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Q8CI19

- PDGFC_MOUSE

UniProt

Q8CI19 - PDGFC_MOUSE

Protein

Platelet-derived growth factor C

Gene

Pdgfc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.8 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei225 – 2262CleavageBy similarity
    Sitei231 – 2322CleavageBy similarity
    Sitei234 – 2352CleavageBy similarity

    GO - Molecular functioni

    1. platelet-derived growth factor receptor binding Source: MGI

    GO - Biological processi

    1. activation of transmembrane receptor protein tyrosine kinase activity Source: MGI
    2. cellular response to amino acid stimulus Source: MGI
    3. organ morphogenesis Source: MGI
    4. platelet-derived growth factor receptor signaling pathway Source: MGI
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of cell proliferation Source: MGI
    7. positive regulation of DNA replication Source: Ensembl
    8. positive regulation of fibroblast proliferation Source: Ensembl
    9. regulation of peptidyl-tyrosine phosphorylation Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-derived growth factor C
    Short name:
    PDGF-C
    Alternative name(s):
    Fallotein
    Spinal cord-derived growth factor
    Short name:
    SCDGF
    VEGF-E
    Cleaved into the following 2 chains:
    Platelet-derived growth factor C, receptor-binding form
    Short name:
    PDGFC receptor-binding form
    Gene namesi
    Name:Pdgfc
    Synonyms:Scdgf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1859631. Pdgfc.

    Subcellular locationi

    Cytoplasm. Secreted. Nucleus. Cytoplasmic granule By similarity
    Note: Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets By similarity. Membrane associated when bound to receptors By similarity. Secretion increased by TGFB1.By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: UniProtKB-SubCell
    3. extracellular region Source: MGI
    4. extracellular space Source: Ensembl
    5. membrane Source: InterPro
    6. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Involved in the development of myocarditis and subsequent fibrosis in the experimental model of coxsackievirus B3-induced chronic myocarditis.1 Publication

    Disruption phenotypei

    Perinatal lethality. Mice have feeding and respiratory difficulties due to a complete cleft of the secondary palate. However, they have reduction of renal fibrogenesis. Mice lacking both PDGFA and PDGFC develop a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 345Platelet-derived growth factor C, receptor-binding formPRO_0000343874
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 345323Platelet-derived growth factor C, latent formPRO_0000343873Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi250 ↔ 294PROSITE-ProRule annotation
    Disulfide bondi274 – 274Interchain (with C-286)PROSITE-ProRule annotation
    Disulfide bondi280 ↔ 335PROSITE-ProRule annotation
    Disulfide bondi286 – 286Interchain (with C-274)PROSITE-ProRule annotation
    Disulfide bondi287 ↔ 337PROSITE-ProRule annotation

    Post-translational modificationi

    Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG By similarity.By similarity
    Sumoylated by SUMO1.1 Publication
    N-glycosylated.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ8CI19.

    PTM databases

    PhosphoSiteiQ8CI19.

    Expressioni

    Tissue specificityi

    Mainly expressed in kidney, testis, liver, heart and brain (at protein level). Highly expressed in airway epithelium, interstitial cells and alveolar macrophages in the lung of mice overexpressing IL13. Expressed in the ovaries.5 Publications

    Developmental stagei

    In stage E9.5-E15.5, widely expressed in the surface ectoderm and later in the germinal layer of the skin, the olfactory and otic placode and their derivatives and the lining of the oral cavity. In stages E14.5-17.5 expressed in ducts connected to epidermis, and in developing epidermal openings. Highly expressed in the early stages of the developing kidney, in the metanephric mesenchymal aggregates, prefusion skeletal muscle, cardiac myoblasts, and in visceral and vascular smooth muscle.4 Publications

    Inductioni

    Expression decreased by hypoxia. Up-regulated by EWS-FLI1 transcription factor in tumor-derived cells. Up-regulated by IL13 overexpression in the lung via STAT6 and EGR1. Elevated expression induced by coxsackievirus B3 infection in immunodeficient mice. Overexpressed in the renal fibrosis. Expression in the lung is significantly increased after bleomycin treatment. Down-regulated by retinoic acid and gonadotropin.7 Publications

