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Q8CIA5

- S35B4_MOUSE

UniProt

Q8CIA5 - S35B4_MOUSE

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Protein

UDP-xylose and UDP-N-acetylglucosamine transporter

Gene

Slc35b4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.By similarity

GO - Molecular functioni

  1. UDP-N-acetylglucosamine transmembrane transporter activity Source: Ensembl
  2. UDP-xylose transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
  2. regulation of gluconeogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_203051. Transport of nucleotide sugars.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-xylose and UDP-N-acetylglucosamine transporter
Alternative name(s):
Solute carrier family 35 member B4
Gene namesi
Name:Slc35b4
ORF Names:MNCb-4414
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1931249. Slc35b4.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331UDP-xylose and UDP-N-acetylglucosamine transporterPRO_0000213387Add
BLAST

Proteomic databases

PRIDEiQ8CIA5.

Expressioni

Gene expression databases

BgeeiQ8CIA5.
CleanExiMM_SLC35B4.
ExpressionAtlasiQ8CIA5. baseline and differential.
GenevestigatoriQ8CIA5.

Structurei

3D structure databases

ProteinModelPortaliQ8CIA5.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei251 – 26717HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250393.
GeneTreeiENSGT00390000002915.
HOGENOMiHOG000234632.
HOVERGENiHBG093926.
InParanoidiQ8CIA5.
KOiK15278.
OMAiPIRYYAV.
OrthoDBiEOG7WX08P.
PhylomeDBiQ8CIA5.
TreeFamiTF312926.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8CIA5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPAFAVGLV FAGCCSNVIF LELLARTHPG CGNIVTFAQF LFIAVEGFLF
60 70 80 90 100
EANLGRKPPA IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS
110 120 130 140 150
LIANMILGII ILKKRYSMFK YTSIALVSAG IFICTFMSAK QVTVQTGLSD
160 170 180 190 200
KDGFQAFAWW LLGIAALTFA LLMSARMGIF QETLYRQFGK HSKEALFYNH
210 220 230 240 250
ALPLPGFIFL ASDIYDHVVL FNKSELYQVP VIGVTMPVMW FYLLMNVVTQ
260 270 280 290 300
YVCIRGVFIL TTECTSLTVT LVVTLRKFVS LIFSILYFQN QFTMWHWLGT
310 320 330
SFVFIGTLMY TEVWKNLGTT KSELQKDDKK D
Length:331
Mass (Da):37,517
Last modified:November 22, 2005 - v2
Checksum:i72AA645C083C8BDA
GO
Isoform 2 (identifier: Q8CIA5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Note: No experimental confirmation available.

Show »
Length:159
Mass (Da):18,582
Checksum:iA968BCF564E771D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381V → I in AAH33512. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 172172Missing in isoform 2. 1 PublicationVSP_016203Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041549 mRNA. Translation: BAA95034.1.
AK029969 mRNA. Translation: BAC26707.1.
AK033913 mRNA. Translation: BAC28512.1.
AK042150 mRNA. Translation: BAC31186.1.
AK138591 mRNA. Translation: BAE23707.1.
AK163299 mRNA. Translation: BAE37285.1.
BC033512 mRNA. Translation: AAH33512.1.
CCDSiCCDS19989.1. [Q8CIA5-1]
RefSeqiNP_067410.1. NM_021435.3. [Q8CIA5-1]
UniGeneiMm.245527.

Genome annotation databases

EnsembliENSMUST00000019143; ENSMUSP00000019143; ENSMUSG00000018999. [Q8CIA5-1]
GeneIDi58246.
KEGGimmu:58246.
UCSCiuc009bgw.1. mouse. [Q8CIA5-2]
uc009bgx.1. mouse. [Q8CIA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041549 mRNA. Translation: BAA95034.1 .
AK029969 mRNA. Translation: BAC26707.1 .
AK033913 mRNA. Translation: BAC28512.1 .
AK042150 mRNA. Translation: BAC31186.1 .
AK138591 mRNA. Translation: BAE23707.1 .
AK163299 mRNA. Translation: BAE37285.1 .
BC033512 mRNA. Translation: AAH33512.1 .
CCDSi CCDS19989.1. [Q8CIA5-1 ]
RefSeqi NP_067410.1. NM_021435.3. [Q8CIA5-1 ]
UniGenei Mm.245527.

3D structure databases

ProteinModelPortali Q8CIA5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8CIA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019143 ; ENSMUSP00000019143 ; ENSMUSG00000018999 . [Q8CIA5-1 ]
GeneIDi 58246.
KEGGi mmu:58246.
UCSCi uc009bgw.1. mouse. [Q8CIA5-2 ]
uc009bgx.1. mouse. [Q8CIA5-1 ]

Organism-specific databases

CTDi 84912.
MGIi MGI:1931249. Slc35b4.

Phylogenomic databases

eggNOGi NOG250393.
GeneTreei ENSGT00390000002915.
HOGENOMi HOG000234632.
HOVERGENi HBG093926.
InParanoidi Q8CIA5.
KOi K15278.
OMAi PIRYYAV.
OrthoDBi EOG7WX08P.
PhylomeDBi Q8CIA5.
TreeFami TF312926.

Enzyme and pathway databases

Reactomei REACT_203051. Transport of nucleotide sugars.

Miscellaneous databases

NextBioi 314305.
PROi Q8CIA5.
SOURCEi Search...

Gene expression databases

Bgeei Q8CIA5.
CleanExi MM_SLC35B4.
ExpressionAtlasi Q8CIA5. baseline and differential.
Genevestigatori Q8CIA5.

Family and domain databases

InterProi IPR013657. UAA.
[Graphical view ]
Pfami PF08449. UAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Diencephalon, Egg, Spinal cord, Testis and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS35B4_MOUSE
AccessioniPrimary (citable) accession number: Q8CIA5
Secondary accession number(s): Q3TQU7, Q5U681, Q9JJF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3