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Q8CI19

- PDGFC_MOUSE

UniProt

Q8CI19 - PDGFC_MOUSE

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Protein

Platelet-derived growth factor C

Gene

Pdgfc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.8 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei225 – 2262CleavageBy similarity
Sitei231 – 2322CleavageBy similarity
Sitei234 – 2352CleavageBy similarity

GO - Molecular functioni

  1. platelet-derived growth factor receptor binding Source: MGI

GO - Biological processi

  1. activation of transmembrane receptor protein tyrosine kinase activity Source: MGI
  2. cellular response to amino acid stimulus Source: MGI
  3. organ morphogenesis Source: MGI
  4. platelet-derived growth factor receptor signaling pathway Source: MGI
  5. positive regulation of cell division Source: UniProtKB-KW
  6. positive regulation of cell proliferation Source: MGI
  7. positive regulation of DNA replication Source: Ensembl
  8. positive regulation of fibroblast proliferation Source: Ensembl
  9. regulation of peptidyl-tyrosine phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiREACT_263353. Signaling by PDGF.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor C
Short name:
PDGF-C
Alternative name(s):
Fallotein
Spinal cord-derived growth factor
Short name:
SCDGF
VEGF-E
Cleaved into the following 2 chains:
Platelet-derived growth factor C, receptor-binding form
Short name:
PDGFC receptor-binding form
Gene namesi
Name:Pdgfc
Synonyms:Scdgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1859631. Pdgfc.

Subcellular locationi

Cytoplasm. Secreted. Nucleus. Cytoplasmic granule By similarity
Note: Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets (By similarity). Membrane associated when bound to receptors (By similarity). Secretion increased by TGFB1.By similarity

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: UniProtKB-KW
  3. extracellular region Source: MGI
  4. extracellular space Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. nucleus Source: UniProtKB-KW
  7. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

Involved in the development of myocarditis and subsequent fibrosis in the experimental model of coxsackievirus B3-induced chronic myocarditis.1 Publication

Disruption phenotypei

Perinatal lethality. Mice have feeding and respiratory difficulties due to a complete cleft of the secondary palate. However, they have reduction of renal fibrogenesis. Mice lacking both PDGFA and PDGFC develop a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 345Platelet-derived growth factor C, receptor-binding formPRO_0000343874
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 345323Platelet-derived growth factor C, latent formPRO_0000343873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Disulfide bondi250 ↔ 294PROSITE-ProRule annotation
Disulfide bondi274 – 274Interchain (with C-286)PROSITE-ProRule annotation
Disulfide bondi280 ↔ 335PROSITE-ProRule annotation
Disulfide bondi286 – 286Interchain (with C-274)PROSITE-ProRule annotation
Disulfide bondi287 ↔ 337PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG (By similarity).By similarity
Sumoylated by SUMO1.1 Publication
N-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ8CI19.

PTM databases

PhosphoSiteiQ8CI19.

Expressioni

Tissue specificityi

Mainly expressed in kidney, testis, liver, heart and brain (at protein level). Highly expressed in airway epithelium, interstitial cells and alveolar macrophages in the lung of mice overexpressing IL13. Expressed in the ovaries.5 Publications

Developmental stagei

In stage E9.5-E15.5, widely expressed in the surface ectoderm and later in the germinal layer of the skin, the olfactory and otic placode and their derivatives and the lining of the oral cavity. In stages E14.5-17.5 expressed in ducts connected to epidermis, and in developing epidermal openings. Highly expressed in the early stages of the developing kidney, in the metanephric mesenchymal aggregates, prefusion skeletal muscle, cardiac myoblasts, and in visceral and vascular smooth muscle.4 Publications

Inductioni

Expression decreased by hypoxia. Up-regulated by EWS-FLI1 transcription factor in tumor-derived cells. Up-regulated by IL13 overexpression in the lung via STAT6 and EGR1. Elevated expression induced by coxsackievirus B3 infection in immunodeficient mice. Overexpressed in the renal fibrosis. Expression in the lung is significantly increased after bleomycin treatment. Down-regulated by retinoic acid and gonadotropin.7 Publications

