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Q8CIA5

- S35B4_MOUSE

UniProt

Q8CIA5 - S35B4_MOUSE

Protein

UDP-xylose and UDP-N-acetylglucosamine transporter

Gene

Slc35b4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.By similarity

    GO - Molecular functioni

    1. UDP-N-acetylglucosamine transmembrane transporter activity Source: Ensembl
    2. UDP-xylose transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. carbohydrate transport Source: UniProtKB-KW
    2. regulation of gluconeogenesis Source: MGI

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_203051. Transport of nucleotide sugars.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-xylose and UDP-N-acetylglucosamine transporter
    Alternative name(s):
    Solute carrier family 35 member B4
    Gene namesi
    Name:Slc35b4
    ORF Names:MNCb-4414
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1931249. Slc35b4.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331UDP-xylose and UDP-N-acetylglucosamine transporterPRO_0000213387Add
    BLAST

    Proteomic databases

    PRIDEiQ8CIA5.

    Expressioni

    Gene expression databases

    BgeeiQ8CIA5.
    CleanExiMM_SLC35B4.
    GenevestigatoriQ8CIA5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CIA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 26717HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG250393.
    GeneTreeiENSGT00390000002915.
    HOGENOMiHOG000234632.
    HOVERGENiHBG093926.
    InParanoidiQ8CIA5.
    KOiK15278.
    OMAiPIRYYAV.
    OrthoDBiEOG7WX08P.
    PhylomeDBiQ8CIA5.
    TreeFamiTF312926.

    Family and domain databases

    InterProiIPR013657. UAA.
    [Graphical view]
    PfamiPF08449. UAA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CIA5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRPAFAVGLV FAGCCSNVIF LELLARTHPG CGNIVTFAQF LFIAVEGFLF    50
    EANLGRKPPA IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS 100
    LIANMILGII ILKKRYSMFK YTSIALVSAG IFICTFMSAK QVTVQTGLSD 150
    KDGFQAFAWW LLGIAALTFA LLMSARMGIF QETLYRQFGK HSKEALFYNH 200
    ALPLPGFIFL ASDIYDHVVL FNKSELYQVP VIGVTMPVMW FYLLMNVVTQ 250
    YVCIRGVFIL TTECTSLTVT LVVTLRKFVS LIFSILYFQN QFTMWHWLGT 300
    SFVFIGTLMY TEVWKNLGTT KSELQKDDKK D 331
    Length:331
    Mass (Da):37,517
    Last modified:November 22, 2005 - v2
    Checksum:i72AA645C083C8BDA
    GO
    Isoform 2 (identifier: Q8CIA5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-172: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:159
    Mass (Da):18,582
    Checksum:iA968BCF564E771D3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti238 – 2381V → I in AAH33512. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 172172Missing in isoform 2. 1 PublicationVSP_016203Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041549 mRNA. Translation: BAA95034.1.
    AK029969 mRNA. Translation: BAC26707.1.
    AK033913 mRNA. Translation: BAC28512.1.
    AK042150 mRNA. Translation: BAC31186.1.
    AK138591 mRNA. Translation: BAE23707.1.
    AK163299 mRNA. Translation: BAE37285.1.
    BC033512 mRNA. Translation: AAH33512.1.
    CCDSiCCDS19989.1. [Q8CIA5-1]
    RefSeqiNP_067410.1. NM_021435.3. [Q8CIA5-1]
    UniGeneiMm.245527.

    Genome annotation databases

    EnsembliENSMUST00000019143; ENSMUSP00000019143; ENSMUSG00000018999. [Q8CIA5-1]
    GeneIDi58246.
    KEGGimmu:58246.
    UCSCiuc009bgw.1. mouse. [Q8CIA5-2]
    uc009bgx.1. mouse. [Q8CIA5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041549 mRNA. Translation: BAA95034.1 .
    AK029969 mRNA. Translation: BAC26707.1 .
    AK033913 mRNA. Translation: BAC28512.1 .
    AK042150 mRNA. Translation: BAC31186.1 .
    AK138591 mRNA. Translation: BAE23707.1 .
    AK163299 mRNA. Translation: BAE37285.1 .
    BC033512 mRNA. Translation: AAH33512.1 .
    CCDSi CCDS19989.1. [Q8CIA5-1 ]
    RefSeqi NP_067410.1. NM_021435.3. [Q8CIA5-1 ]
    UniGenei Mm.245527.

    3D structure databases

    ProteinModelPortali Q8CIA5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8CIA5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019143 ; ENSMUSP00000019143 ; ENSMUSG00000018999 . [Q8CIA5-1 ]
    GeneIDi 58246.
    KEGGi mmu:58246.
    UCSCi uc009bgw.1. mouse. [Q8CIA5-2 ]
    uc009bgx.1. mouse. [Q8CIA5-1 ]

    Organism-specific databases

    CTDi 84912.
    MGIi MGI:1931249. Slc35b4.

    Phylogenomic databases

    eggNOGi NOG250393.
    GeneTreei ENSGT00390000002915.
    HOGENOMi HOG000234632.
    HOVERGENi HBG093926.
    InParanoidi Q8CIA5.
    KOi K15278.
    OMAi PIRYYAV.
    OrthoDBi EOG7WX08P.
    PhylomeDBi Q8CIA5.
    TreeFami TF312926.

    Enzyme and pathway databases

    Reactomei REACT_203051. Transport of nucleotide sugars.

    Miscellaneous databases

    NextBioi 314305.
    PROi Q8CIA5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8CIA5.
    CleanExi MM_SLC35B4.
    Genevestigatori Q8CIA5.

    Family and domain databases

    InterProi IPR013657. UAA.
    [Graphical view ]
    Pfami PF08449. UAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
      Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Diencephalon, Egg, Spinal cord, Testis and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiS35B4_MOUSE
    AccessioniPrimary (citable) accession number: Q8CIA5
    Secondary accession number(s): Q3TQU7, Q5U681, Q9JJF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3