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Protein

Dehydrogenase/reductase SDR family member 7C

Gene

Dhrs7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei191Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 65NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • retinol dehydrogenase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7C (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 2By similarity
Gene namesi
Name:Dhrs7c
Synonyms:Sdr32c2By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915710. Dhrs7c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000033375619 – 311Dehydrogenase/reductase SDR family member 7CAdd BLAST293

Proteomic databases

MaxQBiQ8CHS7.
PaxDbiQ8CHS7.
PRIDEiQ8CHS7.

PTM databases

iPTMnetiQ8CHS7.
PhosphoSitePlusiQ8CHS7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033044.
GenevisibleiQ8CHS7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130924.

Structurei

3D structure databases

ProteinModelPortaliQ8CHS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00900000140775.
HOVERGENiHBG107825.
InParanoidiQ8CHS7.
KOiK11167.
OMAiDISCVQD.
OrthoDBiEOG091G0BO9.
PhylomeDBiQ8CHS7.
TreeFamiTF313474.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CHS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLMAVLMLP LLLLGISGLL FIYQEASRLW SKSAVQNKVV VITDAISGLG
60 70 80 90 100
KECARVFHAG GARLVLCGKN WEGLESLYAT LTSVADPSKT FTPKLVLLDL
110 120 130 140 150
SDISCVQDVA KEVLDCYGCV DILINNASVK VKGPAHKISL ELDKKIMDAN
160 170 180 190 200
YFGPITLTKV LLPNMISRRT GQIVLVNNIQ AKFGIPFRTA YAASKHAVMG
210 220 230 240 250
FFDCLRAEVE EYDVVVSTVS PTFIRSYRAS PEQRNWETSI CKFFCRKLAY
260 270 280 290 300
GVHPVEVAEE VMRTVRRKKQ EVFMANPVPK AAVFIRTFFP EFFFAVVACG
310
VKEKLNVPEE G
Length:311
Mass (Da):34,468
Last modified:May 20, 2008 - v3
Checksum:iE223E8C363153E5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646097 Genomic DNA. Translation: CAI25250.1.
AA063835 mRNA. No translation available.
CCDSiCCDS48822.1.
RefSeqiNP_001013031.2. NM_001013013.2.
UniGeneiMm.22167.

Genome annotation databases

EnsembliENSMUST00000168612; ENSMUSP00000130924; ENSMUSG00000033044.
GeneIDi68460.
KEGGimmu:68460.
UCSCiuc011xwp.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDRS7C_MOUSE
AccessioniPrimary (citable) accession number: Q8CHS7
Secondary accession number(s): B1ATJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families