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Protein

Sphingosine-1-phosphate lyase 1

Gene

Sgpl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity).By similarity

Catalytic activityi

Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.

Cofactori

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Apoptosis, Lipid metabolism, Sphingolipid metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-RNO-1660661. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine-1-phosphate lyase 1 (EC:4.1.2.27)
Short name:
S1PL
Short name:
SP-lyase 1
Short name:
SPL
Short name:
SPL 1
Alternative name(s):
Sphingosine-1-phosphate aldolase
Gene namesi
Name:Sgpl1
Synonyms:Spl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi628599. Sgpl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141LumenalSequence analysisAdd
BLAST
Transmembranei42 – 6221Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini63 – 568506CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Sphingosine-1-phosphate lyase 1PRO_0000147014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei353 – 3531N6-(pyridoxal phosphate)lysine; alternateBy similarity
Modified residuei353 – 3531N6-acetyllysine; alternateBy similarity
Modified residuei356 – 3561Nitrated tyrosineBy similarity
Modified residuei366 – 3661Nitrated tyrosineBy similarity
Modified residuei564 – 5641PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Nitration, Phosphoprotein

Proteomic databases

PaxDbiQ8CHN6.
PRIDEiQ8CHN6.

PTM databases

iPTMnetiQ8CHN6.
PhosphoSiteiQ8CHN6.

Expressioni

Gene expression databases

GenevisibleiQ8CHN6. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4575291.
STRINGi10116.ENSRNOP00000059089.

Structurei

3D structure databases

ProteinModelPortaliQ8CHN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1383. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00390000000046.
HOGENOMiHOG000190693.
HOVERGENiHBG056982.
InParanoidiQ8CHN6.
KOiK01634.
OMAiCTLKEGM.
OrthoDBiEOG76T9QX.
PhylomeDBiQ8CHN6.
TreeFamiTF300777.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CHN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSTDLLKLK DFEPYLEILE AYSTKAKNYV NGYCTKYEPW QLIAGSVLCT
60 70 80 90 100
LLVVWVYELI FQPESLWSRF KNKLFRLIRK MPFIGRKIQQ QLTKAKKDLV
110 120 130 140 150
KNMPFLKLDK DYVKTLPAQG LSTAEVLERL KEYSSMDVFW QEGKASGAVY
160 170 180 190 200
SGEPKLTELL VQAYGEFTWS NPLHPDIFPG LRKLEAEIVR MTCSLFNGGP
210 220 230 240 250
DSCGCVTSGG TESILMACKA YRDLALEKGI KTPEIVAPES AHAAFDKAAH
260 270 280 290 300
YFGMKIVRVA QKKNMEVDVR AMKRAISRNT AMLVCSAPQF PHGVIDPIPE
310 320 330 340 350
VAKLAVKYKI PFHVDACLGG FLIVFMEKAG YPLEKPFDFR VKGVTSISAD
360 370 380 390 400
THKYGYAPKG SSVVMYSNEK YRKYQFFVDA DWQGGIYASP SIAGSRPGGI
410 420 430 440 450
IAACWAALMH FGENGYVEAT KQIIKTARFL KSELENIKNI FILGDPQLSV
460 470 480 490 500
IALGSNDFDI YRLSNMMSAK GWNFNYLQFP RSIHFCITLV HTRKRVAIQF
510 520 530 540 550
LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ ATIDRKMVAE ISSVFLDSLY
560
STDPVTQGNQ MNGSPKPR
Length:568
Mass (Da):63,758
Last modified:March 1, 2003 - v1
Checksum:iA0B59A072CC79F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512838 mRNA. Translation: CAD55407.1.
RefSeqiNP_775139.1. NM_173116.1.
XP_008771092.1. XM_008772870.1.
XP_008771093.1. XM_008772871.1.
XP_008771094.1. XM_008772872.1.
XP_008771095.1. XM_008772873.1.
UniGeneiRn.26953.

Genome annotation databases

EnsembliENSRNOT00000065127; ENSRNOP00000059089; ENSRNOG00000000565.
ENSRNOT00000084391; ENSRNOP00000070983; ENSRNOG00000000565.
GeneIDi286896.
KEGGirno:286896.
UCSCiRGD:628599. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512838 mRNA. Translation: CAD55407.1.
RefSeqiNP_775139.1. NM_173116.1.
XP_008771092.1. XM_008772870.1.
XP_008771093.1. XM_008772871.1.
XP_008771094.1. XM_008772872.1.
XP_008771095.1. XM_008772873.1.
UniGeneiRn.26953.

3D structure databases

ProteinModelPortaliQ8CHN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4575291.
STRINGi10116.ENSRNOP00000059089.

PTM databases

iPTMnetiQ8CHN6.
PhosphoSiteiQ8CHN6.

Proteomic databases

PaxDbiQ8CHN6.
PRIDEiQ8CHN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065127; ENSRNOP00000059089; ENSRNOG00000000565.
ENSRNOT00000084391; ENSRNOP00000070983; ENSRNOG00000000565.
GeneIDi286896.
KEGGirno:286896.
UCSCiRGD:628599. rat.

Organism-specific databases

CTDi8879.
RGDi628599. Sgpl1.

Phylogenomic databases

eggNOGiKOG1383. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00390000000046.
HOGENOMiHOG000190693.
HOVERGENiHBG056982.
InParanoidiQ8CHN6.
KOiK01634.
OMAiCTLKEGM.
OrthoDBiEOG76T9QX.
PhylomeDBiQ8CHN6.
TreeFamiTF300777.

Enzyme and pathway databases

UniPathwayiUPA00222.
ReactomeiR-RNO-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

PROiQ8CHN6.

Gene expression databases

GenevisibleiQ8CHN6. RN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparison of sphingosine-1-phosphate lyases."
    Van Veldhoven P.P.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSGPL1_RAT
AccessioniPrimary (citable) accession number: Q8CHN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.