Short name:
CRP2BP
Gene namesi
Name:Csrp2bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1917264. Csrp2bp.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Mainly nuclear.By similarity

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
  2. cytoplasm Source: UniProtKB-KW
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Early embryonic lethality. Severe growth retardation, increased apoptosis, and alterations in the cell cycle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Cysteine-rich protein 2-binding proteinPRO_0000304937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei230 – 2301N6-acetyllysine1 Publication
Modified residuei291 – 2911N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ8CID0.

PTM databases

PhosphoSiteiQ8CID0.

Expressioni

Gene expression databases

BgeeiQ8CID0.
ExpressionAtlasiQ8CID0. baseline and differential.
GenevestigatoriQ8CID0.

Interactioni

Subunit structurei

Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.By similarity

Protein-protein interaction databases

BioGridi230756. 10 interactions.
IntActiQ8CID0. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8CID0.
SMRiQ8CID0. Positions 664-755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini635 – 779145N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG295186.
GeneTreeiENSGT00390000001146.
HOGENOMiHOG000230880.
HOVERGENiHBG051142.
InParanoidiQ8CID0.
OMAiKEDICAF.
OrthoDBiEOG7M6D6R.
PhylomeDBiQ8CID0.
TreeFamiTF324809.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CID0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSSIHLSGL LSRHDDDATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL
60 70 80 90 100
SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN
110 120 130 140 150
FFRFTCCDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE
160 170 180 190 200
DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPVYFR SGAQEFGEPG
210 220 230 240 250
WWKLVHNRPP TMRPEGEKLA ASTLKVKASK PTLDPIITVE GLRKRASRNP
260 270 280 290 300
VESAMELKEK RSRTQEAKDI RRAQKEAAGL LDRSTSSTPV KFISRGRRPD
310 320 330 340 350
LILEKGEVID FSSLSSSDRT PLTSPSPSPS LDFSAPGTPA SHSATPSLLS
360 370 380 390 400
EADLIPDVMP PQALFHDDDE LEGDGVIDPG MEYIPPPAGS ASGLLGSRKK
410 420 430 440 450
VRAPEQIKQE VDSEEEKPDR MDGDSEDTDS NISLHTRARE KRKPPLEKDM
460 470 480 490 500
KPKGPRYTPV SIYEEKLLLK RLEACPGAVA MTPEARRLKR KLIVRQAKRD
510 520 530 540 550
RGLPLFDLDE VVNAALLLVD GIYGAKDGGA SRLAAGQATY RTTCQDFRIL
560 570 580 590 600
DRYQTALPAR KGFRHQTTRF LYRLVGSEDL AVDQSIISPY TSRILKPYIR
610 620 630 640 650
RDYETKPPKL QLLSQIRSHL HRSDPHWTPG PDAPLDYCYV RPNHIPTINS
660 670 680 690 700
MCQEFFWPGI DLSECLQYPD FSVVVLYKKV IVAFGFMVPD VKYNEAYISF
710 720 730 740 750
LLVHPEWRRA GIATFMIYHL IQTCMGKDVT LHVSASNPAM LLYQKFGFKT
760 770
EEYVLDFYDK YYPLESTECK HAFFLRLRR
Length:779
Mass (Da):88,217
Last modified:October 2, 2007 - v2
Checksum:i6750A26E6DF1B749
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441G → V in AAH31563. (PubMed:15489334)Curated
Sequence conflicti497 – 4971A → L in AAH31563. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL808123 Genomic DNA. Translation: CAM26792.1.
BC031563 mRNA. Translation: AAH31563.1.
CCDSiCCDS16819.1.
RefSeqiNP_852082.2. NM_181417.3.
UniGeneiMm.227925.
Mm.490976.

Genome annotation databases

EnsembliENSMUST00000028911; ENSMUSP00000028911; ENSMUSG00000027425.
GeneIDi228714.
KEGGimmu:228714.
UCSCiuc008mqy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL808123 Genomic DNA. Translation: CAM26792.1 .
BC031563 mRNA. Translation: AAH31563.1 .
CCDSi CCDS16819.1.
RefSeqi NP_852082.2. NM_181417.3.
UniGenei Mm.227925.
Mm.490976.

3D structure databases

ProteinModelPortali Q8CID0.
SMRi Q8CID0. Positions 664-755.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230756. 10 interactions.
IntActi Q8CID0. 2 interactions.

PTM databases

PhosphoSitei Q8CID0.

Proteomic databases

PRIDEi Q8CID0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028911 ; ENSMUSP00000028911 ; ENSMUSG00000027425 .
GeneIDi 228714.
KEGGi mmu:228714.
UCSCi uc008mqy.2. mouse.

Organism-specific databases

CTDi 57325.
MGIi MGI:1917264. Csrp2bp.

Phylogenomic databases

eggNOGi NOG295186.
GeneTreei ENSGT00390000001146.
HOGENOMi HOG000230880.
HOVERGENi HBG051142.
InParanoidi Q8CID0.
OMAi KEDICAF.
OrthoDBi EOG7M6D6R.
PhylomeDBi Q8CID0.
TreeFami TF324809.

Enzyme and pathway databases

Reactomei REACT_226917. HATs acetylate histones.

Miscellaneous databases

NextBioi 379084.
PROi Q8CID0.
SOURCEi Search...

Gene expression databases

Bgeei Q8CID0.
ExpressionAtlasi Q8CID0. baseline and differential.
Genevestigatori Q8CID0.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "The double-histone-acetyltransferase complex ATAC is essential for mammalian development."
    Guelman S., Kozuka K., Mao Y., Pham V., Solloway M.J., Wang J., Wu J., Lill J.R., Zha J.
    Mol. Cell. Biol. 29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-230 AND LYS-291, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCSR2B_MOUSE
AccessioniPrimary (citable) accession number: Q8CID0
Secondary accession number(s): A2ANA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3