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Protein

Sphingosine-1-phosphate lyase 1

Gene

Sgpl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.By similarity

Catalytic activityi

Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processApoptosis, Lipid metabolism, Sphingolipid metabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-RNO-1660661 Sphingolipid de novo biosynthesis
UniPathwayiUPA00222

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine-1-phosphate lyase 1Curated (EC:4.1.2.27By similarity)
Short name:
S1PL
Short name:
SP-lyase 1
Short name:
SPL
Short name:
SPL 1
Alternative name(s):
Sphingosine-1-phosphate aldolase
Gene namesi
Name:Sgpl1Imported
Synonyms:Spl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi628599 Sgpl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41LumenalSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini63 – 568CytoplasmicSequence analysisAdd BLAST506

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3826869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001470141 – 568Sphingosine-1-phosphate lyase 1Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei353N6-(pyridoxal phosphate)lysine; alternateBy similarity1
Modified residuei353N6-acetyllysine; alternateBy similarity1
Modified residuei356Nitrated tyrosineBy similarity1
Modified residuei366Nitrated tyrosineBy similarity1
Modified residuei564PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Nitration, Phosphoprotein

Proteomic databases

PaxDbiQ8CHN6
PRIDEiQ8CHN6

PTM databases

iPTMnetiQ8CHN6
PhosphoSitePlusiQ8CHN6

Expressioni

Gene expression databases

BgeeiENSRNOG00000000565
GenevisibleiQ8CHN6 RN

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059089

Chemistry databases

BindingDBiQ8CHN6

Structurei

3D structure databases

ProteinModelPortaliQ8CHN6
SMRiQ8CHN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1383 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00390000000046
HOGENOMiHOG000190693
HOVERGENiHBG056982
InParanoidiQ8CHN6
KOiK01634
OMAiDPHKMGL
OrthoDBiEOG091G040L
PhylomeDBiQ8CHN6
TreeFamiTF300777

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CHN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSTDLLKLK DFEPYLEILE AYSTKAKNYV NGYCTKYEPW QLIAGSVLCT
60 70 80 90 100
LLVVWVYELI FQPESLWSRF KNKLFRLIRK MPFIGRKIQQ QLTKAKKDLV
110 120 130 140 150
KNMPFLKLDK DYVKTLPAQG LSTAEVLERL KEYSSMDVFW QEGKASGAVY
160 170 180 190 200
SGEPKLTELL VQAYGEFTWS NPLHPDIFPG LRKLEAEIVR MTCSLFNGGP
210 220 230 240 250
DSCGCVTSGG TESILMACKA YRDLALEKGI KTPEIVAPES AHAAFDKAAH
260 270 280 290 300
YFGMKIVRVA QKKNMEVDVR AMKRAISRNT AMLVCSAPQF PHGVIDPIPE
310 320 330 340 350
VAKLAVKYKI PFHVDACLGG FLIVFMEKAG YPLEKPFDFR VKGVTSISAD
360 370 380 390 400
THKYGYAPKG SSVVMYSNEK YRKYQFFVDA DWQGGIYASP SIAGSRPGGI
410 420 430 440 450
IAACWAALMH FGENGYVEAT KQIIKTARFL KSELENIKNI FILGDPQLSV
460 470 480 490 500
IALGSNDFDI YRLSNMMSAK GWNFNYLQFP RSIHFCITLV HTRKRVAIQF
510 520 530 540 550
LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ ATIDRKMVAE ISSVFLDSLY
560
STDPVTQGNQ MNGSPKPR
Length:568
Mass (Da):63,758
Last modified:March 1, 2003 - v1
Checksum:iA0B59A072CC79F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512838 mRNA Translation: CAD55407.1
RefSeqiNP_775139.1, NM_173116.1
XP_008771092.1, XM_008772870.2
XP_008771093.1, XM_008772871.1
XP_008771094.1, XM_008772872.1
XP_008771095.1, XM_008772873.1
UniGeneiRn.26953

Genome annotation databases

EnsembliENSRNOT00000065127; ENSRNOP00000059089; ENSRNOG00000000565
ENSRNOT00000084391; ENSRNOP00000070983; ENSRNOG00000000565
GeneIDi286896
KEGGirno:286896
UCSCiRGD:628599 rat

Similar proteinsi

Entry informationi

Entry nameiSGPL1_RAT
AccessioniPrimary (citable) accession number: Q8CHN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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