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Protein
Submitted name:

Ribosomal protein S6 kinase

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ribonucleoprotein, Ribosomal proteinImported, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ribosomal protein S6 kinaseImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8CHM5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024619.

Structurei

3D structure databases

ProteinModelPortaliQ8CHM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000233033.
HOVERGENiHBG108317.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8CHM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EEGIVKEIDI SNHVKEGFEK ADPSQFELLK VLGQGSYGKV FLVRKVTGSD
60 70 80 90 100
AGQLYAMKVL KKATLKVRDR VRSKMERDIL AEVNHPFIVK LHYAFQTEGK
110 120 130 140 150
LYLILDFLRG GDLFTRLSKE VMFTEEDVKF YLAELALALD HLHGLGIIYR
160 170 180 190 200
DLKPENILLD EEGHIKITDF GLSKEATDHD KRAYSFCGTI EYMAPEVVNR
210 220 230 240 250
RGHTQSADWW SFGVLMFEML TGSLPFQGKD RKETMALILK AKLGMPQFLS
260 270 280 290 300
AEAQSLLRAL FKRNPCNRLG AGVDGVEEIK RHPFFVTIDW NKLYRKEIKP
310 320 330 340 350
PFKPAVGRPE DTFHFDPEFT ARTPTDSPGV PPSANAHHLF RGFSFVASSL
360 370 380 390 400
VQEPSQQDVP KAPIHPIVQQ LHGNNIHFTD GYEIKEDIGV GSYSVCKRCV
410 420 430 440 450
HKATDAEYAV KIIDKSKRDP SEEIEILLRY GQHPNIITLK DVYDDGKYVY
460 470 480 490 500
LVMELMRGGE LLDRILRQRC FSEREASDVL YTIARTMDYL HSQGVGLPAL
510 520 530 540 550
PVVVHRDLKP SNILYMDESG NPESIRICDF GFAKQLRAEN GLLMTPCYTA
560 570 580 590 600
NFVAPEVLKR QGYDAACDVW SLGILLYTML AGFTPFANGP DDTPEEILAR
610 620 630 640 650
IGSGKYALSG GNWDSISDAA KDVVSKMLHV DPQQRLTAVQ VLKHPWIVNR
660 670 680 690 700
EYLSQNQLSR QDVHLVKGAM AATYFALNRT PQAPRLEPVL SSSLAQRRGM

KRLTSTRL
Length:708
Mass (Da):79,908
Last modified:March 1, 2003 - v1
Checksum:i156CDD42B331307E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF551762 Genomic DNA. Translation: AAN71007.1.
UniGeneiMm.268383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF551762 Genomic DNA. Translation: AAN71007.1.
UniGeneiMm.268383.

3D structure databases

ProteinModelPortaliQ8CHM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000233033.
HOVERGENiHBG108317.

Gene expression databases

GenevestigatoriQ8CHM5.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic Sequence Analysis in the Mouse T-complex Region."
    Brathwaite M., Waeltz P., Dudekula D., Qian Y., Schlessinger D., Nagaraja R.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJImported.

Entry informationi

Entry nameiQ8CHM5_MOUSE
AccessioniPrimary (citable) accession number: Q8CHM5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.