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Protein

Aquaporin-11

Gene

Aqp11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-432047 Passive transport by Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-11
Short name:
AQP-11
Gene namesi
Name:Aqp11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628763 Aqp11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei75 – 95Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639701 – 271Aquaporin-11Add BLAST271

Proteomic databases

PaxDbiQ8CHM1

Expressioni

Gene expression databases

BgeeiENSRNOG00000013358
GenevisibleiQ8CHM1 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018091

Structurei

3D structure databases

ProteinModelPortaliQ8CHM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi99 – 101NPA 13
Motifi216 – 218NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUS Eukaryota
ENOG4111GCP LUCA
GeneTreeiENSGT00530000063816
HOGENOMiHOG000034024
HOVERGENiHBG050556
InParanoidiQ8CHM1
KOiK09870
OMAiCCTHELQ
OrthoDBiEOG091G0JBQ
PhylomeDBiQ8CHM1
TreeFamiTF320251

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023266 Aquaporin_11
IPR016697 Aquaporin_11/12
IPR000425 MIP
PANTHERiPTHR21191:SF7 PTHR21191:SF7, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PIRSFiPIRSF017529 Aquaporin_11/12, 1 hit
PRINTSiPR02024 AQUAPORIN11
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CHM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLGLPPE VQDTCISLGL MLLVVLFMGL ARVIARQQLH RPMVHAFVLE
60 70 80 90 100
FLATFQLCYC THELQLLSEQ DSGHPTWTLT LIYFFSLVHG LTLVGTASNP
110 120 130 140 150
CGVMMQMILG GMSPEMGAVR LMAQLVSALC SRYCISALWS LSLTKYHFDE
160 170 180 190 200
RILACRNPIN TDISKAIIIE AICSFIFHSA LLHFQEVRTK LRIHVLAALI
210 220 230 240 250
TFLAYAGGSL TGALFNPALA LSLHFPCFDE SFYKFFVVYW VAPSLGVLLM
260 270
ILMFSFFLPW LHNNQLSNKK E
Length:271
Mass (Da):30,369
Last modified:May 10, 2005 - v2
Checksum:iC309985D82B1E748
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150E → K in BAC45003 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023644 mRNA Translation: BAC45003.1
BC078694 mRNA Translation: AAH78694.1
RefSeqiNP_775128.1, NM_173105.1
UniGeneiRn.20144

Genome annotation databases

EnsembliENSRNOT00000018091; ENSRNOP00000018091; ENSRNOG00000013358
GeneIDi286758
KEGGirno:286758
UCSCiRGD:628763 rat

Similar proteinsi

Entry informationi

Entry nameiAQP11_RAT
AccessioniPrimary (citable) accession number: Q8CHM1
Secondary accession number(s): Q6AZ79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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