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Protein

Aquaporin-11

Gene

Aqp11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein homooligomerization Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-11
Short name:
AQP-11
Gene namesi
Name:Aqp11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628763. Aqp11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytosol Source: RGD
  • dendrite Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Aquaporin-11PRO_0000063970Add
BLAST

Proteomic databases

PaxDbiQ8CHM1.
PRIDEiQ8CHM1.

Expressioni

Gene expression databases

GenevisibleiQ8CHM1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018091.

Structurei

3D structure databases

ProteinModelPortaliQ8CHM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 1013NPA 1
Motifi216 – 2183NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUS. Eukaryota.
ENOG4111GCP. LUCA.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8CHM1.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG7327QH.
PhylomeDBiQ8CHM1.
TreeFamiTF320251.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8CHM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLGLPPE VQDTCISLGL MLLVVLFMGL ARVIARQQLH RPMVHAFVLE
60 70 80 90 100
FLATFQLCYC THELQLLSEQ DSGHPTWTLT LIYFFSLVHG LTLVGTASNP
110 120 130 140 150
CGVMMQMILG GMSPEMGAVR LMAQLVSALC SRYCISALWS LSLTKYHFDE
160 170 180 190 200
RILACRNPIN TDISKAIIIE AICSFIFHSA LLHFQEVRTK LRIHVLAALI
210 220 230 240 250
TFLAYAGGSL TGALFNPALA LSLHFPCFDE SFYKFFVVYW VAPSLGVLLM
260 270
ILMFSFFLPW LHNNQLSNKK E
Length:271
Mass (Da):30,369
Last modified:May 10, 2005 - v2
Checksum:iC309985D82B1E748
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501E → K in BAC45003 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023644 mRNA. Translation: BAC45003.1.
BC078694 mRNA. Translation: AAH78694.1.
RefSeqiNP_775128.1. NM_173105.1.
UniGeneiRn.20144.

Genome annotation databases

EnsembliENSRNOT00000018091; ENSRNOP00000018091; ENSRNOG00000013358.
GeneIDi286758.
KEGGirno:286758.
UCSCiRGD:628763. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023644 mRNA. Translation: BAC45003.1.
BC078694 mRNA. Translation: AAH78694.1.
RefSeqiNP_775128.1. NM_173105.1.
UniGeneiRn.20144.

3D structure databases

ProteinModelPortaliQ8CHM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018091.

Proteomic databases

PaxDbiQ8CHM1.
PRIDEiQ8CHM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018091; ENSRNOP00000018091; ENSRNOG00000013358.
GeneIDi286758.
KEGGirno:286758.
UCSCiRGD:628763. rat.

Organism-specific databases

CTDi282679.
RGDi628763. Aqp11.

Phylogenomic databases

eggNOGiENOG410IHUS. Eukaryota.
ENOG4111GCP. LUCA.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8CHM1.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG7327QH.
PhylomeDBiQ8CHM1.
TreeFamiTF320251.

Enzyme and pathway databases

ReactomeiR-RNO-432047. Passive transport by Aquaporins.

Miscellaneous databases

PROiQ8CHM1.

Gene expression databases

GenevisibleiQ8CHM1. RN.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new superfamily of aquaporin."
    Ishibashi K., Imai M.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiAQP11_RAT
AccessioniPrimary (citable) accession number: Q8CHM1
Secondary accession number(s): Q6AZ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2005
Last modified: June 8, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.