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Protein

THAP domain-containing protein 1

Gene

Thap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 57THAP-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 1
Gene namesi
Name:Thap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921004 Thap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686391 – 210THAP domain-containing protein 1Add BLAST210

Proteomic databases

MaxQBiQ8CHW1
PaxDbiQ8CHW1
PeptideAtlasiQ8CHW1
PRIDEiQ8CHW1

PTM databases

iPTMnetiQ8CHW1
PhosphoSitePlusiQ8CHW1

Expressioni

Tissue specificityi

Highest levels in heart, liver and kidney. Lower levels in brain and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000037214
ExpressionAtlasiQ8CHW1 baseline and differential
GenevisibleiQ8CHW1 MM

Interactioni

Subunit structurei

Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042464

Structurei

3D structure databases

ProteinModelPortaliQ8CHW1
SMRiQ8CHW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili137 – 187Sequence analysisAdd BLAST51

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 134HCFC1-binding motif (HBM)By similarity4

Sequence similaritiesi

Belongs to the THAP1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 57THAP-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGDI Eukaryota
ENOG4111FGC LUCA
GeneTreeiENSGT00840000129785
HOGENOMiHOG000231117
HOVERGENiHBG057457
InParanoidiQ8CHW1
OMAiHQRKRIQ
OrthoDBiEOG091G034R
PhylomeDBiQ8CHW1
TreeFamiTF330127

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026516 THAP1
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF85 PTHR23080:SF85, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CHW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKQWEAAV KRKNFKPTKY
60 70 80 90 100
SSICSEHFTP DCFKRECNNK LLKENAVPTI FLYIEPHEKK EDLESQEQLP
110 120 130 140 150
SPSPPASQVD AAIGLLMPPL QTPDNLSVFC DHNYTVEDTM HQRKRILQLE
160 170 180 190 200
QQVEKLRKKL KTAQQRCRRQ ERQLEKLKEV VHFQREKDDA SERGYVILPN
210
DYFEIVEVPA
Length:210
Mass (Da):24,611
Last modified:March 1, 2003 - v1
Checksum:i2F8EE0E59FA01B3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC038639 mRNA Translation: AAH38639.1
CCDSiCCDS22208.1
RefSeqiNP_950243.1, NM_199042.2
UniGeneiMm.383241

Genome annotation databases

EnsembliENSMUST00000036807; ENSMUSP00000042464; ENSMUSG00000037214
GeneIDi73754
KEGGimmu:73754
UCSCiuc009lhq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTHAP1_MOUSE
AccessioniPrimary (citable) accession number: Q8CHW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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