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Q8CI32

- BAG5_MOUSE

UniProt

Q8CI32 - BAG5_MOUSE

Protein

BAG family molecular chaperone regulator 5

Gene

Bag5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 By similarity.By similarity

    GO - Molecular functioni

    1. chaperone binding Source: BHF-UCL

    GO - Biological processi

    1. negative regulation of protein refolding Source: BHF-UCL
    2. negative regulation of protein ubiquitination Source: BHF-UCL
    3. negative regulation of ubiquitin-protein transferase activity Source: BHF-UCL
    4. neuron death Source: BHF-UCL
    5. regulation of inclusion body assembly Source: BHF-UCL

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BAG family molecular chaperone regulator 5
    Short name:
    BAG-5
    Alternative name(s):
    Bcl-2-associated athanogene 5
    Gene namesi
    Name:Bag5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1917619. Bag5.

    Subcellular locationi

    GO - Cellular componenti

    1. inclusion body Source: BHF-UCL
    2. perinuclear region of cytoplasm Source: BHF-UCL

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447BAG family molecular chaperone regulator 5PRO_0000088873Add
    BLAST

    Proteomic databases

    MaxQBiQ8CI32.
    PaxDbiQ8CI32.
    PRIDEiQ8CI32.

    PTM databases

    PhosphoSiteiQ8CI32.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8CI32.
    BgeeiQ8CI32.
    CleanExiMM_BAG5.
    GenevestigatoriQ8CI32.

    Interactioni

    Subunit structurei

    Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8CI32. 4 interactions.

    Structurei

    Secondary structure

    1
    447
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 2213
    Helixi24 – 285
    Helixi38 – 5518
    Helixi62 – 8625

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UGONMR-A1-86[»]
    ProteinModelPortaliQ8CI32.
    SMRiQ8CI32. Positions 1-89, 276-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8CI32.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 8678BAG 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini95 – 16773BAG 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini182 – 26079BAG 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 35076BAG 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini365 – 44278BAG 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.By similarity

    Sequence similaritiesi

    Contains 5 BAG domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG262724.
    GeneTreeiENSGT00530000063256.
    HOGENOMiHOG000070447.
    HOVERGENiHBG004810.
    InParanoidiQ8CI32.
    KOiK09559.
    OMAiDMGNQHP.
    OrthoDBiEOG7WX08F.
    PhylomeDBiQ8CI32.
    TreeFamiTF102014.

    Family and domain databases

    Gene3Di1.20.58.120. 4 hits.
    InterProiIPR003103. BAG_domain.
    [Graphical view]
    PfamiPF02179. BAG. 4 hits.
    [Graphical view]
    SMARTiSM00264. BAG. 4 hits.
    [Graphical view]
    PROSITEiPS51035. BAG. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CI32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDMGNQHPSI SRLQEIQREV KAIEPQVVGF SGLSDDKNYK RLERILTKQL    50
    FEIDSVDTEG KGDIQQARKR AAQETERLLK ELEQNANHPH RIEIQNIFKE 100
    AQALVKDKIV PFYSGGNCVT DEFEEGIQDI ILRLTHVKTG GKVSLRKARY 150
    RTLTKICAVQ EVIEDCMKKQ PSLPLSEDVH PSVAKINSVM CEVNKARGTL 200
    IALLMGVDSS ETCRHLSCVL SGLIADLDAL DVCGRTEIRN YRREVVEDIN 250
    KLLKYLDLEE EADSTHAFDL GQNHSIIKIE NVLKRMREIK NELLQAQSPP 300
    ELYLRAKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ ILITYLDLKE 350
    ALEKRKLFPC EEHPPHKAVW EILGNLSEIL GEVLSFGGNR TDKNYIRLEE 400
    LLTKQLLALD AVDPQGEEKC KAARKQAVKL AQNILSYLDM KSDEWEY 447
    Length:447
    Mass (Da):50,943
    Last modified:March 1, 2003 - v1
    Checksum:i72E2C5472DA95416
    GO

