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Protein

Zinc finger CCCH domain-containing protein 3

Gene

Zc3h3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the export of polyadenylated mRNAs from the nucleus (By similarity). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (PubMed:16115198).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri662 – 69029C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71724C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri718 – 74427C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri745 – 77228C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri773 – 79523C3H1-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • R-SMAD binding Source: MGI
  • SMAD binding Source: MGI

GO - Biological processi

  • mRNA 3'-end processing Source: MGI
  • mRNA polyadenylation Source: UniProtKB
  • poly(A)+ mRNA export from nucleus Source: UniProtKB
  • positive regulation of activin receptor signaling pathway Source: MGI
  • regulation of mRNA export from nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 3
Alternative name(s):
Smad-interacting CPSF-like factor1 Publication
Gene namesi
Name:Zc3h3
Synonyms:Kiaa0150, Smicl1 Publication, Zc3hdc3, Zfp623
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2663721. Zc3h3.

Subcellular locationi

GO - Cellular componenti

  • mRNA cleavage and polyadenylation specificity factor complex Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Zinc finger CCCH domain-containing protein 3PRO_0000213897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei405 – 4051PhosphoserineBy similarity
Modified residuei851 – 8511PhosphoserineCombined sources
Modified residuei855 – 8551PhosphoserineCombined sources
Modified residuei918 – 9181PhosphoserineBy similarity
Modified residuei920 – 9201PhosphoserineBy similarity
Modified residuei934 – 9341PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CHP0.
MaxQBiQ8CHP0.
PaxDbiQ8CHP0.
PRIDEiQ8CHP0.

PTM databases

iPTMnetiQ8CHP0.
PhosphoSiteiQ8CHP0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000075600.
CleanExiMM_ZC3H3.
ExpressionAtlasiQ8CHP0. baseline.
GenevisibleiQ8CHP0. MM.

Interactioni

Subunit structurei

Interacts with SMAD1, SMAD3, SMAD4, CPSF2 and CPSF3.1 Publication

GO - Molecular functioni

  • R-SMAD binding Source: MGI
  • SMAD binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098106.

Structurei

3D structure databases

ProteinModelPortaliQ8CHP0.
SMRiQ8CHP0. Positions 690-742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi379 – 38810Poly-Ser

