Q8CHP4 (Q8CHP4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
P2X purinoceptor RuleBase RU000681

Gene names

Name:

P2rx7 MGI 1339957 EMBL CAD33538.1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	595 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Homo- or heteropolymers By similarity. RuleBase RU000681
Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU000681.
Sequence similarities	Belongs to the P2X receptor family. RuleBase RU000681

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000681
Molecular function	Ion channel RuleBase RU000681 Receptor RuleBase RU000681
Gene Ontology (GO)
Biological_process	NAD transport Inferred from mutant phenotype PubMed 17803959. Source: MGI T cell homeostasis Inferred from mutant phenotype PubMed 16116196. Source: MGI T cell proliferation Inferred from mutant phenotype PubMed 15914561. Source: MGI activation of MAPK activity Inferred from mutant phenotype PubMed 17306762. Source: MGI bleb assembly Inferred from mutant phenotype PubMed 17135244. Source: MGI cell morphogenesis Inferred from mutant phenotype PubMed 12055263. Source: MGI cell volume homeostasis Inferred from direct assay PubMed 18097031. Source: MGI cellular response to extracellular stimulus Inferred from mutant phenotype PubMed 18082965. Source: MGI ceramide biosynthetic process Inferred from direct assay PubMed 16325464. Source: MGI collagen metabolic process Inferred from mutant phenotype PubMed 16969386. Source: MGI cytolysis Inferred from direct assay PubMed 16116196PubMed 18097031. Source: MGI defense response to Gram-positive bacterium Inferred from mutant phenotype PubMed 11544318. Source: MGI homeostasis of number of cells within a tissue Inferred from mutant phenotype PubMed 16969386. Source: MGI inflammatory response Inferred from mutant phenotype PubMed 12055263PubMed 16969386. Source: MGI membrane budding Inferred from mutant phenotype PubMed 15905573. Source: MGI membrane depolarization Inferred from electronic annotation. Source: Compara membrane protein ectodomain proteolysis Inferred from mutant phenotype PubMed 17286969. Source: MGI mitochondrion organization Inferred from direct assay PubMed 16325464. Source: MGI multicellular organismal protein catabolic process Inferred from direct assay PubMed 11489964. Source: MGI negative regulation of MAPK cascade Inferred from direct assay PubMed 11489964. Source: MGI negative regulation of bone resorption Inferred from mutant phenotype PubMed 12677010. Source: MGI phagolysosome assembly Inferred from mutant phenotype PubMed 11544318. Source: MGI phospholipid transfer to membrane Inferred from mutant phenotype PubMed 12370338. Source: MGI phospholipid translocation Inferred from direct assay PubMed 18097031. Source: MGI plasma membrane organization Inferred from direct assay PubMed 18097031. Source: MGI pore complex assembly Inferred from mutant phenotype PubMed 12370338PubMed 15937334PubMed 16269410. Source: MGI positive regulation of T cell mediated cytotoxicity Inferred from mutant phenotype PubMed 14761980. Source: MGI positive regulation of apoptotic process Inferred from mutant phenotype PubMed 16325464PubMed 16493071PubMed 16969386. Source: MGI positive regulation of bone mineralization Inferred from mutant phenotype PubMed 12677010PubMed 18519738. Source: MGI positive regulation of calcium ion transport into cytosol Inferred from electronic annotation. Source: Compara positive regulation of cytolysis Inferred from electronic annotation. Source: Compara positive regulation of cytoskeleton organization Inferred from electronic annotation. Source: Compara positive regulation of gamma-aminobutyric acid secretion Inferred from mutant phenotype PubMed 15640761. Source: MGI positive regulation of glutamate secretion Inferred from mutant phenotype PubMed 15640761PubMed 17306762. Source: MGI positive regulation of interleukin-1 alpha secretion Inferred from mutant phenotype PubMed 18490713. Source: MGI positive regulation of interleukin-1 beta secretion Inferred from mutant phenotype PubMed 11016935PubMed 15905573PubMed 18490713. Source: MGI positive regulation of interleukin-6 production Inferred from mutant phenotype PubMed 11016935. Source: MGI positive regulation of mitochondrial depolarization Inferred from mutant phenotype PubMed 16198349. Source: MGI positive regulation of prostaglandin secretion Inferred from mutant phenotype PubMed 16269410. Source: MGI protein oligomerization Inferred from direct assay PubMed 15713258. Source: MGI protein processing Inferred from mutant phenotype PubMed 11016935. Source: MGI reactive oxygen species metabolic process Inferred from mutant phenotype PubMed 17448897. Source: MGI regulation of action potential in neuron Inferred from electronic annotation. Source: Compara regulation of sodium ion transport Inferred from electronic annotation. Source: Compara release of sequestered calcium ion into cytosol Inferred from mutant phenotype PubMed 18082965. Source: MGI response to ATP Inferred from direct assay PubMed 15240711PubMed 15713258. Source: MGI response to calcium ion Inferred from direct assay PubMed 15240711. Source: MGI response to drug Inferred from mutant phenotype PubMed 18082965. Source: MGI response to electrical stimulus Inferred from mutant phenotype PubMed 15640761. Source: MGI response to fluid shear stress Inferred from mutant phenotype PubMed 16269410. Source: MGI response to lipopolysaccharide Inferred from direct assay PubMed 15240711. Source: MGI response to mechanical stimulus Inferred from mutant phenotype PubMed 16269410. Source: MGI response to zinc ion Inferred from mutant phenotype PubMed 15978588PubMed 18082965. Source: MGI skeletal system morphogenesis Inferred from mutant phenotype PubMed 18519738. Source: MGI synaptic vesicle exocytosis Inferred from mutant phenotype PubMed 15713258. Source: MGI
Cellular_component	bleb Inferred from electronic annotation. Source: Compara cell-cell junction Inferred from direct assay PubMed 15331634. Source: MGI cytoplasm Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from direct assay PubMed 17286969. Source: MGI integral to nuclear inner membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from mutant phenotype PubMed 12677010. Source: MGI membrane raft Inferred from electronic annotation. Source: Compara neuromuscular junction Inferred from direct assay PubMed 15713258. Source: MGI neuronal cell body Inferred from direct assay PubMed 15964665PubMed 15978588. Source: MGI protein complex Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from mutant phenotype PubMed 12677010. Source: MGI copper ion binding Inferred from electronic annotation. Source: Compara extracellular ATP-gated cation channel activity Inferred from mutant phenotype PubMed 12677010PubMed 15713258. Source: MGI lipopolysaccharide binding Inferred from direct assay PubMed 11489964. Source: MGI magnesium ion binding Inferred from electronic annotation. Source: Compara purinergic nucleotide receptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8CHP4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: BE007FE195AF50A4	FASTA	595	68,388
	10 20 30 40 50 60 MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 70 80 90 100 110 120 VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 130 140 150 160 170 180 EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA 190 200 210 220 230 240 LLRSAENFTV LIKNNIHFPG HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE 250 260 270 280 290 300 NFTEVAVQGG IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 310 320 330 340 350 360 ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLLINTYSS 370 380 390 400 410 420 AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY VSFVDEPHIR MVDQQLLGKS 430 440 450 460 470 480 LQVVKGQEVP RPQMDFSDLS RLSLSLHDSP LTPGQSEEIQ LLHEEVAPKS GDSPSWCQCG 490 500 510 520 530 540 NCLPSRLPEQ RRALEELCCR RKPGRCITTS KLFHKLVLSR DTLQLLLLYQ DPLLVLGEEA 550 560 570 580 590 TNSRLRHRAY RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKTEGQYSG FKYPY

