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Q8CHP4

- Q8CHP4_MOUSE

UniProt

Q8CHP4 - Q8CHP4_MOUSE

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Protein

P2X purinoceptor

Gene

P2rx7

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. channel activity Source: MGI
  3. copper ion binding Source: Ensembl
  4. extracellular ATP-gated cation channel activity Source: MGI
  5. lipopolysaccharide binding Source: MGI
  6. magnesium ion binding Source: Ensembl
  7. purinergic nucleotide receptor activity Source: RefGenome
  8. receptor activity Source: MGI
  9. zinc ion binding Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. bleb assembly Source: MGI
  3. calcium ion transport Source: MGI
  4. cation transmembrane transport Source: GOC
  5. cation transport Source: MGI
  6. cell morphogenesis Source: MGI
  7. cellular response to extracellular stimulus Source: MGI
  8. cell volume homeostasis Source: MGI
  9. ceramide biosynthetic process Source: MGI
  10. collagen metabolic process Source: MGI
  11. cytolysis Source: MGI
  12. defense response to Gram-positive bacterium Source: MGI
  13. extrinsic apoptotic signaling pathway Source: MGI
  14. gene expression Source: MGI
  15. homeostasis of number of cells within a tissue Source: MGI
  16. inflammatory response Source: MGI
  17. membrane budding Source: MGI
  18. membrane depolarization Source: Ensembl
  19. membrane protein ectodomain proteolysis Source: MGI
  20. mitochondrion organization Source: MGI
  21. multicellular organismal protein catabolic process Source: MGI
  22. NAD transport Source: MGI
  23. negative regulation of bone resorption Source: MGI
  24. negative regulation of MAPK cascade Source: MGI
  25. neuronal action potential Source: Ensembl
  26. phagolysosome assembly Source: MGI
  27. phospholipid transfer to membrane Source: MGI
  28. phospholipid translocation Source: MGI
  29. plasma membrane organization Source: MGI
  30. pore complex assembly Source: MGI
  31. positive regulation of apoptotic process Source: MGI
  32. positive regulation of bone mineralization Source: MGI
  33. positive regulation of calcium ion transport into cytosol Source: Ensembl
  34. positive regulation of catalytic activity Source: MGI
  35. positive regulation of cytokine secretion Source: MGI
  36. positive regulation of cytolysis Source: Ensembl
  37. positive regulation of cytoskeleton organization Source: Ensembl
  38. positive regulation of gamma-aminobutyric acid secretion Source: MGI
  39. positive regulation of glutamate secretion Source: MGI
  40. positive regulation of interleukin-1 alpha secretion Source: MGI
  41. positive regulation of interleukin-1 beta production Source: MGI
  42. positive regulation of interleukin-1 beta secretion Source: MGI
  43. positive regulation of interleukin-6 production Source: MGI
  44. positive regulation of lymphocyte apoptotic process Source: MGI
  45. positive regulation of MAPK cascade Source: MGI
  46. positive regulation of mitochondrial depolarization Source: MGI
  47. positive regulation of ossification Source: MGI
  48. positive regulation of prostaglandin secretion Source: MGI
  49. positive regulation of protein phosphorylation Source: MGI
  50. positive regulation of protein secretion Source: MGI
  51. positive regulation of T cell mediated cytotoxicity Source: MGI
  52. programmed cell death Source: MGI
  53. protein oligomerization Source: MGI
  54. protein phosphorylation Source: MGI
  55. protein processing Source: MGI
  56. reactive oxygen species metabolic process Source: MGI
  57. regulation of sodium ion transport Source: Ensembl
  58. release of sequestered calcium ion into cytosol Source: MGI
  59. response to ATP Source: MGI
  60. response to bacterium Source: MGI
  61. response to calcium ion Source: MGI
  62. response to drug Source: MGI
  63. response to electrical stimulus Source: MGI
  64. response to fluid shear stress Source: MGI
  65. response to lipopolysaccharide Source: MGI
  66. response to mechanical stimulus Source: MGI
  67. response to organic cyclic compound Source: MGI
  68. response to organic substance Source: MGI
  69. response to zinc ion Source: MGI
  70. skeletal system morphogenesis Source: MGI
  71. synaptic vesicle exocytosis Source: MGI
  72. T cell homeostasis Source: MGI
  73. T cell proliferation Source: MGI
  74. transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1339957. P2rx7.

