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Protein

Integrator complex subunit 5

Gene

Ints5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 5
Short name:
Int5
Gene namesi
Name:Ints5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1923578. Ints5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Transmembranei929 – 949HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002595422 – 1018Integrator complex subunit 5Add BLAST1017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei278PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CHT3.
MaxQBiQ8CHT3.
PaxDbiQ8CHT3.
PeptideAtlasiQ8CHT3.
PRIDEiQ8CHT3.

PTM databases

iPTMnetiQ8CHT3.
PhosphoSitePlusiQ8CHT3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071652.
CleanExiMM_INTS5.
ExpressionAtlasiQ8CHT3. baseline and differential.
GenevisibleiQ8CHT3. MM.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.By similarity

Protein-protein interaction databases

IntActiQ8CHT3. 1 interactor.
MINTiMINT-4116143.
STRINGi10090.ENSMUSP00000093968.

Family & Domainsi

Sequence similaritiesi

Belongs to the Integrator subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHRN. Eukaryota.
ENOG4110473. LUCA.
GeneTreeiENSGT00390000008374.
HOGENOMiHOG000220929.
HOVERGENiHBG079923.
InParanoidiQ8CHT3.
KOiK13142.
OMAiLRMFHDS.
OrthoDBiEOG091G03OL.
PhylomeDBiQ8CHT3.
TreeFamiTF323720.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR029444. INTS5_C.
IPR029445. INTS5_N.
PfamiView protein in Pfam
PF14838. INTS5_C. 1 hit.
PF14837. INTS5_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CHT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALCDPPGA PGPPGPAPAT HGPAPLSAQE LSQEIKAFLT GVDPILGHQL
60 70 80 90 100
SAREHARCGL LLLRSLPPAR AAVLDHLRGV FDESVRAHLA ALEESPVAGP
110 120 130 140 150
PHLRPPPPSH VPTGGPGLED VVHEVQQVLC EFIRANPKAW APVISAWSID
160 170 180 190 200
LMGQLSSTYS GQHQRVPHAT GSLNELLQLW MGCRATRTLM DIYVQCLSAL
210 220 230 240 250
IGSCPDACVD ALLDTSVQHS PHFDWVVAHI GSSFPGTIIS RVLSCGLKDF
260 270 280 290 300
CVHSGAGGGA SACGNSSQPP STDPFPGSPA IPGEKRVPKI ASVVGILGHL
310 320 330 340 350
ASRHGDSIRR ELLRMFHDSL AGGSGGRNGE PSLQATVPFL LQLAVMSPAL
360 370 380 390 400
LGTVSGELVD CLKPPAVLSQ LQQHLQGFPR EELDNMLNLA VHLVSQASGT
410 420 430 440 450
GAYRLLQFLV DTAMPASVIT TQGLAVPDTV REACDRLIQL LLLHLQKLVH
460 470 480 490 500
HRGGSPGEGV LGPPPPPRPV PFLDALRNHV GELCGETLRL ERKRFLWQHQ
510 520 530 540 550
LLGLLSVYTR PSCGPEALGH LLSRARSPEE LSLATQLYAG LVVSLSGLLP
560 570 580 590 600
LAFRSCLARV HAGTLQPPFT ARFLRNLALL VGWEQQGGEG PSALGARFGE
610 620 630 640 650
SASAHLADLA PLLLHPEEEV AEAAASLLAI CPFPSEALSP SQLLGLVRAG
660 670 680 690 700
VHHFFSSLRL HGPPGVASAS QLLTRLSQTS PAGLKAVLQL LVEGALHRGN
710 720 730 740 750
TELFGGEMDG DNETLSIVST PLASASLLDI NRRHTAAVPG PGGIWSVFHA
760 770 780 790 800
GVIGRGLKPP KIVQSRNHQE VIYNTQSLVS LLVHCCSASG NSEREGCWGA
810 820 830 840 850
PTLSPEAAKA VAVTLVESVC PDAAGAELAW PPEDHARATV ERDLRIGRRF
860 870 880 890 900
REQPLLFELL KLVAAAPPAL CYCSVLLRGL LAALLSHWEA SRHPDTTHSP
910 920 930 940 950
WHLEASCILV AVMAEGSLLP PALGNMHEVF SQLAPFEVRL LLLSVWGFLR
960 970 980 990 1000
EHGPLPQKFI FQSERGRFIR DFAREGGAEG GPHLSVLHSV LHRNIDRLGL
1010
FSGRFQAPPP STLLRQGT
Length:1,018
Mass (Da):108,348
Last modified:March 1, 2003 - v1
Checksum:i6B6C8E0B41F206CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276P → H in BAE38598 (PubMed:16141072).Curated1
Sequence conflicti648R → K in BAE38598 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155499 mRNA. Translation: BAE33294.1.
AK166149 mRNA. Translation: BAE38598.1.
AK168795 mRNA. Translation: BAE40628.1.
AK170584 mRNA. Translation: BAE41894.1.
BC039214 mRNA. Translation: AAH39214.1.
CCDSiCCDS29556.1.
RefSeqiNP_789813.1. NM_176843.3.
UniGeneiMm.290474.

Genome annotation databases

EnsembliENSMUST00000096249; ENSMUSP00000093968; ENSMUSG00000071652.
GeneIDi109077.
KEGGimmu:109077.
UCSCiuc008gnu.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiINT5_MOUSE
AccessioniPrimary (citable) accession number: Q8CHT3
Secondary accession number(s): Q3TM44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families