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Q8CHP4

- Q8CHP4_MOUSE

UniProt

Q8CHP4 - Q8CHP4_MOUSE

Protein

P2X purinoceptor

Gene

P2rx7

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: MGI
    2. channel activity Source: MGI
    3. copper ion binding Source: Ensembl
    4. extracellular ATP-gated cation channel activity Source: MGI
    5. lipopolysaccharide binding Source: MGI
    6. magnesium ion binding Source: Ensembl
    7. protein binding Source: MGI
    8. purinergic nucleotide receptor activity Source: RefGenome
    9. receptor activity Source: MGI
    10. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. bleb assembly Source: MGI
    3. calcium ion transport Source: MGI
    4. cation transport Source: MGI
    5. cell morphogenesis Source: MGI
    6. cellular response to extracellular stimulus Source: MGI
    7. cell volume homeostasis Source: MGI
    8. ceramide biosynthetic process Source: MGI
    9. collagen metabolic process Source: MGI
    10. cytolysis Source: MGI
    11. defense response to Gram-positive bacterium Source: MGI
    12. extrinsic apoptotic signaling pathway Source: MGI
    13. gene expression Source: MGI
    14. homeostasis of number of cells within a tissue Source: MGI
    15. inflammatory response Source: MGI
    16. membrane budding Source: MGI
    17. membrane depolarization Source: Ensembl
    18. membrane protein ectodomain proteolysis Source: MGI
    19. mitochondrion organization Source: MGI
    20. multicellular organismal protein catabolic process Source: MGI
    21. NAD transport Source: MGI
    22. negative regulation of bone resorption Source: MGI
    23. negative regulation of MAPK cascade Source: MGI
    24. neuronal action potential Source: Ensembl
    25. phagolysosome assembly Source: MGI
    26. phospholipid transfer to membrane Source: MGI
    27. phospholipid translocation Source: MGI
    28. plasma membrane organization Source: MGI
    29. pore complex assembly Source: MGI
    30. positive regulation of apoptotic process Source: MGI
    31. positive regulation of bone mineralization Source: MGI
    32. positive regulation of catalytic activity Source: MGI
    33. positive regulation of cytokine secretion Source: MGI
    34. positive regulation of cytolysis Source: Ensembl
    35. positive regulation of cytoskeleton organization Source: Ensembl
    36. positive regulation of gamma-aminobutyric acid secretion Source: MGI
    37. positive regulation of glutamate secretion Source: MGI
    38. positive regulation of interleukin-1 alpha secretion Source: MGI
    39. positive regulation of interleukin-1 beta production Source: MGI
    40. positive regulation of interleukin-1 beta secretion Source: MGI
    41. positive regulation of interleukin-6 production Source: MGI
    42. positive regulation of lymphocyte apoptotic process Source: MGI
    43. positive regulation of MAPK cascade Source: MGI
    44. positive regulation of mitochondrial depolarization Source: MGI
    45. positive regulation of ossification Source: MGI
    46. positive regulation of prostaglandin secretion Source: MGI
    47. positive regulation of protein phosphorylation Source: MGI
    48. positive regulation of protein secretion Source: MGI
    49. positive regulation of T cell mediated cytotoxicity Source: MGI
    50. programmed cell death Source: MGI
    51. protein oligomerization Source: MGI
    52. protein phosphorylation Source: MGI
    53. protein processing Source: MGI
    54. reactive oxygen species metabolic process Source: MGI
    55. regulation of sodium ion transport Source: Ensembl
    56. release of sequestered calcium ion into cytosol Source: MGI
    57. response to ATP Source: MGI
    58. response to bacterium Source: MGI
    59. response to calcium ion Source: MGI
    60. response to drug Source: MGI
    61. response to electrical stimulus Source: MGI
    62. response to fluid shear stress Source: MGI
    63. response to lipopolysaccharide Source: MGI
    64. response to mechanical stimulus Source: MGI
    65. response to organic cyclic compound Source: MGI
    66. response to organic substance Source: MGI
    67. response to zinc ion Source: MGI
    68. skeletal system morphogenesis Source: MGI
    69. synaptic vesicle exocytosis Source: MGI
    70. T cell homeostasis Source: MGI
    71. T cell proliferation Source: MGI
    72. transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Ion channelUniRule annotation, ReceptorUniRule annotation

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2X purinoceptorUniRule annotation
    Gene namesi
    Name:P2rx7Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1339957. P2rx7.