Subcellular locationi

GO - Cellular componenti

  1. bleb Source: Ensembl
  2. cell-cell junction Source: MGI
  3. cytoplasm Source: Ensembl
  4. external side of plasma membrane Source: MGI
  5. integral component of nuclear inner membrane Source: RefGenome
  6. integral component of plasma membrane Source: MGI
  7. membrane Source: MGI
  8. membrane raft Source: Ensembl
  9. neuromuscular junction Source: MGI
  10. neuronal cell body Source: MGI
  11. plasma membrane Source: MGI
  12. protein complex Source: Ensembl
  13. synapse Source: MGI
  14. terminal bouton Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8CHP4.

Expressioni

Gene expression databases

BgeeiQ8CHP4.
ExpressionAtlasiQ8CHP4. baseline and differential.
GenevestigatoriQ8CHP4.

Structurei

3D structure databases

ProteinModelPortaliQ8CHP4.
SMRiQ8CHP4. Positions 35-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG053086.
KOiK05220.
OMAiLCPEYPT.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CHP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL
60 70 80 90 100
YQRKEPVISS VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN
110 120 130 140 150
SFFVMTNYVK SEGQVQTLCP EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG
160 170 180 190 200
RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA LLRSAENFTV LIKNNIHFPG
210 220 230 240 250
HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE NFTEVAVQGG
260 270 280 290 300
IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK
310 320 330 340 350
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC
360 370 380 390 400
IDLLINTYSS AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY
410 420 430 440 450
VSFVDEPHIR MVDQQLLGKS LQVVKGQEVP RPQMDFSDLS RLSLSLHDSP
460 470 480 490 500
LTPGQSEEIQ LLHEEVAPKS GDSPSWCQCG NCLPSRLPEQ RRALEELCCR
510 520 530 540 550
RKPGRCITTS KLFHKLVLSR DTLQLLLLYQ DPLLVLGEEA TNSRLRHRAY
560 570 580 590
RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKTEGQYSG FKYPY
Length:595
Mass (Da):68,388
Last modified:March 1, 2003 - v1
Checksum:iBE007FE195AF50A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ489296 mRNA. Translation: CAD33538.1.
RefSeqiNP_001033928.1. NM_001038839.2.
NP_035157.2. NM_011027.3.
UniGeneiMm.42026.

Genome annotation databases

GeneIDi18439.
KEGGimmu:18439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ489296 mRNA. Translation: CAD33538.1 .
RefSeqi NP_001033928.1. NM_001038839.2.
NP_035157.2. NM_011027.3.
UniGenei Mm.42026.

3D structure databases

ProteinModelPortali Q8CHP4.
SMRi Q8CHP4. Positions 35-355.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8CHP4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 18439.
KEGGi mmu:18439.

Organism-specific databases

CTDi 5027.
MGIi MGI:1339957. P2rx7.

Phylogenomic databases

HOVERGENi HBG053086.
KOi K05220.
OMAi LCPEYPT.

Miscellaneous databases

NextBioi 294114.
SOURCEi Search...

Gene expression databases

Bgeei Q8CHP4.
ExpressionAtlasi Q8CHP4. baseline and differential.
Genevestigatori Q8CHP4.

Family and domain databases

Gene3Di 2.60.490.10. 1 hit.
InterProi IPR003050. P2X7_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view ]
PANTHERi PTHR10125. PTHR10125. 1 hit.
PTHR10125:SF13. PTHR10125:SF13. 1 hit.
Pfami PF00864. P2X_receptor. 1 hit.
[Graphical view ]
PRINTSi PR01314. P2X7RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsi TIGR00863. P2X. 1 hit.
PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor."
    Adriouch S., Dox C., Welge V., Seman M., Koch-Nolte F., Haag F.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: Lymph nodeImported.

Entry informationi

Entry nameiQ8CHP4_MOUSE
AccessioniPrimary (citable) accession number: Q8CHP4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)