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Q8CI15

- SPHK1_MOUSE

UniProt

Q8CI15 - SPHK1_MOUSE

Protein

Sphingosine kinase 1

Gene

Sphk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol By similarity.By similarity

    Catalytic activityi

    ATP + sphinganine = ADP + sphinganine 1-phosphate.
    ATP + sphingosine = ADP + sphingosine 1-phosphate.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei81 – 811Proton donor/acceptorBy similarity
    Binding sitei86 – 861ATPPROSITE-ProRule annotation
    Binding sitei178 – 1781SubstrateBy similarity
    Binding sitei185 – 1851ATPPROSITE-ProRule annotation
    Binding sitei191 – 1911ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 243ATPPROSITE-ProRule annotation
    Nucleotide bindingi54 – 585ATPPROSITE-ProRule annotation
    Nucleotide bindingi111 – 1133ATPPROSITE-ProRule annotation
    Nucleotide bindingi340 – 3423ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calmodulin binding Source: MGI
    3. D-erythro-sphingosine kinase activity Source: UniProtKB
    4. diacylglycerol kinase activity Source: InterPro
    5. DNA binding Source: MGI
    6. magnesium ion binding Source: UniProtKB
    7. NAD+ kinase activity Source: InterPro
    8. sphinganine kinase activity Source: MGI

    GO - Biological processi

    1. blood vessel development Source: MGI
    2. brain development Source: MGI
    3. calcium-mediated signaling Source: Ensembl
    4. cellular response to growth factor stimulus Source: Ensembl
    5. cellular response to hydrogen peroxide Source: Ensembl
    6. cellular response to starvation Source: Ensembl
    7. cyclooxygenase pathway Source: Ensembl
    8. female pregnancy Source: Ensembl
    9. inflammatory response Source: MGI
    10. lipid phosphorylation Source: GOC
    11. negative regulation of apoptotic process Source: Ensembl
    12. positive regulation of angiogenesis Source: Ensembl
    13. positive regulation of cell growth Source: Ensembl
    14. positive regulation of cell migration Source: Ensembl
    15. positive regulation of cell proliferation Source: MGI
    16. positive regulation of fibroblast proliferation Source: Ensembl
    17. positive regulation of mitotic cell cycle Source: Ensembl
    18. positive regulation of neuron projection development Source: Ensembl
    19. positive regulation of neurotransmitter secretion Source: Ensembl
    20. positive regulation of NF-kappaB import into nucleus Source: UniProtKB
    21. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    22. positive regulation of protein phosphorylation Source: Ensembl
    23. positive regulation of protein ubiquitination Source: UniProtKB
    24. positive regulation of smooth muscle contraction Source: Ensembl
    25. protein kinase C-activating G-protein coupled receptor signaling pathway Source: InterPro
    26. regulation of interleukin-1 beta production Source: MGI
    27. regulation of tumor necrosis factor-mediated signaling pathway Source: UniProtKB
    28. response to amine Source: Ensembl
    29. response to ATP Source: Ensembl
    30. response to interleukin-1 Source: Ensembl
    31. response to magnesium ion Source: Ensembl
    32. response to progesterone Source: Ensembl
    33. sphingosine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198151. Sphingolipid de novo biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sphingosine kinase 1 (EC:2.7.1.91)
    Short name:
    SK 1
    Short name:
    SPK 1
    Gene namesi
    Name:Sphk1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1316649. Sphk1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Cell membrane By similarity
    Note: Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner.By similarity

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: Ensembl
    4. nucleus Source: UniProtKB-SubCell
    5. plasma membrane Source: UniProtKB
    6. synaptic vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Sphingosine kinase 1PRO_0000333032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei193 – 1931PhosphothreonineBy similarity
    Modified residuei225 – 2251PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8CI15.
    PRIDEiQ8CI15.

    PTM databases

    PhosphoSiteiQ8CI15.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8CI15.
    BgeeiQ8CI15.
    GenevestigatoriQ8CI15.

    Interactioni

    Subunit structurei

    Binds to calmodulin. Interacts with SPHKAP. Interacts with CIB1, the interaction occurs in a calcium-dependent manner By similarity. Interacts with ACY1.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ8CI15. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CI15.
    SMRiQ8CI15. Positions 9-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 159148DAGKcPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni79 – 824Substrate bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi147 – 1559Nuclear export signal 1By similarity
    Motifi161 – 1699Nuclear export signal 2By similarity

    Sequence similaritiesi

    Contains 1 DAGKc domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1597.
    GeneTreeiENSGT00690000101761.
    HOGENOMiHOG000111460.
    HOVERGENiHBG054796.
    KOiK04718.
    OMAiRWAHAIS.
    OrthoDBiEOG7PCJGK.
    PhylomeDBiQ8CI15.
    TreeFamiTF354296.

