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Protein

Myosin light chain 6B

Gene

Myl6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.Curated

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

  • muscle contraction Source: HGNC
  • muscle filament sliding Source: HGNC
  • skeletal muscle tissue development Source: HGNC

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 6B
Alternative name(s):
Smooth muscle and nonmuscle myosin light chain alkali 6B
Gene namesi
Name:Myl6bImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917789. Myl6b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002488331 – 207Myosin light chain 6BAdd BLAST207

Proteomic databases

EPDiQ8CI43.
MaxQBiQ8CI43.
PaxDbiQ8CI43.
PeptideAtlasiQ8CI43.
PRIDEiQ8CI43.

PTM databases

iPTMnetiQ8CI43.
PhosphoSitePlusiQ8CI43.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039824.
CleanExiMM_MYL6B.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi229752. 1 interactor.
IntActiQ8CI43. 3 interactors.
STRINGi10090.ENSMUSP00000026428.

Structurei

3D structure databases

ProteinModelPortaliQ8CI43.
SMRiQ8CI43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 98EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini140 – 175EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini175 – 207EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ8CI43.
KOiK12751.
OMAiSSGQVNY.
OrthoDBiEOG091G0TQL.
PhylomeDBiQ8CI43.
TreeFamiTF351553.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8CI43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKKDAPVK KPAGPSISKP AAKSTPGTPL AKAKAEPAAP QAPAKSQEPP
60 70 80 90 100
VDLSKVVIEF NKDQLEEFRE AFELFDRVGD GKILYSQCGD LMRALGQNPT
110 120 130 140 150
NAEVLKVLGN PKNEELKSRR VDFETFLPML QAVAKNRDQG TYEDYLEGLR
160 170 180 190 200
VFDKEGNGKV MGAELRHVLT TLGEKMTEEE VETVLAGHED SNGCINYEAF

LKHILSL
Length:207
Mass (Da):22,749
Last modified:March 1, 2003 - v1
Checksum:iF402A5302A44F708
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037527 mRNA. Translation: AAH37527.1.
CCDSiCCDS24279.1.
RefSeqiNP_758463.1. NM_172259.1.
XP_017169402.1. XM_017313913.1.
XP_017169403.1. XM_017313914.1.
XP_017169404.1. XM_017313915.1.
XP_017169405.1. XM_017313916.1.
XP_017169406.1. XM_017313917.1.
UniGeneiMm.291688.

Genome annotation databases

EnsembliENSMUST00000026428; ENSMUSP00000026428; ENSMUSG00000039824.
GeneIDi216459.
KEGGimmu:216459.
UCSCiuc007hne.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMYL6B_MOUSE
AccessioniPrimary (citable) accession number: Q8CI43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot