Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BAG family molecular chaperone regulator 4

Gene

Bag4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (By similarity). Negative regulator of PARK2 translocation to damaged mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • cellular response to tumor necrosis factor Source: MGI
  • negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: UniProtKB
  • negative regulation of protein targeting to mitochondrion Source: MGI
  • positive regulation of actin filament polymerization Source: UniProtKB
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of fibroblast migration Source: UniProtKB
  • positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
  • positive regulation of protein kinase B signaling Source: UniProtKB
  • positive regulation of stress fiber assembly Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • ruffle assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-75893. TNF signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 4
Short name:
BAG-4
Alternative name(s):
Bcl-2-associated athanogene 4
Silencer of death domains
Gene namesi
Name:Bag4
Synonyms:Sodd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914634. Bag4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi387 – 3871L → P: Abolishes interaction with HSP70 and TNFRSF1A. 1 Publication
Mutagenesisi416 – 4161L → P: Abolishes interaction with HSP70 and TNFRSF1A. 1 Publication
Mutagenesisi441 – 4411A → P: Abolishes interaction with HSP70 and TNFRSF1A. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457BAG family molecular chaperone regulator 4PRO_0000088871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CI61.
MaxQBiQ8CI61.
PaxDbiQ8CI61.
PRIDEiQ8CI61.

PTM databases

iPTMnetiQ8CI61.
PhosphoSiteiQ8CI61.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037316.
CleanExiMM_BAG4.
ExpressionAtlasiQ8CI61. baseline and differential.
GenevisibleiQ8CI61. MM.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF12 (By similarity). Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Interacts with PARK2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212150. 2 interactions.
STRINGi10090.ENSMUSP00000044725.

Structurei

3D structure databases

ProteinModelPortaliQ8CI61.
SMRiQ8CI61. Positions 376-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini379 – 45678BAGPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 298270Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BAG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4361. Eukaryota.
ENOG4111WNH. LUCA.
GeneTreeiENSGT00530000063256.
HOGENOMiHOG000290673.
HOVERGENiHBG004809.
InParanoidiQ8CI61.
KOiK09558.
OMAiPAETTWP.
OrthoDBiEOG091G08LY.
PhylomeDBiQ8CI61.
TreeFamiTF102013.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
SUPFAMiSSF63491. SSF63491. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CI61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HVPPPLYPPL RPEPPQPPVS
60 70 80 90 100
WRGRGGAPAE TTWPGEGAGG DGYYPSGGAW AEASRAGGGH QEQPPYPGYN
110 120 130 140 150
SNYWNSVRPR APYPGSYSVR PELQGQSLNS YANGAYGPPY PPGPGASTAS
160 170 180 190 200
YSGAYYVPGY TQSNYSTEVP NTYRSPGNSP TPMSRWMYSQ QDCPTEAPPL
210 220 230 240 250
RGQVPGYPAS QNPGMTLPHY PYGDGNRAVP QSGGTGRPQD DAWASSAYGM
260 270 280 290 300
GARYPWPSAA PSAPSAGSLY MTESASPWPG NSSPQPPPSP PPQQPKDPSY
310 320 330 340 350
SYNPSGQGLS RHSFPCSVHQ YESPGAVNND NSDLLDSQVQ YSAEPQLYGN
360 370 380 390 400
ASSEHPSNQV PSNNLPEECF SSDEGTPPSI KKIIHVLEKV QFLEQEVEEF
410 420 430 440 450
VGKKTDKAYW LLEEMLTKEL LELDSVETGG QDSVRQARKE AVCKIQAILE

KLEKKGL
Length:457
Mass (Da):49,095
Last modified:May 9, 2003 - v2
Checksum:i5A70275BD42A6E20
GO

Sequence cautioni

The sequence AAH37239 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332863 mRNA. Translation: AAL99586.1.
AK010765 mRNA. Translation: BAB27167.1.
AK136899 mRNA. Translation: BAE23161.1.
AK162658 mRNA. Translation: BAE37009.1.
BC009102 mRNA. Translation: AAH09102.1.
BC037239 mRNA. Translation: AAH37239.1. Different initiation.
BC058518 mRNA. Translation: AAH58518.1.
CCDSiCCDS22201.1.
RefSeqiNP_080397.1. NM_026121.3.
UniGeneiMm.118400.

Genome annotation databases

EnsembliENSMUST00000038498; ENSMUSP00000044725; ENSMUSG00000037316.
GeneIDi67384.
KEGGimmu:67384.
UCSCiuc009lgy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332863 mRNA. Translation: AAL99586.1.
AK010765 mRNA. Translation: BAB27167.1.
AK136899 mRNA. Translation: BAE23161.1.
AK162658 mRNA. Translation: BAE37009.1.
BC009102 mRNA. Translation: AAH09102.1.
BC037239 mRNA. Translation: AAH37239.1. Different initiation.
BC058518 mRNA. Translation: AAH58518.1.
CCDSiCCDS22201.1.
RefSeqiNP_080397.1. NM_026121.3.
UniGeneiMm.118400.

3D structure databases

ProteinModelPortaliQ8CI61.
SMRiQ8CI61. Positions 376-456.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212150. 2 interactions.
STRINGi10090.ENSMUSP00000044725.

PTM databases

iPTMnetiQ8CI61.
PhosphoSiteiQ8CI61.

Proteomic databases

EPDiQ8CI61.
MaxQBiQ8CI61.
PaxDbiQ8CI61.
PRIDEiQ8CI61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038498; ENSMUSP00000044725; ENSMUSG00000037316.
GeneIDi67384.
KEGGimmu:67384.
UCSCiuc009lgy.1. mouse.

Organism-specific databases

CTDi9530.
MGIiMGI:1914634. Bag4.

Phylogenomic databases

eggNOGiKOG4361. Eukaryota.
ENOG4111WNH. LUCA.
GeneTreeiENSGT00530000063256.
HOGENOMiHOG000290673.
HOVERGENiHBG004809.
InParanoidiQ8CI61.
KOiK09558.
OMAiPAETTWP.
OrthoDBiEOG091G08LY.
PhylomeDBiQ8CI61.
TreeFamiTF102013.

Enzyme and pathway databases

ReactomeiR-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-75893. TNF signaling.

Miscellaneous databases

PROiQ8CI61.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037316.
CleanExiMM_BAG4.
ExpressionAtlasiQ8CI61. baseline and differential.
GenevisibleiQ8CI61. MM.

Family and domain databases

Gene3Di1.20.58.120. 1 hit.
InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 1 hit.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
SUPFAMiSSF63491. SSF63491. 1 hit.
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAG4_MOUSE
AccessioniPrimary (citable) accession number: Q8CI61
Secondary accession number(s): Q3TRL9, Q91VT5, Q9CWG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 9, 2003
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.