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Protein

Transcriptional adapter 2-alpha

Gene

Tada2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi426 – 43510

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: GO_Central
  • histone H3 acetylation Source: MGI
  • mitotic nuclear division Source: MGI
  • positive regulation of histone acetylation Source: GO_Central
  • regulation of histone deacetylation Source: MGI
  • regulation of protein phosphorylation Source: MGI
  • regulation of protein stability Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • regulation of tubulin deacetylation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional adapter 2-alpha
Alternative name(s):
Transcriptional adapter 2-like
Short name:
ADA2-like protein
Gene namesi
Name:Tada2a
Synonyms:Tada2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144471. Tada2a.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
  • chromosome Source: UniProtKB-SubCell
  • mitotic spindle Source: MGI
  • nucleus Source: MGI
  • PCAF complex Source: MGI
  • SAGA-type complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi426K → A: Reduces DNA binding. 1 Publication1
Mutagenesisi428R → A: Loss of nuclear localization. Reduces DNA binding. 1 Publication1
Mutagenesisi429K → A: Reduces DNA binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406691 – 443Transcriptional adapter 2-alphaAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8CHV6.
PaxDbiQ8CHV6.
PRIDEiQ8CHV6.

PTM databases

iPTMnetiQ8CHV6.
PhosphoSitePlusiQ8CHV6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018651.
ExpressionAtlasiQ8CHV6. baseline and differential.
GenevisibleiQ8CHV6. MM.

Interactioni

Subunit structurei

Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8CHV6. 33 interactors.
MINTiMINT-4606424.
STRINGi10090.ENSMUSP00000018795.

Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi365 – 372Combined sources8
Turni373 – 375Combined sources3
Helixi378 – 386Combined sources9
Helixi391 – 408Combined sources18
Helixi413 – 417Combined sources5
Beta strandi420 – 424Combined sources5
Helixi425 – 436Combined sources12
Beta strandi438 – 440Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AQENMR-A355-443[»]
2AQFNMR-A355-443[»]
2CUJNMR-A343-443[»]
ProteinModelPortaliQ8CHV6.
SMRiQ8CHV6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8CHV6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 122SANTPROSITE-ProRule annotationAdd BLAST53
Domaini356 – 443SWIRMPROSITE-ProRule annotationAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 45Cys-richAdd BLAST29

Sequence similaritiesi

Contains 1 SANT domain.PROSITE-ProRule annotation
Contains 1 SWIRM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0457. Eukaryota.
COG5114. LUCA.
GeneTreeiENSGT00530000063657.
HOGENOMiHOG000068147.
HOVERGENiHBG057413.
InParanoidiQ8CHV6.
KOiK11314.
OMAiQMCTKSK.
OrthoDBiEOG091G06WT.
PhylomeDBiQ8CHV6.
TreeFamiTF313975.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR016827. Ada2/TADA2.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
PIRSFiPIRSF025024. Transcriptional_adaptor_2. 1 hit.
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CHV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLGSFSND PSDKPPCRGC SSYLTEPYIK CAECGPPPFF LCLQCFTRGF
60 70 80 90 100
EYKKHQSDHT YEIMTSDFPV LDPSWTAQEE MALLEAVMDC GFGNWQDVAN
110 120 130 140 150
QMCTKTKEEC EKHYMKHFIN NPLFASTLLN LKQAEAAKAA DTAIPFHSAD
160 170 180 190 200
DPPRPAFDSL LSRDMAGYMP ARADFIEEFD NYAEWDLRDI DFVEDDSDIL
210 220 230 240 250
HALKMAVVDI YHSRLKERQR RKKIIRDHGL VNLRKFRLME RRYPKEVQDL
260 270 280 290 300
YETMRRFARI VGPVEHDKFI ESHALEFELR REIKRLQEYR TAGITNFCSA
310 320 330 340 350
RTYDHLKKTR EEERLKRTML SEVLQYIQDS SACQQWLRRQ ADIDSGLSPS
360 370 380 390 400
VLMASNSGRR SAPPLNLTGL PGTEKLNEKE KELCQVVRLV PGAYLEYKSA
410 420 430 440
LLNECHKQGG LRLAQARALI KIDVNKTRKI YDFLIREGYI TKA
Length:443
Mass (Da):51,339
Last modified:March 1, 2003 - v1
Checksum:iA14E88654CDC34D3
GO

Sequence cautioni

The sequence AAH25448 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC38925 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216K → E in BAE34272 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083467 mRNA. Translation: BAC38925.1. Different initiation.
AK157938 mRNA. Translation: BAE34272.1.
AL596447, AL645615 Genomic DNA. Translation: CAI25269.1.
AL645615, AL596447 Genomic DNA. Translation: CAI25507.1.
BC025448 mRNA. Translation: AAH25448.1. Different initiation.
BC038821 mRNA. Translation: AAH38821.1.
CCDSiCCDS25183.1.
RefSeqiNP_766150.1. NM_172562.3.
UniGeneiMm.45159.

Genome annotation databases

EnsembliENSMUST00000018795; ENSMUSP00000018795; ENSMUSG00000018651.
GeneIDi217031.
KEGGimmu:217031.
UCSCiuc007kqf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083467 mRNA. Translation: BAC38925.1. Different initiation.
AK157938 mRNA. Translation: BAE34272.1.
AL596447, AL645615 Genomic DNA. Translation: CAI25269.1.
AL645615, AL596447 Genomic DNA. Translation: CAI25507.1.
BC025448 mRNA. Translation: AAH25448.1. Different initiation.
BC038821 mRNA. Translation: AAH38821.1.
CCDSiCCDS25183.1.
RefSeqiNP_766150.1. NM_172562.3.
UniGeneiMm.45159.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AQENMR-A355-443[»]
2AQFNMR-A355-443[»]
2CUJNMR-A343-443[»]
ProteinModelPortaliQ8CHV6.
SMRiQ8CHV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CHV6. 33 interactors.
MINTiMINT-4606424.
STRINGi10090.ENSMUSP00000018795.

PTM databases

iPTMnetiQ8CHV6.
PhosphoSitePlusiQ8CHV6.

Proteomic databases

MaxQBiQ8CHV6.
PaxDbiQ8CHV6.
PRIDEiQ8CHV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018795; ENSMUSP00000018795; ENSMUSG00000018651.
GeneIDi217031.
KEGGimmu:217031.
UCSCiuc007kqf.1. mouse.

Organism-specific databases

CTDi6871.
MGIiMGI:2144471. Tada2a.

Phylogenomic databases

eggNOGiKOG0457. Eukaryota.
COG5114. LUCA.
GeneTreeiENSGT00530000063657.
HOGENOMiHOG000068147.
HOVERGENiHBG057413.
InParanoidiQ8CHV6.
KOiK11314.
OMAiQMCTKSK.
OrthoDBiEOG091G06WT.
PhylomeDBiQ8CHV6.
TreeFamiTF313975.

Miscellaneous databases

ChiTaRSiTada2a. mouse.
EvolutionaryTraceiQ8CHV6.
PROiQ8CHV6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018651.
ExpressionAtlasiQ8CHV6. baseline and differential.
GenevisibleiQ8CHV6. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR016827. Ada2/TADA2.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
PIRSFiPIRSF025024. Transcriptional_adaptor_2. 1 hit.
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAD2A_MOUSE
AccessioniPrimary (citable) accession number: Q8CHV6
Secondary accession number(s): Q3TZD7, Q8BNK0, Q8R3H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.