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Protein

Stomatin-like protein 1

Gene

Stoml1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ion channel inhibitor activity Source: MGI

GO - Biological processi

  • negative regulation of acid-sensing ion channel activity Source: MGI
  • SMAD protein signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stomatin-like protein 1
Short name:
SLP-1
Gene namesi
Name:Stoml1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916356. Stoml1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini79 – 399321CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic vesicle Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Stomatin-like protein 1PRO_0000094030Add
BLAST

Proteomic databases

EPDiQ8CI66.
MaxQBiQ8CI66.
PaxDbiQ8CI66.
PRIDEiQ8CI66.

PTM databases

PhosphoSiteiQ8CI66.

Expressioni

Gene expression databases

CleanExiMM_STOML1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034883.

Structurei

3D structure databases

ProteinModelPortaliQ8CI66.
SMRiQ8CI66. Positions 117-217, 307-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini288 – 399112SCP2Add
BLAST

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated
Contains 1 SCP2 domain.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
KOG4170. Eukaryota.
COG0330. LUCA.
HOGENOMiHOG000065698.
HOVERGENiHBG079220.
InParanoidiQ8CI66.
PhylomeDBiQ8CI66.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
InterProiIPR001107. Band_7.
IPR003033. SCP2_sterol-bd_dom.
IPR028517. SLP1.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF89. PTHR10264:SF89. 1 hit.
PfamiPF01145. Band_7. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
SSF55718. SSF55718. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CI66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRSGYRAL PLGDFDRFQQ SSFGFLGSQK GCLSPEPGSV GPGADAPESW
60 70 80 90 100
PSCLCHGLVS VLGFLLLLLT FPISGWFALK IVPTYERMIV FRLGRIRNPQ
110 120 130 140 150
GPGMVLLLPF IDSFQRVDLR TRAFNVPPCK LASKDGAVLS VGADVQFRIW
160 170 180 190 200
DPVLSVMAVK DLNTATRMTA HNAMTKALLR RPLQEIQMEK LKIGDQLLLE
210 220 230 240 250
INDVTRAWGL EVDRVELAVE AVLQPPQDSL TVPSLDSTLQ QLALHLLGGS
260 270 280 290 300
MNSAVGRVPS PGPDTLEMIN EVEPPASLAG AGAEPSPKQP VAEGLLTALQ
310 320 330 340 350
PFLSEALVSQ VGACYQFNVI LPSGTQSIYF LDLTTGQGRV GHGEPDGIPD
360 370 380 390
VVVEMAEADL QALLSKELRP LGAYMSGRLK VKGDLAVVMK LEAVLKALK
Length:399
Mass (Da):42,926
Last modified:March 1, 2003 - v1
Checksum:i1951248C3693B9B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351D → Y in BAC32502 (PubMed:16141072).Curated
Sequence conflicti257 – 2571R → H in BAC32502 (PubMed:16141072).Curated
Sequence conflicti283 – 2831A → P in BAC32502 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045820 mRNA. Translation: BAC32502.1.
BC037074 mRNA. Translation: AAH37074.1.
CCDSiCCDS23241.1.
RefSeqiNP_081218.3. NM_026942.3.
UniGeneiMm.216502.

Genome annotation databases

GeneIDi69106.
KEGGimmu:69106.
UCSCiuc009pws.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045820 mRNA. Translation: BAC32502.1.
BC037074 mRNA. Translation: AAH37074.1.
CCDSiCCDS23241.1.
RefSeqiNP_081218.3. NM_026942.3.
UniGeneiMm.216502.

3D structure databases

ProteinModelPortaliQ8CI66.
SMRiQ8CI66. Positions 117-217, 307-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034883.

PTM databases

PhosphoSiteiQ8CI66.

Proteomic databases

EPDiQ8CI66.
MaxQBiQ8CI66.
PaxDbiQ8CI66.
PRIDEiQ8CI66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69106.
KEGGimmu:69106.
UCSCiuc009pws.2. mouse.

Organism-specific databases

CTDi9399.
MGIiMGI:1916356. Stoml1.

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
KOG4170. Eukaryota.
COG0330. LUCA.
HOGENOMiHOG000065698.
HOVERGENiHBG079220.
InParanoidiQ8CI66.
PhylomeDBiQ8CI66.

Miscellaneous databases

PROiQ8CI66.
SOURCEiSearch...

Gene expression databases

CleanExiMM_STOML1.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
InterProiIPR001107. Band_7.
IPR003033. SCP2_sterol-bd_dom.
IPR028517. SLP1.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF89. PTHR10264:SF89. 1 hit.
PfamiPF01145. Band_7. 1 hit.
PF02036. SCP2. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
SSF55718. SSF55718. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSTML1_MOUSE
AccessioniPrimary (citable) accession number: Q8CI66
Secondary accession number(s): Q8BLA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.