References

[1]	"A natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor." Adriouch S., Dox C., Welge V., Seman M., Koch-Nolte F., Haag F. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6 EMBL CAD33538.1. Tissue: Lymph node EMBL CAD33538.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ489296 mRNA. Translation: CAD33538.1.
IPI	IPI00130271.
RefSeq	NP_035157.2. NM_011027.2.
UniGene	Mm.42026.
3D structure databases
ProteinModelPortal	Q8CHP4.
SMR	Q8CHP4. Positions 35-355.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8CHP4.
Proteomic databases
PRIDE	Q8CHP4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	18439.
KEGG	mmu:18439.
UCSC	uc008zlq.1. mouse.
Organism-specific databases
CTD	5027.
MGI	MGI:1339957. P2rx7.
Phylogenomic databases
HOVERGEN	HBG053086.
InParanoid	Q8CHP4.
KO	K05220.
OMA	LCPEYPT.
Gene expression databases
ArrayExpress	Q8CHP4.
Bgee	Q8CHP4.
Genevestigator	Q8CHP4.
Family and domain databases
Gene3D	2.60.490.10. 1 hit.
InterPro	IPR003050. P2X7_purnocptor. IPR027309. P2X_extracellular_dom. IPR001429. P2X_purnocptor. [Graphical view]
PANTHER	PTHR10125. PTHR10125. 1 hit. PTHR10125:SF13. PTHR10125:SF13. 1 hit.
Pfam	PF00864. P2X_receptor. 1 hit. [Graphical view]
PRINTS	PR01314. P2X7RECEPTOR. PR01307. P2XRECEPTOR.
TIGRFAMs	TIGR00863. P2X. 1 hit.
PROSITE	PS01212. P2X_RECEPTOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294114.
SOURCE	Search...

Entry information

Entry name

Q8CHP4_MOUSE

Accession

Primary (citable) accession number: Q8CHP4

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)