Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CAP-Gly domain-containing linker protein 4

Gene

Clip4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 4
Alternative name(s):
Restin-like protein 2
Gene namesi
Name:Clip4
Synonyms:Rsnl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1919100. Clip4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835301 – 704CAP-Gly domain-containing linker protein 4Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei556PhosphoserineBy similarity1
Modified residuei608PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8CI96.
PRIDEiQ8CI96.

PTM databases

iPTMnetiQ8CI96.
PhosphoSitePlusiQ8CI96.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024059.
GenevisibleiQ8CI96. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024854.

Structurei

Secondary structure

1704
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi268 – 270Combined sources3
Beta strandi273 – 275Combined sources3
Helixi278 – 281Combined sources4
Beta strandi288 – 291Combined sources4
Turni292 – 294Combined sources3
Beta strandi295 – 304Combined sources10
Beta strandi306 – 308Combined sources3
Beta strandi310 – 320Combined sources11
Beta strandi323 – 328Combined sources6
Turni338 – 340Combined sources3
Beta strandi341 – 345Combined sources5
Helixi346 – 348Combined sources3
Beta strandi349 – 354Combined sources6
Beta strandi627 – 633Combined sources7
Beta strandi636 – 639Combined sources4
Beta strandi646 – 656Combined sources11
Beta strandi658 – 660Combined sources3
Beta strandi666 – 668Combined sources3
Helixi686 – 688Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WHJNMR-A266-354[»]
1WHKNMR-A617-694[»]
ProteinModelPortaliQ8CI96.
SMRiQ8CI96.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CI96.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati65 – 101ANK 1Add BLAST37
Repeati149 – 180ANK 2Add BLAST32
Repeati186 – 215ANK 3Add BLAST30
Domaini303 – 345CAP-Gly 1PROSITE-ProRule annotationAdd BLAST43
Domaini504 – 546CAP-Gly 2PROSITE-ProRule annotationAdd BLAST43
Domaini643 – 685CAP-Gly 3PROSITE-ProRule annotationAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi423 – 473Ser-richAdd BLAST51

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 3 CAP-Gly domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0241. Eukaryota.
KOG4568. Eukaryota.
COG5244. LUCA.
GeneTreeiENSGT00760000119173.
HOGENOMiHOG000007206.
HOVERGENiHBG057079.
InParanoidiQ8CI96.
KOiK10423.
OMAiILKRGCN.
OrthoDBiEOG091G04NK.
PhylomeDBiQ8CI96.
TreeFamiTF326096.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.30.190. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000938. CAP-Gly_domain.
IPR028397. CLIP4.
[Graphical view]
PANTHERiPTHR18916:SF32. PTHR18916:SF32. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF01302. CAP_GLY. 3 hits.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
SM01052. CAP_GLY. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF74924. SSF74924. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00845. CAP_GLY_1. 2 hits.
PS50245. CAP_GLY_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CI96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTIEDLPDIP LEGSSLIGRY PFLFTGSDTS VIFSISAAPM PSDCEFSFFD
60 70 80 90 100
PNDASCQEIL FDPKTSVSEL FAILRQWVPQ VQQNIDIIGN EILKRGCNVN
110 120 130 140 150
DRDGLTDMTL LHYTCKSGAH GIGDIETAVK FAAQLIDLGA DASLRSRWTN
160 170 180 190 200
MNALHYASYF DVPELIRVIL KTSKPKDVDA TCSDFNFGTA LHIAAHNLCA
210 220 230 240 250
GAVKTLLELG ANPAFRNDKG QIPAEVVPDP VDMPLEMADA AAIAKEIKQM
260 270 280 290 300
LLDAVPLPCT SAKAVLPNSD HTTSRAMLTS LGLKLGDRVV IAGQKVGTLR
310 320 330 340 350
FCGTTEFASG QWAGIELDEP EGKNNGSVGR VQYFKCAPKY GIFAPLSKIS
360 370 380 390 400
KLKDGRKTTT HTPSTRATPH ARSQKVDVAH FTSRVNSGLT TSKKETASES
410 420 430 440 450
TLTLPPSEEP KTVAENDAAQ PGSMSSSSSS SSLDHKQSYP KKLTTSSGGK
460 470 480 490 500
KTLSKSPSLP SRASAGLKSS ATSAANNSHH EGALHLGERV LVVGQRVGTI
510 520 530 540 550
KFFGTTNFAP GYWYGIELEK PHGKNDGSVG GVQYFSCSPR YGIFAPPSRV
560 570 580 590 600
QRLSDSLDTL SEISSNKQNH SYPGFRRSFS TTSASSQKEI NRRNAFAKTK
610 620 630 640 650
TTLRRSWSSS TTAGGLEGTV KLHEGSQVLL TSSNEMATVR YVGPTDFASG
660 670 680 690 700
IWLGLELRSA KGKNDGAVGD KRYFTCKPNY GVLVRPSRVT YRGISGSKLI

DENC
Length:704
Mass (Da):75,789
Last modified:March 1, 2003 - v1
Checksum:i615B49B7A536B918
GO
Isoform 2 (identifier: Q8CI96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-387: Missing.
     599-704: Missing.

