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Protein

Nucleoporin-like protein 2

Gene

Nupl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 25C3H1-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin-like protein 2
Alternative name(s):
NLP-1
Gene namesi
Name:Nupl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2387631. Nupl2.

Subcellular locationi

  • Nucleusnuclear pore complex By similarity
  • Nucleus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

  • Note: Excluded from the nucleolus.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nuclear membrane Source: UniProtKB-SubCell
  • nuclear pore Source: UniProtKB-SubCell
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • photoreceptor outer segment Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048961 – 420Nucleoporin-like protein 2Add BLAST420

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8CIC2.
PaxDbiQ8CIC2.
PeptideAtlasiQ8CIC2.
PRIDEiQ8CIC2.

PTM databases

iPTMnetiQ8CIC2.
PhosphoSitePlusiQ8CIC2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048439.
CleanExiMM_NUPL2.

Interactioni

Subunit structurei

Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1. Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062766.

Structurei

3D structure databases

ProteinModelPortaliQ8CIC2.
SMRiQ8CIC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 15FG 12
Repeati82 – 83FG 22
Repeati95 – 96FG 32
Repeati218 – 219FG 42
Repeati220 – 221FG 52
Repeati228 – 229FG 62
Repeati265 – 266FG 72
Repeati271 – 272FG 82
Repeati288 – 289FG 92
Repeati345 – 346FG 102
Repeati364 – 365FG 112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni365 – 420Interaction with GLE1By similarityAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 376Ser-richAdd BLAST139

Domaini

The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.By similarity

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 25C3H1-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIH3. Eukaryota.
ENOG4111HKJ. LUCA.
HOGENOMiHOG000113895.
HOVERGENiHBG082070.
InParanoidiQ8CIC2.
KOiK14321.
PhylomeDBiQ8CIC2.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CIC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTICQFFLQG RCRFGDRCWN EHPGARGAGG ARQPPPQQQP PSGNNRRGWN
60 70 80 90 100
ASSQRYSNVI QPSSFPKSTP WGGSRDQDKP PFGSFDSGAS TSRGFGSSQN
110 120 130 140 150
PFASPLSDEQ KDEKKLLEGI VKDVEVWESS GQWMFSVYSP VRKKPNISGF
160 170 180 190 200
TDISPEELRL EYHNFLTSNN LQSYLNSVQQ LVSQWRNRIN ELKNLTMSTK
210 220 230 240 250
GALLSDVKDG VSQAVPAFGF GSKQAGSFGS PGFPVNNSSS STVQNFSFKT
260 270 280 290 300
SPGLATPPSG STSVFGSHPA FGAGPSAGSS ISSSTPAFGL GKPEATSAAS
310 320 330 340 350
FSFKSPEASS FASPGFSGFP ASMAASPSGS TTAPPLRSGS SVVGFGSPSP
360 370 380 390 400
HSQAVFAKPS TDVFGGSGIS TSVLASGAAD NALFTPRDQL MKEELEQFQS
410 420
QRFTLGKIPL KPPPVELLTV
Length:420
Mass (Da):44,337
Last modified:March 1, 2003 - v1
Checksum:iFE2CDDBD6F17492A
GO
Isoform 2 (identifier: Q8CIC2-2) [UniParc]FASTAAdd to basket
Also known as: T

The sequence of this isoform differs from the canonical sequence as follows:
     149-160: GFTDISPEELRL → AKLCSTACKSVE
     161-420: Missing.

Show »
Length:160
Mass (Da):17,619
Checksum:i5B12FDA0D213D7B3
GO

Sequence cautioni

The sequence BAC36589 differs from that shown. Reason: Frameshift at position 227.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137V → A in BAC36589 (PubMed:16141072).Curated1
Sequence conflicti142R → G in BAC36589 (PubMed:16141072).Curated1
Sequence conflicti308A → G in BAC36589 (PubMed:16141072).Curated1
Sequence conflicti308A → G in BAC37297 (PubMed:16141072).Curated1
Sequence conflicti343V → A in BAC36589 (PubMed:16141072).Curated1
Sequence conflicti343V → A in BAC37297 (PubMed:16141072).Curated1
Sequence conflicti375A → T in BAC37297 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016483149 – 160GFTDI…EELRL → AKLCSTACKSVE in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_016484161 – 420Missing in isoform 2. 1 PublicationAdd BLAST260

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067574 mRNA. Translation: BAB62307.1.
AK077066 mRNA. Translation: BAC36589.1. Frameshift.
AK078478 mRNA. Translation: BAC37297.1.
BC033270 mRNA. Translation: AAH33270.1.
CCDSiCCDS19115.1. [Q8CIC2-1]
RefSeqiNP_694732.3. NM_153092.4.
UniGeneiMm.45513.

Genome annotation databases

GeneIDi231042.
KEGGimmu:231042.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067574 mRNA. Translation: BAB62307.1.
AK077066 mRNA. Translation: BAC36589.1. Frameshift.
AK078478 mRNA. Translation: BAC37297.1.
BC033270 mRNA. Translation: AAH33270.1.
CCDSiCCDS19115.1. [Q8CIC2-1]
RefSeqiNP_694732.3. NM_153092.4.
UniGeneiMm.45513.

3D structure databases

ProteinModelPortaliQ8CIC2.
SMRiQ8CIC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062766.

PTM databases

iPTMnetiQ8CIC2.
PhosphoSitePlusiQ8CIC2.

Proteomic databases

EPDiQ8CIC2.
PaxDbiQ8CIC2.
PeptideAtlasiQ8CIC2.
PRIDEiQ8CIC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi231042.
KEGGimmu:231042.

Organism-specific databases

CTDi11097.
MGIiMGI:2387631. Nupl2.

Phylogenomic databases

eggNOGiENOG410IIH3. Eukaryota.
ENOG4111HKJ. LUCA.
HOGENOMiHOG000113895.
HOVERGENiHBG082070.
InParanoidiQ8CIC2.
KOiK14321.
PhylomeDBiQ8CIC2.

Miscellaneous databases

ChiTaRSiNupl2. mouse.
PROiQ8CIC2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048439.
CleanExiMM_NUPL2.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUPL2_MOUSE
AccessioniPrimary (citable) accession number: Q8CIC2
Secondary accession number(s): Q8BJX3, Q8BVP7, Q924S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.