    Sequence cautioni

    The sequence BAB24105.1 differs from that shown. Reason: Frameshift at positions 5, 8, 16, 34, 40, 42, 44, 54, 56 and 64.
    The sequence AAH27827.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61Q → H in BAB24105. (PubMed:16141072)Curated
    Sequence conflicti23 – 231I → K in BAB24105. (PubMed:16141072)Curated
    Sequence conflicti36 – 361D → E in BAB24105. (PubMed:16141072)Curated
    Sequence conflicti52 – 521E → G in BAB24105. (PubMed:16141072)Curated
    Sequence conflicti142 – 1421K → E in BAB24105. (PubMed:16141072)Curated
    Sequence conflicti148 – 1481A → S in BAB24105. (PubMed:16141072)Curated
    Sequence conflicti341 – 3411I → T in AAH27827. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005534 mRNA. Translation: BAB24105.1. Frameshift.
    AK160246 mRNA. Translation: BAE35711.1.
    BC027827 mRNA. Translation: AAH27827.1. Different initiation.
    BC037642 mRNA. Translation: AAH37642.1.
    CCDSiCCDS26185.1.
    RefSeqiNP_081680.1. NM_027404.2.
    XP_006516279.1. XM_006516216.1.
    XP_006516280.1. XM_006516217.1.
    XP_006516281.1. XM_006516218.1.
    UniGeneiMm.44239.

    Genome annotation databases

    EnsembliENSMUST00000054636; ENSMUSP00000051049; ENSMUSG00000049792.
    ENSMUST00000160576; ENSMUSP00000125183; ENSMUSG00000049792.
    GeneIDi70369.
    KEGGimmu:70369.
    UCSCiuc007pdr.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005534 mRNA. Translation: BAB24105.1 . Frameshift.
    AK160246 mRNA. Translation: BAE35711.1 .
    BC027827 mRNA. Translation: AAH27827.1 . Different initiation.
    BC037642 mRNA. Translation: AAH37642.1 .
    CCDSi CCDS26185.1.
    RefSeqi NP_081680.1. NM_027404.2.
    XP_006516279.1. XM_006516216.1.
    XP_006516280.1. XM_006516217.1.
    XP_006516281.1. XM_006516218.1.
    UniGenei Mm.44239.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UGO NMR - A 1-86 [» ]
    ProteinModelPortali Q8CI32.
    SMRi Q8CI32. Positions 1-89, 276-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CI32. 4 interactions.

    PTM databases

    PhosphoSitei Q8CI32.

    Proteomic databases

    MaxQBi Q8CI32.
    PaxDbi Q8CI32.
    PRIDEi Q8CI32.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054636 ; ENSMUSP00000051049 ; ENSMUSG00000049792 .
    ENSMUST00000160576 ; ENSMUSP00000125183 ; ENSMUSG00000049792 .
    GeneIDi 70369.
    KEGGi mmu:70369.
    UCSCi uc007pdr.3. mouse.

    Organism-specific databases

    CTDi 9529.
    MGIi MGI:1917619. Bag5.

    Phylogenomic databases

    eggNOGi NOG262724.
    GeneTreei ENSGT00530000063256.
    HOGENOMi HOG000070447.
    HOVERGENi HBG004810.
    InParanoidi Q8CI32.
    KOi K09559.
    OMAi DMGNQHP.
    OrthoDBi EOG7WX08F.
    PhylomeDBi Q8CI32.
    TreeFami TF102014.

    Miscellaneous databases

    EvolutionaryTracei Q8CI32.
    NextBioi 331467.
    PROi Q8CI32.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CI32.
    Bgeei Q8CI32.
    CleanExi MM_BAG5.
    Genevestigatori Q8CI32.

    Family and domain databases

    Gene3Di 1.20.58.120. 4 hits.
    InterProi IPR003103. BAG_domain.
    [Graphical view ]
    Pfami PF02179. BAG. 4 hits.
    [Graphical view ]
    SMARTi SM00264. BAG. 4 hits.
    [Graphical view ]
    PROSITEi PS51035. BAG. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Placenta and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor.
    3. "The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange."
      Arakawa A., Handa N., Ohsawa N., Shida M., Kigawa T., Hayashi F., Shirouzu M., Yokoyama S.
      Structure 18:309-319(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-86.

    Entry informationi

    Entry nameiBAG5_MOUSE
    AccessioniPrimary (citable) accession number: Q8CI32
    Secondary accession number(s): Q3TVA8, Q8K175, Q9DAU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3