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):59,234
Checksum:i65DAFE3B38259A80
GO
Isoform 3 (identifier: Q8CI96-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-219: NDK → VRD
     220-704: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,005
Checksum:i7D91BF8B66F87720
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30S → Y in BAC35936 (PubMed:16141072).Curated1
Sequence conflicti44C → S in BAC35936 (PubMed:16141072).Curated1
Sequence conflicti190A → S in BAC35936 (PubMed:16141072).Curated1
Sequence conflicti495Q → K in BAC35936 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012973217 – 219NDK → VRD in isoform 3. 1 Publication3
Alternative sequenceiVSP_012974220 – 704Missing in isoform 3. 1 PublicationAdd BLAST485
Alternative sequenceiVSP_012975341 – 387Missing in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_012976599 – 704Missing in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018895 mRNA. Translation: BAB31478.1.
AK075758 mRNA. Translation: BAC35936.1.
BC011280 mRNA. Translation: AAH11280.1.
BC035226 mRNA. Translation: AAH35226.1.
CCDSiCCDS37687.1. [Q8CI96-1]
RefSeqiNP_084455.2. NM_030179.3. [Q8CI96-1]
NP_780587.1. NM_175378.1. [Q8CI96-2]
XP_006525206.1. XM_006525143.3. [Q8CI96-1]
XP_006525207.1. XM_006525144.2. [Q8CI96-1]
XP_006525208.1. XM_006525145.3. [Q8CI96-1]
XP_006525209.1. XM_006525146.1. [Q8CI96-1]
XP_006525217.1. XM_006525154.2. [Q8CI96-2]
UniGeneiMm.196382.

Genome annotation databases

EnsembliENSMUST00000024854; ENSMUSP00000024854; ENSMUSG00000024059. [Q8CI96-1]
GeneIDi78785.
KEGGimmu:78785.
UCSCiuc008dmw.2. mouse. [Q8CI96-3]
uc008dmx.2. mouse. [Q8CI96-1]
uc012awx.1. mouse. [Q8CI96-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018895 mRNA. Translation: BAB31478.1.
AK075758 mRNA. Translation: BAC35936.1.
BC011280 mRNA. Translation: AAH11280.1.
BC035226 mRNA. Translation: AAH35226.1.
CCDSiCCDS37687.1. [Q8CI96-1]
RefSeqiNP_084455.2. NM_030179.3. [Q8CI96-1]
NP_780587.1. NM_175378.1. [Q8CI96-2]
XP_006525206.1. XM_006525143.3. [Q8CI96-1]
XP_006525207.1. XM_006525144.2. [Q8CI96-1]
XP_006525208.1. XM_006525145.3. [Q8CI96-1]
XP_006525209.1. XM_006525146.1. [Q8CI96-1]
XP_006525217.1. XM_006525154.2. [Q8CI96-2]
UniGeneiMm.196382.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WHJNMR-A266-354[»]
1WHKNMR-A617-694[»]
ProteinModelPortaliQ8CI96.
SMRiQ8CI96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024854.

PTM databases

iPTMnetiQ8CI96.
PhosphoSitePlusiQ8CI96.

Proteomic databases

PaxDbiQ8CI96.
PRIDEiQ8CI96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024854; ENSMUSP00000024854; ENSMUSG00000024059. [Q8CI96-1]
GeneIDi78785.
KEGGimmu:78785.
UCSCiuc008dmw.2. mouse. [Q8CI96-3]
uc008dmx.2. mouse. [Q8CI96-1]
uc012awx.1. mouse. [Q8CI96-2]

Organism-specific databases

CTDi79745.
MGIiMGI:1919100. Clip4.

Phylogenomic databases

eggNOGiKOG0241. Eukaryota.
KOG4568. Eukaryota.
COG5244. LUCA.
GeneTreeiENSGT00760000119173.
HOGENOMiHOG000007206.
HOVERGENiHBG057079.
InParanoidiQ8CI96.
KOiK10423.
OMAiILKRGCN.
OrthoDBiEOG091G04NK.
PhylomeDBiQ8CI96.
TreeFamiTF326096.

Miscellaneous databases

EvolutionaryTraceiQ8CI96.
PROiQ8CI96.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024059.
GenevisibleiQ8CI96. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.30.190. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000938. CAP-Gly_domain.
IPR028397. CLIP4.
[Graphical view]
PANTHERiPTHR18916:SF32. PTHR18916:SF32. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF01302. CAP_GLY. 3 hits.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
SM01052. CAP_GLY. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF74924. SSF74924. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS00845. CAP_GLY_1. 2 hits.
PS50245. CAP_GLY_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLIP4_MOUSE
AccessioniPrimary (citable) accession number: Q8CI96
Secondary accession number(s): Q8BW09, Q921Q4, Q9D2S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.