    Family and domain databases

    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view]
    PfamiPF00781. DAGK_cat. 1 hit.
    [Graphical view]
    SMARTiSM00046. DAGKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    PROSITEiPS50146. DAGK. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8CI15-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPVECPRGL LPRPCRVLVL LNPQGGKGKA LQLFQSRVQP FLEEAEITFK    50
    LILTERKNHA RELVCAEELG HWDALAVMSG DGLMHEVVNG LMERPDWETA 100
    IQKPLCSLPG GSGNALAASV NHYAGYEQVT NEDLLINCTL LLCRRRLSPM 150
    NLLSLHTASG LRLYSVLSLS WGFVADVDLE SEKYRRLGEI RFTVGTFFRL 200
    ASLRIYQGQL AYLPVGTVAS KRPASTLVQK GPVDTHLVPL EEPVPSHWTV 250
    VPEQDFVLVL VLLHTHLSSE LFAAPMGRCE AGVMHLFYVR AGVSRAALLR 300
    LFLAMQKGKH MELDCPYLVH VPVVAFRLEP RSQRGVFSVD GELMVCEAVQ 350
    GQVHPNYLWM VCGSRDAPSG RDSRRGPPPE EP 382
    Length:382
    Mass (Da):42,443
    Last modified:March 1, 2003 - v1
    Checksum:iB791FAA58FCE3D29
    GO
    Isoform 2 (identifier: Q8CI15-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MEP → MWWCCVLFV

    Show »
    Length:388
    Mass (Da):43,254
    Checksum:i01EB032322542CAD
    GO
    Isoform 3 (identifier: Q8CI15-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         4-4: Missing.

    Show »
    Length:381
    Mass (Da):42,344
    Checksum:i2F2C1F10D59EB129
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461R → H in BAE33198. (PubMed:9726979)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 33MEP → MWWCCVLFV in isoform 2. 1 PublicationVSP_033448
    Alternative sequencei4 – 41Missing in isoform 3. 1 PublicationVSP_033449

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068749 mRNA. Translation: AAC61698.1.
    AF415213 mRNA. Translation: AAL07499.1.
    AK155332 mRNA. Translation: BAE33198.1.
    AK160900 mRNA. Translation: BAE36079.1.
    AL645851 Genomic DNA. Translation: CAM17116.1.
    AL645851 Genomic DNA. Translation: CAM17117.1.
    BC037710 mRNA. Translation: AAH37710.1.
    CCDSiCCDS25668.1. [Q8CI15-1]
    CCDS25669.1. [Q8CI15-2]
    CCDS48986.1. [Q8CI15-3]
    RefSeqiNP_001165943.1. NM_001172472.1. [Q8CI15-1]
    NP_001165944.1. NM_001172473.1. [Q8CI15-1]
    NP_001165946.1. NM_001172475.1. [Q8CI15-3]
    NP_035581.1. NM_011451.3. [Q8CI15-2]
    NP_079643.2. NM_025367.6. [Q8CI15-1]
    XP_006532733.1. XM_006532670.1. [Q8CI15-3]
    XP_006532734.1. XM_006532671.1. [Q8CI15-3]
    XP_006532735.1. XM_006532672.1. [Q8CI15-3]
    XP_006532736.1. XM_006532673.1. [Q8CI15-1]
    UniGeneiMm.20944.