    Subcellular locationi

    GO - Cellular componenti

    1. bleb Source: Ensembl
    2. cell-cell junction Source: MGI
    3. cytoplasm Source: Ensembl
    4. external side of plasma membrane Source: MGI
    5. integral component of nuclear inner membrane Source: RefGenome
    6. integral component of plasma membrane Source: MGI
    7. membrane Source: MGI
    8. membrane raft Source: Ensembl
    9. neuromuscular junction Source: MGI
    10. neuronal cell body Source: MGI
    11. plasma membrane Source: MGI
    12. protein complex Source: Ensembl
    13. synapse Source: MGI
    14. terminal bouton Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8CHP4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8CHP4.
    BgeeiQ8CHP4.
    GenevestigatoriQ8CHP4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8CHP4.
    SMRiQ8CHP4. Positions 35-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the P2X receptor family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG053086.
    InParanoidiQ8CHP4.
    KOiK05220.
    OMAiLCPEYPT.

    Family and domain databases

    Gene3Di2.60.490.10. 1 hit.
    InterProiIPR003050. P2X7_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view]
    PANTHERiPTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF13. PTHR10125:SF13. 1 hit.
    PfamiPF00864. P2X_receptor. 1 hit.
    [Graphical view]
    PRINTSiPR01314. P2X7RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsiTIGR00863. P2X. 1 hit.
    PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8CHP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL    50
    YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN 100
    SFFVMTNYVK SEGQVQTLCP EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG 150
    RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA LLRSAENFTV LIKNNIHFPG 200
    HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE NFTEVAVQGG 250
    IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 300
    ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC 350
    IDLLINTYSS AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY 400
    VSFVDEPHIR MVDQQLLGKS LQVVKGQEVP RPQMDFSDLS RLSLSLHDSP 450
    LTPGQSEEIQ LLHEEVAPKS GDSPSWCQCG NCLPSRLPEQ RRALEELCCR 500
    RKPGRCITTS KLFHKLVLSR DTLQLLLLYQ DPLLVLGEEA TNSRLRHRAY 550
    RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKTEGQYSG FKYPY 595
    Length:595
    Mass (Da):68,388
    Last modified:March 1, 2003 - v1
    Checksum:iBE007FE195AF50A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ489296 mRNA. Translation: CAD33538.1.
    RefSeqiNP_001033928.1. NM_001038839.2.
    NP_035157.2. NM_011027.3.
    UniGeneiMm.42026.

    Genome annotation databases

    GeneIDi18439.
    KEGGimmu:18439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ489296 mRNA. Translation: CAD33538.1 .
    RefSeqi NP_001033928.1. NM_001038839.2.
    NP_035157.2. NM_011027.3.
    UniGenei Mm.42026.

    3D structure databases

    ProteinModelPortali Q8CHP4.
    SMRi Q8CHP4. Positions 35-355.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8CHP4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 18439.
    KEGGi mmu:18439.

    Organism-specific databases

    CTDi 5027.
    MGIi MGI:1339957. P2rx7.

    Phylogenomic databases

    HOVERGENi HBG053086.
    InParanoidi Q8CHP4.
    KOi K05220.
    OMAi LCPEYPT.

    Miscellaneous databases

    NextBioi 294114.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8CHP4.
    Bgeei Q8CHP4.
    Genevestigatori Q8CHP4.

    Family and domain databases

    Gene3Di 2.60.490.10. 1 hit.
    InterProi IPR003050. P2X7_purnocptor.
    IPR027309. P2X_extracellular_dom.
    IPR001429. P2X_purnocptor.
    [Graphical view ]
    PANTHERi PTHR10125. PTHR10125. 1 hit.
    PTHR10125:SF13. PTHR10125:SF13. 1 hit.
    Pfami PF00864. P2X_receptor. 1 hit.
    [Graphical view ]
    PRINTSi PR01314. P2X7RECEPTOR.
    PR01307. P2XRECEPTOR.
    TIGRFAMsi TIGR00863. P2X. 1 hit.
    PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor."
      Adriouch S., Dox C., Welge V., Seman M., Koch-Nolte F., Haag F.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.
      Tissue: Lymph nodeImported.

    Entry informationi

    Entry nameiQ8CHP4_MOUSE
    AccessioniPrimary (citable) accession number: Q8CHP4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)