Gene expression databases

BgeeiQ8CI19.
ExpressionAtlasiQ8CI19. baseline and differential.
GenevestigatoriQ8CI19.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain) (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8CI19.
SMRiQ8CI19. Positions 53-198, 236-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 163118CUBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated
Contains 1 CUB domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74970.
GeneTreeiENSGT00390000005171.
HOGENOMiHOG000261610.
HOVERGENiHBG057324.
InParanoidiQ8CI19.
KOiK05450.
OMAiDCVCRGN.
OrthoDBiEOG7VB2FN.
PhylomeDBiQ8CI19.
TreeFamiTF332130.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR029034. Cystine-knot_cytokine.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57501. SSF57501. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CI19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLGLLLLT SALAGQRTGT RAESNLSSKL QLSSDKEQNG VQDPRHERVV
60 70 80 90 100
TISGNGSIHS PKFPHTYPRN MVLVWRLVAV DENVRIQLTF DERFGLEDPE
110 120 130 140 150
DDICKYDFVE VEEPSDGSVL GRWCGSGTVP GKQTSKGNHI RIRFVSDEYF
160 170 180 190 200
PSEPGFCIHY SIIMPQVTET TSPSVLPPSS LSLDLLNNAV TAFSTLEELI
210 220 230 240 250
RYLEPDRWQV DLDSLYKPTW QLLGKAFLYG KKSKVVNLNL LKEEVKLYSC
260 270 280 290 300
TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPRK
310 320 330 340
VTKKYHEVLQ LRPKTGVKGL HKSLTDVALE HHEECDCVCR GNAGG
Length:345
Mass (Da):38,741
Last modified:July 22, 2008 - v2
Checksum:i3A58A1F701B84EA2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861I → T in AAF91483. (PubMed:10960785)Curated
Sequence conflicti103 – 1031I → L in AAH37696. (PubMed:15489334)Curated
Sequence conflicti127 – 1271G → E in AAF91483. (PubMed:10960785)Curated
Sequence conflicti230 – 2301G → V in AAF91483. (PubMed:10960785)Curated
Sequence conflicti269 – 2691I → R in AAF91483. (PubMed:10960785)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286725 mRNA. Translation: AAF91483.1.
AF117608 mRNA. Translation: AAF22516.1.
AF266467 mRNA. Translation: AAK58566.1.
AK033734 mRNA. Translation: BAC28455.1.
AK042767 mRNA. Translation: BAC31358.1.
AK052947 mRNA. Translation: BAC35216.1.
BC006027 mRNA. Translation: AAH06027.1.
BC037696 mRNA. Translation: AAH37696.1.
CCDSiCCDS17425.1.
RefSeqiNP_064355.1. NM_019971.2.
UniGeneiMm.331089.

Genome annotation databases

EnsembliENSMUST00000029652; ENSMUSP00000029652; ENSMUSG00000028019.
GeneIDi54635.
KEGGimmu:54635.
UCSCiuc008poi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286725 mRNA. Translation: AAF91483.1 .
AF117608 mRNA. Translation: AAF22516.1 .
AF266467 mRNA. Translation: AAK58566.1 .
AK033734 mRNA. Translation: BAC28455.1 .
AK042767 mRNA. Translation: BAC31358.1 .
AK052947 mRNA. Translation: BAC35216.1 .
BC006027 mRNA. Translation: AAH06027.1 .
BC037696 mRNA. Translation: AAH37696.1 .
CCDSi CCDS17425.1.
RefSeqi NP_064355.1. NM_019971.2.
UniGenei Mm.331089.

3D structure databases

ProteinModelPortali Q8CI19.
SMRi Q8CI19. Positions 53-198, 236-338.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8CI19.

Proteomic databases

PRIDEi Q8CI19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029652 ; ENSMUSP00000029652 ; ENSMUSG00000028019 .
GeneIDi 54635.
KEGGi mmu:54635.
UCSCi uc008poi.1. mouse.

Organism-specific databases

CTDi 56034.
MGIi MGI:1859631. Pdgfc.

Phylogenomic databases

eggNOGi NOG74970.
GeneTreei ENSGT00390000005171.
HOGENOMi HOG000261610.
HOVERGENi HBG057324.
InParanoidi Q8CI19.
KOi K05450.
OMAi DCVCRGN.
OrthoDBi EOG7VB2FN.
PhylomeDBi Q8CI19.
TreeFami TF332130.

Enzyme and pathway databases

Reactomei REACT_263353. Signaling by PDGF.