    Gene expression databases

    ArrayExpressiQ8CI19.
    BgeeiQ8CI19.
    GenevestigatoriQ8CI19.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts (via CUB domain) with PLAT (via kringle domain) By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CI19.
    SMRiQ8CI19. Positions 53-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 163118CUBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated
    Contains 1 CUB domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74970.
    GeneTreeiENSGT00390000005171.
    HOGENOMiHOG000261610.
    HOVERGENiHBG057324.
    InParanoidiQ8CI19.
    KOiK05450.
    OMAiDCVCRGN.
    OrthoDBiEOG7VB2FN.
    PhylomeDBiQ8CI19.
    TreeFamiTF332130.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    2.60.120.290. 1 hit.
    InterProiIPR000859. CUB_dom.
    IPR029034. Cystine-knot_cytokine.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view]
    PfamiPF00431. CUB. 1 hit.
    PF00341. PDGF. 1 hit.
    [Graphical view]
    SMARTiSM00042. CUB. 1 hit.
    SM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 1 hit.
    SSF57501. SSF57501. 1 hit.
    PROSITEiPS01180. CUB. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8CI19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLGLLLLT SALAGQRTGT RAESNLSSKL QLSSDKEQNG VQDPRHERVV    50
    TISGNGSIHS PKFPHTYPRN MVLVWRLVAV DENVRIQLTF DERFGLEDPE 100
    DDICKYDFVE VEEPSDGSVL GRWCGSGTVP GKQTSKGNHI RIRFVSDEYF 150
    PSEPGFCIHY SIIMPQVTET TSPSVLPPSS LSLDLLNNAV TAFSTLEELI 200
    RYLEPDRWQV DLDSLYKPTW QLLGKAFLYG KKSKVVNLNL LKEEVKLYSC 250
    TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPRK 300
    VTKKYHEVLQ LRPKTGVKGL HKSLTDVALE HHEECDCVCR GNAGG 345
    Length:345
    Mass (Da):38,741
    Last modified:July 22, 2008 - v2
    Checksum:i3A58A1F701B84EA2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 861I → T in AAF91483. (PubMed:10960785)Curated
    Sequence conflicti103 – 1031I → L in AAH37696. (PubMed:15489334)Curated
    Sequence conflicti127 – 1271G → E in AAF91483. (PubMed:10960785)Curated
    Sequence conflicti230 – 2301G → V in AAF91483. (PubMed:10960785)Curated
    Sequence conflicti269 – 2691I → R in AAF91483. (PubMed:10960785)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF286725 mRNA. Translation: AAF91483.1.
    AF117608 mRNA. Translation: AAF22516.1.
    AF266467 mRNA. Translation: AAK58566.1.
    AK033734 mRNA. Translation: BAC28455.1.
    AK042767 mRNA. Translation: BAC31358.1.
    AK052947 mRNA. Translation: BAC35216.1.
    BC006027 mRNA. Translation: AAH06027.1.
    BC037696 mRNA. Translation: AAH37696.1.
    CCDSiCCDS17425.1.
    RefSeqiNP_064355.1. NM_019971.2.
    UniGeneiMm.331089.

    Genome annotation databases

    EnsembliENSMUST00000029652; ENSMUSP00000029652; ENSMUSG00000028019.
    GeneIDi54635.
    KEGGimmu:54635.
    UCSCiuc008poi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF286725 mRNA. Translation: AAF91483.1 .
    AF117608 mRNA. Translation: AAF22516.1 .
    AF266467 mRNA. Translation: AAK58566.1 .
    AK033734 mRNA. Translation: BAC28455.1 .
    AK042767 mRNA. Translation: BAC31358.1 .
    AK052947 mRNA. Translation: BAC35216.1 .
    BC006027 mRNA. Translation: AAH06027.1 .
    BC037696 mRNA. Translation: AAH37696.1 .
    CCDSi CCDS17425.1.
    RefSeqi NP_064355.1. NM_019971.2.
    UniGenei Mm.331089.

    3D structure databases

    ProteinModelPortali Q8CI19.
    SMRi Q8CI19. Positions 53-198.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8CI19.

    Proteomic databases

    PRIDEi Q8CI19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029652 ; ENSMUSP00000029652 ; ENSMUSG00000028019 .
    GeneIDi 54635.
    KEGGi mmu:54635.
    UCSCi uc008poi.1. mouse.

    Organism-specific databases

    CTDi 56034.
    MGIi MGI:1859631. Pdgfc.

    Phylogenomic databases

    eggNOGi NOG74970.
    GeneTreei ENSGT00390000005171.
    HOGENOMi HOG000261610.
    HOVERGENi HBG057324.
    InParanoidi Q8CI19.
    KOi K05450.
    OMAi DCVCRGN.
    OrthoDBi EOG7VB2FN.
    PhylomeDBi Q8CI19.
    TreeFami TF332130.

