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Q8CHW1 (THAP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
THAP domain-containing protein 1
Gene names
Name:Thap1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis By similarity.

Subunit structure

Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter By similarity.

Subcellular location

Nucleusnucleoplasm By similarity. NucleusPML body By similarity.

Tissue specificity

Highest levels in heart, liver and kidney. Lower levels in brain and lung. Ref.2

Sequence similarities

Belongs to the THAP1 family.

Contains 1 THAP-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210THAP domain-containing protein 1
PRO_0000068639

Regions

Zinc finger5 – 5753THAP-type
Coiled coil137 – 18751 Potential
Motif131 – 1344HCFC1-binding motif (HBM) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CHW1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2F8EE0E59FA01B3C

FASTA21024,611
        10         20         30         40         50         60 
MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKQWEAAV KRKNFKPTKY SSICSEHFTP 

        70         80         90        100        110        120 
DCFKRECNNK LLKENAVPTI FLYIEPHEKK EDLESQEQLP SPSPPASQVD AAIGLLMPPL 

       130        140        150        160        170        180 
QTPDNLSVFC DHNYTVEDTM HQRKRILQLE QQVEKLRKKL KTAQQRCRRQ ERQLEKLKEV 

       190        200        210 
VHFQREKDDA SERGYVILPN DYFEIVEVPA 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Lung.
[2]"The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."
Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L., Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B., Kristie T.M., Girard J.P.
J. Biol. Chem. 285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC038639 mRNA. Translation: AAH38639.1.
CCDSCCDS22208.1.
RefSeqNP_950243.1. NM_199042.2.
UniGeneMm.383241.

3D structure databases

ProteinModelPortalQ8CHW1.
SMRQ8CHW1. Positions 1-86.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8CHW1.

Protocols and materials databases

DNASU73754.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036807; ENSMUSP00000042464; ENSMUSG00000037214.
GeneID73754.
KEGGmmu:73754.
UCSCuc009lhq.2. mouse.

Organism-specific databases

CTD55145.
MGIMGI:1921004. Thap1.

Phylogenomic databases

eggNOGNOG84669.
GeneTreeENSGT00530000063253.
HOGENOMHOG000231117.
HOVERGENHBG057457.
InParanoidQ8CHW1.
OMADLCKKWE.
OrthoDBEOG7QVM4D.
PhylomeDBQ8CHW1.
TreeFamTF330127.

Gene expression databases

ArrayExpressQ8CHW1.
BgeeQ8CHW1.
GenevestigatorQ8CHW1.

Family and domain databases

InterProIPR026516. THAP1.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERPTHR23080:SF11. PTHR23080:SF11. 1 hit.
PfamPF05485. THAP. 1 hit.
[Graphical view]
SMARTSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio339007.
PROQ8CHW1.
SOURCESearch...

Entry information

Entry nameTHAP1_MOUSE
AccessionPrimary (citable) accession number: Q8CHW1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot