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Protein

Dymeclin

Gene

Dym

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for correct organization of Golgi apparatus. Involved in bone development.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dymeclin
Gene namesi
Name:Dym
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1918480. Dym.

Subcellular locationi

  • Cytoplasm
  • Golgi apparatus By similarity
  • Membrane By similarity; Lipid-anchor By similarity

  • Note: Sequence analysis programs predict 1 transmembrane region. However, it has been shown in human that it is not a stably anchored transmembrane protein but it weakly associates with the Golgi apparatus and shuttles between the Golgi and the cytosol (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 669668DymeclinPRO_0000086884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Post-translational modificationi

Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ8CHY3.
MaxQBiQ8CHY3.
PaxDbiQ8CHY3.
PRIDEiQ8CHY3.

PTM databases

iPTMnetiQ8CHY3.
PhosphoSiteiQ8CHY3.

Expressioni

Gene expression databases

BgeeiQ8CHY3.
CleanExiMM_DYM.
GenevisibleiQ8CHY3. MM.

Interactioni

Subunit structurei

Interacts with GOLM1 and PPIB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047054.

Family & Domainsi

Sequence similaritiesi

Belongs to the dymeclin family.Curated

Phylogenomic databases

eggNOGiKOG2225. Eukaryota.
ENOG410XP0J. LUCA.
GeneTreeiENSGT00390000008772.
HOGENOMiHOG000006864.
HOVERGENiHBG057356.
InParanoidiQ8CHY3.
OMAiIQNIDMV.
OrthoDBiEOG72ZCG2.
PhylomeDBiQ8CHY3.
TreeFamiTF314870.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR019142. Dymeclin.
[Graphical view]
PANTHERiPTHR12895:SF9. PTHR12895:SF9. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CHY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSNSSKISD LPKNEYLKKL SGPESISEND PFWNQLFSFS FPAPTSSSEL
60 70 80 90 100
KLLEEATISV CKSLVENNPR TGNLAALTKV FLSRTRELRL SAECQNHIFI
110 120 130 140 150
WQTHNALFII CCLLKVFIRE LSEEELQLHF TYEEKSPGSY SSDSEDLLEE
160 170 180 190 200
LLCSLVQLIT DTPLLDITYE IAVEAISAMV VFLSCQLFHK EVLRQSISHK
210 220 230 240 250
YLMQGPCLPY TSKLVKTLLY NFIRQEKPPP PGTHVFPQQS DGGGLLYGLA
260 270 280 290 300
SGVATGLWTV FTLGGAGSKA AASPELTSPL ANQSLLLLLV LVNLTDAPDI
310 320 330 340 350
PNPYRQAVSS FKNTQDSSPF PSSIPHTFQI NFNSLYTALC EQQTSDQATL
360 370 380 390 400
LLYTLLHQNS NVRTYVLART DMENLVLPIL EILYHVEERN SHHVYMALII
410 420 430 440 450
LLILTEDDGF NRSIHEVILR NITWYSERVL TEISLGSLLI LVVIRTIQYN
460 470 480 490 500
MTRTRDKYLH TNCLAALANM SAQFRSLHQY AAQRIISLFS LLSKKHNKVL
510 520 530 540 550
EQATQSLRGP LSSSDVPLPD YAQDLSVIEE VIRMMLEIIN SCLTNSLHHN
560 570 580 590 600
PNLVYALLYK RDLFEQFRTH PSFQDIMQNI DLVISFFSSR LLQAGAELSV
610 620 630 640 650
ERVLEIIKQG VVALPKDRLK KFPELKFKYV EEEQPEEFFI PYVWSLVYNS
660
AVGLYWNPQD IQLFAMDSD
Length:669
Mass (Da):75,848
Last modified:March 1, 2003 - v1
Checksum:i47B7200E0E8AD20B
GO
Isoform 2 (identifier: Q8CHY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-216: TSKLVK → PFSPGV
     217-669: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):24,418
Checksum:i530C452CBCDBB7B3
GO

Sequence cautioni

The sequence AAH18220.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC33983.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE32833.1 differs from that shown. Reason: Erroneous termination at position 566. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131N → Y in BAE32833 (PubMed:16141072).Curated
Sequence conflicti505 – 5051Q → K in AAH18220 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei211 – 2166TSKLVK → PFSPGV in isoform 2. 1 PublicationVSP_036444
Alternative sequencei217 – 669453Missing in isoform 2. 1 PublicationVSP_036445Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049909 mRNA. Translation: BAC33983.1. Different initiation.
AK149628 mRNA. Translation: BAE28996.1.
AK149891 mRNA. Translation: BAE29149.1.
AK154794 mRNA. Translation: BAE32833.1. Sequence problems.
BC018220 mRNA. Translation: AAH18220.1. Different initiation.
BC038276 mRNA. Translation: AAH38276.1.
BC092283 mRNA. Translation: AAH92283.1.
CCDSiCCDS29346.1. [Q8CHY3-1]
RefSeqiNP_082003.1. NM_027727.2. [Q8CHY3-1]
XP_006526282.1. XM_006526219.2.
UniGeneiMm.173826.

Genome annotation databases

EnsembliENSMUST00000039608; ENSMUSP00000047054; ENSMUSG00000035765. [Q8CHY3-1]
GeneIDi69190.
KEGGimmu:69190.
UCSCiuc008fpz.1. mouse. [Q8CHY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049909 mRNA. Translation: BAC33983.1. Different initiation.
AK149628 mRNA. Translation: BAE28996.1.
AK149891 mRNA. Translation: BAE29149.1.
AK154794 mRNA. Translation: BAE32833.1. Sequence problems.
BC018220 mRNA. Translation: AAH18220.1. Different initiation.
BC038276 mRNA. Translation: AAH38276.1.
BC092283 mRNA. Translation: AAH92283.1.
CCDSiCCDS29346.1. [Q8CHY3-1]
RefSeqiNP_082003.1. NM_027727.2. [Q8CHY3-1]
XP_006526282.1. XM_006526219.2.
UniGeneiMm.173826.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047054.

PTM databases

iPTMnetiQ8CHY3.
PhosphoSiteiQ8CHY3.

Proteomic databases

EPDiQ8CHY3.
MaxQBiQ8CHY3.
PaxDbiQ8CHY3.
PRIDEiQ8CHY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039608; ENSMUSP00000047054; ENSMUSG00000035765. [Q8CHY3-1]
GeneIDi69190.
KEGGimmu:69190.
UCSCiuc008fpz.1. mouse. [Q8CHY3-1]

Organism-specific databases

CTDi54808.
MGIiMGI:1918480. Dym.

Phylogenomic databases

eggNOGiKOG2225. Eukaryota.
ENOG410XP0J. LUCA.
GeneTreeiENSGT00390000008772.
HOGENOMiHOG000006864.
HOVERGENiHBG057356.
InParanoidiQ8CHY3.
OMAiIQNIDMV.
OrthoDBiEOG72ZCG2.
PhylomeDBiQ8CHY3.
TreeFamiTF314870.

Miscellaneous databases

PROiQ8CHY3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CHY3.
CleanExiMM_DYM.
GenevisibleiQ8CHY3. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR019142. Dymeclin.
[Graphical view]
PANTHERiPTHR12895:SF9. PTHR12895:SF9. 1 hit.
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow and Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Mammary tumor and Salivary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiDYM_MOUSE
AccessioniPrimary (citable) accession number: Q8CHY3
Secondary accession number(s): Q3U3F3
, Q3UDW2, Q569W1, Q8C7M2, Q8VCZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.