Sequence similaritiesi

Contains 5 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri662 – 69029C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71724C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri718 – 74427C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri745 – 77228C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri773 – 79523C3H1-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1492. Eukaryota.
COG5084. LUCA.
GeneTreeiENSGT00390000009627.
HOGENOMiHOG000133053.
HOVERGENiHBG055611.
InParanoidiQ8CHP0.
OMAiGRCNRGE.
OrthoDBiEOG091G038R.
PhylomeDBiQ8CHP0.
TreeFamiTF324375.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 5 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8CHP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKEQLRRQ IRLLQGLIDD YKTLHGNGPA LGNSSATRWQ PPMFPGGRTF
60 70 80 90 100
GARYSRPSRR GFSSHHGPSW RKKYSLVNQP VESSDPASDP AFQTSLRSED
110 120 130 140 150
SQHPEPQQYV LERQVQLSPD QNMVIKIKPP SKSGAINASG VQRGSLEGCD
160 170 180 190 200
DPSWSGQRPQ GSEVEVPGGQ LQPARPGRTK VGYSVDDPLL VCQKEPGKPR
210 220 230 240 250
VVKSVGRVSD SSPEHRRTVS ENEVALRVHF PSVLPHHTAV ALGRKVGPHS
260 270 280 290 300
TSYSEQFIGD QRANTGHSDQ PASLGPVVAS VRPATARQVR EASLLVSCRT
310 320 330 340 350
SKFRKNNYKW VAASEKSPRV ARRALSPRTT LESGNKATLG TVGKTEKPQP
360 370 380 390 400
KVDPEVRPEK LATPSKPGLS PSKYKWKASS PSASSSSSFR WQSEAGSKDH
410 420 430 440 450
TSQLSPVPSR PTSGDRPAGG PSSLKPLFGE SQLSAYKVKS RTKIIRRRGN
460 470 480 490 500
TSIPGDKKNS PTTATTSKNH LTQRRRQALR GKNSPVLRKT PHKGLMQVNR
510 520 530 540 550
HRLCCLPSSR THLSTKEASS VHMGIPPSNK VIKTRYRIVK KTPSSSFGAP
560 570 580 590 600
SFPSSLPSWR ARRIPLSRSL VLNRLRPAIT GGGKAPPGTP RWRNKGYRCI
610 620 630 640 650
GGVLYKVSAN KLSKTSSRPS DGNRTLLRTG RLDPATTCSR SLASRAIQRS
660 670 680 690 700
LAIIRQAKQK KEKKREYCMY YNRFGRCNRG ECCPYIHDPE KVAVCTRFVR
710 720 730 740 750
GTCKKTDGSC PFSHHVSKEK MPVCSYFLKG ICSNSNCPYS HVYVSRKAEV
760 770 780 790 800
CSDFLKGYCP LGAKCKKKHT LLCPDFARRG ICPRGSQCQL LHRNQKRHGR
810 820 830 840 850
RTAAPPIPGP SDGAPRSKAS AGHVLRKPTT TQRSVRQMSS GLASGAEAPA
860 870 880 890 900
SPPPSPRVLA STSTLSSKAT AASSPSPSPS TSSPAPSLEQ EEAVSGTGSG
910 920 930 940 950
TGSSGLCKLP SFISLHSSPS PGGQTETGPQ APRSPRTKDS GKPLHIKPRL
Length:950
Mass (Da):103,224
Last modified:March 1, 2003 - v1
Checksum:iF21F8307492C21E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ516034 mRNA. Translation: CAD56773.1.
BC049953 mRNA. Translation: AAH49953.1.
BC060682 mRNA. Translation: AAH60682.1.
CCDSiCCDS27550.1.
RefSeqiNP_742119.1. NM_172121.1.
UniGeneiMm.209800.

Genome annotation databases

EnsembliENSMUST00000100538; ENSMUSP00000098106; ENSMUSG00000075600.
GeneIDi223642.
KEGGimmu:223642.
UCSCiuc007whf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ516034 mRNA. Translation: CAD56773.1.
BC049953 mRNA. Translation: AAH49953.1.
BC060682 mRNA. Translation: AAH60682.1.
CCDSiCCDS27550.1.
RefSeqiNP_742119.1. NM_172121.1.
UniGeneiMm.209800.

3D structure databases

ProteinModelPortaliQ8CHP0.
SMRiQ8CHP0. Positions 690-742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098106.

PTM databases

iPTMnetiQ8CHP0.
PhosphoSiteiQ8CHP0.

Proteomic databases

EPDiQ8CHP0.
MaxQBiQ8CHP0.
PaxDbiQ8CHP0.
PRIDEiQ8CHP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100538; ENSMUSP00000098106; ENSMUSG00000075600.
GeneIDi223642.
KEGGimmu:223642.
UCSCiuc007whf.1. mouse.

Organism-specific databases

CTDi23144.
MGIiMGI:2663721. Zc3h3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1492. Eukaryota.
COG5084. LUCA.
GeneTreeiENSGT00390000009627.
HOGENOMiHOG000133053.
HOVERGENiHBG055611.
InParanoidiQ8CHP0.
OMAiGRCNRGE.
OrthoDBiEOG091G038R.
PhylomeDBiQ8CHP0.
TreeFamiTF324375.

Miscellaneous databases

ChiTaRSiZc3h3. mouse.
PROiQ8CHP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075600.
CleanExiMM_ZC3H3.
ExpressionAtlasiQ8CHP0. baseline.
GenevisibleiQ8CHP0. MM.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 5 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3H3_MOUSE
AccessioniPrimary (citable) accession number: Q8CHP0
Secondary accession number(s): Q80X78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.