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Protein

Myosin light chain 6B

Gene

Myl6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.Curated

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

  • muscle contraction Source: HGNC
  • muscle filament sliding Source: HGNC
  • skeletal muscle tissue development Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 6B
Alternative name(s):
Smooth muscle and nonmuscle myosin light chain alkali 6B
Gene namesi
Name:Myl6bImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917789. Myl6b.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • myosin complex Source: HGNC
  • unconventional myosin complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Myosin light chain 6BPRO_0000248833Add
BLAST

Proteomic databases

EPDiQ8CI43.
MaxQBiQ8CI43.
PaxDbiQ8CI43.
PRIDEiQ8CI43.

PTM databases

iPTMnetiQ8CI43.
PhosphoSiteiQ8CI43.

Expressioni

Gene expression databases

BgeeiQ8CI43.
CleanExiMM_MYL6B.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi229752. 1 interaction.
IntActiQ8CI43. 3 interactions.
STRINGi10090.ENSMUSP00000026428.

Structurei

3D structure databases

ProteinModelPortaliQ8CI43.
SMRiQ8CI43. Positions 59-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 9836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini140 – 17536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini175 – 20733EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ8CI43.
KOiK12751.
OMAiRVSFEVF.
OrthoDBiEOG7HQN9N.
PhylomeDBiQ8CI43.
TreeFamiTF351553.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CI43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKKDAPVK KPAGPSISKP AAKSTPGTPL AKAKAEPAAP QAPAKSQEPP
60 70 80 90 100
VDLSKVVIEF NKDQLEEFRE AFELFDRVGD GKILYSQCGD LMRALGQNPT
110 120 130 140 150
NAEVLKVLGN PKNEELKSRR VDFETFLPML QAVAKNRDQG TYEDYLEGLR
160 170 180 190 200
VFDKEGNGKV MGAELRHVLT TLGEKMTEEE VETVLAGHED SNGCINYEAF

LKHILSL
Length:207
Mass (Da):22,749
Last modified:March 1, 2003 - v1
Checksum:iF402A5302A44F708
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037527 mRNA. Translation: AAH37527.1.
CCDSiCCDS24279.1.
RefSeqiNP_758463.1. NM_172259.1.
UniGeneiMm.291688.

Genome annotation databases

EnsembliENSMUST00000026428; ENSMUSP00000026428; ENSMUSG00000039824.
GeneIDi216459.
KEGGimmu:216459.
UCSCiuc007hne.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC037527 mRNA. Translation: AAH37527.1.
CCDSiCCDS24279.1.
RefSeqiNP_758463.1. NM_172259.1.
UniGeneiMm.291688.

3D structure databases

ProteinModelPortaliQ8CI43.
SMRiQ8CI43. Positions 59-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229752. 1 interaction.
IntActiQ8CI43. 3 interactions.
STRINGi10090.ENSMUSP00000026428.

PTM databases

iPTMnetiQ8CI43.
PhosphoSiteiQ8CI43.

Proteomic databases

EPDiQ8CI43.
MaxQBiQ8CI43.
PaxDbiQ8CI43.
PRIDEiQ8CI43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026428; ENSMUSP00000026428; ENSMUSG00000039824.
GeneIDi216459.
KEGGimmu:216459.
UCSCiuc007hne.1. mouse.

Organism-specific databases

CTDi140465.
MGIiMGI:1917789. Myl6b.

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ8CI43.
KOiK12751.
OMAiRVSFEVF.
OrthoDBiEOG7HQN9N.
PhylomeDBiQ8CI43.
TreeFamiTF351553.

Enzyme and pathway databases

ReactomeiR-MMU-445355. Smooth Muscle Contraction.

Miscellaneous databases

NextBioi375182.
PROiQ8CI43.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CI43.
CleanExiMM_MYL6B.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary glandImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiMYL6B_MOUSE
AccessioniPrimary (citable) accession number: Q8CI43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.