Miscellaneous databases

ChiTaRSi Pdgfc. mouse.
NextBioi 311464.
PROi Q8CI19.
SOURCEi Search...

Gene expression databases

Bgeei Q8CI19.
ExpressionAtlasi Q8CI19. baseline and differential.
Genevestigatori Q8CI19.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
2.60.120.290. 1 hit.
InterProi IPR000859. CUB_dom.
IPR029034. Cystine-knot_cytokine.
IPR000072. PDGF/VEGF_dom.
[Graphical view ]
Pfami PF00431. CUB. 1 hit.
PF00341. PDGF. 1 hit.
[Graphical view ]
SMARTi SM00042. CUB. 1 hit.
SM00141. PDGF. 1 hit.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 1 hit.
SSF57501. SSF57501. 1 hit.
PROSITEi PS01180. CUB. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis."
    Ding H., Wu X., Kim I., Tam P.P., Koh G.Y., Nagy A.
    Mech. Dev. 96:209-213(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: Swiss Webster / NIH.
  2. "cDNA cloning of fallotein from mouse ovary."
    Tsai Y.-J., Lee R.K.-K., Chen Y.-H., Lin S.-P., Cheng W.T.-K.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  3. "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha receptor."
    Gao Z., Hart C., Piddington C., Sheppard P., Shoemaker K., Gilbertson D., West J., O'Hara P.J.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum, Cerebellum and Head.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  6. Cited for: FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE.
  7. "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."
    Gilbertson D.G., Duff M.E., West J.W., Kelly J.D., Sheppard P.O., Hofstrand P.D., Gao Z., Shoemaker K., Bukowski T.R., Moore M., Feldhaus A.L., Humes J.M., Palmer T.E., Hart C.E.
    J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
  8. "PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors."
    Zwerner J.P., May W.A.
    Oncogene 20:626-633(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. "Expression analysis of PDGF-C in adult and developing mouse tissues."
    Aase K., Abramsson A., Karlsson L., Betsholtz C., Eriksson U.
    Mech. Dev. 110:187-191(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy."
    Ponten A., Li X., Thoren P., Aase K., Sjoblom T., Ostman A., Eriksson U.
    Am. J. Pathol. 163:673-682(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis."
    Zhuo Y., Zhang J., Laboy M., Lasky J.A.
    Am. J. Physiol. 286:L182-L188(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY BLEOMYCIN.
  12. "PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle."
    Fang L., Yan Y., Komuves L.G., Yonkovich S., Sullivan C.M., Stringer B., Galbraith S., Lokker N.A., Hwang S.S., Nurden P., Phillips D.R., Giese N.A.
    Arterioscler. Thromb. Vasc. Biol. 24:787-792(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  13. Cited for: REVIEW.
  14. "Tissue plasminogen activator is a potent activator of PDGF-CC."
    Fredriksson L., Li H., Fieber C., Li X., Eriksson U.
    EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, ACTIVATION BY PROTEOLYTIC CLEAVAGE.
  15. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  16. "Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis."
    Yang D., Qiu D.
    Eur. Heart J. 26:642-643(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY COXSACKIEVIRUS B3 INFECTION, DISEASE.
  17. "Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator."
    Fredriksson L., Ehnman M., Fieber C., Eriksson U.
    J. Biol. Chem. 280:26856-26862(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  18. "PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells."
    Han J., Xiao Y., Lin J., Li Y.
    Birth Defects Res. B Dev. Reprod. Toxicol. 77:438-444(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY RETINOIC ACID.
  19. "Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse."
    Chen X., Aravindakshan J., Yang Y., Tiwari-Pandey R., Sairam M.R.
    Carcinogenesis 27:903-915(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY GONADOTROPIN.
  20. "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines."
    Reigstad L.J., Martinez A., Varhaug J.E., Lillehaug J.R.
    Exp. Cell Res. 312:782-795(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUMOYLATION.
  21. "Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts."
    Ingram J.L., Antao-Menezes A., Mangum J.B., Lyght O., Lee P.J., Elias J.A., Bonner J.C.
    J. Immunol. 177:4141-4148(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY IL13.
  22. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPDGFC_MOUSE
AccessioniPrimary (citable) accession number: Q8CI19
Secondary accession number(s): Q99JM4, Q9JHV8, Q9QY71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 26, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3