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Q8CHV6

- TAD2A_MOUSE

UniProt

Q8CHV6 - TAD2A_MOUSE

Protein

Transcriptional adapter 2-alpha

Gene

Tada2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site By similarity. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi426 – 43510

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. histone acetyltransferase activity Source: Ensembl

    GO - Biological processi

    1. histone H3 acetylation Source: Ensembl
    2. mitotic nuclear division Source: MGI
    3. regulation of histone deacetylation Source: MGI
    4. regulation of protein phosphorylation Source: MGI
    5. regulation of protein stability Source: MGI
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. regulation of tubulin deacetylation Source: MGI
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_226917. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional adapter 2-alpha
    Alternative name(s):
    Transcriptional adapter 2-like
    Short name:
    ADA2-like protein
    Gene namesi
    Name:Tada2a
    Synonyms:Tada2l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2144471. Tada2a.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Chromosome 1 Publication

    GO - Cellular componenti

    1. Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
    2. chromosome Source: UniProtKB-SubCell
    3. mitotic spindle Source: MGI
    4. nucleus Source: MGI
    5. PCAF complex Source: Ensembl

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi426 – 4261K → A: Reduces DNA binding. 1 Publication
    Mutagenesisi428 – 4281R → A: Loss of nuclear localization. Reduces DNA binding. 1 Publication
    Mutagenesisi429 – 4291K → A: Reduces DNA binding. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Transcriptional adapter 2-alphaPRO_0000240669Add
    BLAST

    Proteomic databases

    PaxDbiQ8CHV6.
    PRIDEiQ8CHV6.

    PTM databases

    PhosphoSiteiQ8CHV6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8CHV6.
    BgeeiQ8CHV6.
    GenevestigatoriQ8CHV6.

    Interactioni

    Subunit structurei

    Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ8CHV6. 33 interactions.
    MINTiMINT-4606424.
    STRINGi10090.ENSMUSP00000103735.

    Structurei

    Secondary structure

    1
    443
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi365 – 3728
    Turni373 – 3753
    Helixi378 – 3869
    Helixi391 – 40818
    Helixi413 – 4175
    Beta strandi420 – 4245
    Helixi425 – 43612
    Beta strandi438 – 4403

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AQENMR-A355-443[»]
    2AQFNMR-A355-443[»]
    2CUJNMR-A343-443[»]
    ProteinModelPortaliQ8CHV6.
    SMRiQ8CHV6. Positions 72-118, 349-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8CHV6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 12253SANTPROSITE-ProRule annotationAdd
    BLAST
    Domaini356 – 44388SWIRMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi17 – 4529Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SANT domain.PROSITE-ProRule annotation
    Contains 1 SWIRM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5114.
    GeneTreeiENSGT00530000063657.
    HOGENOMiHOG000068147.
    HOVERGENiHBG057413.
    InParanoidiQ8CHV6.
    KOiK11314.
    OMAiFIESHAW.
    OrthoDBiEOG7RFTK1.
    PhylomeDBiQ8CHV6.
    TreeFamiTF313975.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR007526. SWIRM.
    IPR016827. Transcriptional_adaptor_2.
    [Graphical view]
    PfamiPF00249. Myb_DNA-binding. 1 hit.
    PF04433. SWIRM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF025024. Transcriptional_adaptor_2. 1 hit.
    SMARTiSM00717. SANT. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51293. SANT. 1 hit.
    PS50934. SWIRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CHV6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRLGSFSND PSDKPPCRGC SSYLTEPYIK CAECGPPPFF LCLQCFTRGF    50
    EYKKHQSDHT YEIMTSDFPV LDPSWTAQEE MALLEAVMDC GFGNWQDVAN 100
    QMCTKTKEEC EKHYMKHFIN NPLFASTLLN LKQAEAAKAA DTAIPFHSAD 150
    DPPRPAFDSL LSRDMAGYMP ARADFIEEFD NYAEWDLRDI DFVEDDSDIL 200
    HALKMAVVDI YHSRLKERQR RKKIIRDHGL VNLRKFRLME RRYPKEVQDL 250
    YETMRRFARI VGPVEHDKFI ESHALEFELR REIKRLQEYR TAGITNFCSA 300
    RTYDHLKKTR EEERLKRTML SEVLQYIQDS SACQQWLRRQ ADIDSGLSPS 350
    VLMASNSGRR SAPPLNLTGL PGTEKLNEKE KELCQVVRLV PGAYLEYKSA 400
    LLNECHKQGG LRLAQARALI KIDVNKTRKI YDFLIREGYI TKA 443
    Length:443
    Mass (Da):51,339
    Last modified:March 1, 2003 - v1
    Checksum:iA14E88654CDC34D3
    GO

