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Q8CIA5 (S35B4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-xylose and UDP-N-acetylglucosamine transporter
Alternative name(s):
Solute carrier family 35 member B4
Gene names
Name:Slc35b4
ORF Names:MNCb-4414
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi By similarity.

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8CIA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8CIA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331UDP-xylose and UDP-N-acetylglucosamine transporter
PRO_0000213387

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane30 – 5021Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane124 – 14421Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane251 – 26717Helical; Potential
Transmembrane268 – 28821Helical; Potential
Transmembrane294 – 31421Helical; Potential

Natural variations

Alternative sequence1 – 172172Missing in isoform 2.
VSP_016203

Experimental info

Sequence conflict2381V → I in AAH33512. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: 72AA645C083C8BDA

FASTA33137,517
        10         20         30         40         50         60 
MRPAFAVGLV FAGCCSNVIF LELLARTHPG CGNIVTFAQF LFIAVEGFLF EANLGRKPPA 

        70         80         90        100        110        120 
IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS LIANMILGII ILKKRYSMFK 

       130        140        150        160        170        180 
YTSIALVSAG IFICTFMSAK QVTVQTGLSD KDGFQAFAWW LLGIAALTFA LLMSARMGIF 

       190        200        210        220        230        240 
QETLYRQFGK HSKEALFYNH ALPLPGFIFL ASDIYDHVVL FNKSELYQVP VIGVTMPVMW 

       250        260        270        280        290        300 
FYLLMNVVTQ YVCIRGVFIL TTECTSLTVT LVVTLRKFVS LIFSILYFQN QFTMWHWLGT 

       310        320        330 
SFVFIGTLMY TEVWKNLGTT KSELQKDDKK D 

« Hide

Isoform 2 [UniParc].

Checksum: A968BCF564E771D3
Show »

FASTA15918,582

References

[1]"Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Diencephalon, Egg, Spinal cord, Testis and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB041549 mRNA. Translation: BAA95034.1.
AK029969 mRNA. Translation: BAC26707.1.
AK033913 mRNA. Translation: BAC28512.1.
AK042150 mRNA. Translation: BAC31186.1.
AK138591 mRNA. Translation: BAE23707.1.
AK163299 mRNA. Translation: BAE37285.1.
BC033512 mRNA. Translation: AAH33512.1.
CCDSCCDS19989.1. [Q8CIA5-1]
RefSeqNP_067410.1. NM_021435.3. [Q8CIA5-1]
UniGeneMm.245527.

3D structure databases

ProteinModelPortalQ8CIA5.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8CIA5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019143; ENSMUSP00000019143; ENSMUSG00000018999. [Q8CIA5-1]
GeneID58246.
KEGGmmu:58246.
UCSCuc009bgw.1. mouse. [Q8CIA5-2]
uc009bgx.1. mouse. [Q8CIA5-1]

Organism-specific databases

CTD84912.
MGIMGI:1931249. Slc35b4.

Phylogenomic databases

eggNOGNOG250393.
GeneTreeENSGT00390000002915.
HOGENOMHOG000234632.
HOVERGENHBG093926.
InParanoidQ8CIA5.
KOK15278.
OMAPIRYYAV.
OrthoDBEOG7WX08P.
PhylomeDBQ8CIA5.
TreeFamTF312926.

Gene expression databases

BgeeQ8CIA5.
CleanExMM_SLC35B4.
GenevestigatorQ8CIA5.

Family and domain databases

InterProIPR013657. UAA.
[Graphical view]
PfamPF08449. UAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio314305.
PROQ8CIA5.
SOURCESearch...

Entry information

Entry nameS35B4_MOUSE
AccessionPrimary (citable) accession number: Q8CIA5
Secondary accession number(s): Q3TQU7, Q5U681, Q9JJF7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot