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Protein

P2X purinoceptor

Gene

P2rx7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1339957. P2rx7.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ8CHP4.
PRIDEiQ8CHP4.

Expressioni

Gene expression databases

BgeeiQ8CHP4.
GenevisibleiQ8CHP4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098303.

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IK4U. Eukaryota.
ENOG4110DDY. LUCA.
HOVERGENiHBG053086.
KOiK05220.
OMAiLCPEYPT.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 3 hits.
PTHR10125:SF13. PTHR10125:SF13. 3 hits.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CHP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL
60 70 80 90 100
YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN
110 120 130 140 150
SFFVMTNYVK SEGQVQTLCP EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG
160 170 180 190 200
RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA LLRSAENFTV LIKNNIHFPG
210 220 230 240 250
HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE NFTEVAVQGG
260 270 280 290 300
IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK
310 320 330 340 350
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC
360 370 380 390 400
IDLLINTYSS AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY
410 420 430 440 450
VSFVDEPHIR MVDQQLLGKS LQVVKGQEVP RPQMDFSDLS RLSLSLHDSP
460 470 480 490 500
LTPGQSEEIQ LLHEEVAPKS GDSPSWCQCG NCLPSRLPEQ RRALEELCCR
510 520 530 540 550
RKPGRCITTS KLFHKLVLSR DTLQLLLLYQ DPLLVLGEEA TNSRLRHRAY
560 570 580 590
RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKTEGQYSG FKYPY
Length:595
Mass (Da):68,388
Last modified:March 1, 2003 - v1
Checksum:iBE007FE195AF50A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114632 Genomic DNA. No translation available.
AJ489296 mRNA. Translation: CAD33538.1.
RefSeqiNP_001033928.1. NM_001038839.2.
NP_035157.2. NM_011027.3.
UniGeneiMm.42026.

Genome annotation databases

EnsembliENSMUST00000100737; ENSMUSP00000098303; ENSMUSG00000029468.
GeneIDi18439.
KEGGimmu:18439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114632 Genomic DNA. No translation available.
AJ489296 mRNA. Translation: CAD33538.1.
RefSeqiNP_001033928.1. NM_001038839.2.
NP_035157.2. NM_011027.3.
UniGeneiMm.42026.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098303.

Proteomic databases

PeptideAtlasiQ8CHP4.
PRIDEiQ8CHP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100737; ENSMUSP00000098303; ENSMUSG00000029468.
GeneIDi18439.
KEGGimmu:18439.

Organism-specific databases

CTDi5027.
MGIiMGI:1339957. P2rx7.

Phylogenomic databases

eggNOGiENOG410IK4U. Eukaryota.
ENOG4110DDY. LUCA.
HOVERGENiHBG053086.
KOiK05220.
OMAiLCPEYPT.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ8CHP4.
GenevisibleiQ8CHP4. MM.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 3 hits.
PTHR10125:SF13. PTHR10125:SF13. 3 hits.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor."
    Adriouch S., Dox C., Welge V., Seman M., Koch-Nolte F., Haag F.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: Lymph nodeImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (AUG-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8CHP4_MOUSE
AccessioniPrimary (citable) accession number: Q8CHP4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.