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Protein

Dymeclin

Gene

Dym

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for correct organization of Golgi apparatus. Involved in bone development.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dymeclin
Gene namesi
Name:Dym
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1918480 Dym

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000868842 – 669DymeclinAdd BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Post-translational modificationi

Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ8CHY3
PaxDbiQ8CHY3
PeptideAtlasiQ8CHY3
PRIDEiQ8CHY3

PTM databases

iPTMnetiQ8CHY3
PhosphoSitePlusiQ8CHY3

Expressioni

Gene expression databases

BgeeiENSMUSG00000035765
CleanExiMM_DYM
GenevisibleiQ8CHY3 MM

Interactioni

Subunit structurei

Interacts with GOLM1 and PPIB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213282, 1 interactor
STRINGi10090.ENSMUSP00000047054

Family & Domainsi

Sequence similaritiesi

Belongs to the dymeclin family.Curated

Phylogenomic databases

eggNOGiKOG2225 Eukaryota
ENOG410XP0J LUCA
GeneTreeiENSGT00390000008772
HOGENOMiHOG000006864
HOVERGENiHBG057356
InParanoidiQ8CHY3
OMAiIQYNMLK
OrthoDBiEOG091G031X
PhylomeDBiQ8CHY3
TreeFamiTF314870

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR019142 Dymeclin
PANTHERiPTHR12895 PTHR12895, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CHY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSNSSKISD LPKNEYLKKL SGPESISEND PFWNQLFSFS FPAPTSSSEL
60 70 80 90 100
KLLEEATISV CKSLVENNPR TGNLAALTKV FLSRTRELRL SAECQNHIFI
110 120 130 140 150
WQTHNALFII CCLLKVFIRE LSEEELQLHF TYEEKSPGSY SSDSEDLLEE
160 170 180 190 200
LLCSLVQLIT DTPLLDITYE IAVEAISAMV VFLSCQLFHK EVLRQSISHK
210 220 230 240 250
YLMQGPCLPY TSKLVKTLLY NFIRQEKPPP PGTHVFPQQS DGGGLLYGLA
260 270 280 290 300
SGVATGLWTV FTLGGAGSKA AASPELTSPL ANQSLLLLLV LVNLTDAPDI
310 320 330 340 350
PNPYRQAVSS FKNTQDSSPF PSSIPHTFQI NFNSLYTALC EQQTSDQATL
360 370 380 390 400
LLYTLLHQNS NVRTYVLART DMENLVLPIL EILYHVEERN SHHVYMALII
410 420 430 440 450
LLILTEDDGF NRSIHEVILR NITWYSERVL TEISLGSLLI LVVIRTIQYN
460 470 480 490 500
MTRTRDKYLH TNCLAALANM SAQFRSLHQY AAQRIISLFS LLSKKHNKVL
510 520 530 540 550
EQATQSLRGP LSSSDVPLPD YAQDLSVIEE VIRMMLEIIN SCLTNSLHHN
560 570 580 590 600
PNLVYALLYK RDLFEQFRTH PSFQDIMQNI DLVISFFSSR LLQAGAELSV
610 620 630 640 650
ERVLEIIKQG VVALPKDRLK KFPELKFKYV EEEQPEEFFI PYVWSLVYNS
660
AVGLYWNPQD IQLFAMDSD
Length:669
Mass (Da):75,848
Last modified:March 1, 2003 - v1
Checksum:i47B7200E0E8AD20B
GO
Isoform 2 (identifier: Q8CHY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-216: TSKLVK → PFSPGV
     217-669: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):24,418
Checksum:i530C452CBCDBB7B3
GO

Sequence cautioni

The sequence AAH18220 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33983 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32833 differs from that shown. Reason: Erroneous termination at position 566. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti313N → Y in BAE32833 (PubMed:16141072).Curated1
Sequence conflicti505Q → K in AAH18220 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036444211 – 216TSKLVK → PFSPGV in isoform 2. 1 Publication6
Alternative sequenceiVSP_036445217 – 669Missing in isoform 2. 1 PublicationAdd BLAST453

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049909 mRNA Translation: BAC33983.1 Different initiation.
AK149628 mRNA Translation: BAE28996.1
AK149891 mRNA Translation: BAE29149.1
AK154794 mRNA Translation: BAE32833.1 Sequence problems.
BC018220 mRNA Translation: AAH18220.1 Different initiation.
BC038276 mRNA Translation: AAH38276.1
BC092283 mRNA Translation: AAH92283.1
CCDSiCCDS29346.1 [Q8CHY3-1]
RefSeqiNP_082003.1, NM_027727.2 [Q8CHY3-1]
XP_006526282.1, XM_006526219.3
UniGeneiMm.173826

Genome annotation databases

EnsembliENSMUST00000039608; ENSMUSP00000047054; ENSMUSG00000035765 [Q8CHY3-1]
GeneIDi69190
KEGGimmu:69190
UCSCiuc008fpz.1 mouse [Q8CHY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDYM_MOUSE
AccessioniPrimary (citable) accession number: Q8CHY3
Secondary accession number(s): Q3U3F3
, Q3UDW2, Q569W1, Q8C7M2, Q8VCZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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