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Q8CHW1

- THAP1_MOUSE

UniProt

Q8CHW1 - THAP1_MOUSE

Protein

THAP domain-containing protein 1

Gene

Thap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri5 – 5753THAP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. endothelial cell proliferation Source: UniProtKB
    3. regulation of mitotic cell cycle Source: UniProtKB
    4. regulation of transcription, DNA-templated Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    THAP domain-containing protein 1
    Gene namesi
    Name:Thap1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1921004. Thap1.

    Subcellular locationi

    Nucleusnucleoplasm By similarity. NucleusPML body By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. PML body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210THAP domain-containing protein 1PRO_0000068639Add
    BLAST

    Proteomic databases

    PRIDEiQ8CHW1.

    Expressioni

    Tissue specificityi

    Highest levels in heart, liver and kidney. Lower levels in brain and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ8CHW1.
    BgeeiQ8CHW1.
    GenevestigatoriQ8CHW1.

    Interactioni

    Subunit structurei

    Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CHW1.
    SMRiQ8CHW1. Positions 1-86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili137 – 18751Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi131 – 1344HCFC1-binding motif (HBM)By similarity

    Sequence similaritiesi

    Belongs to the THAP1 family.Curated
    Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri5 – 5753THAP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG84669.
    GeneTreeiENSGT00530000063253.
    HOGENOMiHOG000231117.
    HOVERGENiHBG057457.
    InParanoidiQ8CHW1.
    OMAiDLCKKWE.
    OrthoDBiEOG7QVM4D.
    PhylomeDBiQ8CHW1.
    TreeFamiTF330127.

    Family and domain databases

    InterProiIPR026516. THAP1.
    IPR006612. Znf_C2CH.
    [Graphical view]
    PANTHERiPTHR23080:SF11. PTHR23080:SF11. 1 hit.
    PfamiPF05485. THAP. 1 hit.
    [Graphical view]
    SMARTiSM00692. DM3. 1 hit.
    SM00980. THAP. 1 hit.
    [Graphical view]
    PROSITEiPS50950. ZF_THAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CHW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKQWEAAV KRKNFKPTKY    50
    SSICSEHFTP DCFKRECNNK LLKENAVPTI FLYIEPHEKK EDLESQEQLP 100
    SPSPPASQVD AAIGLLMPPL QTPDNLSVFC DHNYTVEDTM HQRKRILQLE 150
    QQVEKLRKKL KTAQQRCRRQ ERQLEKLKEV VHFQREKDDA SERGYVILPN 200
    DYFEIVEVPA 210
    Length:210
    Mass (Da):24,611
    Last modified:March 1, 2003 - v1
    Checksum:i2F8EE0E59FA01B3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC038639 mRNA. Translation: AAH38639.1.
    CCDSiCCDS22208.1.
    RefSeqiNP_950243.1. NM_199042.2.
    UniGeneiMm.383241.

    Genome annotation databases

    EnsembliENSMUST00000036807; ENSMUSP00000042464; ENSMUSG00000037214.
    GeneIDi73754.
    KEGGimmu:73754.
    UCSCiuc009lhq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC038639 mRNA. Translation: AAH38639.1 .
    CCDSi CCDS22208.1.
    RefSeqi NP_950243.1. NM_199042.2.
    UniGenei Mm.383241.

    3D structure databases

    ProteinModelPortali Q8CHW1.
    SMRi Q8CHW1. Positions 1-86.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8CHW1.

    Protocols and materials databases

    DNASUi 73754.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036807 ; ENSMUSP00000042464 ; ENSMUSG00000037214 .
    GeneIDi 73754.
    KEGGi mmu:73754.
    UCSCi uc009lhq.2. mouse.

    Organism-specific databases

    CTDi 55145.
    MGIi MGI:1921004. Thap1.

    Phylogenomic databases

    eggNOGi NOG84669.
    GeneTreei ENSGT00530000063253.
    HOGENOMi HOG000231117.
    HOVERGENi HBG057457.
    InParanoidi Q8CHW1.
    OMAi DLCKKWE.
    OrthoDBi EOG7QVM4D.
    PhylomeDBi Q8CHW1.
    TreeFami TF330127.

    Miscellaneous databases

    NextBioi 339007.
    PROi Q8CHW1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CHW1.
    Bgeei Q8CHW1.
    Genevestigatori Q8CHW1.

    Family and domain databases

    InterProi IPR026516. THAP1.
    IPR006612. Znf_C2CH.
    [Graphical view ]
    PANTHERi PTHR23080:SF11. PTHR23080:SF11. 1 hit.
    Pfami PF05485. THAP. 1 hit.
    [Graphical view ]
    SMARTi SM00692. DM3. 1 hit.
    SM00980. THAP. 1 hit.
    [Graphical view ]
    PROSITEi PS50950. ZF_THAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Lung.
    2. "The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."
      Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L., Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B., Kristie T.M., Girard J.P.
      J. Biol. Chem. 285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTHAP1_MOUSE
    AccessioniPrimary (citable) accession number: Q8CHW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3