    Miscellaneous databases

    ChiTaRSi PDGFC. mouse.
    NextBioi 311464.
    PROi Q8CI19.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CI19.
    Bgeei Q8CI19.
    Genevestigatori Q8CI19.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    2.60.120.290. 1 hit.
    InterProi IPR000859. CUB_dom.
    IPR029034. Cystine-knot_cytokine.
    IPR000072. PDGF/VEGF_dom.
    [Graphical view ]
    Pfami PF00431. CUB. 1 hit.
    PF00341. PDGF. 1 hit.
    [Graphical view ]
    SMARTi SM00042. CUB. 1 hit.
    SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 1 hit.
    SSF57501. SSF57501. 1 hit.
    PROSITEi PS01180. CUB. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis."
      Ding H., Wu X., Kim I., Tam P.P., Koh G.Y., Nagy A.
      Mech. Dev. 96:209-213(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Strain: Swiss Webster / NIH.
    2. "cDNA cloning of fallotein from mouse ovary."
      Tsai Y.-J., Lee R.K.-K., Chen Y.-H., Lin S.-P., Cheng W.T.-K.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    3. "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha receptor."
      Gao Z., Hart C., Piddington C., Sheppard P., Shoemaker K., Gilbertson D., West J., O'Hara P.J.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum, Cerebellum and Head.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Mammary tumor.
    6. Cited for: FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE.
    7. "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."
      Gilbertson D.G., Duff M.E., West J.W., Kelly J.D., Sheppard P.O., Hofstrand P.D., Gao Z., Shoemaker K., Bukowski T.R., Moore M., Feldhaus A.L., Humes J.M., Palmer T.E., Hart C.E.
      J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
    8. "PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors."
      Zwerner J.P., May W.A.
      Oncogene 20:626-633(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    9. "Expression analysis of PDGF-C in adult and developing mouse tissues."
      Aase K., Abramsson A., Karlsson L., Betsholtz C., Eriksson U.
      Mech. Dev. 110:187-191(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    10. "Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy."
      Ponten A., Li X., Thoren P., Aase K., Sjoblom T., Ostman A., Eriksson U.
      Am. J. Pathol. 163:673-682(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis."
      Zhuo Y., Zhang J., Laboy M., Lasky J.A.
      Am. J. Physiol. 286:L182-L188(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION BY BLEOMYCIN.
    12. "PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle."
      Fang L., Yan Y., Komuves L.G., Yonkovich S., Sullivan C.M., Stringer B., Galbraith S., Lokker N.A., Hwang S.S., Nurden P., Phillips D.R., Giese N.A.
      Arterioscler. Thromb. Vasc. Biol. 24:787-792(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    13. Cited for: REVIEW.
    14. "Tissue plasminogen activator is a potent activator of PDGF-CC."
      Fredriksson L., Li H., Fieber C., Li X., Eriksson U.
      EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, ACTIVATION BY PROTEOLYTIC CLEAVAGE.
    15. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    16. "Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis."
      Yang D., Qiu D.
      Eur. Heart J. 26:642-643(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION BY COXSACKIEVIRUS B3 INFECTION, DISEASE.
    17. "Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator."
      Fredriksson L., Ehnman M., Fieber C., Eriksson U.
      J. Biol. Chem. 280:26856-26862(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    18. "PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells."
      Han J., Xiao Y., Lin J., Li Y.
      Birth Defects Res. B Dev. Reprod. Toxicol. 77:438-444(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY RETINOIC ACID.
    19. "Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse."
      Chen X., Aravindakshan J., Yang Y., Tiwari-Pandey R., Sairam M.R.
      Carcinogenesis 27:903-915(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION BY GONADOTROPIN.
    20. "Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines."
      Reigstad L.J., Martinez A., Varhaug J.E., Lillehaug J.R.
      Exp. Cell Res. 312:782-795(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUMOYLATION.
    21. "Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts."
      Ingram J.L., Antao-Menezes A., Mangum J.B., Lyght O., Lee P.J., Elias J.A., Bonner J.C.
      J. Immunol. 177:4141-4148(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION BY IL13.
    22. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPDGFC_MOUSE
    AccessioniPrimary (citable) accession number: Q8CI19
    Secondary accession number(s): Q99JM4, Q9JHV8, Q9QY71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3