    Sequence cautioni

    The sequence AAH25448.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC38925.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti216 – 2161K → E in BAE34272. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK083467 mRNA. Translation: BAC38925.1. Different initiation.
    AK157938 mRNA. Translation: BAE34272.1.
    AL596447, AL645615 Genomic DNA. Translation: CAI25269.1.
    AL645615, AL596447 Genomic DNA. Translation: CAI25507.1.
    BC025448 mRNA. Translation: AAH25448.1. Different initiation.
    BC038821 mRNA. Translation: AAH38821.1.
    CCDSiCCDS25183.1.
    RefSeqiNP_766150.1. NM_172562.3.
    UniGeneiMm.45159.

    Genome annotation databases

    EnsembliENSMUST00000018795; ENSMUSP00000018795; ENSMUSG00000018651.
    GeneIDi217031.
    KEGGimmu:217031.
    UCSCiuc007kqf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK083467 mRNA. Translation: BAC38925.1 . Different initiation.
    AK157938 mRNA. Translation: BAE34272.1 .
    AL596447 , AL645615 Genomic DNA. Translation: CAI25269.1 .
    AL645615 , AL596447 Genomic DNA. Translation: CAI25507.1 .
    BC025448 mRNA. Translation: AAH25448.1 . Different initiation.
    BC038821 mRNA. Translation: AAH38821.1 .
    CCDSi CCDS25183.1.
    RefSeqi NP_766150.1. NM_172562.3.
    UniGenei Mm.45159.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AQE NMR - A 355-443 [» ]
    2AQF NMR - A 355-443 [» ]
    2CUJ NMR - A 343-443 [» ]
    ProteinModelPortali Q8CHV6.
    SMRi Q8CHV6. Positions 72-118, 349-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8CHV6. 33 interactions.
    MINTi MINT-4606424.
    STRINGi 10090.ENSMUSP00000103735.

    PTM databases

    PhosphoSitei Q8CHV6.

    Proteomic databases

    PaxDbi Q8CHV6.
    PRIDEi Q8CHV6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018795 ; ENSMUSP00000018795 ; ENSMUSG00000018651 .
    GeneIDi 217031.
    KEGGi mmu:217031.
    UCSCi uc007kqf.1. mouse.

    Organism-specific databases

    CTDi 6871.
    MGIi MGI:2144471. Tada2a.

    Phylogenomic databases

    eggNOGi COG5114.
    GeneTreei ENSGT00530000063657.
    HOGENOMi HOG000068147.
    HOVERGENi HBG057413.
    InParanoidi Q8CHV6.
    KOi K11314.
    OMAi FIESHAW.
    OrthoDBi EOG7RFTK1.
    PhylomeDBi Q8CHV6.
    TreeFami TF313975.

    Enzyme and pathway databases

    Reactomei REACT_226917. HATs acetylate histones.

    Miscellaneous databases

    ChiTaRSi TADA2A. mouse.
    EvolutionaryTracei Q8CHV6.
    NextBioi 375522.
    PROi Q8CHV6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CHV6.
    Bgeei Q8CHV6.
    Genevestigatori Q8CHV6.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR007526. SWIRM.
    IPR016827. Transcriptional_adaptor_2.
    [Graphical view ]
    Pfami PF00249. Myb_DNA-binding. 1 hit.
    PF04433. SWIRM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF025024. Transcriptional_adaptor_2. 1 hit.
    SMARTi SM00717. SANT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51293. SANT. 1 hit.
    PS50934. SWIRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Inner ear.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland and Mammary tumor.
    4. "Structure and chromosomal DNA binding of the SWIRM domain."
      Qian C., Zhang Q., Li S., Zeng L., Walsh M.J., Zhou M.-M.
      Nat. Struct. Mol. Biol. 12:1078-1085(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 355-443, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-426; ARG-428 AND LYS-429.
    5. Cited for: STRUCTURE BY NMR OF 343-443.

    Entry informationi

    Entry nameiTAD2A_MOUSE
    AccessioniPrimary (citable) accession number: Q8CHV6
    Secondary accession number(s): Q3TZD7, Q8BNK0, Q8R3H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3