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Protein

Dehydrogenase/reductase SDR family member 7C

Gene

Dhrs7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei191 – 1911Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 6525NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  • retinol dehydrogenase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7C (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 2By similarity
Gene namesi
Name:Dhrs7c
Synonyms:Sdr32c2By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915710. Dhrs7c.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • longitudinal sarcoplasmic reticulum Source: MGI
  • sarcoplasmic reticulum membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 311293Dehydrogenase/reductase SDR family member 7CPRO_0000333756Add
BLAST

Proteomic databases

MaxQBiQ8CHS7.
PaxDbiQ8CHS7.
PRIDEiQ8CHS7.

PTM databases

iPTMnetiQ8CHS7.
PhosphoSiteiQ8CHS7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033044.
GenevisibleiQ8CHS7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130924.

Structurei

3D structure databases

ProteinModelPortaliQ8CHS7.
SMRiQ8CHS7. Positions 31-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00840000129712.
HOVERGENiHBG107825.
InParanoidiQ8CHS7.
KOiK11167.
OMAiDISCVQD.
OrthoDBiEOG091G0BO9.
PhylomeDBiQ8CHS7.
TreeFamiTF313474.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CHS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLMAVLMLP LLLLGISGLL FIYQEASRLW SKSAVQNKVV VITDAISGLG
60 70 80 90 100
KECARVFHAG GARLVLCGKN WEGLESLYAT LTSVADPSKT FTPKLVLLDL
110 120 130 140 150
SDISCVQDVA KEVLDCYGCV DILINNASVK VKGPAHKISL ELDKKIMDAN
160 170 180 190 200
YFGPITLTKV LLPNMISRRT GQIVLVNNIQ AKFGIPFRTA YAASKHAVMG
210 220 230 240 250
FFDCLRAEVE EYDVVVSTVS PTFIRSYRAS PEQRNWETSI CKFFCRKLAY
260 270 280 290 300
GVHPVEVAEE VMRTVRRKKQ EVFMANPVPK AAVFIRTFFP EFFFAVVACG
310
VKEKLNVPEE G
Length:311
Mass (Da):34,468
Last modified:May 20, 2008 - v3
Checksum:iE223E8C363153E5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646097 Genomic DNA. Translation: CAI25250.1.
AA063835 mRNA. No translation available.
CCDSiCCDS48822.1.
RefSeqiNP_001013031.2. NM_001013013.2.
UniGeneiMm.22167.

Genome annotation databases

EnsembliENSMUST00000168612; ENSMUSP00000130924; ENSMUSG00000033044.
GeneIDi68460.
KEGGimmu:68460.
UCSCiuc011xwp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646097 Genomic DNA. Translation: CAI25250.1.
AA063835 mRNA. No translation available.
CCDSiCCDS48822.1.
RefSeqiNP_001013031.2. NM_001013013.2.
UniGeneiMm.22167.

3D structure databases

ProteinModelPortaliQ8CHS7.
SMRiQ8CHS7. Positions 31-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130924.

PTM databases

iPTMnetiQ8CHS7.
PhosphoSiteiQ8CHS7.

Proteomic databases

MaxQBiQ8CHS7.
PaxDbiQ8CHS7.
PRIDEiQ8CHS7.

Protocols and materials databases

DNASUi68460.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168612; ENSMUSP00000130924; ENSMUSG00000033044.
GeneIDi68460.
KEGGimmu:68460.
UCSCiuc011xwp.1. mouse.

Organism-specific databases

CTDi201140.
MGIiMGI:1915710. Dhrs7c.

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00840000129712.
HOVERGENiHBG107825.
InParanoidiQ8CHS7.
KOiK11167.
OMAiDISCVQD.
OrthoDBiEOG091G0BO9.
PhylomeDBiQ8CHS7.
TreeFamiTF313474.

Miscellaneous databases

PROiQ8CHS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033044.
GenevisibleiQ8CHS7. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRS7C_MOUSE
AccessioniPrimary (citable) accession number: Q8CHS7
Secondary accession number(s): B1ATJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.