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Reviewed, UniProtKB/Swiss-Prot Q8CHR6 (DPYD_MOUSE)

Last modified November 25, 2008. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydropyrimidine dehydrogenase [NADP+]
      Short name=DHPDHase
      Short name=DPD
    EC=1.3.1.2
Alternative name(s):
    Dihydrouracil dehydrogenase
    Dihydrothymine dehydrogenase
Gene names
Name: Dpyd
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length1025 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine By similarity.

Catalytic activity

5,6-dihydrouracil + NADP(+) = uracil + NADPH.

Cofactor

Binds 2 4Fe-4S clusters By similarity.

FAD By similarity.

FMN By similarity.

Enzyme regulation

Inactivated by 5-iodouracil By similarity.

Pathway

Amino-acid biosynthesis; beta-alanine biosynthesis.

Subunit structure

Homodimer By similarity.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the dihydropyrimidine dehydrogenase family.

Contains 3 4Fe-4S ferredoxin-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10251025Dihydropyrimidine dehydrogenase [NADP+]
PRO_0000327501

Regions

Domain69 – 100324Fe-4S ferredoxin-type 1
Domain944 – 976334Fe-4S ferredoxin-type 2
Domain978 – 1007304Fe-4S ferredoxin-type 3

Sites

Metal binding9531Iron-sulfur 1 (4Fe-4S) Potential
Metal binding9561Iron-sulfur 1 (4Fe-4S) Potential
Metal binding9591Iron-sulfur 1 (4Fe-4S) Potential
Metal binding9631Iron-sulfur 1 (4Fe-4S) Potential
Metal binding9861Iron-sulfur 2 (4Fe-4S) Potential
Metal binding9891Iron-sulfur 2 (4Fe-4S) Potential
Metal binding9921Iron-sulfur 2 (4Fe-4S) Potential
Metal binding9961Iron-sulfur 2 (4Fe-4S) Potential

Amino acid modifications

Modified residue5771Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CHR6-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: AA1D1B3E3B72C504

FASTA1,025111,253
        10         20         30         40         50         60 
MAGVLSRDAP DIESILALNP RVQAHATLRS TAAKKLDKKH WKRNTDKNCF TCEKLESNFD 

        70         80         90        100        110        120 
DIKHTTLGER GALREAVRCL KCADAPCQKS CPTSLDIKSF ITSIANKNYY GAAKLIFSDN 

       130        140        150        160        170        180 
PLGLTCGMVC PTSDLCVGGC NLHAAEEGPI NIGGLQQFAT EVFKAMNIPQ IRNPSLPPPE 

       190        200        210        220        230        240 
HMPEAYSAKI ALFGAGPASI SCASFLARLG YSNITIFEKQ EYVGGLSTSE IPQFRLPYDV 

       250        260        270        280        290        300 
VNFEIELMKD LGVKIICGKS LSTDEMTLSS LKENGYRAAF IGIGLPEPKK DHIFQGLTQV 

       310        320        330        340        350        360 
QGFYTSKDFL PLVAKSSKTG MCACHSPLPS IRGAVIVLGA GDTAFDCATS ALRCGALRVF 

       370        380        390        400        410        420 
IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVIVKD GKIVAMQFVR TEQDETGNWV 

       430        440        450        460        470        480 
EDEEQTVRLK ADVVISAFGS VLEDPKVKEA LSPIKFNRWG LPEVNPETMQ TSEPWVFAGG 

       490        500        510        520        530        540 
DVVGMANTTV ESVNDGKQAS WYIHKHIQAQ YGTSVPSQPT MPLFYTPVDL VDISVEMAGL 

       550        560        570        580        590        600 
RFPNPFGLAS ATPATSTPMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPLY 

       610        620        630        640        650        660 
GPGQSSFLNI ELISEKTAAY WCHSVTELKA DFPDNILIAS IMCSYNKSDW MELSKMAEAS 

       670        680        690        700        710        720 
GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ AVRVPFFAKL TPNVTDIVSI 

       730        740        750        760        770        780 
ARAAKEGGAD GVTATNTVSG LMGLKADGTP WPAVGIGRRT TYGGVSGTAI RPIALRAVTA 

       790        800        810        820        830        840 
IARALPGFPI LATGGIDSAE SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL 

       850        860        870        880        890        900 
KSIEELADWD GQSPPIISHQ KGKPVPRVAE LMGQKLPSFG PYLEQRKKII AASKIRQKDQ 

       910        920        930        940        950        960 
NTACSPLQRK HFNSQKPIPA IKDVIGKSLQ YLGTFGEMSI MEQVVALIDE EMCINCGKCY 

       970        980        990       1000       1010       1020 
MTCNDSGYQA IQFDPETHLP TVSDTCTGCT LCLSVCPIMD CIRMVSRATP YQPKRGLPLA 


VKPVC 

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

BC039699 mRNA. Translation: AAH39699.1.
RefSeqNP_740748.1.
UniGeneMm.27907

3D structure databases

HSSPHSSP built from PDB template 1GTE based on UniProtKB Q28943.
SMRQ8CHR6. Positions 2-1017.
ModBaseSearch...

PTM databases

PhosphoSiteQ8CHR6.

Genome annotation databases

EnsemblENSMUSG00000033308. Mus musculus. [Contig view]
GeneID99586.
KEGGmmu:99586.

Organism-specific databases

MGIMGI:2139667. Dpyd.

Phylogenomic databases

HOGENOMQ8CHR6.
HOVERGENQ8CHR6.

Gene expression databases

ArrayExpressQ8CHR6.

Family and domain databases

InterProIPR001450. 4Fe4S_Fe_S_bd.
IPR000759. Adrndx_reductase.
IPR013785. Aldolase_TIM.
IPR005720. DHO_DHase_1_core.
IPR001295. Dihydroorotate_DHase_core.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR012285. Fum_reductase_C.
IPR016040. NAD(P)-bd.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01180. DHO_dh. 1 hit.
PF00037. Fer4. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00353. 4FE4SFRDOXIN.
PR00419. ADXRDTASE.
PR00368. FADPNR.
PR00469. PNDRDTASEII.
TIGRFAMsTIGR01037. pyrD_sub1_fam. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio354029.
SOURCESearch...

Entry information

Entry nameDPYD_MOUSE
AccessionPrimary (citable) accession number: Q8CHR6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2003
Last modified: November 25, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents