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Q8CHP4 (Q8CHP4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
P2X purinoceptor RuleBase RU000681
Gene names
Name:P2rx7 MGI 1339957 EMBL CAD33538.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length595 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the P2X receptor family. RuleBase RU000681

Ontologies

Keywords
   Biological processIon transport
Transport
   Molecular functionIon channel RuleBase RU000681
Receptor RuleBase RU000681
Gene Ontology (GO)
   Biological_processNAD transport

Inferred from mutant phenotype PubMed 17803959. Source: MGI

T cell homeostasis

Inferred from mutant phenotype PubMed 16116196. Source: MGI

T cell proliferation

Inferred from mutant phenotype PubMed 15914561. Source: MGI

activation of MAPK activity

Inferred from mutant phenotype PubMed 17306762. Source: MGI

apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

bleb assembly

Inferred from mutant phenotype PubMed 17135244. Source: MGI

calcium ion transport

Inferred from mutant phenotype PubMed 12370338. Source: MGI

cation transport

Inferred from mutant phenotype PubMed 12677010. Source: MGI

cell death

Inferred from direct assay PubMed 18097031. Source: MGI

cell morphogenesis

Inferred from mutant phenotype PubMed 12055263. Source: MGI

cell volume homeostasis

Inferred from direct assay PubMed 18097031. Source: MGI

cellular response to extracellular stimulus

Inferred from mutant phenotype PubMed 18082965. Source: MGI

ceramide biosynthetic process

Inferred from direct assay PubMed 16325464. Source: MGI

collagen metabolic process

Inferred from mutant phenotype PubMed 16969386. Source: MGI

cytolysis

Inferred from direct assay PubMed 16116196PubMed 18097031. Source: MGI

defense response to Gram-positive bacterium

Inferred from mutant phenotype PubMed 11544318. Source: MGI

gene expression

Inferred from mutant phenotype PubMed 18519738. Source: MGI

homeostasis of number of cells within a tissue

Inferred from mutant phenotype PubMed 16969386. Source: MGI

inflammatory response

Inferred from mutant phenotype PubMed 12055263PubMed 16969386. Source: MGI

membrane budding

Inferred from mutant phenotype PubMed 15905573. Source: MGI

membrane depolarization

Inferred from electronic annotation. Source: Ensembl

membrane protein ectodomain proteolysis

Inferred from mutant phenotype PubMed 17286969. Source: MGI

mitochondrion organization

Inferred from direct assay PubMed 16325464. Source: MGI

multicellular organismal protein catabolic process

Inferred from direct assay PubMed 11489964. Source: MGI

negative regulation of MAPK cascade

Inferred from direct assay PubMed 11489964. Source: MGI

negative regulation of bone resorption

Inferred from mutant phenotype PubMed 12677010. Source: MGI

neuronal action potential

Inferred from electronic annotation. Source: Ensembl

phagolysosome assembly

Inferred from mutant phenotype PubMed 11544318. Source: MGI

phospholipid transfer to membrane

Inferred from mutant phenotype PubMed 12370338. Source: MGI

phospholipid translocation

Inferred from direct assay PubMed 18097031. Source: MGI

plasma membrane organization

Inferred from direct assay PubMed 18097031. Source: MGI

pore complex assembly

Inferred from mutant phenotype PubMed 12370338PubMed 15937334PubMed 16269410. Source: MGI

positive regulation of MAPK cascade

Inferred from mutant phenotype PubMed 15937334. Source: MGI

positive regulation of T cell mediated cytotoxicity

Inferred from mutant phenotype PubMed 14761980. Source: MGI

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 16325464PubMed 16969386. Source: MGI

positive regulation of bone mineralization

Inferred from mutant phenotype PubMed 12677010PubMed 18519738. Source: MGI

positive regulation of calcium ion transport into cytosol

Inferred from electronic annotation. Source: Ensembl

positive regulation of catalytic activity

Inferred from mutant phenotype PubMed 14761980. Source: MGI

positive regulation of cytokine secretion

Inferred from mutant phenotype PubMed 18490713. Source: MGI

positive regulation of cytolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytoskeleton organization

Inferred from electronic annotation. Source: Ensembl

positive regulation of gamma-aminobutyric acid secretion

Inferred from mutant phenotype PubMed 15640761. Source: MGI

positive regulation of glutamate secretion

Inferred from mutant phenotype PubMed 15640761PubMed 17306762. Source: MGI

positive regulation of interleukin-1 alpha secretion

Inferred from mutant phenotype PubMed 18490713. Source: MGI

positive regulation of interleukin-1 beta production

Inferred from mutant phenotype PubMed 11016935. Source: MGI

positive regulation of interleukin-1 beta secretion

Inferred from mutant phenotype PubMed 11016935PubMed 15905573PubMed 18490713. Source: MGI

positive regulation of interleukin-6 production

Inferred from mutant phenotype PubMed 11016935. Source: MGI

positive regulation of lymphocyte apoptotic process

Inferred from mutant phenotype PubMed 16493071. Source: MGI

positive regulation of mitochondrial depolarization

Inferred from mutant phenotype PubMed 16198349. Source: MGI

positive regulation of ossification

Inferred from mutant phenotype PubMed 16269410PubMed 18519738. Source: MGI

positive regulation of prostaglandin secretion

Inferred from mutant phenotype PubMed 16269410. Source: MGI

positive regulation of protein phosphorylation

Inferred from mutant phenotype PubMed 15937334PubMed 17448897. Source: MGI

positive regulation of protein secretion

Inferred from direct assay PubMed 15240711. Source: MGI

protein oligomerization

Inferred from direct assay PubMed 15713258. Source: MGI

protein phosphorylation

Inferred from mutant phenotype PubMed 17306762. Source: MGI

protein processing

Inferred from mutant phenotype PubMed 11016935. Source: MGI

reactive oxygen species metabolic process

Inferred from mutant phenotype PubMed 17448897. Source: MGI

regulation of sodium ion transport

Inferred from electronic annotation. Source: Ensembl

release of sequestered calcium ion into cytosol

Inferred from mutant phenotype PubMed 18082965. Source: MGI

response to ATP

Inferred from direct assay PubMed 15240711PubMed 15713258. Source: MGI

response to bacterium

Inferred from mutant phenotype PubMed 10395640. Source: MGI

response to calcium ion

Inferred from direct assay PubMed 15240711. Source: MGI

response to drug

Inferred from mutant phenotype PubMed 18082965. Source: MGI

response to electrical stimulus

Inferred from mutant phenotype PubMed 15640761. Source: MGI

response to fluid shear stress

Inferred from mutant phenotype PubMed 16269410. Source: MGI

response to lipopolysaccharide

Inferred from direct assay PubMed 15240711. Source: MGI

response to mechanical stimulus

Inferred from mutant phenotype PubMed 16269410. Source: MGI

response to organic cyclic compound

Inferred from direct assay PubMed 15240711. Source: MGI

response to organic substance

Inferred from mutant phenotype PubMed 16116196PubMed 16455971PubMed 17286969. Source: MGI

response to zinc ion

Inferred from mutant phenotype PubMed 15978588PubMed 18082965. Source: MGI

skeletal system morphogenesis

Inferred from mutant phenotype PubMed 18519738. Source: MGI

synaptic vesicle exocytosis

Inferred from mutant phenotype PubMed 15713258. Source: MGI

transmembrane transport

Inferred from mutant phenotype PubMed 18519738. Source: GOC

   Cellular_componentbleb

Inferred from electronic annotation. Source: Ensembl

cell-cell junction

Inferred from direct assay PubMed 15331634. Source: MGI

cytoplasm

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from direct assay PubMed 17286969. Source: MGI

integral component of nuclear inner membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from mutant phenotype PubMed 12677010. Source: MGI

membrane

Inferred from direct assay PubMed 15713258. Source: MGI

membrane raft

Inferred from electronic annotation. Source: Ensembl

neuromuscular junction

Inferred from direct assay PubMed 15713258. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 15964665PubMed 15978588. Source: MGI

plasma membrane

Inferred from direct assay PubMed 15331634. Source: MGI

protein complex

Inferred from electronic annotation. Source: Ensembl

synapse

Inferred from direct assay PubMed 18082965. Source: MGI

terminal bouton

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from mutant phenotype PubMed 12677010. Source: MGI

channel activity

Inferred from mutant phenotype PubMed 18519738. Source: MGI

copper ion binding

Inferred from electronic annotation. Source: Ensembl

extracellular ATP-gated cation channel activity

Inferred from mutant phenotype PubMed 12677010PubMed 15713258. Source: MGI

lipopolysaccharide binding

Inferred from direct assay PubMed 11489964. Source: MGI

magnesium ion binding

Inferred from electronic annotation. Source: Ensembl

purinergic nucleotide receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor activity

Inferred from mutant phenotype PubMed 12677010. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8CHP4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: BE007FE195AF50A4

FASTA59568,388
        10         20         30         40         50         60 
MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 

        70         80         90        100        110        120 
VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 

       130        140        150        160        170        180 
EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA 

       190        200        210        220        230        240 
LLRSAENFTV LIKNNIHFPG HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE 

       250        260        270        280        290        300 
NFTEVAVQGG IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 

       310        320        330        340        350        360 
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLLINTYSS 

       370        380        390        400        410        420 
AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY VSFVDEPHIR MVDQQLLGKS 

       430        440        450        460        470        480 
LQVVKGQEVP RPQMDFSDLS RLSLSLHDSP LTPGQSEEIQ LLHEEVAPKS GDSPSWCQCG 

       490        500        510        520        530        540 
NCLPSRLPEQ RRALEELCCR RKPGRCITTS KLFHKLVLSR DTLQLLLLYQ DPLLVLGEEA 

       550        560        570        580        590 
TNSRLRHRAY RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKTEGQYSG FKYPY 

« Hide

References

[1]"A natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor."
Adriouch S., Dox C., Welge V., Seman M., Koch-Nolte F., Haag F.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6 EMBL CAD33538.1.
Tissue: Lymph node EMBL CAD33538.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ489296 mRNA. Translation: CAD33538.1.
RefSeqNP_001033928.1. NM_001038839.2.
NP_035157.2. NM_011027.3.
UniGeneMm.42026.

3D structure databases

ProteinModelPortalQ8CHP4.
SMRQ8CHP4. Positions 35-355.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8CHP4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID18439.
KEGGmmu:18439.

Organism-specific databases

CTD5027.
MGIMGI:1339957. P2rx7.

Phylogenomic databases

HOVERGENHBG053086.
InParanoidQ8CHP4.
KOK05220.
OMAFFVMTNF.

Gene expression databases

ArrayExpressQ8CHP4.
BgeeQ8CHP4.
GenevestigatorQ8CHP4.

Family and domain databases

Gene3D2.60.490.10. 1 hit.
InterProIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsTIGR00863. P2X. 1 hit.
PROSITEPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294114.
SOURCESearch...

Entry information

Entry nameQ8CHP4_MOUSE
AccessionPrimary (citable) accession number: Q8CHP4
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)