Q8CHR6 (DPYD_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 79.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Dihydropyrimidine dehydrogenase [NADP+] Short name=DHPDHase Short name=DPD EC=1.3.1.2 Alternative name(s): Dihydrothymine dehydrogenase Dihydrouracil dehydrogenase | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 1025 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine By similarity. |
| Catalytic activity | 5,6-dihydrouracil + NADP+ = uracil + NADPH. |
| Cofactor | Binds 2 4Fe-4S clusters By similarity. FAD By similarity. FMN By similarity. |
| Enzyme regulation | Inactivated by 5-iodouracil By similarity. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the dihydropyrimidine dehydrogenase family. Contains 3 4Fe-4S ferredoxin-type domains. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1025 | 1025 | Dihydropyrimidine dehydrogenase [NADP+] | PRO_0000327501 | |||||
Regions | |||||||||
| Domain | 69 – 100 | 32 | 4Fe-4S ferredoxin-type 1 | ||||||
| Domain | 944 – 976 | 33 | 4Fe-4S ferredoxin-type 2 | ||||||
| Domain | 978 – 1007 | 30 | 4Fe-4S ferredoxin-type 3 | ||||||
Sites | |||||||||
| Metal binding | 953 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 956 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 959 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 963 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 986 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 989 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 992 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 996 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 384 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 577 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC039699 mRNA. Translation: AAH39699.1. |
| IPI | IPI00229705. |
| RefSeq | NP_740748.1. NM_170778.2. |
| UniGene | Mm.27907. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GTE based on UniProtKB Q28943. |
| ProteinModelPortal | Q8CHR6. |
| SMR | Q8CHR6. Positions 2-1019. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8CHR6. |
PTM databases | |
| PhosphoSite | Q8CHR6. |
Proteomic databases | |
| PRIDE | Q8CHR6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000039177; ENSMUSP00000039429; ENSMUSG00000033308. |
| GeneID | 99586. |
| KEGG | mmu:99586. |
| UCSC | uc008rdh.1. mouse. |
Organism-specific databases | |
| CTD | 1806. |
| MGI | MGI:2139667. Dpyd. |
Phylogenomic databases | |
| HOGENOM | HBG314257. |
| HOVERGEN | HBG004351. |
| InParanoid | Q8CHR6. |
| OMA | AYWCQSV. |
| OrthoDB | EOG44J2H8. |
| PhylomeDB | Q8CHR6. |
Gene expression databases | |
| ArrayExpress | Q8CHR6. |
| Bgee | Q8CHR6. |
| Genevestigator | Q8CHR6. |
Family and domain databases | |
| InterPro | IPR001450. 4Fe4S-bd_dom. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR013785. Aldolase_TIM. IPR005720. Dihydroorotate_DH. IPR012135. Dihydroorotate_DH_1_2. IPR012285. Fum_reductase_C. IPR009051. Helical_ferredxn. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit. |
| KO | K00207. |
| Pfam | PF01180. DHO_dh. 1 hit. PF12838. Fer4_7. 1 hit. [Graphical view] |
| SUPFAM | SSF46548. Helical_ferredxn. 1 hit. |
| TIGRFAMs | TIGR01037. PyrD_sub1_fam. 1 hit. |
| PROSITE | PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 354029. |
| SOURCE | Search... |
Entry information
| Entry name | DPYD_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8CHR6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with