    Genome annotation databases

    EnsembliENSMUST00000063396; ENSMUSP00000064743; ENSMUSG00000061878. [Q8CI15-1]
    ENSMUST00000063446; ENSMUSP00000067865; ENSMUSG00000061878. [Q8CI15-1]
    ENSMUST00000100201; ENSMUSP00000097775; ENSMUSG00000061878. [Q8CI15-3]
    ENSMUST00000106386; ENSMUSP00000101994; ENSMUSG00000061878. [Q8CI15-1]
    ENSMUST00000106387; ENSMUSP00000101995; ENSMUSG00000061878. [Q8CI15-1]
    ENSMUST00000106388; ENSMUSP00000101996; ENSMUSG00000061878. [Q8CI15-1]
    ENSMUST00000141798; ENSMUSP00000131010; ENSMUSG00000061878. [Q8CI15-2]
    GeneIDi20698.
    KEGGimmu:20698.
    UCSCiuc007mlg.2. mouse. [Q8CI15-3]
    uc007mlh.2. mouse. [Q8CI15-1]
    uc007mll.2. mouse. [Q8CI15-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068749 mRNA. Translation: AAC61698.1 .
    AF415213 mRNA. Translation: AAL07499.1 .
    AK155332 mRNA. Translation: BAE33198.1 .
    AK160900 mRNA. Translation: BAE36079.1 .
    AL645851 Genomic DNA. Translation: CAM17116.1 .
    AL645851 Genomic DNA. Translation: CAM17117.1 .
    BC037710 mRNA. Translation: AAH37710.1 .
    CCDSi CCDS25668.1. [Q8CI15-1 ]
    CCDS25669.1. [Q8CI15-2 ]
    CCDS48986.1. [Q8CI15-3 ]
    RefSeqi NP_001165943.1. NM_001172472.1. [Q8CI15-1 ]
    NP_001165944.1. NM_001172473.1. [Q8CI15-1 ]
    NP_001165946.1. NM_001172475.1. [Q8CI15-3 ]
    NP_035581.1. NM_011451.3. [Q8CI15-2 ]
    NP_079643.2. NM_025367.6. [Q8CI15-1 ]
    XP_006532733.1. XM_006532670.1. [Q8CI15-3 ]
    XP_006532734.1. XM_006532671.1. [Q8CI15-3 ]
    XP_006532735.1. XM_006532672.1. [Q8CI15-3 ]
    XP_006532736.1. XM_006532673.1. [Q8CI15-1 ]
    UniGenei Mm.20944.

    3D structure databases

    ProteinModelPortali Q8CI15.
    SMRi Q8CI15. Positions 9-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CI15. 3 interactions.

    Chemistry

    ChEMBLi CHEMBL2401605.

    PTM databases

    PhosphoSitei Q8CI15.

    Proteomic databases

    PaxDbi Q8CI15.
    PRIDEi Q8CI15.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063396 ; ENSMUSP00000064743 ; ENSMUSG00000061878 . [Q8CI15-1 ]
    ENSMUST00000063446 ; ENSMUSP00000067865 ; ENSMUSG00000061878 . [Q8CI15-1 ]
    ENSMUST00000100201 ; ENSMUSP00000097775 ; ENSMUSG00000061878 . [Q8CI15-3 ]
    ENSMUST00000106386 ; ENSMUSP00000101994 ; ENSMUSG00000061878 . [Q8CI15-1 ]
    ENSMUST00000106387 ; ENSMUSP00000101995 ; ENSMUSG00000061878 . [Q8CI15-1 ]
    ENSMUST00000106388 ; ENSMUSP00000101996 ; ENSMUSG00000061878 . [Q8CI15-1 ]
    ENSMUST00000141798 ; ENSMUSP00000131010 ; ENSMUSG00000061878 . [Q8CI15-2 ]
    GeneIDi 20698.
    KEGGi mmu:20698.
    UCSCi uc007mlg.2. mouse. [Q8CI15-3 ]
    uc007mlh.2. mouse. [Q8CI15-1 ]
    uc007mll.2. mouse. [Q8CI15-2 ]

    Organism-specific databases

    CTDi 8877.
    MGIi MGI:1316649. Sphk1.

    Phylogenomic databases

    eggNOGi COG1597.
    GeneTreei ENSGT00690000101761.
    HOGENOMi HOG000111460.
    HOVERGENi HBG054796.
    KOi K04718.
    OMAi RWAHAIS.
    OrthoDBi EOG7PCJGK.
    PhylomeDBi Q8CI15.
    TreeFami TF354296.

    Enzyme and pathway databases

    Reactomei REACT_198151. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    NextBioi 299241.
    PROi Q8CI15.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CI15.
    Bgeei Q8CI15.
    Genevestigatori Q8CI15.

    Family and domain databases

    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00781. DAGK_cat. 1 hit.
    [Graphical view ]
    SMARTi SM00046. DAGKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    PROSITEi PS50146. DAGK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of murine sphingosine kinase."
      Kohama T., Olivera A., Edsall L., Nagiec M.M., Dickson R., Spiegel S.
      J. Biol. Chem. 273:23722-23728(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. Thompson D., Pyne S.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J and NOD.
      Tissue: Placenta.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Kidney.
    6. "Aminoacylase 1 is a sphingosine kinase 1-interacting protein."
      Maceyka M., Nava V.E., Milstien S., Spiegel S.
      FEBS Lett. 568:30-34(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ACY1.

    Entry informationi

    Entry nameiSPHK1_MOUSE
    AccessioniPrimary (citable) accession number: Q8CI15
    Secondary accession number(s): O88886, Q3U2E3, Q91ZN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Sphingosine 1-phosphate stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3