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Q8CI85

- CAH12_MOUSE

UniProt

Q8CI85 - CAH12_MOUSE

Protein

Carbonic anhydrase 12

Gene

Ca12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Reversible hydration of carbon dioxide.

    Catalytic activityi

    H2CO3 = CO2 + H2O.

    Cofactori

    Zinc.By similarity

    Enzyme regulationi

    Inhibited by acetazolamide.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941Proton acceptorBy similarity
    Metal bindingi120 – 1201Zinc; catalytic
    Metal bindingi122 – 1221Zinc; catalytic
    Metal bindingi146 – 1461Zinc; catalytic
    Active sitei155 – 1551By similarity

    GO - Molecular functioni

    1. carbonate dehydratase activity Source: MGI
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbon dioxide transport Source: MGI
    2. one-carbon metabolic process Source: InterPro
    3. regulation of pH Source: MGI

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_199096. Reversible hydration of carbon dioxide.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase 12 (EC:4.2.1.1)
    Alternative name(s):
    Carbonate dehydratase XII
    Carbonic anhydrase XII
    Short name:
    CA-XII
    Gene namesi
    Name:Ca12
    Synonyms:Car12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1923709. Car12.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 354330Carbonic anhydrase 12PRO_0000004249Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi50 ↔ 231By similarity
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8CI85.
    PaxDbiQ8CI85.
    PRIDEiQ8CI85.

    PTM databases

    PhosphoSiteiQ8CI85.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8CI85.
    BgeeiQ8CI85.
    CleanExiMM_CAR12.
    GenevestigatoriQ8CI85.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ8CI85. 2 interactions.
    MINTiMINT-4089721.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CI85.
    SMRiQ8CI85. Positions 31-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 301277ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini323 – 35432CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni227 – 2282Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the alpha-carbonic anhydrase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3338.
    GeneTreeiENSGT00660000095420.
    HOGENOMiHOG000112637.
    HOVERGENiHBG002837.
    InParanoidiQ8CI85.
    KOiK01672.
    OrthoDBiEOG7WMCK7.
    PhylomeDBiQ8CI85.
    TreeFamiTF316425.

    Family and domain databases

    Gene3Di3.10.200.10. 1 hit.
    InterProiIPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    IPR018338. Carbonic_anhydrase_a-class_CS.
    IPR018430. Carbonic_anhydrase_CA12.
    [Graphical view]
    PANTHERiPTHR18952. PTHR18952. 1 hit.
    PTHR18952:SF19. PTHR18952:SF19. 1 hit.
    PfamiPF00194. Carb_anhydrase. 1 hit.
    [Graphical view]
    SMARTiSM01057. Carb_anhydrase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51069. SSF51069. 1 hit.
    PROSITEiPS00162. ALPHA_CA_1. 1 hit.
    PS51144. ALPHA_CA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CI85-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPHRSLRATV VLLLVILKKQ PSSSAPLNGS KWTYVGPAGE KNWSKKYPSC    50
    GGLLQSPIDL HSDILQYDAS LAPLQFQGYN VSVEKLLNLT NDGHSVRLNL 100
    NSDMYIQGLQ PHHYRAEQLH LHWGNRNDPH GSEHTVSGKH FAAELHIVHY 150
    NSDLYPDFST ASDKSEGLAV LAVLIEIGSA NPSYDKIFSH LQHVKYKGQQ 200
    VLIPGFNIEE LLPESPGEYY RYEGSLTTPP CYPTVLWTVF RNPVQISQEQ 250
    LLALETALYF THMDDPTPRE MINNFRQVQK FDERLVYISF RQGLLTDTGL 300
    SLGIILSVAL AGVLGISIVL AVSIWLFKRK KSKKGDNKGV IYKPAIKKEA 350
    EVHA 354
    Length:354
    Mass (Da):39,695
    Last modified:March 1, 2003 - v1
    Checksum:i98ED581BF2A16111
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti297 – 2971D → N in BAC35074. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052639 mRNA. Translation: BAC35074.1.
    BC035941 mRNA. Translation: AAH35941.1.
    CCDSiCCDS23306.1.
    RefSeqiNP_848483.3. NM_178396.4.
    UniGeneiMm.277921.

    Genome annotation databases

    EnsembliENSMUST00000071889; ENSMUSP00000071786; ENSMUSG00000032373.
    GeneIDi76459.
    KEGGimmu:76459.
    UCSCiuc009qfc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052639 mRNA. Translation: BAC35074.1 .
    BC035941 mRNA. Translation: AAH35941.1 .
    CCDSi CCDS23306.1.
    RefSeqi NP_848483.3. NM_178396.4.
    UniGenei Mm.277921.

    3D structure databases

    ProteinModelPortali Q8CI85.
    SMRi Q8CI85. Positions 31-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CI85. 2 interactions.
    MINTi MINT-4089721.

    PTM databases

    PhosphoSitei Q8CI85.

    Proteomic databases

    MaxQBi Q8CI85.
    PaxDbi Q8CI85.
    PRIDEi Q8CI85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071889 ; ENSMUSP00000071786 ; ENSMUSG00000032373 .
    GeneIDi 76459.
    KEGGi mmu:76459.
    UCSCi uc009qfc.2. mouse.

    Organism-specific databases

    CTDi 76459.
    MGIi MGI:1923709. Car12.

    Phylogenomic databases

    eggNOGi COG3338.
    GeneTreei ENSGT00660000095420.
    HOGENOMi HOG000112637.
    HOVERGENi HBG002837.
    InParanoidi Q8CI85.
    KOi K01672.
    OrthoDBi EOG7WMCK7.
    PhylomeDBi Q8CI85.
    TreeFami TF316425.

    Enzyme and pathway databases

    Reactomei REACT_199096. Reversible hydration of carbon dioxide.

    Miscellaneous databases

    NextBioi 345196.
    PROi Q8CI85.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CI85.
    Bgeei Q8CI85.
    CleanExi MM_CAR12.
    Genevestigatori Q8CI85.

    Family and domain databases

    Gene3Di 3.10.200.10. 1 hit.
    InterProi IPR001148. Carbonic_anhydrase_a.
    IPR023561. Carbonic_anhydrase_a-class.
    IPR018338. Carbonic_anhydrase_a-class_CS.
    IPR018430. Carbonic_anhydrase_CA12.
    [Graphical view ]
    PANTHERi PTHR18952. PTHR18952. 1 hit.
    PTHR18952:SF19. PTHR18952:SF19. 1 hit.
    Pfami PF00194. Carb_anhydrase. 1 hit.
    [Graphical view ]
    SMARTi SM01057. Carb_anhydrase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51069. SSF51069. 1 hit.
    PROSITEi PS00162. ALPHA_CA_1. 1 hit.
    PS51144. ALPHA_CA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.

    Entry informationi

    Entry nameiCAH12_MOUSE
    AccessioniPrimary (citable) accession number: Q8CI85
    Secondary accession number(s): Q8BKG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3