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Q8CHN6 (SGPL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sphingosine-1-phosphate lyase 1
Short name=S1PL
Short name=SP-lyase 1
Short name=SPL
Short name=SPL 1
EC=4.1.2.27
Alternative name(s):
Sphingosine-1-phosphate aldolase
Gene names
Name:Sgpl1
Synonyms:Spl
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis By similarity.

Catalytic activity

Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Lipid metabolism; sphingolipid metabolism.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity.

Sequence similarities

Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568Sphingosine-1-phosphate lyase 1
PRO_0000147014

Regions

Topological domain1 – 4141Lumenal Potential
Transmembrane42 – 6221Helical; Signal-anchor for type III membrane protein; Potential
Topological domain63 – 568506Cytoplasmic Potential

Amino acid modifications

Modified residue3531N6-(pyridoxal phosphate)lysine By similarity
Modified residue3531N6-acetyllysine By similarity
Modified residue5641Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8CHN6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A0B59A072CC79F48

FASTA56863,758
        10         20         30         40         50         60 
MPSTDLLKLK DFEPYLEILE AYSTKAKNYV NGYCTKYEPW QLIAGSVLCT LLVVWVYELI 

        70         80         90        100        110        120 
FQPESLWSRF KNKLFRLIRK MPFIGRKIQQ QLTKAKKDLV KNMPFLKLDK DYVKTLPAQG 

       130        140        150        160        170        180 
LSTAEVLERL KEYSSMDVFW QEGKASGAVY SGEPKLTELL VQAYGEFTWS NPLHPDIFPG 

       190        200        210        220        230        240 
LRKLEAEIVR MTCSLFNGGP DSCGCVTSGG TESILMACKA YRDLALEKGI KTPEIVAPES 

       250        260        270        280        290        300 
AHAAFDKAAH YFGMKIVRVA QKKNMEVDVR AMKRAISRNT AMLVCSAPQF PHGVIDPIPE 

       310        320        330        340        350        360 
VAKLAVKYKI PFHVDACLGG FLIVFMEKAG YPLEKPFDFR VKGVTSISAD THKYGYAPKG 

       370        380        390        400        410        420 
SSVVMYSNEK YRKYQFFVDA DWQGGIYASP SIAGSRPGGI IAACWAALMH FGENGYVEAT 

       430        440        450        460        470        480 
KQIIKTARFL KSELENIKNI FILGDPQLSV IALGSNDFDI YRLSNMMSAK GWNFNYLQFP 

       490        500        510        520        530        540 
RSIHFCITLV HTRKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ ATIDRKMVAE 

       550        560 
ISSVFLDSLY STDPVTQGNQ MNGSPKPR

« Hide

References

[1]"Comparison of sphingosine-1-phosphate lyases."
Van Veldhoven P.P.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ512838 mRNA. Translation: CAD55407.1.
IPIIPI00193172.
RefSeqNP_775139.1. NM_173116.1.
UniGeneRn.26953.

3D structure databases

ProteinModelPortalQ8CHN6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8CHN6.

PTM databases

PhosphoSiteQ8CHN6.

Proteomic databases

PRIDEQ8CHN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000065127; ENSRNOP00000059089; ENSRNOG00000000565.
GeneID286896.
KEGGrno:286896.
UCSCNM_173116. rat.

Organism-specific databases

CTD8879.
RGD628599. Sgpl1.

Phylogenomic databases

eggNOGroNOG05892.
GeneTreeENSGT00390000000046.
HOVERGENHBG056982.
InParanoidQ8CHN6.
OrthoDBEOG46T318.
PhylomeDBQ8CHN6.

Gene expression databases

ArrayExpressQ8CHN6.
GenevestigatorQ8CHN6.
GermOnlineENSRNOG00000000565. Rattus norvegicus.

Family and domain databases

InterProIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KOK01634.
PANTHERPTHR11999. Pyridoxal_deC. 1 hit.
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00392. DDC_GAD_HDC_YDC. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio624977.

Entry information

Entry nameSGPL1_RAT
AccessionPrimary (citable) accession number: Q8CHN6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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