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Protein

THAP domain-containing protein 1

Gene

Thap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri5 – 5753THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: UniProtKB
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. endothelial cell proliferation Source: UniProtKB
  3. regulation of mitotic cell cycle Source: UniProtKB
  4. regulation of transcription, DNA-templated Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 1
Gene namesi
Name:Thap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1921004. Thap1.

Subcellular locationi

Nucleusnucleoplasm By similarity. NucleusPML body By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. PML body Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210THAP domain-containing protein 1PRO_0000068639Add
BLAST

Proteomic databases

PRIDEiQ8CHW1.

Expressioni

Tissue specificityi

Highest levels in heart, liver and kidney. Lower levels in brain and lung.1 Publication

Gene expression databases

BgeeiQ8CHW1.
ExpressionAtlasiQ8CHW1. baseline and differential.
GenevestigatoriQ8CHW1.

Interactioni

Subunit structurei

Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8CHW1.
SMRiQ8CHW1. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili137 – 18751Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1344HCFC1-binding motif (HBM)By similarity

Sequence similaritiesi

Belongs to the THAP1 family.Curated
Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri5 – 5753THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG84669.
GeneTreeiENSGT00780000121923.
HOGENOMiHOG000231117.
HOVERGENiHBG057457.
InParanoidiQ8CHW1.
OMAiSCDHNYT.
OrthoDBiEOG7QVM4D.
PhylomeDBiQ8CHW1.
TreeFamiTF330127.

Family and domain databases

InterProiIPR026516. THAP1.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF11. PTHR23080:SF11. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CHW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKQWEAAV KRKNFKPTKY
60 70 80 90 100
SSICSEHFTP DCFKRECNNK LLKENAVPTI FLYIEPHEKK EDLESQEQLP
110 120 130 140 150
SPSPPASQVD AAIGLLMPPL QTPDNLSVFC DHNYTVEDTM HQRKRILQLE
160 170 180 190 200
QQVEKLRKKL KTAQQRCRRQ ERQLEKLKEV VHFQREKDDA SERGYVILPN
210
DYFEIVEVPA
Length:210
Mass (Da):24,611
Last modified:March 1, 2003 - v1
Checksum:i2F8EE0E59FA01B3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC038639 mRNA. Translation: AAH38639.1.
CCDSiCCDS22208.1.
RefSeqiNP_950243.1. NM_199042.2.
UniGeneiMm.383241.

Genome annotation databases

EnsembliENSMUST00000036807; ENSMUSP00000042464; ENSMUSG00000037214.
GeneIDi73754.
KEGGimmu:73754.
UCSCiuc009lhq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC038639 mRNA. Translation: AAH38639.1.
CCDSiCCDS22208.1.
RefSeqiNP_950243.1. NM_199042.2.
UniGeneiMm.383241.

3D structure databases

ProteinModelPortaliQ8CHW1.
SMRiQ8CHW1. Positions 1-86.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8CHW1.

Protocols and materials databases

DNASUi73754.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036807; ENSMUSP00000042464; ENSMUSG00000037214.
GeneIDi73754.
KEGGimmu:73754.
UCSCiuc009lhq.2. mouse.

Organism-specific databases

CTDi55145.
MGIiMGI:1921004. Thap1.

Phylogenomic databases

eggNOGiNOG84669.
GeneTreeiENSGT00780000121923.
HOGENOMiHOG000231117.
HOVERGENiHBG057457.
InParanoidiQ8CHW1.
OMAiSCDHNYT.
OrthoDBiEOG7QVM4D.
PhylomeDBiQ8CHW1.
TreeFamiTF330127.

Miscellaneous databases

NextBioi339007.
PROiQ8CHW1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8CHW1.
ExpressionAtlasiQ8CHW1. baseline and differential.
GenevestigatoriQ8CHW1.

Family and domain databases

InterProiIPR026516. THAP1.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF11. PTHR23080:SF11. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Lung.
  2. "The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."
    Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L., Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B., Kristie T.M., Girard J.P.
    J. Biol. Chem. 285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiTHAP1_MOUSE
AccessioniPrimary (citable) accession number: Q8CHW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.